KEGG   Oryctolagus cuniculus (rabbit): 100351645
Entry
100351645         CDS       T03373                                 

Gene name
MSH6
Definition
(RefSeq) mutS homolog 6
  KO
K08737  DNA mismatch repair protein MSH6
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu01524  Platinum drug resistance
ocu03430  Mismatch repair
ocu05200  Pathways in cancer
ocu05210  Colorectal cancer
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03430 Mismatch repair
    100351645 (MSH6)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100351645 (MSH6)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100351645 (MSH6)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    100351645 (MSH6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:ocu03400]
    100351645 (MSH6)
DNA repair and recombination proteins [BR:ocu03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   MMR (mismatch excision repair)
    Mismatch and loop recognition factors
     100351645 (MSH6)
SSDB
Motif
Pfam: MutS_V MutS_III MutS_I PWWP MutS_IV MutS_II HORMA
Other DBs
NCBI-GeneID: 100351645
NCBI-ProteinID: XP_002709926
Ensembl: ENSOCUG00000014615
UniProt: G1T7S2
LinkDB
Position
2
AA seq 1361 aa
MSRQSTLFSFFPKTPLPNKSPGRASRDGGGARAATGASASPSGDEAWSEAGPGPRPLADS
ASSPKARNLNGGLRRSAAPAVHVSSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIRQ
KGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQKGGHFYSSKPEILRAMERADEA
LNKDKIKRLELAVCDEPSEQEEEEEEMEVAPTYTSDKSEEDNEIESEEEVQPKLQGSRRS
SRQIKKRRVISDSESDIGGSDVEFKPDAKEEGSSDEVSSAVGDSESEGLDSPVKVVPKRK
RMVTGNGSLKRKNSRKEMPSATKRAPGILAETKSTLSTFSAPQNSESPAQVSGGGGDDSG
RPTTWYHETLEWLKKEKRRDAHRRRPDHPDFDASTLHVPEDFLNSCTPGMRKWWQIKSQN
FDLVIFYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKV
ARVEQTETPEMMEARCRKMAHISKHDRVVRREICRIITKGTQTYSVLEGDPSENYSKFLL
SLKEKEEDSSGHTRVYGVCFVDTSLGKFSIGQFADDRHCSRFRTLVAHYPPAQVLFEKGN
LSVETKAVLKGSLSSSLQEGLIPGSQFWDAAKTLRTLLEEGYFTEKSNEESGVLLPQVLK
GMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDMVSAT
RPGAVFSKASQRMVLDAVTLNNLEVFLNGTNGSTEGTLLEKIDTCYTPFGKRLLKHWLCA
PLCSPCAINDRLDAIEDLMAVPDKVSEVVDLLKKLPDLERLLSKIHNVGSPLKSQNHPDS
RAIMYEETTYSKKKIIDFLSALEGFKTMCKIVEVVEDVVDDFKSKLLTQVVTLQTKNPEG
RFPDLTMELHRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLDYLEKQRS
RIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLIN
AEERRDLSLKDCMRRLFYNFDKNYKDWHSAVECIAVLDVLLCLANYSRGGDGPMCRPVIL
LPGENTAPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEDEEENGKAYCVLVTGPNMGG
KSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETAS
ILTHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQN
DAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRK
AREFEKMTQSLRLFREVCLASERSTIDAEALHKLLTLIKEL
NT seq 4086 nt   +upstreamnt  +downstreamnt
atgtcgcgacagagcaccctgtttagcttcttccccaagactccgctgccgaacaagtcc
ccgggcagggcctcacgagacggcggcggtgcccgcgctgccacgggggcctccgcttcc
cccagcggggatgaggcctggagcgaggctgggcctgggcccaggcccctggcggactct
gcgtcgtcaccaaaggcgaggaacctgaacggagggcttcgcaggtcagcggcgcccgcc
gtccacgtcagttcttgtgacttctcaccaggtgatttggtttgggccaagatggagggt
tacccctggtggccttgtctggtgtacaaccacccctttgatggaacattcatccgccag
aaagggaaatcagttcgtgtccatgtacagttttttgatgacagcccaacaagaggctgg
gttagcaaaaggctgttaaagccgtacacaggttcaaaatcgaaggaagcccagaaggga
ggtcatttttatagttcaaagcctgaaatactgagagcaatggaacgcgcagatgaagcc
ttaaataaagacaaaattaagaggcttgaattggcagtgtgtgatgagccctcagagcaa
gaggaggaggaagaagagatggaggtagctccaacttacacatcagataagagtgaagaa
gataatgagattgagagtgaagaggaagtgcagcctaaattgcaaggatctaggcgaagt
agccgccaaataaaaaaacgaagggtcatttcagattctgagagtgacattggtggctct
