KEGG   Mustela lutreola (European mink): 131839655
Entry
131839655         CDS       T09578                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
mlk  Mustela lutreola (European mink)
Pathway
mlk01522  Endocrine resistance
mlk04010  MAPK signaling pathway
mlk04015  Rap1 signaling pathway
mlk04068  FoxO signaling pathway
mlk04071  Sphingolipid signaling pathway
mlk04114  Oocyte meiosis
mlk04148  Efferocytosis
mlk04218  Cellular senescence
mlk04261  Adrenergic signaling in cardiomyocytes
mlk04370  VEGF signaling pathway
mlk04380  Osteoclast differentiation
mlk04550  Signaling pathways regulating pluripotency of stem cells
mlk04611  Platelet activation
mlk04613  Neutrophil extracellular trap formation
mlk04620  Toll-like receptor signaling pathway
mlk04621  NOD-like receptor signaling pathway
mlk04622  RIG-I-like receptor signaling pathway
mlk04625  C-type lectin receptor signaling pathway
mlk04657  IL-17 signaling pathway
mlk04658  Th1 and Th2 cell differentiation
mlk04659  Th17 cell differentiation
mlk04660  T cell receptor signaling pathway
mlk04664  Fc epsilon RI signaling pathway
mlk04668  TNF signaling pathway
mlk04670  Leukocyte transendothelial migration
mlk04714  Thermogenesis
mlk04722  Neurotrophin signaling pathway
mlk04723  Retrograde endocannabinoid signaling
mlk04728  Dopaminergic synapse
mlk04750  Inflammatory mediator regulation of TRP channels
mlk04912  GnRH signaling pathway
mlk04914  Progesterone-mediated oocyte maturation
mlk04917  Prolactin signaling pathway
mlk04926  Relaxin signaling pathway
mlk04932  Non-alcoholic fatty liver disease
mlk04933  AGE-RAGE signaling pathway in diabetic complications
mlk04935  Growth hormone synthesis, secretion and action
mlk04936  Alcoholic liver disease
mlk05014  Amyotrophic lateral sclerosis
mlk05020  Prion disease
mlk05022  Pathways of neurodegeneration - multiple diseases
mlk05132  Salmonella infection
mlk05133  Pertussis
mlk05135  Yersinia infection
mlk05140  Leishmaniasis
mlk05142  Chagas disease
mlk05145  Toxoplasmosis
mlk05152  Tuberculosis
mlk05161  Hepatitis B
mlk05163  Human cytomegalovirus infection
mlk05167  Kaposi sarcoma-associated herpesvirus infection
mlk05169  Epstein-Barr virus infection
mlk05170  Human immunodeficiency virus 1 infection
mlk05171  Coronavirus disease - COVID-19
mlk05205  Proteoglycans in cancer
mlk05208  Chemical carcinogenesis - reactive oxygen species
mlk05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlk05415  Diabetic cardiomyopathy
mlk05417  Lipid and atherosclerosis
mlk05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlk00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    131839655 (MAPK12)
   04015 Rap1 signaling pathway
    131839655 (MAPK12)
   04370 VEGF signaling pathway
    131839655 (MAPK12)
   04668 TNF signaling pathway
    131839655 (MAPK12)
   04068 FoxO signaling pathway
    131839655 (MAPK12)
   04071 Sphingolipid signaling pathway
    131839655 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    131839655 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    131839655 (MAPK12)
   04218 Cellular senescence
    131839655 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    131839655 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    131839655 (MAPK12)
   04613 Neutrophil extracellular trap formation
    131839655 (MAPK12)
   04620 Toll-like receptor signaling pathway
    131839655 (MAPK12)
   04621 NOD-like receptor signaling pathway
    131839655 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    131839655 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    131839655 (MAPK12)
   04660 T cell receptor signaling pathway
    131839655 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    131839655 (MAPK12)
   04659 Th17 cell differentiation
    131839655 (MAPK12)
   04657 IL-17 signaling pathway
    131839655 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    131839655 (MAPK12)
   04670 Leukocyte transendothelial migration
    131839655 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    131839655 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    131839655 (MAPK12)
   04917 Prolactin signaling pathway
