Pongo abelii (Sumatran orangutan): 100173732
Help
Entry
100173732 CDS
T01416
Gene name
RAF1
Definition
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon01521
EGFR tyrosine kinase inhibitor resistance
pon01522
Endocrine resistance
pon04010
MAPK signaling pathway
pon04012
ErbB signaling pathway
pon04014
Ras signaling pathway
pon04015
Rap1 signaling pathway
pon04022
cGMP-PKG signaling pathway
pon04024
cAMP signaling pathway
pon04062
Chemokine signaling pathway
pon04068
FoxO signaling pathway
pon04071
Sphingolipid signaling pathway
pon04072
Phospholipase D signaling pathway
pon04140
Autophagy - animal
pon04150
mTOR signaling pathway
pon04151
PI3K-Akt signaling pathway
pon04210
Apoptosis
pon04218
Cellular senescence
pon04270
Vascular smooth muscle contraction
pon04360
Axon guidance
pon04370
VEGF signaling pathway
pon04371
Apelin signaling pathway
pon04510
Focal adhesion
pon04540
Gap junction
pon04550
Signaling pathways regulating pluripotency of stem cells
pon04613
Neutrophil extracellular trap formation
pon04625
C-type lectin receptor signaling pathway
pon04630
JAK-STAT signaling pathway
pon04650
Natural killer cell mediated cytotoxicity
pon04660
T cell receptor signaling pathway
pon04662
B cell receptor signaling pathway
pon04664
Fc epsilon RI signaling pathway
pon04666
Fc gamma R-mediated phagocytosis
pon04720
Long-term potentiation
pon04722
Neurotrophin signaling pathway
pon04726
Serotonergic synapse
pon04730
Long-term depression
pon04810
Regulation of actin cytoskeleton
pon04910
Insulin signaling pathway
pon04912
GnRH signaling pathway
pon04914
Progesterone-mediated oocyte maturation
pon04915
Estrogen signaling pathway
pon04916
Melanogenesis
pon04917
Prolactin signaling pathway
pon04919
Thyroid hormone signaling pathway
pon04921
Oxytocin signaling pathway
pon04926
Relaxin signaling pathway
pon04928
Parathyroid hormone synthesis, secretion and action
pon04929
GnRH secretion
pon04935
Growth hormone synthesis, secretion and action
pon05010
Alzheimer disease
pon05022
Pathways of neurodegeneration - multiple diseases
pon05034
Alcoholism
pon05132
Salmonella infection
pon05152
Tuberculosis
pon05160
Hepatitis C
pon05161
Hepatitis B
pon05163
Human cytomegalovirus infection
pon05164
Influenza A
pon05165
Human papillomavirus infection
pon05167
Kaposi sarcoma-associated herpesvirus infection
pon05170
Human immunodeficiency virus 1 infection
pon05200
Pathways in cancer
pon05205
Proteoglycans in cancer
pon05206
MicroRNAs in cancer
pon05210
Colorectal cancer
pon05211
Renal cell carcinoma
pon05212
Pancreatic cancer
pon05213
Endometrial cancer
pon05214
Glioma
pon05215
Prostate cancer
pon05218
Melanoma
pon05219
Bladder cancer
pon05220
Chronic myeloid leukemia
pon05221
Acute myeloid leukemia
pon05223
Non-small cell lung cancer
pon05224
Breast cancer
pon05225
Hepatocellular carcinoma
pon05226
Gastric cancer
pon05230
Central carbon metabolism in cancer
pon05231
Choline metabolism in cancer
pon05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100173732 (RAF1)
04012 ErbB signaling pathway
100173732 (RAF1)
04014 Ras signaling pathway
100173732 (RAF1)
04015 Rap1 signaling pathway
100173732 (RAF1)
04370 VEGF signaling pathway
100173732 (RAF1)
04371 Apelin signaling pathway
100173732 (RAF1)
04630 JAK-STAT signaling pathway
100173732 (RAF1)
04068 FoxO signaling pathway
100173732 (RAF1)
04072 Phospholipase D signaling pathway
100173732 (RAF1)
04071 Sphingolipid signaling pathway
100173732 (RAF1)
04024 cAMP signaling pathway
100173732 (RAF1)
04022 cGMP-PKG signaling pathway
100173732 (RAF1)
04151 PI3K-Akt signaling pathway
100173732 (RAF1)
04150 mTOR signaling pathway
100173732 (RAF1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100173732 (RAF1)
09143 Cell growth and death
04210 Apoptosis
100173732 (RAF1)
04218 Cellular senescence
100173732 (RAF1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100173732 (RAF1)
04540 Gap junction
100173732 (RAF1)
04550 Signaling pathways regulating pluripotency of stem cells
100173732 (RAF1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100173732 (RAF1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100173732 (RAF1)
04625 C-type lectin receptor signaling pathway
100173732 (RAF1)
04650 Natural killer cell mediated cytotoxicity
100173732 (RAF1)
04660 T cell receptor signaling pathway
100173732 (RAF1)
04662 B cell receptor signaling pathway
100173732 (RAF1)
04664 Fc epsilon RI signaling pathway
100173732 (RAF1)
