Pongo abelii (Sumatran orangutan): 100174343 Help Entry 100174343         CDS       T01416                                  Gene name ACTN4 Definition (RefSeq) alpha-actinin-4   KO K05699   actinin alpha 1/4 Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04510   Focal adhesion pon04520   Adherens junction pon04530   Tight junction pon04670   Leukocyte transendothelial migration pon04810   Regulation of actin cytoskeleton pon05146   Amoebiasis pon05203   Viral carcinogenesis pon05322   Systemic lupus erythematosus Brite KEGG Orthology (KO) [BR:pon00001]  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     100174343 (ACTN4)    04520 Adherens junction     100174343 (ACTN4)    04530 Tight junction     100174343 (ACTN4)   09142 Cell motility    04810 Regulation of actin cytoskeleton     100174343 (ACTN4)  09150 Organismal Systems   09151 Immune system    04670 Leukocyte transendothelial migration     100174343 (ACTN4)  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     100174343 (ACTN4)   09163 Immune disease    05322 Systemic lupus erythematosus     100174343 (ACTN4)   09174 Infectious disease: parasitic    05146 Amoebiasis     100174343 (ACTN4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:pon04131]     100174343 (ACTN4)   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:pon04812]     100174343 (ACTN4)    04147 Exosome [BR:pon04147]     100174343 (ACTN4) Membrane trafficking [BR:pon04131]  Exocytosis   Small GTPases and associated proteins    Rab associated proteins     100174343 (ACTN4) Cytoskeleton proteins [BR:pon04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Cross-linking proteins      100174343 (ACTN4) Exosome [BR:pon04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    100174343 (ACTN4)   Exosomal proteins of colorectal cancer cells    100174343 (ACTN4)   Exosomal proteins of bladder cancer cells    100174343 (ACTN4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Spectrin CH EFhand_Ca_insen EF-hand_1 EF-hand_6 CAMSAP_CH EF-hand_7 EF-hand_8 Motif Other DBs NCBI-GeneID:  100174343 NCBI-ProteinID:  NP_001127286 Ensembl:  ENSPPYG00000009939 UniProt:  Q5RCS6 LinkDB All DBs Position 19 AA seq 911 aa AA seqDB search MVDYHAASQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWC NSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIA SKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKM LDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICRVLAVNQENEHLMEDYEK LASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ KASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAES NHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV VGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIF DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKD HGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETT DTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKS FSTALYGESDL NT seq 2736 nt NT seq  +upstreamnt  +downstreamnt atggtggactaccacgcggcgagccagtcgtaccagtacggccccagcagcgcgggcaat ggcgctggcggcgggggcagcatgggcgactacatggcccaggaggacgactgggaccgg gacctgctgctggacccggcctgggagaagcagcagcgcaagaccttcacggcgtggtgc aactcccacttgcggaaggcaggcacacagatcgagaacattgatgaggacttccgagac gggctcaagctcatgctgctcctggaggtcatatcaggggagcggttacctaagccggag cgggggaagatgagagtgcacaaaatcaacaatgtgaacaaagcgctggactttattgcc agcaaaggcgtcaagctggtctccatcggggcagaagagattgtggacggcaatgcaaag atgaccctgggaatgatctggaccatcatccttaggttcgccatccaggacatctccgtg gaagagacctcggccaaggaagggctccttctctggtgccagagaaagacagccccgtat aagaacgtcaatgtgcagaacttccacatcagctggaaggatggtcttgccttcaatgcc ctgatccaccggcacagaccagagctgattgagtatgacaagctgaggaaggacgaccct gtcaccaacctgaacaatgccttcgaagtggctgagaaatacctcgacatccccaagatg ctggatgcagaggacatcgtgaacacggcccggcccgacgagaaggccataatgacctat gtgtccagcttctaccatgccttttcaggagcgcagaaggctgaaactgccgccaaccgg atctgcagggtgttggctgtcaaccaagagaacgagcacttgatggaggactacgagaag ctggccagcgatctcctggagtggatccggcgcaccatcccctggctggaggaccgtgtg ccccaaaagactatccaggagatgcagcagaagctggaggacttccgcgactaccggcgc gtgcacaagccgcccaaggtgcaggagaagtgccagctggagatcaacttcaacacactg cagaccaagctgcgcctcagcaaccggcccgccttcatgccctccgagggcaagatggtc