KEGG   Oryctolagus cuniculus (rabbit): 100350395
Entry
100350395         CDS       T03373                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu00562  Inositol phosphate metabolism
ocu01100  Metabolic pathways
ocu04015  Rap1 signaling pathway
ocu04020  Calcium signaling pathway
ocu04022  cGMP-PKG signaling pathway
ocu04062  Chemokine signaling pathway
ocu04070  Phosphatidylinositol signaling system
ocu04071  Sphingolipid signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04261  Adrenergic signaling in cardiomyocytes
ocu04270  Vascular smooth muscle contraction
ocu04310  Wnt signaling pathway
ocu04371  Apelin signaling pathway
ocu04540  Gap junction
ocu04611  Platelet activation
ocu04613  Neutrophil extracellular trap formation
ocu04621  NOD-like receptor signaling pathway
ocu04713  Circadian entrainment
ocu04720  Long-term potentiation
ocu04723  Retrograde endocannabinoid signaling
ocu04724  Glutamatergic synapse
ocu04725  Cholinergic synapse
ocu04726  Serotonergic synapse
ocu04728  Dopaminergic synapse
ocu04730  Long-term depression
ocu04742  Taste transduction
ocu04750  Inflammatory mediator regulation of TRP channels
ocu04911  Insulin secretion
ocu04912  GnRH signaling pathway
ocu04915  Estrogen signaling pathway
ocu04916  Melanogenesis
ocu04918  Thyroid hormone synthesis
ocu04919  Thyroid hormone signaling pathway
ocu04921  Oxytocin signaling pathway
ocu04922  Glucagon signaling pathway
ocu04924  Renin secretion
ocu04925  Aldosterone synthesis and secretion
ocu04926  Relaxin signaling pathway
ocu04927  Cortisol synthesis and secretion
ocu04928  Parathyroid hormone synthesis, secretion and action
ocu04929  GnRH secretion
ocu04933  AGE-RAGE signaling pathway in diabetic complications
ocu04934  Cushing syndrome
ocu04935  Growth hormone synthesis, secretion and action
ocu04961  Endocrine and other factor-regulated calcium reabsorption
ocu04970  Salivary secretion
ocu04971  Gastric acid secretion
ocu04972  Pancreatic secretion
ocu04973  Carbohydrate digestion and absorption
ocu05010  Alzheimer disease
ocu05016  Huntington disease
ocu05017  Spinocerebellar ataxia
ocu05022  Pathways of neurodegeneration - multiple diseases
ocu05142  Chagas disease
ocu05143  African trypanosomiasis
ocu05146  Amoebiasis
ocu05163  Human cytomegalovirus infection
ocu05200  Pathways in cancer
ocu05415  Diabetic cardiomyopathy
ocu05417  Lipid and atherosclerosis
Module
ocu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100350395
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100350395
   04310 Wnt signaling pathway
    100350395
   04371 Apelin signaling pathway
    100350395
   04020 Calcium signaling pathway
    100350395
   04070 Phosphatidylinositol signaling system
    100350395
   04072 Phospholipase D signaling pathway
    100350395
   04071 Sphingolipid signaling pathway
    100350395
   04022 cGMP-PKG signaling pathway
    100350395
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100350395
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100350395
   04613 Neutrophil extracellular trap formation
    100350395
   04621 NOD-like receptor signaling pathway
    100350395
   04062 Chemokine signaling pathway
    100350395
  09152 Endocrine system
   04911 Insulin secretion
    100350395
   04922 Glucagon signaling pathway
    100350395
   04929 GnRH secretion
    100350395
   04912 GnRH signaling pathway
    100350395
   04915 Estrogen signaling pathway
    100350395
   04921 Oxytocin signaling pathway
    100350395
   04926 Relaxin signaling pathway
    100350395
   04935 Growth hormone synthesis, secretion and action
