Komagataella phaffii: PAS_chr2-2_0302
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Entry
PAS_chr2-2_0302 CDS
T01092
Name
(RefSeq) Multifunctional enzyme of the folic acid biosynthesis pathway
KO
K13939
dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:
4.1.2.25
2.7.6.3
2.5.1.15
]
Organism
ppa
Komagataella phaffii
Pathway
ppa00790
Folate biosynthesis
ppa01100
Metabolic pathways
ppa01240
Biosynthesis of cofactors
Module
ppa_M00126
Tetrahydrofolate biosynthesis, GTP => THF
Brite
KEGG Orthology (KO) [BR:
ppa00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
PAS_chr2-2_0302
Enzymes [BR:
ppa01000
]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.15 dihydropteroate synthase
PAS_chr2-2_0302
2.7 Transferring phosphorus-containing groups
2.7.6 Diphosphotransferases
2.7.6.3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
PAS_chr2-2_0302
4. Lyases
4.1 Carbon-carbon lyases
4.1.2 Aldehyde-lyases
4.1.2.25 dihydroneopterin aldolase
PAS_chr2-2_0302
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Motif
Pfam:
Pterin_bind
FolB
HPPK
Motif
Other DBs
NCBI-GeneID:
8198202
NCBI-ProteinID:
XP_002491885
UniProt:
C4R281
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Position
2:1809739..1812066
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AA seq
775 aa
AA seq
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MISGTSKSPDLVKISRLHFNAQLTNGNFWHQTSLQPFTCSVILKTDFFKASETDDLRYSL
NYATISNNILSVFRNSDEVYGSIESIAHRIAESVFSDESNGRSAEISVSSEKSEIRCDSI
DLSISRYRKNDSTNELIAPSLDKFTFKGLNLFTIIGVYTFERYNKQSVVLNLSVHYNTNK
DKLKFSQLTETVSSYVESTQFKTVEALAGNVASLVLQEFEFIEAADVEVVKLNAIIFADG
VGVATSKLRNQLQRSKIVVNPTKSEFSTLPNLNKETSFEGHPNIENHRVFIAFGTNEGDY
LENIEKTIIELDKRGCKVEKTSSLYESAPMYHLDQARFQNGVFQISTKLSPRDLLKTLKE
IEYGELKRVKHFDNGPRTIDLDILLYDDLIHDEPDLKIPHVSLIERNFVLYPLCDLLPPT
AIHPVTAEPFHQHLKKLSAHDTSIQADDGLVNIIPIPSIPNRKADIRIDTIGNKLTKSLV
MAVLNVTPDSFSDGGLHNTNESIISVYEEMVHSGVDIIDIGGVSTRPGAAAPSEEEELSR
VIPAIQLIRNHEKENNLQPQVISVDTFRSQVALKSLESGANIVNDISGGRFDEQIFDVVA
KFGAPYMVGHTRGENMTDMHTHTKYKHTQKIGEVEFWQSSPLIDTIGREIAESIQLATRK
GVKRWQLIVDPGLGFAKTVEQNISLIRNLPNLAKYGVEADGDYQSLHRVPFLLGPSRKRF
IGVITGEELPRSVGTCAAVMSCIGFGGHLIRVHDFKAVKVTCGMADAIYKGLIQS
NT seq
2328 nt
NT seq
+upstream
nt +downstream
nt
atgataagcggaacttccaaatcgccagatttggtcaagatatcaagactgcatttcaat
gcacagttaaccaatggaaacttctggcaccagacaagcctccagccatttacctgttca
gttattctgaaaacagactttttcaaggctagtgagacagacgatttaaggtattctctt
aactatgcaacgatatcgaacaacatcttgtccgtgtttcgaaatagtgatgaagtctac
ggatcaattgagtcaatagctcacagaatcgcagagagtgtgttcagtgatgaatccaat
ggacggtcagctgaaataagtgtttcgtctgaaaagtctgaaatccgttgcgattcgatt
gatttgagcatttccaggtatcgaaagaacgattcaacgaatgagttgattgccccatcg
ctggacaaattcactttcaagggactaaatctgtttacaataattggtgtctacactttt
gaaagatacaataagcaatcagttgtcttgaatttgtctgtacattataacacgaataaa
gataagttgaaattttcacagctcacggaaaccgtttcttcttacgttgaaagcacacag
ttcaagacagtagaggctctagcaggaaatgtcgcttcgttagtattgcaagagtttgag
ttcatcgaggctgcagacgtggaagttgtcaaacttaatgcaatcatttttgcggatggt
gtgggggtggcaacctctaagcttcgcaatcaacttcaacgctccaaaattgtggtgaat
ccaacaaagtctgagttcagtacgttgccaaatctgaataaagagacttcttttgaaggc
catccaaacatcgagaaccaccgtgtttttatcgcttttggaactaatgagggagattat
ctggaaaatattgagaaaacaattattgagctagacaagcggggttgtaaagtagagaag
acctcctccttatatgaatcagcgcccatgtaccacttagatcaggcaaggtttcagaat
ggtgttttccaaatttccactaaattatcacctcgagatcttttgaaaactctgaaagag
atagagtatggtgagttgaagcgcgtaaagcattttgataatgggccaagaacaatcgat
ttggatattttgttgtacgatgatttaatccatgacgaacctgacctgaagattccacat
gtctcactgattgaacgaaattttgttctttatccgttgtgtgacctgcttcctccaacc
gccatccacccagttaccgctgaacctttccaccagcatttgaaaaagctcagtgcccat
gacacttcgatacaagcagacgatgggctggtaaatatcatccctatacccagtattcct
aatagaaaagctgacatcagaattgacacgataggcaacaaacttacaaagtccctagtg
atggcagttctgaatgtaactccggattcgttcagtgatgggggtcttcacaataccaat
gaatcaattatatctgtttatgaggaaatggtgcattctggcgttgatatcatcgatatt
ggaggtgtttccactagacctggcgcagcagctccatccgaagaagaggaattatctcga
gtgatcccagctattcaattgattcggaatcatgagaaagaaaacaatttacagccacag
gtaatcagtgtggatacatttcggagtcaagttgcacttaaaagtttggagagtggtgca
aacatagtgaatgacataagcggaggtagatttgacgaacaaatctttgacgtggtagca
aaatttggtgctccatatatggttgggcacacaagaggagagaatatgaccgatatgcac
actcataccaaatacaagcatactcagaagatcggagaagttgaattttggcaaagcagt
cctttaattgatacgattggcagagaaatcgcagaatccatacaattggccacaaggaag
ggagtgaaaaggtggcagttgattgtagaccctgggcttggatttgcaaagactgtggaa
cagaatatttctctgattcgaaatttacccaatcttgccaaatacggcgttgaagcagat
ggagactatcaatctctccacagagtaccctttttactaggacctagccgaaaacgattc
ataggcgttatcactggagaagagcttccaagatcggtaggaacctgcgccgcagtaatg
agttgcataggatttggaggacacttgattagagttcacgatttcaaggctgtcaaagtt
acgtgcgggatggctgatgctatttacaaagggctcattcaaagctaa
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