KEGG   Panthera pardus (leopard): 109267527
Entry
109267527         CDS       T06062                                 

Gene name
ADCY3
Definition
(RefSeq) adenylate cyclase type 3 isoform X1
  KO
K08043  adenylate cyclase 3 [EC:4.6.1.1]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad00230  Purine metabolism
ppad01100  Metabolic pathways
ppad01522  Endocrine resistance
ppad04015  Rap1 signaling pathway
ppad04020  Calcium signaling pathway
ppad04022  cGMP-PKG signaling pathway
ppad04024  cAMP signaling pathway
ppad04062  Chemokine signaling pathway
ppad04072  Phospholipase D signaling pathway
ppad04114  Oocyte meiosis
ppad04211  Longevity regulating pathway
ppad04213  Longevity regulating pathway - multiple species
ppad04261  Adrenergic signaling in cardiomyocytes
ppad04270  Vascular smooth muscle contraction
ppad04371  Apelin signaling pathway
ppad04540  Gap junction
ppad04611  Platelet activation
ppad04713  Circadian entrainment
ppad04714  Thermogenesis
ppad04723  Retrograde endocannabinoid signaling
ppad04724  Glutamatergic synapse
ppad04725  Cholinergic synapse
ppad04727  GABAergic synapse
ppad04740  Olfactory transduction
ppad04750  Inflammatory mediator regulation of TRP channels
ppad04911  Insulin secretion
ppad04912  GnRH signaling pathway
ppad04913  Ovarian steroidogenesis
ppad04914  Progesterone-mediated oocyte maturation
ppad04915  Estrogen signaling pathway
ppad04916  Melanogenesis
ppad04918  Thyroid hormone synthesis
ppad04921  Oxytocin signaling pathway
ppad04923  Regulation of lipolysis in adipocytes
ppad04925  Aldosterone synthesis and secretion
ppad04926  Relaxin signaling pathway
ppad04927  Cortisol synthesis and secretion
ppad04928  Parathyroid hormone synthesis, secretion and action
ppad04934  Cushing syndrome
ppad04935  Growth hormone synthesis, secretion and action
ppad04962  Vasopressin-regulated water reabsorption
ppad04970  Salivary secretion
ppad04971  Gastric acid secretion
ppad04972  Pancreatic secretion
ppad04976  Bile secretion
ppad05032  Morphine addiction
ppad05163  Human cytomegalovirus infection
ppad05166  Human T-cell leukemia virus 1 infection
ppad05200  Pathways in cancer
ppad05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    109267527 (ADCY3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    109267527 (ADCY3)
   04371 Apelin signaling pathway
    109267527 (ADCY3)
   04020 Calcium signaling pathway
    109267527 (ADCY3)
   04072 Phospholipase D signaling pathway
    109267527 (ADCY3)
   04024 cAMP signaling pathway
    109267527 (ADCY3)
   04022 cGMP-PKG signaling pathway
    109267527 (ADCY3)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    109267527 (ADCY3)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    109267527 (ADCY3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109267527 (ADCY3)
   04062 Chemokine signaling pathway
    109267527 (ADCY3)
  09152 Endocrine system
   04911 Insulin secretion
    109267527 (ADCY3)
   04923 Regulation of lipolysis in adipocytes
    109267527 (ADCY3)
   04912 GnRH signaling pathway
    109267527 (ADCY3)
   04913 Ovarian steroidogenesis
    109267527 (ADCY3)
   04915 Estrogen signaling pathway
    109267527 (ADCY3)
   04914 Progesterone-mediated oocyte maturation
    109267527 (ADCY3)
   04921 Oxytocin signaling pathway
    109267527 (ADCY3)
   04926 Relaxin signaling pathway
    109267527 (ADCY3)
   04935 Growth hormone synthesis, secretion and action
    109267527 (ADCY3)
   04918 Thyroid hormone synthesis
    109267527 (ADCY3)