    100350395
   04918 Thyroid hormone synthesis
    100350395
   04919 Thyroid hormone signaling pathway
    100350395
   04928 Parathyroid hormone synthesis, secretion and action
    100350395
   04916 Melanogenesis
    100350395
   04924 Renin secretion
    100350395
   04925 Aldosterone synthesis and secretion
    100350395
   04927 Cortisol synthesis and secretion
    100350395
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100350395
   04270 Vascular smooth muscle contraction
    100350395
  09154 Digestive system
   04970 Salivary secretion
    100350395
   04971 Gastric acid secretion
    100350395
   04972 Pancreatic secretion
    100350395
   04973 Carbohydrate digestion and absorption
    100350395
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100350395
  09156 Nervous system
   04724 Glutamatergic synapse
    100350395
   04725 Cholinergic synapse
    100350395
   04728 Dopaminergic synapse
    100350395
   04726 Serotonergic synapse
    100350395
   04720 Long-term potentiation
    100350395
   04730 Long-term depression
    100350395
   04723 Retrograde endocannabinoid signaling
    100350395
  09157 Sensory system
   04742 Taste transduction
    100350395
   04750 Inflammatory mediator regulation of TRP channels
    100350395
  09159 Environmental adaptation
   04713 Circadian entrainment
    100350395
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100350395
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100350395
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100350395
   05142 Chagas disease
    100350395
   05143 African trypanosomiasis
    100350395
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100350395
   05016 Huntington disease
    100350395
   05017 Spinocerebellar ataxia
    100350395
   05022 Pathways of neurodegeneration - multiple diseases
    100350395
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100350395
   05415 Diabetic cardiomyopathy
    100350395
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100350395
   04934 Cushing syndrome
    100350395
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocu04131]
    100350395
Enzymes [BR:ocu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100350395
Membrane trafficking [BR:ocu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100350395
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100350395
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y DUF1154 EF-hand_like C2 EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 100350395
NCBI-ProteinID: XP_051702196
Ensembl: ENSOCUG00000010755
LinkDB
Position
4:complement(34326964..34824714)
AA seq 1210 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSVRLGAVPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTTGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKHALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLDHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEGNTT
ERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGC
QMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCS
VQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVIL
PDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYV
PDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKAN
VTPQSSSELRPTTTAALGSGMEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELSSLKK
KHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQT
LTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQ
LKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKR
LAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTS
NSSVKLQNTN
NT seq 3633 nt   +upstreamnt  +downstreamnt
