KEGG   Pongo abelii (Sumatran orangutan): 100173994
Entry
100173994         CDS       T01416                                 

Gene name
HIF1A
Definition
(RefSeq) hypoxia-inducible factor 1-alpha
  KO
K08268  hypoxia-inducible factor 1 alpha
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon04066  HIF-1 signaling pathway
pon04137  Mitophagy - animal
pon04140  Autophagy - animal
pon04659  Th17 cell differentiation
pon04919  Thyroid hormone signaling pathway
pon05167  Kaposi sarcoma-associated herpesvirus infection
pon05200  Pathways in cancer
pon05205  Proteoglycans in cancer
pon05211  Renal cell carcinoma
pon05230  Central carbon metabolism in cancer
pon05231  Choline metabolism in cancer
pon05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    100173994 (HIF1A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100173994 (HIF1A)
   04137 Mitophagy - animal
    100173994 (HIF1A)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    100173994 (HIF1A)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    100173994 (HIF1A)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100173994 (HIF1A)
   05205 Proteoglycans in cancer
    100173994 (HIF1A)
   05230 Central carbon metabolism in cancer
    100173994 (HIF1A)
   05231 Choline metabolism in cancer
    100173994 (HIF1A)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100173994 (HIF1A)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    100173994 (HIF1A)
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    100173994 (HIF1A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:pon03000]
    100173994 (HIF1A)
Transcription factors [BR:pon03000]
 Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Factors with PAS domain
    100173994 (HIF1A)
SSDB
Motif
Pfam: PAS_3 HIF-1a_CTAD PAS_11 HIF-1 PAS PAS_9 PAS_4 DDRGK HLH
Other DBs
NCBI-GeneID: 100173994
NCBI-ProteinID: NP_001126975
UniProt: Q5R4G1
LinkDB
Position
14
AA seq 827 aa
MEGAGGANDKKNRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASV
MRLTISYLRVRKLLDAGDLDIEDEMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKY
MGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGPVKKGKEQNTQRSFFLRMKCTLTSRG
RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDS
KTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQ
VTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTEC
VLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTE
TDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLE
PNPESLELSFTMPQIQDQPPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKL
FAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTV
TVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPY
RDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRK
RKMEHDGSLFQAVGIGTLLQQPEDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLA
CRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
NT seq 2484 nt   +upstreamnt  +downstreamnt
atggagggcgccggcggcgcgaacgacaagaaaaataggataagttctgaacgtcgaaaa
gaaaagtctcgagatgcagccagatctcggcgaagtaaagaatctgaagttttttatgag
cttgctcatcagttgccacttccacataatgtgagttcgcatcttgataaggcctctgtg
atgaggcttaccatcagctatttgcgtgtgaggaaacttctggatgctggtgatttggat
attgaagatgaaatgaaagcacagatgaattgcttttatttgaaagccttggatggtttt
gttatggttctcacagatgatggtgacatgatttacatttctgataatgtgaacaaatac
atgggattaactcagtttgaactaactggacacagtgtgtttgattttactcatccatgt
gaccatgaggaaatgagagaaatgcttacacacagaaatggccctgtgaaaaagggtaaa
gaacagaacacacagcgaagcttttttctcagaatgaagtgtaccctaactagccgagga
agaactatgaacataaagtctgcaacatggaaggtattgcactgcacaggccatattcac
gtatatgataccaacagtaaccaacctcagtgtgggtataagaaaccacctatgacctgc
ttggtgctgatttgtgaacccattcctcacccatcaaatattgaaattcctttagatagc
aagactttcctcagtcgacacagcctggatatgaaattttcttattgtgatgaaagaatt
accgaattgatgggatatgagccagaagaacttttaggccgctcaatttatgaatattat
catgctttggactctgatcatctgaccaaaactcatcatgacatgtttactaaaggacaa
gttaccacaggacagtacaggatgcttgccaaaagaggtggatatgtctgggttgaaact
caagcaactgtcatatataacaccaagaattctcaaccacagtgcattgtatgtgtgaat
tatgttgtgagtggtattattcagcacgacttgattttctcccttcaacaaacagaatgt
gtccttaaaccggttgaatcttcagatatgaaaatgactcagctattcaccaaagttgaa
tcagaagacacaagtagcctctttgacaaacttaagaaggaacctgatgctttaactttg
ctggccccagccgctggagacacaatcatatctttagattttggcagcaatgacacagaa
actgatgaccagcaacttgaggaagtaccattatataatgatgtaatgctcccctcaccc
aacgaaaaattacagaatataaatttggcaatgtctccattacccaccgctgaaacacca
aagccacttcgaagtagtgctgaccctgcactcaatcaagaagttgcattaaaattagaa
ccaaatccagagtcactggaactttcttttaccatgccccagattcaggatcagccacct
agtccttctgatggaagcactagacaaagttcacctgagcctaatagtcccagtgaatat
tgtttttatgtggatagtgatatggtcaatgaattcaagttggaattggtagaaaaactt
tttgctgaagacacagaagcaaagaacccattttctactcaggacacagatttagacttg
gagatgttagctccctatatcccaatggatgatgacttccagttacgttccttcgatcag
ttgtcaccattagaaagcagttccgcaagccctgaaagcgcaagtcctcaaagcacagtt
acagtattccagcagactcaaatacaagaacctactgctaatgccaccactaccactgcc
accactgatgaattaaaaacagtgacaaaagaccgtatggaagacattaaaatactgatt
gcatctccatctcctacccacatacataaagaaactactagtgccacatcatcaccatat
agagatactcaaagtcggacagcctcaccaaacagagcaggaaaaggagtcatagaacag
acagaaaaatctcatccaagaagccctaacgtgttatctgtcgctttgagtcaaagaact
acagttcctgaggaagaactaaatccaaagatactagctttgcagaatgctcagagaaag
cgaaaaatggaacatgatggttcactttttcaagcagtaggaattggaacattattacag
cagccagaggatcatgcagctactacatcactttcttggaaacgtgtaaaaggatgcaaa
tctagtgaacagaatggaatggagcaaaagacaattattttaataccttctgatttagca
tgtagactgctggggcaatcaatggatgaaagtggattaccacagctgaccagttatgat
tgtgaagttaatgctcctatacaaggcagcagaaacctactgcagggtgaagaattactc
agagctttggatcaagttaactga

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