KEGG   Pongo abelii (Sumatran orangutan): 100462634
Entry
100462634         CDS       T01416                                 

Gene name
CBL
Definition
(RefSeq) E3 ubiquitin-protein ligase CBL
  KO
K04707  E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon04012  ErbB signaling pathway
pon04120  Ubiquitin mediated proteolysis
pon04144  Endocytosis
pon04910  Insulin signaling pathway
pon05100  Bacterial invasion of epithelial cells
pon05200  Pathways in cancer
pon05205  Proteoglycans in cancer
pon05220  Chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:pon00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    100462634 (CBL)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100462634 (CBL)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    100462634 (CBL)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    100462634 (CBL)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100462634 (CBL)
   05205 Proteoglycans in cancer
    100462634 (CBL)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    100462634 (CBL)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    100462634 (CBL)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pon04131]
    100462634 (CBL)
   04121 Ubiquitin system [BR:pon04121]
    100462634 (CBL)
Enzymes [BR:pon01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     100462634 (CBL)
Membrane trafficking [BR:pon04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    100462634 (CBL)
Ubiquitin system [BR:pon04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   CBL proteins
    100462634 (CBL)
SSDB
Motif
Pfam: Cbl_N Cbl_N3 Cbl_N2 Prok-RING_4 zf-C3HC4_3 zf-C3HC4 zf-RING_2 UBA zf-C3HC4_2 zf-RING_UBOX zf-RING_5 zf-rbx1 zf-C3HC4_4 zf-RING_4
Other DBs
NCBI-GeneID: 100462634
NCBI-ProteinID: XP_002822650
Ensembl: ENSPPYG00000003962
LinkDB
Position
11
AA seq 905 aa
MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHLSPHPPGTVDKKMVEKCWK
LMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMEN
LMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRI
TKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEF
DIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLG
QWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHI
KVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRC
EIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVERP
PSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLRD
LPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVS
APSSSDAWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSVNSSPLVGPECDH
PKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRACD
CDQQIDSCTYEAMYNIQSQAPSVTESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPV
PAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQ
QGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSP
AHVAT
NT seq 2718 nt   +upstreamnt  +downstreamnt
atggccggcaacgtgaagaagagctctggggccgggggcggcagcggctccgggggctcg
ggttcgggtggcctgattgggctcatgaaggacgccttccagccgcaccaccaccaccac
cacctcagcccccacccgccggggacggtggacaagaagatggtggagaagtgctggaag
ctcatggacaaggtggtgcggttgtgtcagaacccaaagctggcgctaaagaatagccca
ccttatatcttagacctgctaccagatacctaccagcatctccgtactatcttgtcaaga
tatgaggggaagatggagacacttggagaaaatgagtattttagggtgtttatggagaat
ttgatgaagaaaactaagcaaaccataagcctcttcaaggagggaaaagaaagaatgtat
gaggagaattctcagcctaggcgaaacctaaccaaactgtccctcatcttcagccacatg
ctggcagaactaaaaggaatctttccaagtggactctttcagggagacacatttaggatt
actaaagcagatgctgcggaattttggagaaaagcttttggggaaaagacaatagtccct
tggaagagctttcgacaggctttacatgaagtgcatcccatcagttctgggctggaggcc
atggctctgaaatccactattgatctgacctgcaatgattatatttcggtttttgaattt
gacatcttcacccgactctttcagccctggtcctctttgctcaggaattggaacagcctc
gctgtaactcatcctggctacatggcttttttgacgtatgacgaagtgaaagctcggctc
cagaaattcattcacaaacctggcagttatatcttccggctgagctgtactcgtctgggt
cagtgggctattgggtatgttactgctgatgggaacattctccagacaatccctcacaat
aaacctctcttccaagcactgattgatggcttcagggaaggcttctatttgtttcctgat
ggacgaaatcagaatcctgatctgactggcttatgtgaaccaactccccaagaccatatc
aaagtgacccaggaacaatatgaattatactgtgagatgggctccacattccaactgtgt
aaaatatgtgctgaaaatgataaggatgtaaagattgagccctgtggacacctcatgtgc
acatcctgtcttacatcctggcaggaatcagaaggtcagggctgtcctttctgccgatgt
gaaattaaaggtactgaacccatcgtggtagatccgtttgatcctagagggagtggcagc
ctattgaggcaaggagcagagggagctccctccccaaattatgatgatgatgatgatgaa
cgagctgatgatactctcttcatgatgaaggaattggctggtgccaaggtggaacggccg
ccttctccattctccatggccccacaagcttcccttcccccagtgccaccacgacttgac
cttctgccgcagcgagtatgtgttccctcaagtgcttctgctcttggaactgcttctaag
gctgcttctggctcccttcataaagacaaaccattgccagtacctcccacacttcgagat
cttccaccaccaccacctccagaccggccatattccgttggagcagaatcccgacctcaa
agacgccccttgccttgtacaccaggcgattgtccatccagagacaaactgccccctgtc
ccctctagccgccttggagattcatggctgccccggccaatccccaaagtaccagtatct
gccccaagttccagtgatgcctggacaggaagagaattaaccaaccggcactcacttcca
ttttcattgccctcacaaatggagcccagaccagatgtgcctaggctcggaagcacattc
agtctggatacctccatgagtgtgaatagcagcccattagtaggtccagagtgtgaccac
cccaaaatcaaaccttcctcatctgccaatgccatttattctctggctgccagacctctt
cctgtgccaaaactgccacctggggagcaatgtgagggtgaagaggacacagagtacatg
actccctcctccaggcctctacggcctttggatacatcccagagttcacgagcatgtgat
tgcgaccagcagattgatagctgtacgtatgaagcaatgtataatattcagtcccaggcg
ccatctgtcaccgagagcagcacctttggtgaagggaatttggctgcagcccatgccaac
actggtcccgaggagtcagaaaatgaggatgatgggtatgatgtcccaaagccacctgtg
ccggccgtgctggcccgccgaactctctcagatatctctaatgccagctcctcctttggc
tggttgtctctggatggtgatcccacaacaaatgtcactgaaggttcccaagttcccgag
aggcctcctaaaccattccctcggagaatcaactctgaacggaaagctggcagctgtcag
caaggtagtggtcctgccgcctctgctgccaccgcctcgcctcagctctccagtgagatc
gagaacctcatgagtcaggggtactcctaccaggacatccagaaagctttggtcattgcc
cagaacaacatcgagatggccaaaaacatcctccgggaatttgtttccatttcttctcct
gcccatgtagctacctag

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