Nannospalax galili (Upper Galilee mountains blind mole rat): 103745303
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Entry
103745303 CDS
T03372
Symbol
Nos3
Name
(RefSeq) nitric oxide synthase 3
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00220
Arginine biosynthesis
ngi00330
Arginine and proline metabolism
ngi01100
Metabolic pathways
ngi04020
Calcium signaling pathway
ngi04022
cGMP-PKG signaling pathway
ngi04066
HIF-1 signaling pathway
ngi04071
Sphingolipid signaling pathway
ngi04151
PI3K-Akt signaling pathway
ngi04370
VEGF signaling pathway
ngi04371
Apelin signaling pathway
ngi04611
Platelet activation
ngi04915
Estrogen signaling pathway
ngi04921
Oxytocin signaling pathway
ngi04926
Relaxin signaling pathway
ngi04931
Insulin resistance
ngi04933
AGE-RAGE signaling pathway in diabetic complications
ngi05415
Diabetic cardiomyopathy
ngi05417
Lipid and atherosclerosis
ngi05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
103745303 (Nos3)
00330 Arginine and proline metabolism
103745303 (Nos3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
103745303 (Nos3)
04371 Apelin signaling pathway
103745303 (Nos3)
04066 HIF-1 signaling pathway
103745303 (Nos3)
04020 Calcium signaling pathway
103745303 (Nos3)
04071 Sphingolipid signaling pathway
103745303 (Nos3)
04022 cGMP-PKG signaling pathway
103745303 (Nos3)
04151 PI3K-Akt signaling pathway
103745303 (Nos3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
103745303 (Nos3)
09152 Endocrine system
04915 Estrogen signaling pathway
103745303 (Nos3)
04921 Oxytocin signaling pathway
103745303 (Nos3)
04926 Relaxin signaling pathway
103745303 (Nos3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
103745303 (Nos3)
05418 Fluid shear stress and atherosclerosis
103745303 (Nos3)
05415 Diabetic cardiomyopathy
103745303 (Nos3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
103745303 (Nos3)
04933 AGE-RAGE signaling pathway in diabetic complications
103745303 (Nos3)
Enzymes [BR:
ngi01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
103745303 (Nos3)
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Paralog
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
103745303
NCBI-ProteinID:
XP_008845434
UniProt:
A0A8C6RCQ3
LinkDB
All DBs
Position
Un
AA seq
1202 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLSLGLCGKQGPASPAPEPSQAPASPSPTPPAPDHSSPLTR
PPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQSRPSQGPLPTE
QLLGQARDFINQYYSSIKRGGSQAHDQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA
PRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDF
RIWNSQLIRYAGYRQQDGSVRGDPANVEITELCVQHGWTPGNGRFDVLPLLLQAPDESPE
LFTLPPELVLEVSLEHPTLEWFTALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSE
IGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHH
AATASFMKHLENEQKARGGCPADWAWIVPPISSSLTPVFHQEMVNYVLSPAFRYQPDPWK
GSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRL
FRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP
RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC
AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAAR
DIFSPKRSWKRQRYRLSTQAEGLQLLPGLTHVHRRKMFQATILSVENLQSSKSTRATILV
RLDTGGQGGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPPTEPVVVEQLEKGSPGGPP
PGWVRDPRLPPCTLRQALTFFLDITSPPSPRLLQLLSTLAEESSEQQELEALSQDPRRYE
EWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHITVAVLA
YRTQDGLGPLHYGVCSTWLSQLKAGDLVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPF
RGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGHVHTAFSRDP
GSPKTYVQDILRTELATEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGDMELDE
AGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPNPDNP
GS
NT seq
3609 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagtgtgggccaggagcctgggccaccctgtggcctcgggctcggg
