Pongo abelii (Sumatran orangutan): 100450864 Help Entry 100450864         CDS       T01416                                  Gene name TGFBR1 Definition (RefSeq) TGF-beta receptor type-1 isoform X2   KO K04674   TGF-beta receptor type-1 [EC:2.7.11.30] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04060   Cytokine-cytokine receptor interaction pon04068   FoxO signaling pathway pon04144   Endocytosis pon04218   Cellular senescence pon04350   TGF-beta signaling pathway pon04371   Apelin signaling pathway pon04380   Osteoclast differentiation pon04390   Hippo signaling pathway pon04520   Adherens junction pon04659   Th17 cell differentiation pon04926   Relaxin signaling pathway pon04933   AGE-RAGE signaling pathway in diabetic complications pon05142   Chagas disease pon05161   Hepatitis B pon05166   Human T-cell leukemia virus 1 infection pon05200   Pathways in cancer pon05210   Colorectal cancer pon05212   Pancreatic cancer pon05220   Chronic myeloid leukemia pon05225   Hepatocellular carcinoma pon05226   Gastric cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100450864 (TGFBR1)    04350 TGF-beta signaling pathway     100450864 (TGFBR1)    04390 Hippo signaling pathway     100450864 (TGFBR1)    04371 Apelin signaling pathway     100450864 (TGFBR1)    04068 FoxO signaling pathway     100450864 (TGFBR1)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     100450864 (TGFBR1)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     100450864 (TGFBR1)   09143 Cell growth and death    04218 Cellular senescence     100450864 (TGFBR1)   09144 Cellular community - eukaryotes    04520 Adherens junction     100450864 (TGFBR1)  09150 Organismal Systems   09151 Immune system    04659 Th17 cell differentiation     100450864 (TGFBR1)   09152 Endocrine system    04926 Relaxin signaling pathway     100450864 (TGFBR1)   09158 Development and regeneration    04380 Osteoclast differentiation     100450864 (TGFBR1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100450864 (TGFBR1)   09162 Cancer: specific types    05210 Colorectal cancer     100450864 (TGFBR1)    05212 Pancreatic cancer     100450864 (TGFBR1)    05225 Hepatocellular carcinoma     100450864 (TGFBR1)    05226 Gastric cancer     100450864 (TGFBR1)    05220 Chronic myeloid leukemia     100450864 (TGFBR1)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     100450864 (TGFBR1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100450864 (TGFBR1)    05161 Hepatitis B     100450864 (TGFBR1)   09174 Infectious disease: parasitic    05142 Chagas disease     100450864 (TGFBR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100450864 (TGFBR1) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.30  receptor protein serine/threonine kinase      100450864 (TGFBR1) Protein kinases [BR:pon01001]  Receptor serine/threonine kinases (RSTK): TKL group   TGFBR1 family [OT]    100450864 (TGFBR1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr TGF_beta_GS Activin_recp Pkinase_fungal APH FTA2 Motif Other DBs NCBI-GeneID:  100450864 NCBI-ProteinID:  XP_009242963 Ensembl:  ENSPPYG00000019439 UniProt:  A0A663DA69 H2PSV9 LinkDB All DBs Position 9 AA seq 503 aa AA seqDB search MEAAAAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA ARLTALRIKKTLSQLSQQEGIKM NT seq 1512 nt NT seq  +upstreamnt  +downstreamnt atggaggcggcggccgctgctccgcgtccccggctgctcctcctcgtgctggcggcggcg gcggcggcggcggcggcgctgctcccgggggcgacggcgttacagtgtttctgccacctc tgtacaaaagacaattttacttgtgtgacagatgggctctgctttgtctctgtcacagag accacagacaaagttatacacaacagcatgtgtatagctgaaattgacttaattcctcga