04666 Fc gamma R-mediated phagocytosis
100173732 (RAF1)
04062 Chemokine signaling pathway
100173732 (RAF1)
09152 Endocrine system
04910 Insulin signaling pathway
100173732 (RAF1)
04929 GnRH secretion
100173732 (RAF1)
04912 GnRH signaling pathway
100173732 (RAF1)
04915 Estrogen signaling pathway
100173732 (RAF1)
04914 Progesterone-mediated oocyte maturation
100173732 (RAF1)
04917 Prolactin signaling pathway
100173732 (RAF1)
04921 Oxytocin signaling pathway
100173732 (RAF1)
04926 Relaxin signaling pathway
100173732 (RAF1)
04935 Growth hormone synthesis, secretion and action
100173732 (RAF1)
04919 Thyroid hormone signaling pathway
100173732 (RAF1)
04928 Parathyroid hormone synthesis, secretion and action
100173732 (RAF1)
04916 Melanogenesis
100173732 (RAF1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100173732 (RAF1)
09156 Nervous system
04726 Serotonergic synapse
100173732 (RAF1)
04720 Long-term potentiation
100173732 (RAF1)
04730 Long-term depression
100173732 (RAF1)
04722 Neurotrophin signaling pathway
100173732 (RAF1)
09158 Development and regeneration
04360 Axon guidance
100173732 (RAF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100173732 (RAF1)
05206 MicroRNAs in cancer
100173732 (RAF1)
05205 Proteoglycans in cancer
100173732 (RAF1)
05230 Central carbon metabolism in cancer
100173732 (RAF1)
05231 Choline metabolism in cancer
100173732 (RAF1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100173732 (RAF1)
09162 Cancer: specific types
05210 Colorectal cancer
100173732 (RAF1)
05212 Pancreatic cancer
100173732 (RAF1)
05225 Hepatocellular carcinoma
100173732 (RAF1)
05226 Gastric cancer
100173732 (RAF1)
05214 Glioma
100173732 (RAF1)
05221 Acute myeloid leukemia
100173732 (RAF1)
05220 Chronic myeloid leukemia
100173732 (RAF1)
05218 Melanoma
100173732 (RAF1)
05211 Renal cell carcinoma
100173732 (RAF1)
05219 Bladder cancer
100173732 (RAF1)
05215 Prostate cancer
100173732 (RAF1)
05213 Endometrial cancer
100173732 (RAF1)
05224 Breast cancer
100173732 (RAF1)
05223 Non-small cell lung cancer
100173732 (RAF1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100173732 (RAF1)
05022 Pathways of neurodegeneration - multiple diseases
100173732 (RAF1)
09165 Substance dependence
05034 Alcoholism
100173732 (RAF1)
09171 Infectious disease: bacterial
05132 Salmonella infection
100173732 (RAF1)
05152 Tuberculosis
100173732 (RAF1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
100173732 (RAF1)
05161 Hepatitis B
100173732 (RAF1)
05160 Hepatitis C
100173732 (RAF1)
05164 Influenza A
100173732 (RAF1)
05163 Human cytomegalovirus infection
100173732 (RAF1)
05167 Kaposi sarcoma-associated herpesvirus infection
100173732 (RAF1)
05165 Human papillomavirus infection
100173732 (RAF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100173732 (RAF1)
01522 Endocrine resistance
100173732 (RAF1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pon01001
]
100173732 (RAF1)
Enzymes [BR:
pon01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100173732 (RAF1)
Protein kinases [BR:
pon01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100173732 (RAF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
100173732
NCBI-ProteinID:
NP_001126730
Ensembl:
ENSPPYG00000013388
UniProt:
Q5R5M7
A0A2J8TVZ9
LinkDB
All DBs
Position
3
AA seq
648 aa
AA seq
DB search
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq
1947 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagatccttctaagacaagcaacactatccgtgtt
ttcttgccgaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcgtct
ttgattggagaagaacttcaagtagatttcctggatcatgttccgctcacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaagttcctgctc
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaacatcagacaactcttattgtttccaaattccact
attggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtct
gtttccaggatgcctgttagttctcagcacagatattctacacctcacgccttcaccttt
aacacctccagtccctcatctgaaggttccctctcccagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcactaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctg
agcccaacaggctggtcacagccgaaaacccccgtgccagcacaaagagagcgggcacca
gtatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctctttt
ggaactgtttataagggtaaatggcacggagatgttgcagtaaagatcctaaaggttgtc
gacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaaca
cggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttt
cagatgttccagctaattgacattgcccggcagacggctcagggaatggactatttgcac
gcaaagaacatcatccatagagacatgaaatccaacaatatatttctccatgaaggctta
acagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacctactggctctgtcctgtggatggccccagaggtgatccgaatgcag
gataacaacccattcagtttccagtcggatgtctactcctatggcattgtattgtatgag
ctgatgacgggggagcttccttattctcacatcaacaaccgagatcagatcatcttcatg
gtgggccgaggatatgcctccccagatcttagtaagctatataagaactgccccaaagca
atgaagaggctggtagctgactgtgtgaagaaagtaaaggaggagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagcgct
tccgagccatccttgcatcgggcagcccacactgaggatatcaacgcttgcacactgacc
acgtccccgaggctgcctgtcttctaa
Pongo abelii (Sumatran orangutan): 100431871
Help
Entry
100431871 CDS
T01416
Gene name
ARAF
Definition
(RefSeq) serine/threonine-protein kinase A-Raf isoform X4
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon01521
EGFR tyrosine kinase inhibitor resistance
pon01522
Endocrine resistance
pon04010
MAPK signaling pathway
pon04012
ErbB signaling pathway
pon04068
FoxO signaling pathway
pon04270
Vascular smooth muscle contraction
pon04650
Natural killer cell mediated cytotoxicity
pon04720
Long-term potentiation
pon04726
Serotonergic synapse
pon04730
Long-term depression
pon04810
Regulation of actin cytoskeleton
pon04910
Insulin signaling pathway
pon04914
Progesterone-mediated oocyte maturation
pon04928
Parathyroid hormone synthesis, secretion and action
pon05010
Alzheimer disease
pon05022
Pathways of neurodegeneration - multiple diseases
pon05034
Alcoholism
pon05160
Hepatitis C
pon05161
Hepatitis B
pon05200
Pathways in cancer
pon05205
Proteoglycans in cancer
pon05210
Colorectal cancer
pon05211
Renal cell carcinoma
pon05212
Pancreatic cancer
pon05213
Endometrial cancer
pon05214
Glioma
pon05215
Prostate cancer
pon05218
Melanoma
pon05219
Bladder cancer
pon05220
Chronic myeloid leukemia
pon05221
Acute myeloid leukemia
pon05223
Non-small cell lung cancer
pon05224
Breast cancer
pon05225
Hepatocellular carcinoma
pon05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100431871 (ARAF)
04012 ErbB signaling pathway
100431871 (ARAF)
04068 FoxO signaling pathway
100431871 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
100431871 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100431871 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
100431871 (ARAF)
04914 Progesterone-mediated oocyte maturation
100431871 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
100431871 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100431871 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
100431871 (ARAF)
04720 Long-term potentiation
100431871 (ARAF)
04730 Long-term depression
100431871 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100431871 (ARAF)
05205 Proteoglycans in cancer
100431871 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
100431871 (ARAF)
05212 Pancreatic cancer
100431871 (ARAF)
05225 Hepatocellular carcinoma
100431871 (ARAF)
05226 Gastric cancer
100431871 (ARAF)
05214 Glioma
100431871 (ARAF)
05221 Acute myeloid leukemia
100431871 (ARAF)
05220 Chronic myeloid leukemia
100431871 (ARAF)
05218 Melanoma
100431871 (ARAF)
05211 Renal cell carcinoma
100431871 (ARAF)
05219 Bladder cancer
100431871 (ARAF)
05215 Prostate cancer
100431871 (ARAF)
05213 Endometrial cancer
100431871 (ARAF)
05224 Breast cancer
100431871 (ARAF)
05223 Non-small cell lung cancer
100431871 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
100431871 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
100431871 (ARAF)
09165 Substance dependence
05034 Alcoholism
100431871 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
100431871 (ARAF)
05160 Hepatitis C
100431871 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100431871 (ARAF)
01522 Endocrine resistance
100431871 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pon01001
]
100431871 (ARAF)
Enzymes [BR:
pon01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100431871 (ARAF)
Protein kinases [BR:
pon01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100431871 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
APH
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
100431871
NCBI-ProteinID:
XP_009233060
Ensembl:
ENSPPYG00000020295
UniProt:
A0A663DAS1
H2PVG7
LinkDB
All DBs
Position
X
AA seq
606 aa
AA seq
DB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGSSRQHEAPSNRPLNELL
TPQGPSPCTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAASSRGGSDGTPRGSPSPASVSSGRKSPHSKSPVEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq
1821 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggcccccctgccaatggggccgagccatcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacggtcactgcctgggacacagccatcgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgactatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggcagctccagacagcatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccagcccctgcacccagcactgtgacccggagcacttccccttccct
gccccagccaatgcccccctacagcgcatccgctccacgtccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgccagtagtagaggaggtagtgacggaaccccccgggggagccccagccca
gccagcgtgtcctcggggaggaagtccccacattccaagtcaccagtagagcagcgcgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaggtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcactgtgtttcgagggcggtggcatggagatgtggccgtgaaggtgctcaaggtg
tcccagcccacagctgagcaggcccaggctttcaagaatgagatgcaggtgctcaggaag
acacgacatgtcaacatcttgctgtttatgggcttcatgacccggccgggatttgccatc
atcacacagtggtgtgagggctccagcctctaccatcacctgcatgtggccgacacacgc
ttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacggtgaagattggtgactttggcttggccacagtgaagactcgatggagcggggcc
cagcccttggagcagccctcaggctctgtgctgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagacgtctatgcctacggggttgtgctctac
gagcttatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgattgcctcaagttccagcgggaggagcggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagcggagt
gcctcggaaccctccttgcaccgcacccaggccgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag
Pongo abelii (Sumatran orangutan): 100442288
Help
Entry
100442288 CDS
T01416
Gene name
BRAF
Definition
(RefSeq) serine/threonine-protein kinase B-raf isoform X1
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon01521
EGFR tyrosine kinase inhibitor resistance
pon01522
Endocrine resistance
pon04010
MAPK signaling pathway
pon04012
ErbB signaling pathway
pon04015
Rap1 signaling pathway
pon04024
cAMP signaling pathway
pon04062
Chemokine signaling pathway
pon04068
FoxO signaling pathway
pon04150
mTOR signaling pathway
pon04270
Vascular smooth muscle contraction
pon04510
Focal adhesion
pon04650
Natural killer cell mediated cytotoxicity
pon04720
Long-term potentiation
pon04722
Neurotrophin signaling pathway
pon04726
Serotonergic synapse
pon04730
Long-term depression
pon04810
Regulation of actin cytoskeleton
pon04910
Insulin signaling pathway
pon04914
Progesterone-mediated oocyte maturation
pon04928
Parathyroid hormone synthesis, secretion and action
pon04934
Cushing syndrome
pon05010
Alzheimer disease
pon05022
Pathways of neurodegeneration - multiple diseases
pon05034
Alcoholism
pon05160
Hepatitis C
pon05161
Hepatitis B
pon05200
Pathways in cancer
pon05205
Proteoglycans in cancer
pon05210
Colorectal cancer
pon05211
Renal cell carcinoma
pon05212
Pancreatic cancer
pon05213
Endometrial cancer
pon05214
Glioma
pon05215
Prostate cancer
pon05216
Thyroid cancer
pon05218
Melanoma
pon05219
Bladder cancer
pon05220
Chronic myeloid leukemia
pon05221
Acute myeloid leukemia
pon05223
Non-small cell lung cancer
pon05224
Breast cancer
pon05225
Hepatocellular carcinoma
pon05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100442288 (BRAF)
04012 ErbB signaling pathway
100442288 (BRAF)
04015 Rap1 signaling pathway
100442288 (BRAF)
04068 FoxO signaling pathway
100442288 (BRAF)
04024 cAMP signaling pathway
100442288 (BRAF)
04150 mTOR signaling pathway
100442288 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
100442288 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100442288 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100442288 (BRAF)
04062 Chemokine signaling pathway
100442288 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
100442288 (BRAF)
04914 Progesterone-mediated oocyte maturation
100442288 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
100442288 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100442288 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
100442288 (BRAF)
04720 Long-term potentiation
100442288 (BRAF)
04730 Long-term depression
100442288 (BRAF)
04722 Neurotrophin signaling pathway
100442288 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100442288 (BRAF)
05205 Proteoglycans in cancer
100442288 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
100442288 (BRAF)
05212 Pancreatic cancer
100442288 (BRAF)
05225 Hepatocellular carcinoma
100442288 (BRAF)
05226 Gastric cancer
100442288 (BRAF)
05214 Glioma
100442288 (BRAF)
05216 Thyroid cancer
100442288 (BRAF)
05221 Acute myeloid leukemia
100442288 (BRAF)
05220 Chronic myeloid leukemia
100442288 (BRAF)