gatgtggaattcaagccagatgctaaggaggaaggaagcagtgatgaagttagcagtgca
gtgggtgacagtgagagtgaaggcctggacagccctgtcaaagttgttcccaagcgaaag
agaatggtgactggaaatgggtctcttaaaaggaaaaattcaaggaaggagatgccctca
gccaccaagcgagcacctggcattttggcagaaaccaagagtactttgagtactttctct
gctcctcagaattctgagtcccctgcccaggttagtggaggaggaggtgatgacagtggt
cgccccactacctggtaccatgaaactttagaatggcttaaaaaggaaaagagaagagat
gcacacaggaggcggcccgatcaccccgactttgatgcatccacgctccatgtgcctgaa
gatttcctgaattcctgtactcccggcatgaggaagtggtggcagattaagtctcagaac
tttgatcttgtcatcttctataaggtggggaagttttatgaactgtatcatatggatgct
cttattggcgtcagtgaactggggctggtattcatgaaaggcaactgggcgcattctggt
tttcctgaaattgcttttggccgatactcggattccttggtgcagaagggctataaagta
gcacgcgttgaacagactgaaaccccagaaatgatggaggcaagatgccgaaagatggca
cacatatctaagcatgacagagtggtaaggagggagatttgtaggatcatcaccaagggt
acacagacctacagtgtgctggaaggtgacccttctgagaactacagtaagtttcttctt
agcctgaaggagaaagaggaagattcttctgggcacactcgtgtgtatggtgtgtgcttt
gttgacacgtcactggggaagttttccataggtcagtttgcagatgaccgccattgctcc
aggtttaggaccctagtggcacactatcctccagcgcaagtcttgtttgagaaaggaaat
ctctcagtcgaaaccaaggcagtcctgaagggctcattatcctcttctcttcaggagggt
ctgataccaggctcccagttttgggatgcagccaaaactctgagaactctcctcgaagaa
gggtattttacagaaaagtcaaatgaggagagtggggtgctgttaccccaggtgcttaaa
ggtatgacctcagagtccgattccattgggttgacaccaggagagaagagtgaattggcc
ctctctgctcttggtggttgtgtcttctacctcaaaaaatgccttattgatcaggagctt
ttatcaatggctaattttgaagaatatattcctttggattctgacatggtcagtgctaca
agacctggtgctgtcttctctaaagccagtcagcgaatggtgctagatgcagtgacctta
aacaacttggaggtttttctgaatgggacaaatggctccactgaagggaccttgttagag
aagattgatacttgctacactccctttggtaagcggctcctcaagcactggctttgtgcc
ccactctgtagcccttgtgctatcaatgatcgtctagatgccatagaagacctcatggct
gtgcctgataaagtctctgaagttgtagaccttctgaagaagcttccagatcttgaaagg
cttctgagtaaaattcacaacgttgggtctcccctaaagagccaaaaccacccagacagt
agggctataatgtatgaagaaactacatacagcaaaaaaaagataattgattttctttct
gctcttgaaggattcaaaacaatgtgtaagattgtagaggttgtggaagacgtcgtcgat
gactttaagtcaaaactcctgacgcaggtcgtaactttgcagacaaaaaaccctgaaggc
cgttttcctgatttgactatggaactgcaccgatgggatacggcctttgaccatgaaaag
gctcggaagactggactcatcactcccaaagcaggatttgacagtgattatgaccaagct
cttgctgatataagagaaaatgaacagagcctcctggactacttagagaaacaacgcagt
cgaattggctgtaggaccatagtctactgggggattggtaggaaccgctaccagttggaa
atcccagagaatttcaccacccgcaatttgccagaagagtatgagttgaaatctaccaag
aaaggctgcaaaagatactggaccaaaactattgagaagaaattggccaatctgataaac
gcagaagaacggagagacctatcactgaaggactgcatgcgacgactattctacaacttt
gataaaaactacaaggactggcattctgctgtagagtgcatcgcagtgctggatgtctta
ctgtgcttggctaactacagtcgagggggtgatggccctatgtgccgtccagtaattctg
ttgccaggagaaaacacggctcccttcttagagcttaaaggatcacgtcacccctgcatt
acaaagacattttttggagatgattttattcctaacgacattctaataggctgtgaggaa
gatgaggaagaaaatggcaaagcctattgtgtgcttgttactggaccgaatatggggggc
aagtctaccctcatgagacaggctggcctattagctgtaatggcccagatgggttgttat
gtacctgctgaagtgtgtaggctcacgccaattgatagagtgtttactagactcggtgcc
tcagatagaataatgtcaggtgaaagtacattttttgttgaattgagtgagacggccagc
atacttacacatgcaacagcacattccctggttcttgtagatgaattaggaagaggtact
gcaacctttgatgggacagcaatagccaatgcagttgttaaagaacttgctgagactatt
aagtgtcgtactttgttttctactcactaccattcattagtagaagattattctcaaaat
gatgctgtgcgtctaggacatatggcatgcatggtagaaaatgagtgtgaagaccccagt
caggagactattaccttcctctataaattcattaagggagcttgtcccaagagctatggc
ttcaatgcagcgagacttgctaatcttccagaagaggtcattcaaaagggacacagaaaa
gcgagagaatttgagaagatgactcaatcactacgattatttcgggaagtttgcctggct
agtgagaggtcgactatagatgctgaagcgctccataagttgctgactctgattaaggaa
ttatag

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