KEGG   Pongo abelii (Sumatran orangutan): 100173732
Entry
100173732         CDS       T01416                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon01521  EGFR tyrosine kinase inhibitor resistance
pon01522  Endocrine resistance
pon04010  MAPK signaling pathway
pon04012  ErbB signaling pathway
pon04014  Ras signaling pathway
pon04015  Rap1 signaling pathway
pon04022  cGMP-PKG signaling pathway
pon04024  cAMP signaling pathway
pon04062  Chemokine signaling pathway
pon04068  FoxO signaling pathway
pon04071  Sphingolipid signaling pathway
pon04072  Phospholipase D signaling pathway
pon04140  Autophagy - animal
pon04150  mTOR signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04210  Apoptosis
pon04218  Cellular senescence
pon04270  Vascular smooth muscle contraction
pon04360  Axon guidance
pon04370  VEGF signaling pathway
pon04371  Apelin signaling pathway
pon04510  Focal adhesion
pon04540  Gap junction
pon04550  Signaling pathways regulating pluripotency of stem cells
pon04613  Neutrophil extracellular trap formation
pon04625  C-type lectin receptor signaling pathway
pon04630  JAK-STAT signaling pathway
pon04650  Natural killer cell mediated cytotoxicity
pon04660  T cell receptor signaling pathway
pon04662  B cell receptor signaling pathway
pon04664  Fc epsilon RI signaling pathway
pon04666  Fc gamma R-mediated phagocytosis
pon04720  Long-term potentiation
pon04722  Neurotrophin signaling pathway
pon04726  Serotonergic synapse
pon04730  Long-term depression
pon04810  Regulation of actin cytoskeleton
pon04910  Insulin signaling pathway
pon04912  GnRH signaling pathway
pon04914  Progesterone-mediated oocyte maturation
pon04915  Estrogen signaling pathway
pon04916  Melanogenesis
pon04917  Prolactin signaling pathway
pon04919  Thyroid hormone signaling pathway
pon04921  Oxytocin signaling pathway
pon04926  Relaxin signaling pathway
pon04928  Parathyroid hormone synthesis, secretion and action
pon04929  GnRH secretion
pon04935  Growth hormone synthesis, secretion and action
pon05010  Alzheimer disease
pon05022  Pathways of neurodegeneration - multiple diseases
pon05034  Alcoholism
pon05132  Salmonella infection
pon05152  Tuberculosis
pon05160  Hepatitis C
pon05161  Hepatitis B
pon05163  Human cytomegalovirus infection
pon05164  Influenza A
pon05165  Human papillomavirus infection
pon05167  Kaposi sarcoma-associated herpesvirus infection
pon05170  Human immunodeficiency virus 1 infection
pon05200  Pathways in cancer
pon05205  Proteoglycans in cancer
pon05206  MicroRNAs in cancer
pon05207  Chemical carcinogenesis - receptor activation
pon05208  Chemical carcinogenesis - reactive oxygen species
pon05210  Colorectal cancer
pon05211  Renal cell carcinoma
pon05212  Pancreatic cancer
pon05213  Endometrial cancer
pon05214  Glioma
pon05215  Prostate cancer
pon05218  Melanoma
pon05219  Bladder cancer
pon05220  Chronic myeloid leukemia
pon05221  Acute myeloid leukemia
pon05223  Non-small cell lung cancer
pon05224  Breast cancer
pon05225  Hepatocellular carcinoma
pon05226  Gastric cancer
pon05230  Central carbon metabolism in cancer
pon05231  Choline metabolism in cancer
pon05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100173732 (RAF1)
   04012 ErbB signaling pathway
    100173732 (RAF1)
   04014 Ras signaling pathway
    100173732 (RAF1)
   04015 Rap1 signaling pathway
    100173732 (RAF1)
   04370 VEGF signaling pathway
    100173732 (RAF1)
   04371 Apelin signaling pathway
    100173732 (RAF1)
   04630 JAK-STAT signaling pathway
    100173732 (RAF1)
   04068 FoxO signaling pathway
    100173732 (RAF1)
   04072 Phospholipase D signaling pathway
    100173732 (RAF1)
   04071 Sphingolipid signaling pathway
    100173732 (RAF1)
   04024 cAMP signaling pathway
    100173732 (RAF1)
   04022 cGMP-PKG signaling pathway
    100173732 (RAF1)
   04151 PI3K-Akt signaling pathway
    100173732 (RAF1)
   04150 mTOR signaling pathway
    100173732 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100173732 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    100173732 (RAF1)
   04218 Cellular senescence
    100173732 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100173732 (RAF1)
   04540 Gap junction
    100173732 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100173732 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100173732 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100173732 (RAF1)
   04625 C-type lectin receptor signaling pathway
    100173732 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    100173732 (RAF1)
   04660 T cell receptor signaling pathway
    100173732 (RAF1)
