KEGG   NETWORK: N00136Help
Entry
N00136                      Network                                

Name
EWSR1-ATF1 fusion to transcriptional activation
Definition
EWSR1-ATF1 => (ARNT2,ATM,MITF)
  Expanded
466v1 => (9915,472,4286)
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00052  Clear cell sarcoma of soft tissue
Gene
466  ATF1; activating transcription factor 1
9915  ARNT2; aryl hydrocarbon receptor nuclear translocator 2
472  ATM; ATM serine/threonine kinase
64083  GOLPH3; golgi phosphoprotein 3
4286  MITF; melanogenesis associated transcription factor
Variant
466v1  EWSR1-ATF1 fusion
Reference
  Authors
Jishage M, Fujino T, Yamazaki Y, Kuroda H, Nakamura T
  Title
Identification of target genes for EWS/ATF-1 chimeric transcription factor.
  Journal
Oncogene 22:41-9 (2003)
DOI:10.1038/sj.onc.1206074
Reference
  Authors
Davis IJ, Kim JJ, Ozsolak F, Widlund HR, Rozenblatt-Rosen O, Granter SR, Du J, Fletcher JA, Denny CT, Lessnick SL, Linehan WM, Kung AL, Fisher DE
  Title
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.
  Journal
Cancer Cell 9:473-84 (2006)
DOI:10.1016/j.ccr.2006.04.021
Reference
  Authors
Thway K, Fisher C
  Title
Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status.
  Journal
Am J Surg Pathol 36:e1-e11 (2012)
DOI:10.1097/PAS.0b013e31825485c5
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