Pongo abelii (Sumatran orangutan): 100440586
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Entry
100440586 CDS
T01416
Gene name
IKBKB
Definition
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3
KO
K07209
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:
2.7.11.10
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon01523
Antifolate resistance
pon04010
MAPK signaling pathway
pon04014
Ras signaling pathway
pon04062
Chemokine signaling pathway
pon04064
NF-kappa B signaling pathway
pon04068
FoxO signaling pathway
pon04150
mTOR signaling pathway
pon04151
PI3K-Akt signaling pathway
pon04210
Apoptosis
pon04380
Osteoclast differentiation
pon04620
Toll-like receptor signaling pathway
pon04621
NOD-like receptor signaling pathway
pon04622
RIG-I-like receptor signaling pathway
pon04623
Cytosolic DNA-sensing pathway
pon04625
C-type lectin receptor signaling pathway
pon04657
IL-17 signaling pathway
pon04658
Th1 and Th2 cell differentiation
pon04659
Th17 cell differentiation
pon04660
T cell receptor signaling pathway
pon04662
B cell receptor signaling pathway
pon04668
TNF signaling pathway
pon04722
Neurotrophin signaling pathway
pon04910
Insulin signaling pathway
pon04920
Adipocytokine signaling pathway
pon04930
Type II diabetes mellitus
pon04931
Insulin resistance
pon04932
Non-alcoholic fatty liver disease
pon05010
Alzheimer disease
pon05132
Salmonella infection
pon05135
Yersinia infection
pon05142
Chagas disease
pon05145
Toxoplasmosis
pon05160
Hepatitis C
pon05161
Hepatitis B
pon05162
Measles
pon05163
Human cytomegalovirus infection
pon05164
Influenza A
pon05165
Human papillomavirus infection
pon05166
Human T-cell leukemia virus 1 infection
pon05167
Kaposi sarcoma-associated herpesvirus infection
pon05168
Herpes simplex virus 1 infection
pon05169
Epstein-Barr virus infection
pon05170
Human immunodeficiency virus 1 infection
pon05171
Coronavirus disease - COVID-19
pon05200
Pathways in cancer
pon05206
MicroRNAs in cancer
pon05212
Pancreatic cancer
pon05215
Prostate cancer
pon05220
Chronic myeloid leukemia
pon05221
Acute myeloid leukemia
pon05222
Small cell lung cancer
pon05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
pon05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100440586 (IKBKB)
04014 Ras signaling pathway
100440586 (IKBKB)
04064 NF-kappa B signaling pathway
100440586 (IKBKB)
04668 TNF signaling pathway
100440586 (IKBKB)
04068 FoxO signaling pathway
100440586 (IKBKB)
04151 PI3K-Akt signaling pathway
100440586 (IKBKB)
04150 mTOR signaling pathway
100440586 (IKBKB)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
100440586 (IKBKB)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
100440586 (IKBKB)
04621 NOD-like receptor signaling pathway
100440586 (IKBKB)
04622 RIG-I-like receptor signaling pathway
100440586 (IKBKB)
04623 Cytosolic DNA-sensing pathway
100440586 (IKBKB)
04625 C-type lectin receptor signaling pathway
100440586 (IKBKB)
04660 T cell receptor signaling pathway
100440586 (IKBKB)
04658 Th1 and Th2 cell differentiation
100440586 (IKBKB)
04659 Th17 cell differentiation
100440586 (IKBKB)
04657 IL-17 signaling pathway
100440586 (IKBKB)
04662 B cell receptor signaling pathway
100440586 (IKBKB)
04062 Chemokine signaling pathway
100440586 (IKBKB)
09152 Endocrine system
04910 Insulin signaling pathway
100440586 (IKBKB)
04920 Adipocytokine signaling pathway
100440586 (IKBKB)
09156 Nervous system
04722 Neurotrophin signaling pathway
100440586 (IKBKB)
09158 Development and regeneration
04380 Osteoclast differentiation
100440586 (IKBKB)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100440586 (IKBKB)
05206 MicroRNAs in cancer
100440586 (IKBKB)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100440586 (IKBKB)
09162 Cancer: specific types
05212 Pancreatic cancer
100440586 (IKBKB)
05221 Acute myeloid leukemia
100440586 (IKBKB)
05220 Chronic myeloid leukemia
100440586 (IKBKB)
05215 Prostate cancer
100440586 (IKBKB)
05222 Small cell lung cancer
100440586 (IKBKB)
09164 Neurodegenerative disease
05010 Alzheimer disease
100440586 (IKBKB)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
100440586 (IKBKB)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
100440586 (IKBKB)
04932 Non-alcoholic fatty liver disease
100440586 (IKBKB)
04931 Insulin resistance
100440586 (IKBKB)
09171 Infectious disease: bacterial
05132 Salmonella infection
100440586 (IKBKB)
05135 Yersinia infection