   04662 B cell receptor signaling pathway
    100173732 (RAF1)
   04664 Fc epsilon RI signaling pathway
    100173732 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    100173732 (RAF1)
   04062 Chemokine signaling pathway
    100173732 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100173732 (RAF1)
   04929 GnRH secretion
    100173732 (RAF1)
   04912 GnRH signaling pathway
    100173732 (RAF1)
   04915 Estrogen signaling pathway
    100173732 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    100173732 (RAF1)
   04917 Prolactin signaling pathway
    100173732 (RAF1)
   04921 Oxytocin signaling pathway
    100173732 (RAF1)
   04926 Relaxin signaling pathway
    100173732 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    100173732 (RAF1)
   04919 Thyroid hormone signaling pathway
    100173732 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    100173732 (RAF1)
   04916 Melanogenesis
    100173732 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100173732 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    100173732 (RAF1)
   04720 Long-term potentiation
    100173732 (RAF1)
   04730 Long-term depression
    100173732 (RAF1)
   04722 Neurotrophin signaling pathway
    100173732 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    100173732 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100173732 (RAF1)
   05206 MicroRNAs in cancer
    100173732 (RAF1)
   05205 Proteoglycans in cancer
    100173732 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    100173732 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100173732 (RAF1)
   05230 Central carbon metabolism in cancer
    100173732 (RAF1)
   05231 Choline metabolism in cancer
    100173732 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100173732 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100173732 (RAF1)
   05212 Pancreatic cancer
    100173732 (RAF1)
   05225 Hepatocellular carcinoma
    100173732 (RAF1)
   05226 Gastric cancer
    100173732 (RAF1)
   05214 Glioma
    100173732 (RAF1)
   05221 Acute myeloid leukemia
    100173732 (RAF1)
   05220 Chronic myeloid leukemia
    100173732 (RAF1)
   05218 Melanoma
    100173732 (RAF1)
   05211 Renal cell carcinoma
    100173732 (RAF1)
   05219 Bladder cancer
    100173732 (RAF1)
   05215 Prostate cancer
    100173732 (RAF1)
   05213 Endometrial cancer
    100173732 (RAF1)
   05224 Breast cancer
    100173732 (RAF1)
   05223 Non-small cell lung cancer
    100173732 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100173732 (RAF1)
   05161 Hepatitis B
    100173732 (RAF1)
   05160 Hepatitis C
    100173732 (RAF1)
   05164 Influenza A
    100173732 (RAF1)
   05163 Human cytomegalovirus infection
    100173732 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100173732 (RAF1)
   05165 Human papillomavirus infection
    100173732 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100173732 (RAF1)
   05152 Tuberculosis
    100173732 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100173732 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    100173732 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    100173732 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100173732 (RAF1)
   01522 Endocrine resistance
    100173732 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100173732 (RAF1)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100173732 (RAF1)
Protein kinases [BR:pon01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100173732 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 100173732
NCBI-ProteinID: NP_001126730
Ensembl: ENSPPYG00000013388
UniProt: Q5R5M7 A0A2J8TVZ9
LinkDB
Position
2:complement(5213111..5293019)
AA seq 648 aa
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagatccttctaagacaagcaacactatccgtgtt
ttcttgccgaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcgtct
ttgattggagaagaacttcaagtagatttcctggatcatgttccgctcacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaagttcctgctc
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaacatcagacaactcttattgtttccaaattccact
attggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtct
gtttccaggatgcctgttagttctcagcacagatattctacacctcacgccttcaccttt
aacacctccagtccctcatctgaaggttccctctcccagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcactaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctg
agcccaacaggctggtcacagccgaaaacccccgtgccagcacaaagagagcgggcacca
gtatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctctttt
ggaactgtttataagggtaaatggcacggagatgttgcagtaaagatcctaaaggttgtc
gacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaaca
cggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttt
cagatgttccagctaattgacattgcccggcagacggctcagggaatggactatttgcac
gcaaagaacatcatccatagagacatgaaatccaacaatatatttctccatgaaggctta
acagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacctactggctctgtcctgtggatggccccagaggtgatccgaatgcag
gataacaacccattcagtttccagtcggatgtctactcctatggcattgtattgtatgag
ctgatgacgggggagcttccttattctcacatcaacaaccgagatcagatcatcttcatg
gtgggccgaggatatgcctccccagatcttagtaagctatataagaactgccccaaagca
atgaagaggctggtagctgactgtgtgaagaaagtaaaggaggagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagcgct
tccgagccatccttgcatcgggcagcccacactgaggatatcaacgcttgcacactgacc
acgtccccgaggctgcctgtcttctaa

KEGG   Pongo abelii (Sumatran orangutan): 100431871
Entry
100431871         CDS       T01416                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X2
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon01521  EGFR tyrosine kinase inhibitor resistance
pon01522  Endocrine resistance
pon04010  MAPK signaling pathway
pon04012  ErbB signaling pathway
pon04068  FoxO signaling pathway
pon04270  Vascular smooth muscle contraction
pon04650  Natural killer cell mediated cytotoxicity
pon04720  Long-term potentiation
pon04726  Serotonergic synapse
pon04730  Long-term depression
pon04810  Regulation of actin cytoskeleton
pon04910  Insulin signaling pathway
pon04914  Progesterone-mediated oocyte maturation
pon04928  Parathyroid hormone synthesis, secretion and action
pon05010  Alzheimer disease
pon05022  Pathways of neurodegeneration - multiple diseases
pon05034  Alcoholism
pon05160  Hepatitis C
pon05161  Hepatitis B
pon05200  Pathways in cancer
pon05205  Proteoglycans in cancer
pon05208  Chemical carcinogenesis - reactive oxygen species
pon05210  Colorectal cancer
pon05211  Renal cell carcinoma
pon05212  Pancreatic cancer
pon05213  Endometrial cancer
pon05214  Glioma
pon05215  Prostate cancer
pon05218  Melanoma
pon05219  Bladder cancer
pon05220  Chronic myeloid leukemia
pon05221  Acute myeloid leukemia
pon05223  Non-small cell lung cancer
pon05224  Breast cancer
pon05225  Hepatocellular carcinoma
pon05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100431871 (ARAF)
   04012 ErbB signaling pathway
    100431871 (ARAF)
   04068 FoxO signaling pathway
    100431871 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100431871 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100431871 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100431871 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    100431871 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    100431871 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100431871 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    100431871 (ARAF)
   04720 Long-term potentiation
    100431871 (ARAF)
   04730 Long-term depression
    100431871 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100431871 (ARAF)
   05205 Proteoglycans in cancer
    100431871 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    100431871 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100431871 (ARAF)
   05212 Pancreatic cancer
    100431871 (ARAF)
   05225 Hepatocellular carcinoma
    100431871 (ARAF)
   05226 Gastric cancer
    100431871 (ARAF)
   05214 Glioma
    100431871 (ARAF)
   05221 Acute myeloid leukemia
    100431871 (ARAF)
   05220 Chronic myeloid leukemia
    100431871 (ARAF)
   05218 Melanoma
    100431871 (ARAF)
   05211 Renal cell carcinoma
    100431871 (ARAF)
   05219 Bladder cancer
    100431871 (ARAF)
   05215 Prostate cancer
    100431871 (ARAF)
   05213 Endometrial cancer
    100431871 (ARAF)
   05224 Breast cancer
    100431871 (ARAF)
   05223 Non-small cell lung cancer
    100431871 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100431871 (ARAF)
   05160 Hepatitis C
    100431871 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100431871 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    100431871 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    100431871 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100431871 (ARAF)
   01522 Endocrine resistance
    100431871 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100431871 (ARAF)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100431871 (ARAF)
Protein kinases [BR:pon01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100431871 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 100431871
NCBI-ProteinID: XP_009233060
Ensembl: ENSPPYG00000020295
UniProt: A0A663DAS1
LinkDB
Position
X:47946416..47957120
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGSSRQHEAPSNRPLNELL
TPQGPSPCTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAASSRGGSDGTPRGSPSPASVSSGRKSPHSKSPVEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaatggggccgagccatcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacggtcactgcctgggacacagccatcgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgactatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggcagctccagacagcatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccagcccctgcacccagcactgtgacccggagcacttccccttccct
gccccagccaatgcccccctacagcgcatccgctccacgtccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgccagtagtagaggaggtagtgacggaaccccccgggggagccccagccca
gccagcgtgtcctcggggaggaagtccccacattccaagtcaccagtagagcagcgcgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaggtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcactgtgtttcgagggcggtggcatggagatgtggccgtgaaggtgctcaaggtg
tcccagcccacagctgagcaggcccaggctttcaagaatgagatgcaggtgctcaggaag
acacgacatgtcaacatcttgctgtttatgggcttcatgacccggccgggatttgccatc
atcacacagtggtgtgagggctccagcctctaccatcacctgcatgtggccgacacacgc
ttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacggtgaagattggtgactttggcttggccacagtgaagactcgatggagcggggcc
cagcccttggagcagccctcaggctctgtgctgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagacgtctatgcctacggggttgtgctctac
gagcttatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgattgcctcaagttccagcgggaggagcggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagcggagt
gcctcggaaccctccttgcaccgcacccaggccgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

KEGG   Pongo abelii (Sumatran orangutan): 100442288
Entry
100442288         CDS       T01416                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X6
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon01521  EGFR tyrosine kinase inhibitor resistance
pon01522  Endocrine resistance
pon04010  MAPK signaling pathway
pon04012  ErbB signaling pathway
pon04015  Rap1 signaling pathway
pon04024  cAMP signaling pathway
pon04062  Chemokine signaling pathway
pon04068  FoxO signaling pathway
pon04150  mTOR signaling pathway
pon04270  Vascular smooth muscle contraction
pon04510  Focal adhesion
pon04650  Natural killer cell mediated cytotoxicity
pon04720  Long-term potentiation
pon04722  Neurotrophin signaling pathway
pon04726  Serotonergic synapse
pon04730  Long-term depression
pon04810  Regulation of actin cytoskeleton
pon04910  Insulin signaling pathway
pon04914  Progesterone-mediated oocyte maturation
pon04928  Parathyroid hormone synthesis, secretion and action
pon04934  Cushing syndrome
pon05010  Alzheimer disease
pon05022  Pathways of neurodegeneration - multiple diseases
pon05034  Alcoholism
pon05160  Hepatitis C
pon05161  Hepatitis B
pon05200  Pathways in cancer
pon05205  Proteoglycans in cancer
pon05208  Chemical carcinogenesis - reactive oxygen species
pon05210  Colorectal cancer
pon05211  Renal cell carcinoma
pon05212  Pancreatic cancer
pon05213  Endometrial cancer
pon05214  Glioma
pon05215  Prostate cancer
pon05216  Thyroid cancer
pon05218  Melanoma
pon05219  Bladder cancer
pon05220  Chronic myeloid leukemia
pon05221  Acute myeloid leukemia
pon05223  Non-small cell lung cancer
pon05224  Breast cancer
pon05225  Hepatocellular carcinoma
pon05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100442288 (BRAF)
   04012 ErbB signaling pathway
    100442288 (BRAF)
   04015 Rap1 signaling pathway
    100442288 (BRAF)
   04068 FoxO signaling pathway
    100442288 (BRAF)
   04024 cAMP signaling pathway
    100442288 (BRAF)
   04150 mTOR signaling pathway
    100442288 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100442288 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100442288 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100442288 (BRAF)
   04062 Chemokine signaling pathway
    100442288 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100442288 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    100442288 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    100442288 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100442288 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    100442288 (BRAF)
   04720 Long-term potentiation
    100442288 (BRAF)
   04730 Long-term depression
    100442288 (BRAF)
   04722 Neurotrophin signaling pathway
    100442288 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100442288 (BRAF)
   05205 Proteoglycans in cancer
    100442288 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    100442288 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100442288 (BRAF)
   05212 Pancreatic cancer
    100442288 (BRAF)
   05225 Hepatocellular carcinoma
    100442288 (BRAF)
   05226 Gastric cancer
    100442288 (BRAF)
   05214 Glioma
    100442288 (BRAF)
