Mus pahari (shrew mouse): 110319080 Help Entry 110319080         CDS       T05929                                  Symbol Ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism mpah  Mus pahari (shrew mouse) Pathway mpah04020   Calcium signaling pathway mpah04371   Apelin signaling pathway mpah04713   Circadian entrainment mpah04921   Oxytocin signaling pathway mpah04970   Salivary secretion mpah05010   Alzheimer disease mpah05012   Parkinson disease mpah05020   Prion disease mpah05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:mpah00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110319080 (Ryr3)    04020 Calcium signaling pathway     110319080 (Ryr3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     110319080 (Ryr3)   09154 Digestive system    04970 Salivary secretion     110319080 (Ryr3)   09159 Environmental adaptation    04713 Circadian entrainment     110319080 (Ryr3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     110319080 (Ryr3)    05012 Parkinson disease     110319080 (Ryr3)    05020 Prion disease     110319080 (Ryr3)    05022 Pathways of neurodegeneration - multiple diseases     110319080 (Ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mpah04040]     110319080 (Ryr3) Ion channels [BR:mpah04040]  Voltage-gated cation channels   Ryanodine receptor    110319080 (Ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  110319080 NCBI-ProteinID:  XP_021050159 Ensembl:  MGP_PahariEiJ_G0025538 LinkDB All DBs Position 3:complement(96220053..96745312) Genome browser AA seq 4888 aa AA seqDB search MLVDATISIFHESTRHLDGHLLHYRPFNFYGPCFPMQEDEVVLQCIANIHKEQRKFCLAA EGLGNRLCFLEPTSEAKYIPPDLCVCSFVLEQSLSVRALQEMLANTVENGGEGAAQGGSH RTLLYGHAILLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRS EGEKVRIGDDLILVSVSSERYLHLSISNGSIQVDASFMQTLWNVHPTCSGSSIEEGYLLG GHVVRLFHGHDECLTIPSTDQNDSQHRRVFYEAGGAGTRARSLWRVEPLRISWSGSNIRW GQAFRLRHLTTGHYLALTEDQGLLLQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIEG MGVPEIKYGDSVCFVQHVASGLWVTYKAQDAKTSRLGPLRRKVILHQEGHMDDGLTLQRC QQEESQAARIIRNTTALFSQFVSGNNRTTAPVALPTEEVLQTLQDLIAYFQPPEEEMQHE DKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIVREESGMAWKEILNLL YKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGH IKSIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVT SIRPNIFLGVAEGSPQYKKWYFELIIDQVEPFLTAEPTHLRVGWASSSGYAPYPGGGEGW GGNGVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQ PVQGMFENFSTDGLFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMR LEPVKEYKRDADGVRDLLGTTQFLSQASFIPCPIDTSQVVLPLHLEKIRDRLAENIHELW GMNKIELGWTYGKVRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHV NPAAEEDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIK QGWTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELAD PTVEKVSIDKIRFFRVERSYAVKSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQA FVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMVFTLNGELLITNKGSELAFAD YEIENGFVPICSLGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAVWFSKR LPTFVNVPKDHPHIEVVRIDGTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHSSF SHSPCLDSEAFQKRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFD LNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVASSQRSSRSNVDLEIGCLLDLAMG MLSFSANGKELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEK NPIPQCPPRLDVQTIQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEEN RCVDILELCEQEDLMQFHYHTLRLYSAVCALGNSRVASALCSHVDLSQLFYAIDNKYLPG LLRSGFYDLLISIHLANAKERKLMMKNEYIIPITSATRNIRLYPDESKRHGLPGVGLRTC LKPGFRFSTPCFVVTSEEHQKQSPEIPLQILKTKALSMLTEAVHCSGAHIRDPVGGSVEF QFVPVLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSGETEEGVDKEVTHAEEKAVEA GEKACKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQ KFRYNELMQALNMSAALTARKTREFRSPPQEQINMLLNFHLGENCPCPEEIREELYAFHE DLLVHCGVPLEEEEEEEEDTSWTGKLCALVYKIKGPPKPEKEQPTEEEKPYPTTLKELVS QTMIRWAQENQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVNDTINLLAAL GQIRSLLSVRMGREEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEK LQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAA SSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLLARGYPDVGWNPIEGERYLSFLRF AVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQ GYKTEVTQDDGEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRS LVPTEDLVGIISIPLKLPSLNKDGSVTEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLL HLLEVGFLPDLRASASLDTVSLSTTEAALALNRYLCSAVLPLLTRCAPLFSGTEHCTSLI DSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLSEYCKM PLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDLDLFRMA LPCLSAIAGALPPDYLDTRITATLEKQVSVDADGNFDPKPINTMNFSLPEKLEYIVTKYA EHSHDKWACDKSHSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAV GWTVERTKEGEALVQQRENEKLRCVSQTNQGNSYSPAPLDLSNVVLSRELQGMVEVVAEN YHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGILVSRGM KDMALDASSMEKRFAYKFLKKILKYVDAAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKV LLPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDS TTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQ IKGVSQNINYTTVALLPILTSIFEHIAQHQFGVDLLLSDVQISCYHILCSLYSLGTGKNI YVERQRPALGECLASLAAAIPVAFLEPSLTRYNPLSVFNTKTPRERSILGMPDKVEDMCP DIPQLEGLMKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCT KVTSEHLSLILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKL KKKAVKTVQEEEQLKTDGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLK SPDPDSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVK SGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCRDT DEEVKEHLRNNLHLQEKSDDPAVKWQLNLYKDVLRNDEPSNPEKTVERVQSISAALFHLE QVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEAY SFEEKLVQDLAKSPRVEDEEEEETERQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSS MMAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMS PMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQN KAEGLGMVTEEGTLIVRERGEKVLQNDEFTQDLFRFLQLLCEGHNSDFQNFLRTQMGNTT TVNIIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQG PCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLL EGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISRK EFQKAMEGLKQYTQSEIDFLLSCTEADENDMFNYADFVERFHEPAKDIGFNVAVLLTNLS EHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVK ESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSTERPEEEEEEDEDSA YLIETEGEEEDKSFESASAFTMACVSVKRNVTKFLKRATLKNLRKQYRNVKKMSAKELVR VFFFFFWMLFVGLFQLLFTILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFG IHDDVIETDRVEVTEPGVTTELVHFVKGEAGDTDLMSDLFGIHSKKEGGLKQGPEVGLGD LSEIIGKDEPPTLESTVRKKRKAQAAEMKAVHEAEGKAESEKADMEDREKEDKIKEEGQA EYPWADMTVKKTRRRGQKAEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAF AINFILLFYKVTEEPLEEETEDVANLWHSFNDDDEEEAMVFFVLQESTGYMAPTLRALAI VHTVISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINT PSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEEAKAEAASLVSWLS SIDMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSS VTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYV GVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQ VREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESY VWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14667 nt NT seq  +upstreamnt  +downstreamnt atgttagtggatgccacaattagcatttttcatgagagcactaggcacttggatggccat ctcctacattacagaccgtttaacttctatggcccctgcttcccaatgcaagaggatgaa gttgtactccagtgcattgcaaacattcacaaggagcagcggaagttctgcctggcagcc gagggacttgggaatcgcctgtgcttcttggaacccacctcagaagccaagtacattcct ccggatctctgtgtctgcagtttcgtgctggaacagtccttatctgtcagagcgctgcaa gaaatgcttgccaacaccgttgagaacggcggagaaggggcggcacaagggggtagccac aggaccctgctctatgggcatgcaattctcctgcggcactctttcagtggaatgtatcta acgtgcttgaccacgtcaagatcccagacggataaacttgcctttgatgtaggtctgcgg gagcatgccaccggagaagcctgttggtggaccatacatcctgcttccaaacaaaggtct gaaggggagaaagtacgaatcggagatgaccttatccttgtcagtgtgtcctctgaaaga taccttcatctctcaatatcaaatggtagcatccaagtggatgcctccttcatgcaaacg ctctggaatgtacatcctacctgctcaggaagtagcattgaagaagggtacttactcggt ggccatgtagttcgtcttttccatggtcatgatgaatgtttgacgataccatctacagat cagaatgattctcagcacaggagggtgttctatgaagctggaggagctgggaccagagcc aggtctctatggagagtggaaccccttcggataagctggagtggcagtaacatcaggtgg ggtcaggctttccgactccggcatcttaccacaggccactacttggccttgacagaagac caaggccttcttctacaagaccgtgggaaatccgacaccaaatccacagccttctccttc cgagcatcaaaggaaatcaaggagaaattagattccagtcacaagagagatattgaaggc atgggagttccagaaatcaagtatggggattctgtctgctttgttcagcatgtagccagt ggcctttgggtcacctacaaagcacaagatgccaaaacttcccgcctgggacctctgaga agaaaggtcatactccatcaggaaggccacatggatgacggattaacactgcagaggtgc cagcaggaagagtcccaggctgctcgtatcatccggaacacaaccgccttattcagtcag tttgtcagtggaaacaatcgcacaactgcccctgtcgccttgccaacagaagaggttctg cagaccctgcaagacttgatagcctacttccagccaccagaggaggagatgcaacatgaa gacaaacaaaataaactccgctctctaaagaacagacaaaatcttttcaaggaggagggg atgctggccctcgtattgaattgcattgatcgattaaacatctacaatagtgtagcacac tttgcagggatcgtaagggaagagagtggcatggcctggaaggaaattctgaacctgcta tacaaattactagccgctctcatacgtggaaacagaaacaattgtgctcaattctccaat aaccttgattggttaattagtaagttggacagactagaatcttcctcaggtatcttggag gtcttgcactgcatcttgattgaaagcccagaagccttaaacctaatagcagagggccac atcaagtccatcatctcgctactggataagcatgggcggaatcacaaggttcttgatgtc ctgtgctccctctgtctctgcaatggggttgcagtaagagccaaccagaatctgatctgt gacaacctactaccccggaggaacctgcttctgcagacacggctaattaatgatgtcacc agcatccggccaaacatcttcctgggagttgctgaaggttcaccacagtacaagaagtgg tactttgagttaataattgaccaggtggaacctttcctaacagcagagcctacacatctt cgggtgggctgggcctcctcttcaggctatgccccgtaccctggtggaggagaaggatgg ggaggcaacggtgtnggtgatgacctgtactcctatggctttgatgggcttcatctgtgg tcaggacggatacccagagctgtggcctccatcaaccagcatctgctcaagtcagacgat gtggtgagctgctgccttgacctcggagtgcccagcatttcattccgaatcaacggacaa cctgtgcaggggatgtttgagaacttcagcacagacggactcttcttccccgtgatgagt