KEGG   Oryctolagus cuniculus (rabbit): 100355888
Entry
100355888         CDS       T03373                                 

Gene name
CHUK
Definition
(RefSeq) conserved helix-loop-helix ubiquitous kinase
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu01523  Antifolate resistance
ocu04010  MAPK signaling pathway
ocu04014  Ras signaling pathway
ocu04062  Chemokine signaling pathway
ocu04064  NF-kappa B signaling pathway
ocu04068  FoxO signaling pathway
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04210  Apoptosis
ocu04380  Osteoclast differentiation
ocu04620  Toll-like receptor signaling pathway
ocu04621  NOD-like receptor signaling pathway
ocu04622  RIG-I-like receptor signaling pathway
ocu04623  Cytosolic DNA-sensing pathway
ocu04625  C-type lectin receptor signaling pathway
ocu04657  IL-17 signaling pathway
ocu04658  Th1 and Th2 cell differentiation
ocu04659  Th17 cell differentiation
ocu04660  T cell receptor signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04668  TNF signaling pathway
ocu04920  Adipocytokine signaling pathway
ocu05010  Alzheimer disease
ocu05132  Salmonella infection
ocu05135  Yersinia infection
ocu05142  Chagas disease
ocu05145  Toxoplasmosis
ocu05160  Hepatitis C
ocu05161  Hepatitis B
ocu05162  Measles
ocu05163  Human cytomegalovirus infection
ocu05164  Influenza A
ocu05165  Human papillomavirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05168  Herpes simplex virus 1 infection
ocu05169  Epstein-Barr virus infection
ocu05170  Human immunodeficiency virus 1 infection
ocu05200  Pathways in cancer
ocu05212  Pancreatic cancer
ocu05215  Prostate cancer
ocu05220  Chronic myeloid leukemia
ocu05221  Acute myeloid leukemia
ocu05222  Small cell lung cancer
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100355888 (CHUK)
   04014 Ras signaling pathway
    100355888 (CHUK)
   04064 NF-kappa B signaling pathway
    100355888 (CHUK)
   04668 TNF signaling pathway
    100355888 (CHUK)
   04068 FoxO signaling pathway
    100355888 (CHUK)
   04151 PI3K-Akt signaling pathway
    100355888 (CHUK)
   04150 mTOR signaling pathway
    100355888 (CHUK)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    100355888 (CHUK)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100355888 (CHUK)
   04621 NOD-like receptor signaling pathway
    100355888 (CHUK)
   04622 RIG-I-like receptor signaling pathway
    100355888 (CHUK)
   04623 Cytosolic DNA-sensing pathway
    100355888 (CHUK)
   04625 C-type lectin receptor signaling pathway
    100355888 (CHUK)
   04660 T cell receptor signaling pathway
    100355888 (CHUK)
   04658 Th1 and Th2 cell differentiation
    100355888 (CHUK)
   04659 Th17 cell differentiation
    100355888 (CHUK)
   04657 IL-17 signaling pathway
    100355888 (CHUK)
   04662 B cell receptor signaling pathway
    100355888 (CHUK)
   04062 Chemokine signaling pathway
    100355888 (CHUK)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    100355888 (CHUK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100355888 (CHUK)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100355888 (CHUK)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100355888 (CHUK)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    100355888 (CHUK)
   05221 Acute myeloid leukemia
    100355888 (CHUK)
   05220 Chronic myeloid leukemia
    100355888 (CHUK)
   05215 Prostate cancer
    100355888 (CHUK)
   05222 Small cell lung cancer
    100355888 (CHUK)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100355888 (CHUK)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    100355888 (CHUK)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100355888 (CHUK)
   05135 Yersinia infection
    100355888 (CHUK)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100355888 (CHUK)
   05170 Human immunodeficiency virus 1 infection
    100355888 (CHUK)
   05162 Measles
    100355888 (CHUK)
   05164 Influenza A
    100355888 (CHUK)
   05161 Hepatitis B
