KEGG   Macaca thibetana thibetana (Pere David's macaque): 126929447
Entry
126929447         CDS       T08579                                 
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
mthb  Macaca thibetana thibetana (Pere David's macaque)
Pathway
mthb01522  Endocrine resistance
mthb04010  MAPK signaling pathway
mthb04015  Rap1 signaling pathway
mthb04068  FoxO signaling pathway
mthb04071  Sphingolipid signaling pathway
mthb04114  Oocyte meiosis
mthb04148  Efferocytosis
mthb04218  Cellular senescence
mthb04261  Adrenergic signaling in cardiomyocytes
mthb04370  VEGF signaling pathway
mthb04380  Osteoclast differentiation
mthb04550  Signaling pathways regulating pluripotency of stem cells
mthb04611  Platelet activation
mthb04613  Neutrophil extracellular trap formation
mthb04620  Toll-like receptor signaling pathway
mthb04621  NOD-like receptor signaling pathway
mthb04622  RIG-I-like receptor signaling pathway
mthb04625  C-type lectin receptor signaling pathway
mthb04657  IL-17 signaling pathway
mthb04658  Th1 and Th2 cell differentiation
mthb04659  Th17 cell differentiation
mthb04660  T cell receptor signaling pathway
mthb04664  Fc epsilon RI signaling pathway
mthb04668  TNF signaling pathway
mthb04670  Leukocyte transendothelial migration
mthb04714  Thermogenesis
mthb04722  Neurotrophin signaling pathway
mthb04723  Retrograde endocannabinoid signaling
mthb04728  Dopaminergic synapse
mthb04750  Inflammatory mediator regulation of TRP channels
mthb04912  GnRH signaling pathway
mthb04914  Progesterone-mediated oocyte maturation
mthb04917  Prolactin signaling pathway
mthb04926  Relaxin signaling pathway
mthb04932  Non-alcoholic fatty liver disease
mthb04933  AGE-RAGE signaling pathway in diabetic complications
mthb04935  Growth hormone synthesis, secretion and action
mthb04936  Alcoholic liver disease
mthb05014  Amyotrophic lateral sclerosis
mthb05020  Prion disease
mthb05022  Pathways of neurodegeneration - multiple diseases
mthb05132  Salmonella infection
mthb05133  Pertussis
mthb05135  Yersinia infection
mthb05140  Leishmaniasis
mthb05142  Chagas disease
mthb05145  Toxoplasmosis
mthb05152  Tuberculosis
mthb05161  Hepatitis B
mthb05163  Human cytomegalovirus infection
mthb05167  Kaposi sarcoma-associated herpesvirus infection
mthb05169  Epstein-Barr virus infection
mthb05170  Human immunodeficiency virus 1 infection
mthb05171  Coronavirus disease - COVID-19
mthb05205  Proteoglycans in cancer
mthb05208  Chemical carcinogenesis - reactive oxygen species
mthb05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mthb05415  Diabetic cardiomyopathy
mthb05417  Lipid and atherosclerosis
mthb05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mthb00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    126929447
   04015 Rap1 signaling pathway
    126929447
   04370 VEGF signaling pathway
    126929447
   04668 TNF signaling pathway
    126929447
   04068 FoxO signaling pathway
    126929447
   04071 Sphingolipid signaling pathway
    126929447
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    126929447
  09143 Cell growth and death
   04114 Oocyte meiosis
    126929447
   04218 Cellular senescence
    126929447
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    126929447
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    126929447
   04613 Neutrophil extracellular trap formation
    126929447
   04620 Toll-like receptor signaling pathway
    126929447
   04621 NOD-like receptor signaling pathway
    126929447
   04622 RIG-I-like receptor signaling pathway
    126929447
   04625 C-type lectin receptor signaling pathway
    126929447
   04660 T cell receptor signaling pathway
    126929447
   04658 Th1 and Th2 cell differentiation
    126929447
   04659 Th17 cell differentiation
    126929447
   04657 IL-17 signaling pathway
    126929447
   04664 Fc epsilon RI signaling pathway
    126929447
   04670 Leukocyte transendothelial migration
    126929447
  09152 Endocrine system
   04912 GnRH signaling pathway
    126929447
   04914 Progesterone-mediated oocyte maturation
    126929447
   04917 Prolactin signaling pathway