    131839655 (MAPK12)
   04926 Relaxin signaling pathway
    131839655 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    131839655 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    131839655 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    131839655 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    131839655 (MAPK12)
   04722 Neurotrophin signaling pathway
    131839655 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    131839655 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    131839655 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    131839655 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    131839655 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    131839655 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    131839655 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    131839655 (MAPK12)
   05161 Hepatitis B
    131839655 (MAPK12)
   05171 Coronavirus disease - COVID-19
    131839655 (MAPK12)
   05163 Human cytomegalovirus infection
    131839655 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    131839655 (MAPK12)
   05169 Epstein-Barr virus infection
    131839655 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    131839655 (MAPK12)
   05135 Yersinia infection
    131839655 (MAPK12)
   05133 Pertussis
    131839655 (MAPK12)
   05152 Tuberculosis
    131839655 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    131839655 (MAPK12)
   05140 Leishmaniasis
    131839655 (MAPK12)
   05142 Chagas disease
    131839655 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    131839655 (MAPK12)
   05020 Prion disease
    131839655 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    131839655 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    131839655 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    131839655 (MAPK12)
   05415 Diabetic cardiomyopathy
    131839655 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    131839655 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    131839655 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    131839655 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    131839655 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mlk01001]
    131839655 (MAPK12)
Enzymes [BR:mlk01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     131839655 (MAPK12)
Protein kinases [BR:mlk01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   131839655 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 131839655
NCBI-ProteinID: XP_059043348
LinkDB
Position
8:complement(151032363..151041400)
AA seq 371 aa
MSSPPPARRGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELYAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWTRYTQTVDIWSAGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSADAKNYMKGLPELEKKDFASILTNASPLALPVAVNLLEKMLVLDA
ERRVTAAEALTHPYFESLQDTEDEPTAQKYDESFDDMDHTLDDWKRVTYKEVLSFKPPRQ
LGTKVSKETAL
NT seq 1116 nt   +upstreamnt  +downstreamnt
atgagctcgccgccgcccgcccgcaggggcttctaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtgtaccaggacctgcagcccgtgggctcgggcgcctacggcgcg
gtgtgctcggccgtggacagccgcactggcgccaaggtggccatcaagaagctgtaccgg
cccttccagtcggagctgtacgccaagcgcgcctaccgcgagctgcgtctcctcaagcac
atgcgccacgagaacgtcatcgggctgctggatgtgttcactcctgatgaaaccctggat
gatttcacagacttttacctggtgatgccgttcatggggactgacctgggcaagctcatg
aagcacgagaagctgagtgaggaccgaatccagttcctcgtctaccagatgctgaagggg
ctaaagtatatccatgctgctggcatcatccacagggacctgaagcccggcaatctggcg
gtgaacgaggactgtgagctgaagatcctggactttggcctggcgaggcaggccgacagc
gagatgaccgggtatgtggtgacccggtggtaccgggcacctgaagtcatcttgaattgg
acgcgctacacgcagacagtggacatctggtcggcgggctgcatcatggcagagatgatc
actgggaagacgctgttcaagggcagtgaccacctggaccagctgaaggagatcatgaag
gtgaccgggacgcctcctgcggagtttgttcagaggctgcagagtgccgatgcgaagaac
tacatgaagggcctccccgagctggagaagaaggatttcgcctccatcctgactaatgca
agccctctggccctccctgtagccgtgaaccttctggagaaaatgctggtgctggatgca
gagcggcgggtgactgcggccgaggcgctgacccacccctacttcgagtcactacaggac
acggaggacgagcccacggcccagaagtacgacgagtcctttgatgatatggatcacacg
ctggacgactggaaacgtgtcacatataaagaagtgctcagcttcaagcctccccggcag
ctggggaccaaggtctccaaggagacggctctgtga

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