05218 Melanoma
100442288 (BRAF)
05211 Renal cell carcinoma
100442288 (BRAF)
05219 Bladder cancer
100442288 (BRAF)
05215 Prostate cancer
100442288 (BRAF)
05213 Endometrial cancer
100442288 (BRAF)
05224 Breast cancer
100442288 (BRAF)
05223 Non-small cell lung cancer
100442288 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
100442288 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
100442288 (BRAF)
09165 Substance dependence
05034 Alcoholism
100442288 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100442288 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
100442288 (BRAF)
05160 Hepatitis C
100442288 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100442288 (BRAF)
01522 Endocrine resistance
100442288 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pon01001
]
100442288 (BRAF)
Enzymes [BR:
pon01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100442288 (BRAF)
Protein kinases [BR:
pon01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100442288 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
C1_2
Pkinase_fungal
APH
Kdo
Motif
Other DBs
NCBI-GeneID:
100442288
NCBI-ProteinID:
XP_009241581
Ensembl:
ENSPPYG00000018061
UniProt:
H2PNQ1
LinkDB
All DBs
Position
7
AA seq
765 aa
AA seq
DB search
MAALSGGGGGGAEPGQSLFNGDMEPEAGAGAAASSAADPAIPEEVWNIRQMIKLTQEHIE
ALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTS
SSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLK
KALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTF
FTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQ
EEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDR
SSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGP
QRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAV
KMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKS
RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNR
DQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP
KIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq
2298 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgctgagcggtggcggtggtggcggcgcggagccgggccagtctctgttcaac
ggggacatggagcccgaggccggcgccggcgccgcggcctcttcggctgcggaccctgcc
attccggaggaggtgtggaatatcagacaaatgattaagttgacacaggaacatatagag
gccctattggacaaatttggtggggagcataatccaccatcaatatatctggaggcctat
gaagaatacaccagcaagctagatgcactccaacaaagagaacaacagttattggaatct
ctggggaacggaactgatttttctgtttctagctctgcatcaatggataccgttacatct
tcttcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaatcccaca
gatgtggcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttcctgccc
aacaaacagaggacagtggtacctgcaaggtgtggagttacagtccgagacagtctaaag
aaagcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaattcaggat
ggagagaagaaaccaattggctgggacactgatatttcctggcttactggagaagaattg
catgtggaagtgttggagaatgttccacttacaacacacaactttgtacgaaaaacgttt
ttcaccttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgctgtcaa
acatgtggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaat
tatgaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaataccacag
gaagaggcctccttagcagagactgccctaacatctggatcatccccttccgcacccgcc
tcagactctattgggccccaaattctcaccagtccatctccttcaaaatccattccaatt
ccacagcccttccgaccagcagatgaagatcatcgaaatcaatttgggcaacgagaccgg
tcctcatcagctcccaatgtgcatataaacacaatagaacctgtcaatattgatgacttg
attagagaccaaggatttcgtggtgatggaggatcaaccacaggtttgtctgccaccccc
cctgcctcattacctggctcactaactaacgtgaaagccttacagaaatctccaggacct
cagcgagaaaggaagtcatcttcatcctcagaagacaggaatcgaatgaaaacacttggt
agacgagactcgagtgatgattgggagattcctgatgggcagattacagtgggacaaaga
attggatctggatcatttggaacagtctacaagggaaagtggcatggtgatgtggcagtg
aaaatgttgaatgtgacagcacctacacctcagcagttacaagccttcaaaaatgaagta
ggagtactcaggaaaacacgacatgtgaatatcctactcttcatgggctattccacaaag
ccacaactggctattgttacccagtggtgtgagggctccagcttgtatcaccatctccat
atcattgagaccaaatttgagatgatcaaacttatagatattgcacgacagactgcacag
ggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatata
tttcttcatgaagacctcacagtaaaaataggtgattttggtctagctacagtgaaatct
cgatggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcacca
gaagtcatcagaatgcaagataaaaatccatacagctttcagtcagatgtatatgcattt
gggattgttctgtatgaattgatgactggacagttaccttattcaaacatcaacaacagg
gaccagataatttttatggtgggacgaggatacctatctccagatctcagtaaggtacgg
agtaactgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaaagagat
gagagaccactctttccccaaattctcgcctctattgagctgctggcccgctcattgcca
aaaattcaccgcagtgcatcagaaccctccttgaatcgggctggtttccaaacagaggat
tttagtctatatgcttgtgcttctccaaaaacacccatccaggcagggggatatggagaa
tttgcagccttcaagtag
DBGET
integrated database retrieval system