   04928 Parathyroid hormone synthesis, secretion and action
    109267527 (ADCY3)
   04916 Melanogenesis
    109267527 (ADCY3)
   04925 Aldosterone synthesis and secretion
    109267527 (ADCY3)
   04927 Cortisol synthesis and secretion
    109267527 (ADCY3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    109267527 (ADCY3)
   04270 Vascular smooth muscle contraction
    109267527 (ADCY3)
  09154 Digestive system
   04970 Salivary secretion
    109267527 (ADCY3)
   04971 Gastric acid secretion
    109267527 (ADCY3)
   04972 Pancreatic secretion
    109267527 (ADCY3)
   04976 Bile secretion
    109267527 (ADCY3)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    109267527 (ADCY3)
  09156 Nervous system
   04724 Glutamatergic synapse
    109267527 (ADCY3)
   04727 GABAergic synapse
    109267527 (ADCY3)
   04725 Cholinergic synapse
    109267527 (ADCY3)
   04723 Retrograde endocannabinoid signaling
    109267527 (ADCY3)
  09157 Sensory system
   04740 Olfactory transduction
    109267527 (ADCY3)
   04750 Inflammatory mediator regulation of TRP channels
    109267527 (ADCY3)
  09149 Aging
   04211 Longevity regulating pathway
    109267527 (ADCY3)
   04213 Longevity regulating pathway - multiple species
    109267527 (ADCY3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    109267527 (ADCY3)
   04714 Thermogenesis
    109267527 (ADCY3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109267527 (ADCY3)
  09165 Substance dependence
   05032 Morphine addiction
    109267527 (ADCY3)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    109267527 (ADCY3)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    109267527 (ADCY3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109267527 (ADCY3)
   05163 Human cytomegalovirus infection
    109267527 (ADCY3)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    109267527 (ADCY3)
Enzymes [BR:ppad01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     109267527 (ADCY3)
SSDB
Motif
Pfam: Guanylate_cyc AC_N HNOBA NCE101 Peptidase_S49_N
Other DBs
NCBI-GeneID: 109267527
NCBI-ProteinID: XP_019305893
Ensembl: ENSPPRG00000022933
LinkDB
Position
Unknown
AA seq 1152 aa
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPE
SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVYSSDKLAPLVVAGMGLLLDIL
LFVLCKKGLLPDRVTRKVVPYLLWLLITAQIFSYLGLNFARAHAASDTVGWQTFFVFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDGLKGRHLLREILANVCLYLCAIMVG
VMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES
QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ
LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV
LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCE
YLDEKGIETYLIIASKPEVKKTAAQHGLDGPALLNGAPASSKPSSPALIETKEPNGSIHT
SGSTSEEPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESA
QVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTN
YMTFVVGEVLLLILTVCSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN
VVDMLSCLQYHTGPVNSTAGTEAEDGCVENPKYYNYVAVLSLIATIMLVQVSHMVKLTLM
LLVTGAVAVINIYAWRPIFDEYDRKRFQEHDFPVVALEKMQVLSTPGLNSTDRLPLVPSK
YSMTVMIFIMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEH
VARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDF
DSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFANSNKEEKSDRERWQHLADLADF
ALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGV
MGNIQVCPARAEHVLRPRDRAQSQNRGCFATCYCLLSVGPGYRVGVFGRLKARVERDASV
EGKKYFDPISKI
NT seq 3459 nt   +upstreamnt  +downstreamnt
atgccaaggaaccagggcttttccgagcccgagtactcggctgagtactccgccgaatac