   05216 Thyroid cancer
    100442288 (BRAF)
   05221 Acute myeloid leukemia
    100442288 (BRAF)
   05220 Chronic myeloid leukemia
    100442288 (BRAF)
   05218 Melanoma
    100442288 (BRAF)
   05211 Renal cell carcinoma
    100442288 (BRAF)
   05219 Bladder cancer
    100442288 (BRAF)
   05215 Prostate cancer
    100442288 (BRAF)
   05213 Endometrial cancer
    100442288 (BRAF)
   05224 Breast cancer
    100442288 (BRAF)
   05223 Non-small cell lung cancer
    100442288 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100442288 (BRAF)
   05160 Hepatitis C
    100442288 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100442288 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    100442288 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    100442288 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100442288 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100442288 (BRAF)
   01522 Endocrine resistance
    100442288 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pon01001]
    100442288 (BRAF)
Enzymes [BR:pon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100442288 (BRAF)
Protein kinases [BR:pon01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100442288 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal
Other DBs
NCBI-GeneID: 100442288
NCBI-ProteinID: XP_009241581
Ensembl: ENSPPYG00000018061
UniProt: A0A8I5SZ13
LinkDB
Position
6:complement(138117320..138324768)
AA seq 765 aa
MAALSGGGGGGAEPGQSLFNGDMEPEAGAGAAASSAADPAIPEEVWNIRQMIKLTQEHIE
ALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTS
SSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLK
KALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTF
FTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQ
EEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDR
SSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGP
QRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAV
KMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKS
RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNR
DQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP
KIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq 2298 nt   +upstreamnt  +downstreamnt
atggcggcgctgagcggtggcggtggtggcggcgcggagccgggccagtctctgttcaac
ggggacatggagcccgaggccggcgccggcgccgcggcctcttcggctgcggaccctgcc
attccggaggaggtgtggaatatcagacaaatgattaagttgacacaggaacatatagag
gccctattggacaaatttggtggggagcataatccaccatcaatatatctggaggcctat
gaagaatacaccagcaagctagatgcactccaacaaagagaacaacagttattggaatct
ctggggaacggaactgatttttctgtttctagctctgcatcaatggataccgttacatct
tcttcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaatcccaca
gatgtggcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttcctgccc
aacaaacagaggacagtggtacctgcaaggtgtggagttacagtccgagacagtctaaag
aaagcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaattcaggat
ggagagaagaaaccaattggctgggacactgatatttcctggcttactggagaagaattg
catgtggaagtgttggagaatgttccacttacaacacacaactttgtacgaaaaacgttt
ttcaccttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgctgtcaa
acatgtggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaat
tatgaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaataccacag
gaagaggcctccttagcagagactgccctaacatctggatcatccccttccgcacctgcc
tcagactctattgggccccaaattctcaccagtccatctccttcaaaatccattccaatt
ccacagcccttccgaccagcagatgaagatcatcgaaatcaatttgggcaacgagaccgg
tcctcatcagctcccaatgtgcatataaacacaatagaacctgtcaatattgatgacttg
attagagaccaaggatttcgtggtgatggaggatcaaccacaggtttgtctgccaccccc
cctgcctcattacctggctcactaactaacgtgaaagccttacagaaatctccaggacct
cagcgagaaaggaagtcatcttcatcctcagaagacaggaatcgaatgaaaacacttggt
agacgagactcgagtgatgattgggagattcctgatgggcagattacagtgggacaaaga
attggatctggatcatttggaacagtctacaagggaaagtggcatggtgatgtggcagtg
aaaatgttgaatgtgacagcacctacacctcagcagttacaagccttcaaaaatgaagta
ggagtactcaggaaaacacgacatgtgaatatcctactcttcatgggctattccacaaag
ccacaactggctattgttacccagtggtgtgagggctccagcttgtatcaccatctccat
atcattgagaccaaatttgagatgatcaaacttatagatattgcacgacagactgcacag
ggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatata
tttcttcatgaagacctcacagtaaaaataggtgattttggtctagctacagtgaaatct
cgatggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcacca
gaagtcatcagaatgcaagataaaaatccatacagctttcagtcagatgtatatgcattt
gggattgttctgtatgaattgatgactggacagttaccttattcaaacatcaacaacagg
gaccagataatttttatggtgggacgaggatacctatctccagatctcagtaaggtacgg
agtaactgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaaagagat
gagagaccactctttccccaaattctcgcctctattgagctgctggcccgctcattgcca
aaaattcaccgcagtgcatcagaaccctccttgaatcgggctggtttccaaacagaggat
tttagtctatatgcttgtgcttctccaaaaacacccatccaggcagggggatatggagaa
tttgcagccttcaagtag

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