Pongo abelii (Sumatran orangutan): 100450307
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Entry
100450307 CDS
T01416
Gene name
ERBB2
Definition
(RefSeq) receptor tyrosine-protein kinase erbB-2 isoform X1
KO
K05083
receptor tyrosine-protein kinase erbB-2 [EC:
2.7.10.1
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon01521
EGFR tyrosine kinase inhibitor resistance
pon01522
Endocrine resistance
pon01524
Platinum drug resistance
pon04010
MAPK signaling pathway
pon04012
ErbB signaling pathway
pon04020
Calcium signaling pathway
pon04066
HIF-1 signaling pathway
pon04151
PI3K-Akt signaling pathway
pon04510
Focal adhesion
pon04520
Adherens junction
pon04530
Tight junction
pon05200
Pathways in cancer
pon05205
Proteoglycans in cancer
pon05206
MicroRNAs in cancer
pon05212
Pancreatic cancer
pon05213
Endometrial cancer
pon05215
Prostate cancer
pon05219
Bladder cancer
pon05223
Non-small cell lung cancer
pon05224
Breast cancer
pon05226
Gastric cancer
pon05230
Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100450307 (ERBB2)
04012 ErbB signaling pathway
100450307 (ERBB2)
04066 HIF-1 signaling pathway
100450307 (ERBB2)
04020 Calcium signaling pathway
100450307 (ERBB2)
04151 PI3K-Akt signaling pathway
100450307 (ERBB2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
100450307 (ERBB2)
04520 Adherens junction
100450307 (ERBB2)
04530 Tight junction
100450307 (ERBB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100450307 (ERBB2)
05206 MicroRNAs in cancer
100450307 (ERBB2)
05205 Proteoglycans in cancer
100450307 (ERBB2)
05230 Central carbon metabolism in cancer
100450307 (ERBB2)
09162 Cancer: specific types
05212 Pancreatic cancer
100450307 (ERBB2)
05226 Gastric cancer
100450307 (ERBB2)
05219 Bladder cancer
100450307 (ERBB2)
05215 Prostate cancer
100450307 (ERBB2)
05213 Endometrial cancer
100450307 (ERBB2)
05224 Breast cancer
100450307 (ERBB2)
05223 Non-small cell lung cancer
100450307 (ERBB2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100450307 (ERBB2)
01524 Platinum drug resistance
100450307 (ERBB2)
01522 Endocrine resistance
100450307 (ERBB2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pon01001
]
100450307 (ERBB2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
pon04147
]
100450307 (ERBB2)
04090 CD molecules [BR:
pon04090
]
100450307 (ERBB2)
Enzymes [BR:
pon01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
100450307 (ERBB2)
Protein kinases [BR:
pon01001
]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
100450307 (ERBB2)
Exosome [BR:
pon04147
]
Exosomal proteins
Exosomal proteins of breast cancer cells
100450307 (ERBB2)
CD molecules [BR:
pon04090
]
Proteins
100450307 (ERBB2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
GF_recep_IV
Pkinase
Furin-like
APH
Kinase-like
Motif
Other DBs
NCBI-GeneID:
100450307
NCBI-ProteinID:
XP_024090162
Ensembl:
ENSPPYG00000008479
LinkDB
All DBs
Position
17
AA seq
1267 aa
AA seq
DB search
MARTNAVQHRDSDPDSHACAGSDESDMYCCGHAQKRVCTGTDMKLRLPASPETHLDMLRH
LYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLF
EDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIERNPQLCYQDTIL
WKDIFHKNNQLAVTLIDTNRSRACHPCSSVCKGSRCWGESSEDCQSLTRTVCAGGCARCK
GPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGR
YTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGME
HLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLRVFETLEEITG
YLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALI
HHNTRLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQC
VNCSQFLRGQECVEECRVLQGLPREYVNARYCLPCHPECQPQNGSVTCFGPEADQCVACA
HYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGTCQPCPINCTHSCVDLDDKGCPAEQRA
SPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPN
QAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEIL
DEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQ
IAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKW
MALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICT
IDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSL
LEDDDMGDLVDAEEYLVPQQGFFCPDPAPGVGGMVHHRHRSSSTRSGGGDLTLGLEPSEE
EAPRSPLAPSDGAGSDVFDGDLGMGAAKGLQSLPAHDPSPLQRYSEDPTVPLPSETDGYV