    126929447
   04926 Relaxin signaling pathway
    126929447
   04935 Growth hormone synthesis, secretion and action
    126929447
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    126929447
  09156 Nervous system
   04728 Dopaminergic synapse
    126929447
   04723 Retrograde endocannabinoid signaling
    126929447
   04722 Neurotrophin signaling pathway
    126929447
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    126929447
  09158 Development and regeneration
   04380 Osteoclast differentiation
    126929447
  09159 Environmental adaptation
   04714 Thermogenesis
    126929447
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    126929447
   05208 Chemical carcinogenesis - reactive oxygen species
    126929447
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    126929447
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    126929447
   05161 Hepatitis B
    126929447
   05171 Coronavirus disease - COVID-19
    126929447
   05163 Human cytomegalovirus infection
    126929447
   05167 Kaposi sarcoma-associated herpesvirus infection
    126929447
   05169 Epstein-Barr virus infection
    126929447
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    126929447
   05135 Yersinia infection
    126929447
   05133 Pertussis
    126929447
   05152 Tuberculosis
    126929447
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    126929447
   05140 Leishmaniasis
    126929447
   05142 Chagas disease
    126929447
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    126929447
   05020 Prion disease
    126929447
   05022 Pathways of neurodegeneration - multiple diseases
    126929447
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    126929447
   05418 Fluid shear stress and atherosclerosis
    126929447
   05415 Diabetic cardiomyopathy
    126929447
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    126929447
   04932 Non-alcoholic fatty liver disease
    126929447
   04933 AGE-RAGE signaling pathway in diabetic complications
    126929447
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    126929447
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mthb01001]
    126929447
Enzymes [BR:mthb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     126929447
Protein kinases [BR:mthb01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   126929447
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1
Other DBs
NCBI-GeneID: 126929447
NCBI-ProteinID: XP_050601745
LinkDB
Position
10:536085..546019
AA seq 390 aa
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRVSPGGGATHQPSPSAIPRLHVLPDLKPG
NLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMA
EMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASIL
TNASPLAVNLLEKMLVLDAEQRVTAAEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTL
DEWKRVTYKEVLSFKPPRQLGARVSKETAL
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcctgcccgcagtggcttttaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtgtaccgggacctgcagcccgtgggctcgggcgcctatggcgcg
gtgtgctcggccgtggacagccgcaccggcgctaaggtggccatcaagaagctgtaccgg
cccttccagtccgagctgttcgccaagcgcgcctaccgcgagctgcgcctgctcaagcac
atgcgccacgagaacgtgattgggctgctggatgtgttcactcctgatgagaccctggat
gacttcacagacttttacctggtgatgccattcatgggcaccgacctgggcaagcttatg
aaacatgagaagctgggcgaggaccggatccagttcctcgtgtaccagatgctgaagggg
ctgaggtatatccatgctgccggcatcatccacagagtgagtcctggtggaggagccacc
catcagccctcccccagcgcaatcccccgcctccacgtcctacctgacctgaagcctggc
aacctggctgtgaacgaagactgtgagctgaagatcctggactttggcctggccaggcag
gcagacagcgagatgactggctatgtggtgacccggtggtaccgggcacccgaggtcatc
ttgaattggatgcgctacacgcagacggtggacatctggtctgtggggtgcatcatggcg
gagatgatcacaggcaagacgctgttcaaaggcagcgaccacctggaccagctgaaggag
atcatgaaagtgacagggacgcctccagctgagtttgtgcagcggctgcagagtgatgag
gccaagaactacatgaagggcctccctgagttggagaagaaggattttgcctccatcctg
accaatgcaagccctctggctgtgaacctcctggagaagatgctggtgctggatgcggag
cagcgggtgacggcagccgaggcactggcccatccctacttcgagtccctgcacgacacg
gaagatgagccccaggtccagaagtatgacgactcctttgatgacgtggaccgcacgctg
gatgaatggaagcgtgttacttacaaagaggtgctcagcttcaagcctccccggcagctg
ggagccagggtctccaaggagacggctctgtga

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