gataggccgtttgtatgtgcaccctcttcaaaaactgggtctgtgactacaacatattgc tgcaatcaggaccattgcaataaaatagaacttccaactactgtaaagtcatcacctggc cttggtcctgtggaactggcagctgtcattgctggaccagtgtgcttcgtctgcatctca ctcatgttgatggtctatatctgccacaaccgcactgtcattcaccatcgagtgccaaat gaagaggacccttcattagatcgcccttttatttcagagggtactacgttgaaagactta atttatgatatgacaacgtcaggttctggctcaggtttaccattgcttgttcagagaaca attgcgagaactattgtgttacaagaaagcattggcaaaggtcgatttggagaagtttgg agaggaaagtggcggggagaagaagttgctgttaagatattctcctctagagaagaacgt tcgtggttccgtgaggcagagatttatcaaactgtaatgttacgtcatgaaaacatcctg ggatttatagcagcagacaataaagacaatggtacttggactcagctctggttggtgtca gattatcatgagcatggatccctttttgattacttaaacagatacacagttactgtggaa ggaatgataaaacttgctctgtctacggcgagcggtcttgcccatcttcacatggagatt gttggtacccaaggaaagccagccattgctcatagagatttgaaatcaaagaatatcttg gtaaagaagaatggaacttgctgtattgcagacttaggactggcagtaagacatgattca gccacagataccattgatattgctccaaaccacagagtgggaacaaaaaggtacatggcc cctgaagttctcgatgattccataaatatgaaacattttgaatccttcaaacgtgctgac atctatgcaatgggcttagtattctgggaaattgctcgacgatgttccattggtggaatt catgaagattaccaactgccttattatgatcttgtaccttctgacccatcagttgaagaa atgagaaaagttgtttgtgaacagaagttaaggccaaatatcccaaacagatggcagagc tgtgaagccttgagagtaatggctaaaattatgagagaatgttggtatgccaatggagca gctaggcttacagcattgcggattaagaaaacattatcacaactcagtcaacaggaaggc atcaaaatgtaa

Pongo abelii (Sumatran orangutan): 100459236 Help Entry 100459236         CDS       T01416                                  Gene name TGFBR2 Definition (RefSeq) TGF-beta receptor type-2 isoform X1   KO K04388   TGF-beta receptor type-2 [EC:2.7.11.30] Organism pon  Pongo abelii (Sumatran orangutan) Pathway pon04010   MAPK signaling pathway pon04060   Cytokine-cytokine receptor interaction pon04068   FoxO signaling pathway pon04144   Endocytosis pon04218   Cellular senescence pon04350   TGF-beta signaling pathway pon04380   Osteoclast differentiation pon04390   Hippo signaling pathway pon04520   Adherens junction pon04659   Th17 cell differentiation pon04926   Relaxin signaling pathway pon04933   AGE-RAGE signaling pathway in diabetic complications pon05142   Chagas disease pon05161   Hepatitis B pon05166   Human T-cell leukemia virus 1 infection pon05200   Pathways in cancer pon05202   Transcriptional misregulation in cancer pon05210   Colorectal cancer pon05212   Pancreatic cancer pon05220   Chronic myeloid leukemia pon05225   Hepatocellular carcinoma pon05226   Gastric cancer Brite KEGG Orthology (KO) [BR:pon00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100459236 (TGFBR2)    04350 TGF-beta signaling pathway     100459236 (TGFBR2)    04390 Hippo signaling pathway     100459236 (TGFBR2)    04068 FoxO signaling pathway     100459236 (TGFBR2)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     100459236 (TGFBR2)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     100459236 (TGFBR2)   09143 Cell growth and death    04218 Cellular senescence     100459236 (TGFBR2)   09144 Cellular community - eukaryotes    04520 Adherens junction     100459236 (TGFBR2)  09150 Organismal Systems   09151 Immune system    04659 Th17 cell differentiation     100459236 (TGFBR2)   09152 Endocrine system    04926 Relaxin signaling pathway     100459236 (TGFBR2)   09158 Development and regeneration    04380 Osteoclast differentiation     100459236 (TGFBR2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100459236 (TGFBR2)    05202 Transcriptional misregulation in cancer     100459236 (TGFBR2)   09162 Cancer: specific types    05210 Colorectal cancer     100459236 (TGFBR2)    05212 Pancreatic cancer     100459236 (TGFBR2)    05225 Hepatocellular