APLTCSPQPEYVNQPDVRPQPPSPREGPLPPARPAGATLERPKTLSPGKNGVVKDVFAFG
GAVENPEYLAPRGGAAPQPHPPPAFSPAFDNLYYWDQDPSERGAPPSTFKGTPTAENPEY
LGLDVPV
NT seq
3804 nt
NT seq
+upstream
nt +downstream
nt
atggccaggacaaacgcagtgcagcacagagactcagaccctgacagccatgcctgcgca
ggcagtgatgagagtgacatgtactgttgtggacacgcacaaaagcgagtgtgcaccggc
acagacatgaagctgcggctccctgccagtcccgagacccacctggacatgctccgccac
ctctaccagggctgccaggtggtgcaaggaaacctggaactcacctacctgcccaccaat
gccagcctctccttcctgcaggatatccaggaggtgcagggctacgtgctcatcgctcac
aaccaagtgaggcaggtcccactgcagaggctgcggattgtgcgaggcacccagctcttt
gaggacaactatgccctggccgtgctagacaatggagacccgctgaacaataccacccct
gtcacaggggcctccccaggaggcctgcgggagctgcagcttcgaagcctcacagagatc
ttgaaaggaggggtcttgatcgagcggaacccccagctctgctaccaggacacgattttg
tggaaggacatcttccacaagaacaaccagctggctgtcacactgatagacaccaaccgc
tctcgggcctgccacccctgttcttcggtgtgtaagggctcccgctgctggggagagagt
tctgaggattgtcagagcctgacgcgcactgtctgtgccggtggctgtgcccgctgcaag
gggccactgcccactgactgctgccatgagcagtgtgctgccggctgcacgggccccaag
cactctgactgcctggcctgcctccacttcaaccacagtggcatctgtgagctgcactgc
ccagccctggtcacctacaacacagacacctttgagtccatgcccaatcccgagggccga
tatacattcggcgccagctgtgtgactgcctgtccctacaactacctttctacggacgtg
ggatcctgcaccctcgtctgccccctgcacaaccaagaggtgacagcagaggacggaaca
cagcggtgtgagaagtgcagcaagccctgtgcccgagtgtgctatggtctgggcatggag
cacttgcgagaggtgagggcagtcaccagtgccaatatccaggagtttgctggctgcaag
aagatctttgggagcctggcatttctgccggagagctttgatggggacccagcctccaac
accgccccgctccagccagagcagctccgagtgtttgagactctggaagagatcacaggt
tacctatacatctcagcatggccagacagcctgcctgacctcagcgtcttccagaacctg
caagtaatccggggacgaattctgcacaatggcgcctactcgctgaccctgcaagggctg
ggcatcagctggctggggctgcgctcgctgcgggaactgggcagtggactggccctcatc
caccataacacccgcctctgcttcgtgcacacggtgccctgggaccagctcttccggaac
ccgcaccaagctctgctccacactgccaaccggccagaggacgagtgtgtgggcgagggc
ctggcctgccaccagctgtgcgcccgagggcactgctggggtccagggcccacccagtgt
gtcaactgcagccagttccttcggggccaggagtgcgtggaggaatgccgagtactgcag
gggctccccagggagtatgtgaatgccaggtactgtttgccgtgccaccctgagtgtcag
ccccagaatggctcagtgacctgttttggaccggaggctgaccagtgtgtggcctgtgcc
cactataaggaccctcccttctgcgtggcccgctgccccagcggtgtgaaacctgacctc
tcctacatgcccatctggaagtttccagatgaggagggcacgtgccagccttgccccatc
aactgcacccactcctgtgtggacctggatgacaagggctgccccgccgagcagagagcc
agccctctgacgtccatcatctctgcggtggtgggcattctgctggtcgtggtcttgggg
gtggtctttgggatcctcatcaagcgacggcagcagaagatccggaagtacacgatgcgg
aggctgctgcaggaaacggagctggtggagccgctgacacctagcggagcgatgcccaac
caggcgcagatgcgtatcctgaaagagacggagctgaggaaggtgaaggtgcttggatct
ggcgcttttggcacagtctacaagggcatctggatccctgatggggaaaatgtgaaaatt
ccagtggccatcaaagtgttgagggaaaacacatcccccaaagccaacaaagaaatctta
gacgaagcatacgtgatggctggtgtgggctccccatatgtctcccgcctcctgggcatc
tgcctgacatccacggtgcagctggtgacacagcttatgccctatggctgcctcttagac
catgtccgggaaaaccgcggacgcctgggctcccaggacctgctgaactggtgtatgcag
attgccaaggggatgagctacctggaggatgtgcggctcgtacacagggacttggctgct
cggaacgtgctggtcaagagtcccaaccatgtcaaaattacagacttcgggctggctcgg
ctgctggacattgacgagacagagtaccatgcagatgggggcaaggtgcccatcaagtgg
atggcgctggagtccattctccgccggcggttcacccaccagagtgatgtgtggagttat
ggtgtgactgtgtgggagctgatgacttttggggccaaaccttacgatgggatcccagcc
cgggagatccctgacctgctggaaaagggggagcggctgccccagcctcccatctgcacc
attgatgtctacatgatcatggtcaaatgttggatgattgactctgaatgtcggccgaga
ttccgggagttggtgtctgaattctcccgcatggccagggacccccagcgctttgtggtc
atccagaatgaggacttgggcccagccagtcccttggacagcaccttctaccgctcactg
ctggaggacgatgacatgggggacctggtggatgctgaggagtatctggtaccccagcag
ggcttcttctgtccagaccctgccccgggagttgggggcatggtccaccacaggcaccgc
agctcatctaccaggagtggcggtggggacctgacgctagggctggagccctctgaagag
gaggcccccaggtctccactggcaccctccgatggggctggctccgatgtatttgatggt
gacctgggaatgggggcagccaaggggctgcaaagcctccccgcacatgaccccagccct
ctacagcggtacagtgaggaccccacagtacccctgccctctgagactgatggctacgtt
gcccccctgacctgcagcccccagcccgaatatgtgaaccagccagatgttcggccacag
cctccttcgccccgagagggccctctgcctcctgcccgacctgctggtgccactctggaa
aggcctaagactctctccccagggaagaatggggttgtcaaagacgtttttgcctttggg
ggtgccgtggagaaccccgagtacttggcaccccggggaggagctgcccctcagccccac
cctcctcctgccttcagcccagccttcgacaacctctattactgggaccaggacccatca
gagcggggggctccacccagcaccttcaaagggacacctacggcagaaaacccagagtac
ctgggtctggacgtgccagtgtga
DBGET
integrated database retrieval system