ctgagcctcggactatgtggcaagcaaggtccagcctctccagcaccagagcctagccag
gcaccagcatccccatccccgaccccgccagcaccagaccacagctccccactaactcgg
cccccagagggacccaagttccctcgagtgaagaactgggaagtgggcagcattacctac
gacaccctcagtgcccaggctcagcaggatggaccttgtaccccaagacgctgcctagga
tccctggtatttccaaggaagctacagagccggccctcccagggtcctctacccactgag
cagctgttaggtcaggccagggacttcatcaaccagtactacagctccatcaagaggggt
ggctcccaggcccatgaccagcggcttcaggaagtagaggctgaggtggcagccactggc
acctaccagctccgggaaagtgagttggtattcggagctaagcaggcctggcgcaatgct
ccccgctgtgtgggccggatccagtggggaaagctgcaggtgtttgatgcccgggactgc
agaactgcacaggaaatgttcacctacatctgcaaccacatcaagtatgccaccaaccga
ggcaaccttcgttcggccatcacagtgttcccccagcgctgccccggccggggagacttc
cggatctggaacagccagctgatacgctacgcaggctataggcaacaggatggctccgtg
cgaggggaccctgccaacgtggagatcactgagctctgtgtccagcatggttggacccca
ggaaatggtcgctttgacgtgctgcctctgctgctccaggcccctgatgagtccccagaa
ctcttcactctgcccccagagctggtcctcgaggtgtccctggagcaccccacgctggag
tggttcactgccctgggcctgcgctggtacgccctcccagctgtgtccaacatgctgcta
gaaatcgggggccttgagttccctgccgcccccttcagtggctggtacatgagctcagag
attggcatgagggacttgtgtgaccctcaccgttacaacattcttgaggacgtggccgtc
tgtatggatttagacacccggacaacctcatccctgtggaaagacaaggcggccgtggag
attaatgtggccgtgctgcacagttaccagctcgccaaagtgaccattgtggaccaccat
gccgccactgcctccttcatgaagcacctggagaacgaacaaaaggccagggggggctgc
cctgctgactgggcctggatcgtgccccccatctccagcagcctcactcctgtcttccat
caagagatggtcaactatgtcttgtcacctgccttccgctaccagccagacccctggaag
ggaagtgcagcgaagggcacaggcatcaccaggaagaagacctttaaggaagtggccaat
gcagtgaagatctctgcctcactcatgggcacagtgatggcaaagcgcgtgaaggcaacc
atcctgtatggctctgagactggcagagcccagagctatgcacagcagctggggaggctc
ttccggaaggcgtttgacccccgggtcctgtgcatggatgagtacgatgtggtgtcccta
gaacatgaagcactggtgttggtggtgaccagcacattcgggaacggagatcccccagag
aatggagagagctttgcagcagcgttgatggagatgtcaggcccctacaacagctcccca
aggcctgagcaacataagagttacaaaatccgattcaacagtgtctcatgctcagacccc
ctggtgtcctcttggcgacgcaagaggaaggaatctagcaacacagacagtgcaggggcc
ctgggcaccctcaggttctgtgtgtttggactgggatctcgggcctacccccacttctgt
gcctttgcacgggctgtggatacacggctagaagagctgggtggggagcggctactacag
ctgggccagggtgacgagctctgtggccaggaggaggcctttcgtggctgggcacaggct
gccttccaggccgcctgtgagaccttctgtgtgggagaggatgccaaggccgctgctcgg
gacatcttcagccccaaacgcagctggaagcgccagaggtatcgactgagtacccaggct
gagggcctgcagctgctgccaggcctgacccacgtgcacaggcggaagatgttccaggct
acgatcctctctgtggaaaacctgcagagcagcaaatctacccgggccacgatcctggtg
cgcctggacaccggaggccagggagggctgcagtaccagccaggggaccacataggtgtg
tgcccacccaaccggcctggactcgtggaggcattgctgagccgtgtggaggacccaccc
ccacccacagagcccgtggtcgtggagcagctggagaagggaagccctggtggccctccc
cccggctgggtacgggacccccggctgcccccatgcacgctgcgacaggctctcaccttc
ttcctggacatcacttccccgcccagtcctcgtctccttcaactgctcagcaccctggcc
gaagagtccagcgaacagcaggaacttgaggccctcagccaggacccccgacgctatgaa
gagtggaagtggttccgctgccccacgctgttggaggtgctggagcagttcccatcagtg
gccctgcctgccccactgctcctcacccagctgcccctgctccagccccggtactactca
gtcagctcagcacccagcacccacccaggagagatccacatcactgtggctgtgctggca
tacaggacccaggatgggctgggccctcttcactatggtgtctgctccacgtggctgagc
caactcaaggctggagacctggtaccctgcttcatcaggggggctccctccttccgactg
ccacctgatcccaacttgccctgcattctggtgggcccagggactggcattgcacccttc
cggggattctggcaagagcgactgcacgatattgagagtaaagggctgcagccggctccc
atgactttggtgttcggctgccgatgctcccaactggatcatctctaccgagatgaggtg
ctggacgcccagcagcgcggggtgtttggacatgtccacaccgccttctccagggatcct
ggcagccccaagacctacgtgcaggacatcctgaggactgagctggctacggaagtgcac
cgcgtgctgtgcctcgagcaaggccacatgtttgtgtgcggggatgtcaccatggcaacc
agcgtgctgcagacagtgcagcgaattctggcgacagagggcgacatggagctggacgag
gcgggtgacgtcatcggcgtgctgcgggatcagcaacgctaccacgaggacatttttggg
ctcacattgcgcacccaggaggtgacaagccgtatacgcacccagagtttttctttgcag
gagcgacagttgcggggtgcagtgccctgggccttcgacccgcccaacccagacaaccct
ggttcatga
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