tcggtcagcctgccctctgaccccgaccgcggggtgggccggacccatgaaatctctgtc
cggaactcgggatcctgcctctgcctgcctcgattcatgcggctgacctttgtgcccgag
tccttggagaacttgtaccagacctacttcaaacggcagcgccatgagacgctgctggtg
ctggtggtctttgcggccctcttcgactgctacgtggtggtcatgtgcgcggtggtctac
tccagcgacaagctggctcccctggtcgtcgctgggatgggactgctgttggacatcctc
ctgttcgtgctctgcaaaaaggggctgctccccgaccgcgtcacccggaaagtggtgccc
tacctgctgtggctgctgataactgcccagattttctcctacctgggcctgaactttgcc
cgcgcgcatgcggccagcgacacggtgggctggcagaccttctttgtcttctccttcttc
atcacgctgcccctcagcctcagccccatcgtcatcatctccgtggtctcctgtgttgtg
cacacactcgtcttgggggtcaccgtggcccagcagcagcaggatgggctgaaaggcagg
cacttgctgagggagatcctggccaacgtctgcctctacctgtgcgccatcatggtgggc
gtcatgtcctactacatggcggaccgcaagcaccgcaaggccttcctggaggcccgccag
tcgctggaggtgaaaatgaacctcgaggagcagagccagcagcaggagaaccttatgctt
tccatcctgcccaagcatgtggctgacgagatgctaaaggacatgaagaaggacgagagc
caaaaggaccagcagcagttcaacaccatgtacatgtatcgccacgagaacgtcagcatc
ctctttgcggacatcgtgggcttcacccagctgtcttccgcctgcagtgcccaggagctc
gtgaagctgctcaacgagctcttcgcccgctttgacaagctggcggccaaataccaccag
ctgcggattaagatcctgggcgactgttactactgcatctgcggcctgcccgactaccgg
gaggaccacgccgtctgctccatccttatggggctcgccatggtggaggccatctcgtac
gtgcgggagaagacgaagactggggtggacatgcgtgtgggggtgcacacaggcacggtg
ctggggggcgtcctgggccagaagcgctggcagtatgacgtgtggtccaccgacgtcact
gtggccaacaagatggaggccggtggcatccccgggcgtgtgcacatctcccagagcacc
atggactgcctaaagggcgagttcgatgtggagccgggcgacgggggcagccgctgtgag
tacctggacgagaagggcatcgagacctacctcatcatcgcgtccaagccagaggtgaag
aaaacagccgcccagcacggcctcgacggcccggccctgctgaatggagcgccagcttcc
tcaaagcccagctctcccgccctcattgagaccaaggagcccaacggaagcatccacacc
agcggctccacgtcggaggagcccgaggagcaggatgcccaggcggacaacccctcgttc
cccaacccgcgccggaggctgcgccttcaggacctggctgatcgagtggtggacgcctct
gaggacgagcatgagctcaaccagctactcaatgaggccctgcttgagcgagagtccgcc
caggtagtgaagaagagaaacaccttcctcctttccatgcggttcatggaccccgagatg
gaaacccgctactccgtggagaaggaaaagcagagtggggccgcctttagctgctcctgt
gttgtcctgctctgtacggccctggtcgagatactcatcgacccctggctgatgacaaac
tacatgacctttgtggtcggggaggttctccttctgatcctgacggtctgctcgctggcc
gccatctttccccgggcctttcctaagaagctcgtggccttctcgacttggatcgaccgg
acccgctgggccagaaacacctgggccatgttagccatcttcattctggttatggcaaac
gttgtggacatgcttagctgcctgcagtaccacacaggccccgtcaacagcaccgcaggg
acggaggcagaggatggctgcgtagagaaccccaagtattacaactatgtcgctgtgctg
tccctcatcgccaccatcatgctggtgcaggtcagccacatggtgaagctcacactcatg
ctgcttgtcacgggtgctgtggctgtcatcaacatctacgcctggcgccccatctttgat
gaatatgaccgcaaacgtttccaggaacatgactttcctgtggtcgccttagagaagatg
caggtactttccacccccgggctcaacagcactgaccggctgcccctggtgccttctaag
tactccatgacagtgatgatcttcatcatgatgctgagcttttactacttctcgcgccac
gtggaaaaattggcacggacactgttcttgtggaagattgaggtccatgaccagaaggaa
cgcgtctacgagatgcggcgctggaatgaggccttggtcaccaacatgttgcctgagcac
gtggcacgccatttcctggggtccaagaagagagatgaggagctgtacagccagtcttat
gatgagattggagtcatgtttgcctccctgcccaacttcgccgacttctacacagaggag
agcatcaataacggtggcatcgagtgtctgcgcttcctcaacgagatcatctcagatttt
gattctctcctggataatcctaagttccgggtcatcaccaagatcaaaaccatcggcagc
acctatatggcagcttcaggagtcaccccggatgtcaacaccaatggcttcgccaactcc
aacaaggaggaaaagtctgaccgggagcgctggcaacacctggctgacctggctgacttc
gctctggccatgaaggacacactcaccaacatcaacaaccagtccttcaacaacttcatg
ctgcgcataggcatgaacaaaggaggggtactggctggggtcattggagcccggaaacca
cattatgacatctggggcaatacggtgaacgtagccagcaggatggagtccacaggggtc
atgggtaacattcaggtatgtccagcgagagccgagcatgtgctcagacccagggaccgg
gcacaaagtcagaatagggggtgctttgccacatgctactgcctcctttctgttggccca
ggttatcgagttggtgtttttggaagattaaaggcaagggtggaaagggatgcctcagta
gaagggaagaaatacttcgaccccatttccaaaatttag

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