Physeter catodon (sperm whale): 102974072
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Entry
102974072 CDS
T06011
Symbol
SRD5A2
Name
(RefSeq) 3-oxo-5-alpha-steroid 4-dehydrogenase 2
KO
K12344
3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:
1.3.1.22
]
Organism
pcad
Physeter catodon (sperm whale)
Pathway
pcad00140
Steroid hormone biosynthesis
pcad01100
Metabolic pathways
pcad05215
Prostate cancer
Module
pcad_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
pcad00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
102974072 (SRD5A2)
09160 Human Diseases
09162 Cancer: specific types
05215 Prostate cancer
102974072 (SRD5A2)
Enzymes [BR:
pcad01000
]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
102974072 (SRD5A2)
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Gene cluster
GFIT
Motif
Pfam:
Steroid_dh
DUF1295
DUF6832
Motif
Other DBs
NCBI-GeneID:
102974072
NCBI-ProteinID:
XP_023974841
Ensembl:
ENSPCTG00005009686
UniProt:
A0A2Y9S846
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Position
12:complement(49572362..49635038)
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AA seq
254 aa
AA seq
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MSVRCQESPVLAGSATLAVLGALVLCLAEPAGYGKYTESRMPVATRLSARAAWFLQELPS
FVVPAGILAGQPRPLFGQPATVLLGLFCAHYFHRTFVYSLLTRGRPFPVLFLFRGFVFCM
GNGLLQGYYLVYCAEYPAEWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEIIYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPVIF
NT seq
765 nt
NT seq
+upstream
nt +downstream
nt
atgtccgttcgctgccaggagagtccggtgctggcaggcagcgccactttggccgtcctg
ggggcactggttctgtgcctcgcggagcccgccggctacgggaagtacacggagagccgg
atgcccgtggctacccgcctgtccgcccgcgccgcctggttcctgcaggagctgccctcc
tttgtggtgcccgcggggatcctcgccgggcagccccgccctctcttcggccagcctgcg
actgtgcttctgggcctcttctgcgcacattacttccacaggacgtttgtttactcactg
ctcactagagggaggccgtttccagttttattccttttcagaggctttgtcttctgcatg
ggaaatggactcctccaaggctactatctggtttactgtgctgaataccctgctgagtgg
tacacagacatacgatttagcttgggtgtcttcttatttattttgggaatgggaatcaac
attcatagtgactatatattgcgccagctcaggaagcctggagaaatcatctataggatt
ccacaaggtggcttgttcacgtacgtttctggagccaatttccttggcgagatcattgaa
tggatcggctatgccctggccacttggtccctcccagcacttgcatttgcatttttctca
ctttgtttccttgggctgcgagcttttcaccaccatagattctacctcaagatgtttgag
gactaccccaagtctcggaaagccctcattccagtcatcttttaa
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