tcggacatcaacaacggctggcagcacttggagcaggctgagaagggctatgaggaatgg ctgctgaatgagatccgcaggctggagcggctcgaccacctggcagagaagttccggcag aaggcctccatccacgaggcctggactgacgggaaggaagccatgctgaagcaccgagac tacgagacggccacgctatcggacatcaaagccctcattcgcaagcacgaggccttcgag agtgacctggccgcgcaccaggaccgcgtggagcagatcgccgccattgcccaggagctc aacgagctggattactacgactcccacaatgtcaacacccggtgccagaagatctgcgac cagtgggacgccctcggctctctgacgcacagtcgcagggaagccctggagaaaacagag aagcagctggaggccatcgaccagctgcacctggagtatgccaagcgcgcagccccattc aacaactggatggagagcgccatggaggacctccaggacatgttcattgtccataccatc gaggagattgagggcctgatctcagcccacgaccagttcaagtccaccctgccggacgcc gacagggagcgcgaggccatcctggccatccacaaggaggcccagaggatcgctgaaagt aaccacatcaagctgtcgggcagcaacccctacaccactgtcaccccacagatcatcaac tccaagtgggagaaggtacagcagctggtgccaaaacgggaccacgccctcctggaggag cagagcaagcagcagtccaacgagcacctgcgccgccagtttgccagccaggccaacgtc gtggggccctggatccagaccaagatggaggagatcgggcgcatctccattgagatgaac gggaccctggaggaccagctgagccacctgaagcagtatgaacgcagcatcgtggactac aagcctaacctggacctgctggagcagcagcaccagctcatccaggaggccctcatcttc gacaacaagcacaccaactataccatggagcacatccgtgtgggctgggagcagctgctc accaccattgcccgcaccatcaatgaggtggagaaccagatcctcacccgcgacgccaag ggcatcagccaggagcagatgcaggagttccgggcgtccttcaaccacttcgacaaggat catggcggggcgctggggcccgaggagttcaaggcctgcctcatcagcctgggctacgac gtggagaacgaccggcagggtgaggccgagttcaaccgcatcatgagcctggtcgacccc aaccatagtggccttgtgaccttccaagccttcatcgacttcatgtcgcgggagaccacc gacacggacacggccgaccaggtcatcgcttccttcaaggtcctggcaggggacaagaac ttcatcacagctgaggagctgcggagagagctgccccccgaccaggctgagtactgcatc gcccgcatggcgccgtaccagggccctgatgccgtgcccggcgcccttgactacaagtcc ttctccacagccctgtatggcgagagcgacctgtga

Pongo abelii (Sumatran orangutan): 100460195 Help Entry 100460195         CDS       T01416                                  Gene name ACTN1 Definition (RefSeq) alpha-actinin-1 isoform X1   KO K05699   actinin alpha 1/4 Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04510   Focal adhesion pon04520   Adherens junction pon04530   Tight junction pon04670   Leukocyte transendothelial migration pon04810   Regulation of actin cytoskeleton pon05146   Amoebiasis pon05203   Viral carcinogenesis pon05322   Systemic lupus erythematosus Brite KEGG Orthology (KO) [BR:pon00001]  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     100460195 (ACTN1)    04520 Adherens junction     100460195 (ACTN1)    04530 Tight junction     100460195 (ACTN1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     100460195 (ACTN1)  09150 Organismal Systems   09151 Immune system    04670 Leukocyte transendothelial migration     100460195 (ACTN1)  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     100460195 (ACTN1)   09163 Immune disease    05322 Systemic lupus erythematosus     100460195 (ACTN1)   09174 Infectious disease: parasitic    05146 Amoebiasis     100460195 (ACTN1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:pon04131]     100460195 (ACTN1)   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:pon04812]     100460195 (ACTN1)    04147 Exosome [BR:pon04147]     100460195 (ACTN1) Membrane trafficking [BR:pon04131]  Exocytosis   Small GTPases and associated proteins    Rab associated proteins     100460195 (ACTN1) Cytoskeleton proteins [BR:pon04812]  Eukaryotic cytoskeleton proteins   Actin filaments / Microfilaments    Actin-binding proteins     Cross-linking proteins      100460195 (ACTN1) Exosome [BR:pon04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    100460195 (ACTN1)   Exosomal proteins of colorectal cancer cells    100460195 (ACTN1)   Exosomal proteins of bladder cancer cells    100460195 (ACTN1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Spectrin CH EFhand_Ca_insen EF-hand_1 EF-hand_6 EF-hand_7 CAMSAP_CH EF-hand_8 EF-hand_5 XisI Motif Other DBs NCBI-GeneID:  100460195 NCBI-ProteinID:  XP_024087662 Ensembl:  ENSPPYG00000005935 LinkDB All DBs Position 14 AA seq 1020 aa AA seqDB search MPGIPNERRWGEVWATRPGQWRASGGLCPFPPPPPASAHAALVCPPSSVCVEIRSKRPPR GRQSASPAAAVAASSSLRQQRRGGTGRRGASPAPPAQPSPTPSPRQGSSRCSERRWRKKS RPQHARTIMDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQI ENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGA EEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHIS WKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTAR PDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRR TIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPA FMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDG KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSV NARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDL QDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPY TTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEE IGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH IRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFK ACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMAS FKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL NT seq 3063 nt NT seq  +upstreamnt  +downstreamnt atgccaggaattcccaatgagaggcgatggggggaagtttgggcaactcggcctggccaa tggagagcctcgggagggctctgccccttccccccgcccccgcccgcctcggctcacgca gcgctagtgtgtccgcctagctcagtgtgcgtggagattaggtccaagcgcccgcccaga ggcaggcagtccgcgagcccagccgccgctgtcgccgccagtagcagccttcgccagcag cgccgcggcggaaccgggcgcaggggagcgagcccggccccgccagcccagcccagccct actccctccccacgccagggcagcagccgttgctcagagagaaggtggaggaagaaatcc agaccccagcacgcgcgcaccatcatggaccattatgattctcagcaaaccaacgattac atgcagccagaagaggactgggaccgggacctgctcctggacccggcctgggagaagcag cagagaaagacattcacggcatggtgtaactcccacctccggaaggcggggacacagatc gagaacatcgaagaggacttccgggatggcctgaagctcatgctgctgctggaggtcatc tcaggtgaacgcttggctaagccagagcgaggcaagatgagagtgcacaagatctccaac gtcaacaaggccctggatttcatagctagcaaaggcgtcaaactggtgtccatcggagcc gaagaaatcgtggatgggaatgtgaagatgaccctgggcatgatctggaccatcatcctg cgctttgccatccaggacatctctgtggaagagacttcagctaaggaagggctgctcctg tggtgtcagagaaagacagccccttacaaaaacgtcaacatccagaacttccacataagc tggaaggatggcctcggcttctgtgccttgattcaccgacaccggcccgagctgattgac tacgggaagctgcggaaggatgatccactcacaaatctgaatacggcttttgacgtggca gagaagtacctggacatccctaagatgctggatgccgaagacatcgttggaactgcccga ccggatgagaaagccatcatgacttatgtgtctagcttctaccacgccttctctggagcc cagaaggcggagacagcagccaatcgcatctgcaaggtgttggccgtcaaccaggagaac gagcagcttatggaagactacgagaagttggccagtgatctgttggagtggatccgccgc acaatcccgtggctggagaaccgggtgcccgagaacaccatgcatgccatgcagcagaag ctggaggatttccgggactaccggcgcctgcacaagccgcccaaggtgcaggagaagtgc cagctggagatcaacttcaacacgctgcagaccaagctgcggctcagcaaccggcctgcc ttcatgccctctgagggcaggatggtctcggacatcaacaatgcctggggctgcctggag caggtggagaagggctatgaggagtggttgctgaacgagatccggaggctggagcgactg gaccacctggcagagaagttccggcagaaggcctccatccacgaggcctggactgacggc aaagaggccatgctgcgacagaaggactatgagacagccaccctctcggagatcaaggcc ctgctcaagaagcatgaggccttcgagagtgacctggctgcccaccaggaccgcgtggag cagattgccgccatcgcacaggagctcaatgagctggactattatgactcacccagtgtc aacgcccgttgccaaaagatctgtgaccagtgggacaatctgggggccctaactcagaag cgaagggaagctctggagcggaccgagaaactgctggagaccattgaccagctgtacttg gagtatgccaagcgggctgcacccttcaacaactggatggagggggccatggaggacctg caggacaccttcattgtgcacaccattgaggagatccagggactgaccacagcccatgag cagttcaaggccaccctccctgatgccgacaaggagcgcctggccatactgggcatccac aacgaggtgtccaagattgtccagacctaccacgtcaatatggcgggcaccaacccctac acaaccatcacgcctcaggagatcaatggcaaatgggaccacgtgcggcagctggtgcca cggagggaccaagctctgacggaggagcatgcccgacagcagcacaatgagaggctacgc aagcagtttggggcccaggccaatgtcatcgggccctggatccagaccaagatggaggag atcgggaggatctccattgagatgcacgggaccctggaggaccagctcagccacctgcgg cagtatgagaagagtatcgtcaactacaagccaaagattgatcagctggagggcgaccac cagctcatccaggaggcactcatctttgacaacaagcacaccaactacaccatggagcac atccgtgtgggctgggagcagctgctcaccaccatcgccaggaccatcaatgaggtggag aaccagatcctgacccgggatgccaagggcattagccaggagcagatgaatgagttccgg gcctccttcaaccactttgaccgggatcactccggcacactgggtcccgaggagttcaaa gcctgcctcatcagcttgggttatgatattggcaacgacccccagggagaagcagaattt gcccgcatcatgagcattgtggaccccaaccgcctgggggtagtgacattccaggccttc attgacttcatgtcccgcgagacagccgacacagatacagcagaccaagtcatggcttcc ttcaagatcctggccggggacaagaactacattaccatggacgagctgcgccgcgagctg ccgcccgaccaggctgagtactgcatcgcgcggatggccccctacaccggccccgactcc gtgccaggtgctctggactacatgtccttctccacggcgctgtacggcgagagtgacctc taa

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