100440586 (IKBKB)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
100440586 (IKBKB)
05170 Human immunodeficiency virus 1 infection
100440586 (IKBKB)
05161 Hepatitis B
100440586 (IKBKB)
05160 Hepatitis C
100440586 (IKBKB)
05171 Coronavirus disease - COVID-19
100440586 (IKBKB)
05164 Influenza A
100440586 (IKBKB)
05162 Measles
100440586 (IKBKB)
05168 Herpes simplex virus 1 infection
100440586 (IKBKB)
05163 Human cytomegalovirus infection
100440586 (IKBKB)
05167 Kaposi sarcoma-associated herpesvirus infection
100440586 (IKBKB)
05169 Epstein-Barr virus infection
100440586 (IKBKB)
05165 Human papillomavirus infection
100440586 (IKBKB)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
100440586 (IKBKB)
05142 Chagas disease
100440586 (IKBKB)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
100440586 (IKBKB)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pon01001
]
100440586 (IKBKB)
Enzymes [BR:
pon01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.10 IkappaB kinase
100440586 (IKBKB)
Protein kinases [BR:
pon01001
]
Serine/threonine kinases: Other
IKK family [OT]
100440586 (IKBKB)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
IKBKB_SDD
Pkinase
PK_Tyr_Ser-Thr
IKKbetaNEMObind
Pkinase_fungal
Kdo
ubiquitin
APH
YrbL-PhoP_reg
Glyco_hydro_65m
Motif
Other DBs
NCBI-GeneID:
100440586
NCBI-ProteinID:
XP_002819086
Ensembl:
ENSPPYG00000018550
UniProt:
A0A663D575
H2PQ71
LinkDB
All DBs
Position
8
AA seq
697 aa
AA seq
DB search
MSSDGTIRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLRE
GAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLC
TSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKS
EVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGC
FKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGL
ALIPDKPATQCVSDGKLNEGRTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKR
NLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQL
KAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMA
LQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQ
SFEKKVRVIYTQLSKTVVCKQKALELLPKVEELVSLMNEDEKTVVRLQEKRQKELWNLLK
IACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLL
ENAIQDTVREQHQSFTALDWSWLQTEEEEHSCLEQAS
NT seq
2094 nt
NT seq
+upstream
nt +downstream
nt
atgtcatccgatggcacaatcaggctgacccaccccaatgtggtggctgcccgagatgtc
cctgaggggatgcagaacttggcgcccaatgacctgcccctgctggccatggaatactgc
caaggaggagatctccggaagtacctgaaccagtttgagaactgctgtggtctgcgggaa
ggcgccatcctcaccttgctgagtgacattgcctctgcgcttagataccttcatgaaaac
agaatcatccatcgggatctaaagccagaaaacatcgtcctgcagcaaggagaacagagg
ttaatacacaaaattattgacctaggatatgccaaggagctggatcagggcagtctttgc
acatcattcgtggggaccctgcagtacctggccccagagctactggagcagcagaagtac
acagtgaccgtcgactactggagcttcggcaccctggcctttgagtgcatcacgggcttc
cggcccttcctccccaactggcagcccgtgcaatggcattcgaaagtgcggcagaagagt
gaggtggacattgttgttagcgaagacttgaatggaacagtgaagttttcaagttcttta
ccctaccccaataatcttaacagcgtcctggctgagcgactggagaagtggctgcaactg
atgctgatgtggcatccccgacagaggggcacagatcccacgtatgggcccaacggctgc
ttcaaggccctggatgacatcttaaacttaaagctggttcatatcttgaacatggtcacg
ggcaccatccacacctaccctgtgacagaggatgagagtctgcagagcttgaaggccaga
atccagcaggacacaggcatcccagaggaggaccaggagctgctgcaggaagcgggcctg
gcgttgatccccgataagcctgccactcagtgtgtttcagacggcaagttaaatgagggc
cgcacattggacatggatcttgtttttctctttgacaacagtaaaatcacctatgaaact
cagatctccccacggccccaacctgaaagtgtcagctgtatccttcaagagcccaagagg
aacctcgccttcttccagctgaggaaggtgtggggccaggtctggcacagcatccagacc
ctgaaggaggattgcaaccggctgcagcagggacagcgagccgccatgatgaatctcctc
cgaaacaacagctgcctctctaagatgaagaattccatggcttccatgtctcagcagctc
aaggccaagttggatttcttcaaaaccagcatccagattgacctggagaagtacagcgag
caaaccgagtttgggatcacatcagataaactgctgctggcctggagggaaatggagcag
gctgtggagctctgtgggcgggagaacgaagtgaaactcctggtagaacggatgatggct
ctacagaccgacatcgtagacttacagcggagccccatgggccggaagcaggggggaacg
ctggacgacctagaggagcaagcaagggagctgtacaggagactaagggaaaaacctcga
gaccagcgaactgagggtgacagtcaggaaatggtacggctgctgcttcaggcaattcag
agcttcgagaagaaagtgcgagtgatctatacgcagctcagtaaaactgtggtttgcaag
cagaaggcactggaactgttgcccaaggtggaagagttggtgagcttaatgaatgaggat
gagaagactgttgtccggctgcaggagaagcggcagaaggaactctggaatctcctgaag
attgcttgtagcaaggtccgtggtcctgtcagtggaagcccggatagcatgaatgcctct
cgacttagccagcctgggcagctgatgtctcagccctccacggcctccaacagcttacct
gagccagccaagaagagtgaagaactggtggctgaagcacataacctctgcaccctgcta
gaaaatgccatacaggacaccgtgagggaacaacaccagagtttcacggccctagactgg
agctggttacagacggaagaagaagagcacagctgcctggagcaggcctcatga
DBGET
integrated database retrieval system