ttttcagctggtgtcaaagtacgcttcttgatgggtggtcggcatggagaatttaagttc ctgcctccctctggctatgccccttgctatgaagccttacttcctaaggagaagatgaga ttggagcctgtcaaagaatataagcgtgatgctgatggtgttagagatctgttgggtacc acacagttcctctcccaagcctctttcatcccatgtcccatagataccagtcaggttgtt ttgccacttcacctagagaagattcgagacagactggctgagaatatccacgagctttgg gggatgaataaaatagaactcggctggacttatggcaaagtgcgagatgacaacaaaaga cagcatccatgccttgtggagttttcaaagctccctgaaactgagaagaactataacctg cagatgtcaacagaaaccttgaaaaccttgctggccctggggtgccacattgctcacgtt aacccagctgcagaagaggatctaaagaaagtcaagctgcccaaaaactatatgatgtcc aatggctataagccagcccctttggatttatctgatgtgaagctgttaccacctcaagaa attttagtggataagctggcagaaaatgcacacaatgtttgggcaaaggacagaataaaa caaggttggacctatggtattcaacaggatctaaagaataaaagaaatccccgcctggtg ccatatgcattactagatgagcgcaccaagaaatcaaacagggacagcctacgtgaagct gtacggacatttgttggttatggatataacattgagccatcagaccaagaactagctgat cctactgtcgagaaggtcagcatagacaagatccgatttttccgagtagaacggtcatat gctgtaaaatctggaaagtggtactttgaatttgaagtggtaactggaggagacatgcgt gttggctgggccagaccaggctgtcgtcctgacattgagctgggggctgatgaccaagcc ttcgtgtttgaaggcagcaggggtcagcgttggcatcaaggcagtgggtattttggacga acttggcagccaggagacgtggtcgggtgcatgattaacctggacgatgcctccatggtc ttcacactgaatggggaactgctcatcaccaacaaaggttctgaacttgccttcgcagac tatgagattgagaatggttttgtgcccatttgctctctgggcctatcccagattggccgc atgaatcttgggacagatgccagtaccttcaagttttataccatgtgtggactccaggag ggctttgagccttttgcggtaaatatgaaccgagatgttgcagtgtggtttagcaagcgc ctcccaacatttgtgaatgtgcccaaggatcatccccacatagaggttgtgagaattgat ggcaccatggacagccctccatgcctcaaggtgacccacaagaccttcggcacacagaac agcaatgccaacatgatctactgccgcctgagcatgcctgttgaatgtcattcctctttc agtcacagtccctgtctagacagtgaagccttccaaaaaaggaaacagatgcaagaaata ctctctcacacaacaacacaatgctactacgctatccgcatttttgctgggcaggaccca tcatgtgtctgggttggatgggtgactccggactaccatttatacagtgaaaagtttgac ctgaataaaaactgcactgtgactgtcaccctgggagatgaaagaggccgggtccatgaa agtgtgaaacgcagcaactgctacatggtctggggtggggatattgtagccagttcccaa agatcaagtcggagcaatgtagacttggagattggctgccttctagatctggcaatgggc atgttgtccttctcagctaatgggaaggaacttggcacctgctaccaggtggagcctaac accaaagtgttccctgcagtcttcctccagcctaccagcacgtccttgtttcagtttgaa cttggaaaactgaagaatgcaatgcctttgtcagcagccatatttaagagtgaagagaag aatcccatcccgcagtgtccacctcggctggatgtccaaaccatccagcccgtgctctgg agtcgcatgcccagcagcttcctcaaagtggagacagagcgggtgagcgagcgccatggc tgggtggtgcagtgcctagaacccctgcagatgatggcactccacatccctgaggagaac aggtgcgtggacatcctggagctctgtgagcaggaggacctgatgcagttccattaccac acactgagactttacagcgctgtgtgcgctctgggaaatagccgagtagcttctgccctg tgcagccacgtggacctctcacagctcttctatgccattgacaacaagtatttgcctggc ctccttcggtctggcttctatgacctgctcattagcatccacctggccaatgctaaggag agaaagctgatgatgaagaatgagtacatcatccctatcaccagcgccaccaggaatatc cgcctatacccggatgagtccaagagacacggattgcctggggtgggcttgaggacatgc ctcaagccaggcttcaggttctctaccccttgctttgtggtgacgagtgaggagcatcag aagcagagccctgagattcccttgcagattctcaagacgaaggccctgagcatgctaacc gaggccgtgcactgtagcggggcccacatccgtgaccctgtcgggggttctgtggagttc cagtttgttcctgtgctgaaactcattggaaccttgttagtcatgggggttttcgacgac gatgatgttcgccagattctcctcctgattgatccctctgtgtttggggagcacagtggg gagacggaggagggagtggacaaagaagtgacccacgcagaggaaaaggcagtggaggct ggagaaaaggcctgcaaggaggctccagtcaaaggcttgctgcagacccgattgcctgag