    100355888 (CHUK)
   05160 Hepatitis C
    100355888 (CHUK)
   05168 Herpes simplex virus 1 infection
    100355888 (CHUK)
   05163 Human cytomegalovirus infection
    100355888 (CHUK)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100355888 (CHUK)
   05169 Epstein-Barr virus infection
    100355888 (CHUK)
   05165 Human papillomavirus infection
    100355888 (CHUK)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100355888 (CHUK)
   05142 Chagas disease
    100355888 (CHUK)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    100355888 (CHUK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ocu01001]
    100355888 (CHUK)
Enzymes [BR:ocu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     100355888 (CHUK)
Protein kinases [BR:ocu01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   100355888 (CHUK)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo TBK1_ULD
Other DBs
NCBI-GeneID: 100355888
NCBI-ProteinID: XP_002718658
Ensembl: ENSOCUG00000013114
UniProt: G1T4S2
LinkDB
Position
18
AA seq 745 aa
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSSKNRERWCH
EIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIMHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPKC
FILMDHILNLKIGHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPV
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEIGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPADHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSDIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGTVTPQASAWLPPTSAQREHPLSCVVTPQDGDTFAQMIEENLNCLGHL
STIIREANEEQGNSMMNLDWSWLTG
NT seq 2238 nt   +upstreamnt  +downstreamnt
atggagcggcctccggggctgcggccgggtgcgggcgggccctgggagatgcgggagcgg
ctaggcaccggcggcttcgggaacgtgtgcttgtaccagcatcgggaacttgaccttaaa
atagcaattaagtcttgtcgcctagagctaagttccaaaaacagagaacggtggtgccat
gaaatccagatcatgaaaaagttgaatcatgccaatgttgtaaaggcctgtgatgttcct
gaggaattgaattttttgattaatgatgtgcctcttctagcaatggagtactgttctgga
ggagatcttcggaagctactcaacaaaccagaaaattgttgtggacttaaagaaagccag
atactttctttattaagtgatatagggtctgggattcgatatttgcatgaaaacaaaatt
atacatcgagatctaaaacctgaaaacatagttcttcaggatgttggtggaaagataatg
cataaaataattgatctgggatatgccaaagatgttgatcaaggaagtctatgtacatct
tttgtgggaacactgcagtatttggccccagagctttttgagaataagccctacacagca
actgttgattactggagctttgggaccatggtctttgaatgtattgctggatataggcct
tttctacatcatctgcagccgtttacctggcatgagaagattaagaagaaggatccaaag
tgtatatttgcatgtgaagagatgacaggagaagttcggtttagtagccatttgcctcaa
ccaaatagcctttgtagtttaatagtagaacctatggaaaactggctacagttgatgctg
aattgggaccctcagcagagagggggacctgttgaccttactttgaagcagccaaaatgt
ttcatcttaatggatcacattctgaatttgaagatagggcacatcctaaacatgacttct
gcaaagataatttcttttctgttaccacctgatgaaagtcttcattcactacagtctcgt
attgagcgtgaaactggaataaatactggttctcaagagcttctttcagagacaggaatt
tctctggatcctcgaaaaccagcctctcagtgtgttctagatggagttagaggctgtgat
agctatatggtttatttgtttgataaaagtaaaactgtatatgaagggccatttgcttcc
agaagtttatctgattgtgtaaattatattgtacaggacagcaaaatacaacttccagtt
atacagctacgtaaagtatgggctgaagcagtgcactatgtgtctgggctgaaggaagat
tacagcaggctctttcagggacaaagagcagcaatgttaagccttcttagatataatgct
aacttgacaaaaatgaagaacactttgatctcggcatcacagcaactgaaagctaaattg
gaattttttcacaaaagcattcagcttgacttggagagatacagcgaacaaatgacatat
gggatatcttcagaaaaaatgctaaaggcatggaaagaaatggaagaaaaggccatccac
tatgctgagatcggtgtcattgggtacctggaggatcagattatgtccttgcacactgaa
atcatggagctacagaagagcccctacggaagacgtcagggagacttgatggaatctctg
gaacagcgtgccattgatctttataagcagttaaagcacagacctgcagatcattcctac
agcgacagcacagagatggtgaagatcattgtgcatactgtgcagagtcaggaccgagtt
cttaaggagctgtttggccatctaagcaagttgttgggctgtaagcagaagattattgat
ctactccccaaggtggaagtggccctcagtgacatcaaagaagctgacaatactgtcatg
tttatgcaaggaaagaggcagaaagaaatatggcatctccttaaaattgcctgtacacag
agttctgcccggtctcttgtaggatccagtttagagggcacagtaacccctcaggcatca
gcatggctgcccccaacttcagcacaacgtgaacatcctctgtcatgcgtggtaactcct
caagatggggacacttttgcacaaatgatagaagaaaatttgaattgtcttggccattta
agcactattatccgtgaagcaaatgaggaacagggcaatagtatgatgaatctagattgg
agttggttaacaggatga

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