KEGG   NETWORK: N00071Help
Entry
N00071                      Network                                

Name
Deleted p16(INK4a) to p16-cell cycle G1/S
Definition
CDKN2A* // (CCND+CDK4/6) -> RB1 // E2F
  Expanded
1029v1 // ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06262 Pancreatic cancer
nt06263 Hepatocellular carcinoma
nt06265 Bladder cancer
nt06268 Melanoma
nt06273 Glioma
Type
Variant
Pathway
hsa05212  Pancreatic cancer
hsa05225  Hepatocellular carcinoma
hsa05214  Glioma
hsa05218  Melanoma
hsa05219  Bladder cancer
Disease
H00019  Pancreatic cancer
H00048  Hepatocellular carcinoma
H00042  Glioma
H00038  Melanoma
H00022  Bladder cancer
Gene
1029  CDKN2A; cyclin dependent kinase inhibitor 2A
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
1029v1  CDKN2A deletion
Reference
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
  Authors
Lee JS
  Title
The mutational landscape of hepatocellular carcinoma.
  Journal
Clin Mol Hepatol 21:220-9 (2015)
DOI:10.3350/cmh.2015.21.3.220
Reference
  Authors
Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
  Journal
Dig Dis 29:289-302 (2011)
DOI:10.1159/000327562
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