tctgtcaagctgcagatgtgtgaactcctcagctacctctgtgactgtgaactgcagcac cgagtagaggctattgtggcatttggtgacatttacgtgtccaagctgcaggcaaatcag aagttccgctacaatgagctcatgcaggccctgaacatgtctgcagccctaactgccaga aagacacgagagttccgctcaccgccccaggagcagatcaacatgcttctcaactttcac ctgggagagaactgcccatgcccagaggagatccgcgaggagctgtatgccttccatgag gaccttctggttcactgcggggttcccttggaggaagaggaagaggaggaagaggacact tcctggacaggaaaactgtgtgctctggtgtataaaatcaagggcccaccgaagcccgag aaggagcagccaacggaggaagagaaaccgtatcctacaacactgaaggaactagtttca caaacaatgatccgctgggcccaggagaaccaaatccaggatgcggaactggtgaggatg atgttcaacctccttcggagacagtatgacagcattggggagttgctccaggctctgcgg aagacctacaccatcagccaggcctctgtgaatgacactatcaacctgctggctgccctg ggccagattaggtccctacttagtgtcaggatgggcagagaagaggagctcctcatgatc aacgggctaggggacataatgaacaacaaggtgttttaccagcaccccaacctgatgaga gtcctcggcatgcatgagaccgtgatggaagtgatggtcaatgtgctgggtaccgagaag ttgcagattgccttcccaaagatggttgctagctgctgtcgcttcctttgctatttctgt cgaattagccggcaaaatcagaaggccatgtttgagcatctaagttacctgctggagaac agtagtgtgggcctagcgtccccatcgatgagggggtccaccccactggatgtggcagct tcctctgtgatggacaataatgaactagcactgggattagaagaaccagatcttgagaag gttgtaacctacttggcaggctgtggccttcagagctgccccatgcttctggccagaggc taccctgacgttggctggaaccccatcgaaggggagcgctacctgtccttcctgaggttt gccgtcttcgtgaacagcgaaagtgttgaagaaaatgccagcgttgtggtcaagctgctc atcagacgtcccgagtgcttcggcccagctctgaggggtgaagggggcaacggactgctg gcggctatgcaaggtgctattaagatctcagagaaccctgccctcgacctcccttcccag ggttacaagacagaagtcacacaggacgatggagaggaggaagagattgtgcatatgggc aatgcaattatgtcgttttattcggcacttatagatctattgggccgctgtgctcccgaa atgcatctcatccaaacagggaaaggagaagccatccggatccggtccatcctgcgctcc ctggtccccacggaagacctggttgggatcatcagtatccccctgaagctgccctcccta aacaaagatgggtcagtcactgagccagacatggcggccaacttctgccctgaccacaaa gcacccatggtactgttcttggaccgtgtttatggcattaaagatcaaactttcctgctc cacttgctggaagttgggtttttacctgacttgcgggcttctgcatctctagacacagtg tccctcagcaccacagaggctgcgctggcactgaataggtatttatgttcggctgtactc ccactccttactagatgcgcccctctcttttctgggacagagcactgtacttctctgatt gattctacactgcagacaatatacaggctttccaaaggacgttccctcaccaaggcacag agggacaccatagaagaatgtttgctagccatttgcaatcacttgagaccttccatgtta cagcaactcctacgccgtctggtttttgacgtgccacagctcagcgagtactgcaagatg ccccttaagcttctgacaaatcactatgagcagtgctggaagtattactgcctaccttcg ggctgggggagctatgggctagctgtggaggaggagctgcacctcactgagaagctcttc tgggggatttttgactccctctcccacaagaaatatgacctggaccttttccgaatggcc ctgccttgtctcagtgctattgctggggccttgccaccagactatttagatacgagaatt acagccacattggagaagcaggtctcagtggatgcagatggaaactttgaccccaaacct atcaacaccatgaatttttccttgcctgaaaaattggaatacattgtcaccaagtatgct gagcattctcatgataaatgggcttgtgacaagagtcacagtggatggaaatatgggatt tctctggatgaaaatgtgaagacccacccactaatacggcccttcaagacattaacagag aaggagaaggaaatctatcgctggcctgccagagagtccctgaaaaccatgctggctgtg ggctggacggtggaaaggaccaaagaaggagaagccttggttcaacaaagagagaatgag aagcttcgatgtgtgtcccagaccaatcagggcaacagctacagccctgcccctctggat ctctcgaatgttgtgctgtccagggagcttcagggaatggtggaggtggtggctgagaac tatcacaatatctgggccaagaagaagaagctggagctggaaagcaaaggtggtggcagc caccctcttttggtaccatatgacaccttgactgccaaggaaaagttcagggatcgagag aaggcccaggacctgttcaaattcctccaggtgaatggcattctagtttctagaggcatg aaggacatggcgctggatgcctcctccatggagaagagatttgcctacaagtttttgaag aagatcctgaagtatgttgacgctgctcaagagtttattgctcacttggaagccattgtc