atggctaaaccttatgaatttaactggcagaaggaagttccttcttttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggtttctttctgacatggaaaagtgagggcaaggaaggacaagtgcta
gaatgctccctcatcaacagtgttcggttgggagccgtcccaaaggatcccaaaatcctt
gctgctcttgaagctgttggaaaatcagaaaatgatctggaagggcggatagtttgtgtc
tgcagtggtacagatctggtgaacattagtttcacatatatggtggctgaaaatccagaa
gtaactaagcaatgggtggaaggcctgagatcaatcatacacaacttcagggccaacaat
gtcagtccgatgacatgcctcaagaaacactggatgaaattggctttcatgaccaacaca
actggaaaaattccagttaggagtattactagaacatttgcatcgggaaaaacagaaaag
gtcatcttccaagcactcaaggagttaggtcttcccagtggaaagaatgatgagattgag
cctgcagcatttacttacgaaaagttctatgaactgacgcaaaagatttgtcctcggacg
gatatagaagatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattt
ccattttatgatgctaaaagggcaatgcagatcattgagatgtatgagcctgatgaagat
ttgaagaaaaaaggtctcatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgctccagtcttcctagatcgtctagaactctaccaagaaatggaccatcccctggct
cactacttcatcagttcttcccacaatacctatctcaccggccgacagtttggaggaaag
tcttcagtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaactagac
tgttgggatggaaaaggtgaagaccaagaacctataataactcatggaaaagcaatgtgc
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatct
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacatgcgcttgaatcacat
ccactcgaaccaggcagacctttgccatcccccaatgacctcaaaagaaagattctcatc
aaaaataaacgactgaaacctgaagttgaaaaaaaacagctcgaagctttgaaaagcatg
atggaggctggagaatctgcttccccagctaacattttagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccccgaattcaaatttggaaatgaactt
tctgcagatgacttgggtcacaaggaagctgttgcaaatagtgtcaaaaaggcctcagat
gatcttgaccatgaaaataacaaaaagggcctggttactgtagaagatgagcaggcgtgg
atggcatcttataaatatgtaggtgctaccactaatatccacccgtatttgtccacaatg
atcaactacgcacagcctgtaaagtttcagggtttccatgtggctgaaggtaacactaca
gaacgcaatattcattataacatgtcttcttttaatgaatcagttggccttggctacttg
aagacacatgcaattgaatttgtaaattataacaaacggcaaatgagtcgcatttaccca
aagggaggccgagtcgattccagtaattacatgcctcagattttctggaacgccggctgc
cagatggtttcactgaactatcaaaccccagatttagcaatgcaattgaatcagggaaaa
tttgagtataatggatcgtgcgggtaccttctcaaaccggatttcatgaggcggcctgat
cgaacatttgatcccttctctgaaactcctgttgatggtgtcatagccgctacttgctca
gtgcaggtcatatcaggtcagttcttatcagataagaaaattggcacatacgtagaagtg
gatatgtatggattgccaactgacaccatacgtaaagaattccgaacacgtatggttatg
aacaatggactcaatccagtttacaatgaagaatctttcgtatttcggaaggtaatcctg
cctgacctggctgtcttgagaatagcagtgtatgatgacaacaacaagctgattggccag
aggatcctccccctggatggcctccaagcaggctaccgacacatttccctgcggaatgaa
ggaaataaaccattatcactgccaacaattttctgcaatattgttcttaaaacatatgtg
cctgatggatttggagatattgtggatgctttatccgatccaaagaaatttctttcaatt
acagaaaagagagcagaccaaatgagagctatgggcattgaaactagtgacatagccgac
gtgcccagtgacacttccaagaatgacaaaaagggaaaggccaacacagccaaagcaaac
gtcactccacagagtagctctgaactcagaccgaccaccacggccgccctaggttctggc
atggaagccaagaaaggtattgaactcatccctcaagtgagaatagaagatttgaagcag
atgaaggcttacttgaagcacttaaagaaacaacagaaggagctaagttctttaaagaag
aaacatgcaaaggagcacagcaccatgcagaagttacactgcacccaagtggacaagatc
gtggcgcagtatgacaaagagaagtcgactcatgagaagatcctagagaaagccatgaag
aaaaaggggggaagtaattgtcttgaaatgaaaaaagaaacagaaattaaaattcagaca
ctgacatcagatcacaaatctaaggtcaaagagattgtggcacagcacacaaaggagtgg
tcggaaatgatcaacacccacagtgcagaggagcaagaaatccgggacctgcacctcagc
cagcagtgtgagctgttgaaaaagctgctaatcaacgcccacgagcaacaaacccagcag
ctgaaactgtcccacgacagggaaagcaaggaaatgcgagctcaccaggccaagatttct
atggaaaatagcaaagccatcagccaggataaatcaatcaagaataaagcagaacgagaa
aggcgggtcagagagttaaacagcagcaacactaaaaagtttctggaagaaagaaagaga
cttgcaatgaagcaatccaaagaaatggatcagttgaaaaaagtccaacttgaacaccta
gaattcctagagaagcagaatgaacagcttttgaaatcctgtcatgcagtgtcccaaaca
caaggcgaaggagatgcagcagatggtgaaattggaagccgagatggaccgcagaccagc
aacagtagtgtgaaactccagaatacaaactga

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