carcinoma     100459236 (TGFBR2)    05226 Gastric cancer     100459236 (TGFBR2)    05220 Chronic myeloid leukemia     100459236 (TGFBR2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     100459236 (TGFBR2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100459236 (TGFBR2)    05161 Hepatitis B     100459236 (TGFBR2)   09174 Infectious disease: parasitic    05142 Chagas disease     100459236 (TGFBR2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pon01001]     100459236 (TGFBR2) Enzymes [BR:pon01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.30  receptor protein serine/threonine kinase      100459236 (TGFBR2) Protein kinases [BR:pon01001]  Receptor serine/threonine kinases (RSTK): TKL group   TGFBR2 family [OT]    100459236 (TGFBR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  ecTbetaR2 PK_Tyr_Ser-Thr Pkinase Pkinase_fungal APH Motif Other DBs NCBI-GeneID:  100459236 NCBI-ProteinID:  XP_002814024 Ensembl:  ENSPPYG00000014049 UniProt:  A0A6D2WRM0 H2PBA1 LinkDB All DBs Position 3 AA seq 592 aa AA seqDB search MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRTAHPLRHINND MMVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENI TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT SNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSSWETGKTRKLMEFSEH CAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVA VKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE YLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCL CDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLW EMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCE TLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK NT seq 1779 nt NT seq  +upstreamnt  +downstreamnt atgggtcgggggctgctcaggggcctgtggccgctgcacatcgtcctgtggacgcgtatc gccagcacgatcccaccgcacgttcagaagtcggatgtggaaatggaggcccagaaagat gaaatcatctgccccagctgtaataggactgcccatccactgagacatattaataatgac atgatggtcactgacaacaatggtgcagtcaagtttccacaactgtgtaaattttgtgat gtgagattttccacctgtgacaaccagaaatcctgcatgagcaactgcagcatcacctcc atctgtgagaagccacaggaagtctgtgtggctgtatggagaaagaatgatgagaacata acactagagacagtttgccatgaccccaagctgccctaccatgactttattctggaagat gctgcttctccaaagtgcattatgaaggaaaaaaaaaagcctggtgagactttcttcatg tgttcctgtagctctgatgagtgcaatgacaacatcatcttctcagaagaatataacacc agcaatcctgacttgttgctagtcatatttcaagtgacaggcatcagcctcctgccacca ctgggagttgccatatctgtcatcatcatcttctactgctaccgcgttaaccggcagcag aagctgagttcatcctgggaaaccggcaagacgcggaagctcatggagttcagtgagcac tgtgccatcatcctggaagacgaccgctctgacatcagctccacgtgcgccaacaacatc aaccacaacacagagctgctgcccattgagctggacacgctggtggggaaaggtcgcttt gctgaggtctataaggccaagctgaagcagaacacttcagagcagtttgagacagtggca gtcaagatctttccctatgaggagtatgcctcttggaagacagagaaggacatcttctca gacatcaacctgaagcatgagaacatactccagttcctgacggctgaggagcggaagacg gagttggggaaacagtactggctgatcaccgctttccacgccaagggcaacctacaggag tacctgacacggcatgtcatcagctgggaggacctgcgcaagctgggcagctccctcgcc cgggggattgctcacctccacagtgatcacactccatgtgggaggcccaagatgcccatc gtgcacagggacctcaagagctccaatatcctcgtgaagaacgacctaacctgctgcctg tgtgactttgggctttccctgcgtctggaccctactctgtctgtggatgacctggctaac agtgggcaggtgggaactgcaagatacatggctccagaagtcctagaatccaggatgaat ttggagaatgttgagtccttcaagcagaccgatgtctactccatggctctggtgctctgg gaaatgacatctcgttgtaatgcagtgggagaagtaaaagattatgagcctccatttggt tccaaggtgcgggagcacccctgtgtggaaagcatgaaggacaacgtgttgagagatcga gggcgaccagaaattcccagcttctggctcaaccaccagggcatccagatggtgtgtgag acgttgactgagtgctgggaccacgacccagaggcccgtctcacagcccagtgtgtggca gaacgcttcagtgagctggagcatctggacaggctctcggggaggagctgctcggaggag aagattcctgaagacggctccctaaacactaccaagtag

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