agcagtgggaagacagaaaagtctccccatgaccaggagatcaaattctttgccaaggtt ctcctcccactggttgaccagtacttcaccaaccaccgcctttacttcctgtcctctccc ctgaagccgctcagcagcagtgggtatgcttcccataaagagaaagaaatggtggccagc ctattctgcaagctggccgctcttgttagacacaggatttcactctttgggagtgattca actaccatggtgagctgtcttcatatcttagctcagacacttgacacaaggacagtgatg aagtcaggctcagagctggtgaaagctgggctgcgggcattctttgaaaatgctgctgaa gacttagagaagacctccgaaaacctgaagctggggaagtttacccattcccgaacgcag atcaaaggtgtttctcagaatattaactacaccacagtggctctgcttcccatcctgaca tccatctttgagcacatcgctcagcatcagtttggggtggatctactcttgagcgacgtg cagatttcatgctaccacattctgtgcagcctctactcccttgggactgggaaaaacatc tatgttgaaaggcaacgtcctgctcttggagaatgtctggcttccttagcagctgctatc cctgtggcctttctggagcccagccttacccgctataatcccctctcagtcttcaacacc aaaacacccagggagcggtctattctggggatgccagacaaggtggaggacatgtgtcct gacatcccccagctggaagggctgatgaaggaaatcaatgacttggccgagtcaggtgcc cggtacactgagatgccccatgtcattgaagtaatcttgcccatgctctgcaactacctg tcctactggtgggagcggggacctgagaacctaccccccagcacaggaccctgctgcacc aaggtcacgtctgaacacctcagcctcatcctgggcaacattctgaaaatcatcaacaac aacctgggcattgatgaggcctcctggatgaagcgcatcgcagtgtatgcccagccaatc atcagcaaagccaggcctgacctgctccgaagccatttcatccccaccttggagaagcta aagaagaaggcggtgaagactgtgcaagaagaggagcagctgaagactgatggcaagggg gacacgcaggaggctgagctcctcatcctagatgagtttgccgtcctctgcagggacctc tatgccttctaccccatgctgatccgctatgtggacaacaacagatctaactggctcaaa agcccggatcctgattctgaccagctcttccgcatggtggccgaggtcttcattctgtgg tgtaaatctcataacttcaagagggaagagcaaaattttgtgattcaaaatgaaattaat aacttggcatttttaactggagacagcaaaagcaagatgtcaaaagccatgcaagtaaag tctggaggacaggaccaggaacggaagaagacaaagaggcgaggagacttgtattccatc cagacgtcccttatcgtggccgcgctcaagaaaatgctgcccattggtctgaacatgtgt accccaggcgaccaggagctcatctcactcgcaaaatcacgatacagctgtagggacact gatgaagaagtcaaggaacatcttcggaataacctgcacctgcaggaaaagtctgatgac ccagctgtgaaatggcaactgaacctctacaaggacgttctgaggaatgacgagccttct aatccagaaaagacggtggagcgggtgcagagcatttcggcagctcttttccacctggag caggtggaacagcctttgaggtccaaaaaggctgtgtggcacaaattgttgtcaaagcaa cggaaacgggcagtggtggcctgtttcaggatggctcccctctacaatctgcccaggcac cgctctattaacctcttcctccatggctatcaaagattttggatagaaacagaggcgtat tcctttgaagagaaactagtacaggatttggctaagtctcccagggttgaagatgaggaa gaagaggagacagagaggcaacctgacccacttcaccagatcattctgcattttagccgc aatgcgctcacggagaggagcaaattggaagatgatccattgtacacttcctattccagc atgatggccaagagctgtcagagtggtgaggacgaagaagaagatgaagacaaggaaaaa acatttgaagagaaggagatggagaagcaaaaaaccctgtatcaacaagcaaggctgcac gagcgtggtgctgccgagatggtccttcagatgataagtgccagcaaaggtgagatgagc cccatggtggttgagacactgaagctggggattgccattctgaacggaggcaatgctggt gtgcaacagaaaatgctagattacttaaaggagaaaaaagatgctggattctttcaaagt ctttctggtcttatgcagtcctgcagtgtccttgatttgaatgcatttgagagacagaat aaagctgaaggcctggggatggttacagaagaagggacactcattgttcgtgagcgtggt gaaaaggtactccagaatgatgaattcacacaagatctctttagattcctacagttgctt tgtgaaggacataacagtgactttcagaacttcctgaggactcagatgggcaacaccact actgtgaacatcatcattagcactgtggactaccttctgcgtctgcaggaatcaatcagc gatttctattggtactattcaggaaaggacatcattgatgaatctggacagcataatttc tctaaagctctggcagtcaccaagcaaatttttaattctcttacagagtacatccagggc ccgtgcatcgggaaccagcaaagcctggctcacagccggctgtgggatgcggtggttgga ttcctccacgtgtttgctaacatgcagatgaagctttctcaggattccagtcagatcgag ctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctg gaaggaaatgtggtaaatgggactattggaaagcagatggttgacacgctggtagagtca tccactaatgtagagatgatcttgaaattctttgacatgttcttgaaacttaaagactta accagctcagacaccttcaaagaatacgacccagatggcaaagggatcatctctcgaaaa gaatttcagaaggccatggaaggtctaaagcaatatacacagtcagagatcgactttctc ctttcatgtacagaggctgatgagaacgacatgtttaattatgcggattttgtagagagg ttccatgagccagccaaggacatagggttcaatgtggcagtgttattgacaaatctctct gaacatatgcccaacgattcccgtctcaagtgtctgttggacccagcagaaagtgtgcta aattacttcgagccatacctgggtcgaatcgagatcatgggtggggccaagaaaattgag cgtgtttattttgagatcagtgaatccagtcgaactcagtgggaaaagcctcaagtgaag gaatctaagcgacagttcatcttcgatgttgtcaatgaaggcggggagcaagagaagatg gaactgtttgtgaacttctgtgaggatacaatctttgagatgcaactagcatctcagata tcagagtctgactcaactgagaggccggaagaggaagaggaagaagatgaagattctgct tatttgatagaaactgagggggaggaggaagataaatcttttgagtctgcctctgctttt accatggcctgtgtctcagtgaagagaaatgtcaccaagtttctgaagagggcaaccttg aagaacctcaggaaacaatataggaatgtgaaaaagatgagtgcaaaggaactggtcagg gtgttcttcttcttcttctggatgctctttgtgggcctctttcagttgctcttcaccatc ttgggaggaatctttcagatcctctggaacacagtgtttggagggggccttgtcgaaggg gcaaagaacatcagagtgactaagatccttggtgacatgcccgaccccactcagtttggg atccatgatgatgtaatagagactgacagggtagaagtgactgagccaggtgtcaccact gagctggtccactttgtaaagggtgaggcaggagatacagacctcatgtcagacctcttt ggaatccactcaaagaaagaaggtggcttaaagcaagggcctgaagtgggattaggtgac ctctctgaaattattggcaaggacgaacccccaacattagagagtactgtccggaagaaa aggaaagctcaggcagcagagatgaaagcagtgcatgaagctgaagggaaagctgaatct gagaaggccgacatggaagacagagaaaaggaagacaaaatcaaggaggaggggcaagca gagtacccgtgggcagacatgacagtaaagaagacgagacggcgcggtcagaaggccgag aagccagaagccttcatggccaacttcttcaaaggactggagatttatcagaccaagtta ctgcactacctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttc gctatcaacttcatcctgcttttctataaggtcactgaagaacctttagaggaagagaca gaggatgttgcaaacctgtggcactccttcaatgatgatgatgaggaagaagcgatggta ttctttgttcttcaggagagcactggttatatggcaccgacactgcgggctctggccatt gtccacaccgtcatctctctggtctgtgtggtgggctattactgcctgaaggtacctttg gtggtattcaaaagggagaaagaaattgccaggaagctggagtttgatggcctctatatt actgaacagccatctgaagatgacatcaaggggcagtgggaccgcttggtgatcaacacg ccatcttttcctaataactactgggacaagtttgtgaagagaaaggtgatcaacaagtat ggagatctctatggagcagagcgcattgctgaactcctgggtttggacaaaaatgccctt gactttagcccagtagaagaggccaaagcagaggcggcatctctggtgtcatggctaagt tccatcgacatgaagtaccatatttggaagctaggggtggttttcactgacaactccttt ctctaccttgcctggtacacaaccatgtctgtcctgggccactacaacaacttcttcttt gctgctcatctgttggatattgccatgggctttaagactttgaggacgatcctgtcatct gtaactcacaatggcaaacagctggttctgactgttggcctcctggctgtggttgtttac ctctacactgtggtggctttcaacttcttccgcaagttctacaacaaaagtgaagatgag gatgaaccggatatgaagtgtgacgacatgatgacgtgctacctcttccacatgtatgtg ggcgtaagagcaggtggaggcattggtgatgaaattgaagaccccgctggtgacccttat gaaatgtatcgcatcgtctttgatattactttcttcttcttcgtcattgtcatcttgctg gccatcattcaaggtcttattattgatgcttttggagagctgagggaccagcaggagcaa gtacgagaagacatggagactaagtgcttcatctgtggcattggcaatgactactttgac acaacccctcatggttttgaaacacacacactgcaagagcacaacttagccaattatcta ttctttctgatgtatttgattaacaaggatgaaacagaacacacgggtcaggaatcctat gtgtggaagatgtaccaggaaaggtgttgggacttcttccccgctggagattgctttcgg aagcaatatgaagatcagctcgggtaa

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