KEGG   REACTION: R00978
Entry
R00978                      Reaction                               
Name
5,6-dihydrouracil:NADP+ oxidoreductase
Definition
5,6-Dihydrouracil + NADP+ <=> Uracil + NADPH + H+
Equation
C00429 + C00006 <=> C00106 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00072  C00106_C00429
Enzyme
1.3.1.2
Pathway
rn00240  Pyrimidine metabolism
rn00410  beta-Alanine metabolism
rn00770  Pantothenate and CoA biosynthesis
rn01100  Metabolic pathways
Module
M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2
     R00978  5,6-Dihydrouracil + NADP+ <=> Uracil + NADPH + H+
Orthology
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Other DBs
RHEA: 18096
LinkDB

KEGG   REACTION: R01415
Entry
R01415                      Reaction                               
Name
5,6-dihydrothymine:NADP+ oxidoreductase
Definition
(R)-5,6-Dihydrothymine + NADP+ <=> Thymine + NADPH + H+
Equation
C21028 + C00006 <=> C00178 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00123  C00178_C21028
Enzyme
1.3.1.2
Pathway
rn00240  Pyrimidine metabolism
rn01100  Metabolic pathways
Module
M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2
     R01415  (R)-5,6-Dihydrothymine + NADP+ <=> Thymine + NADPH + H+
Orthology
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Other DBs
RHEA: 58287
LinkDB

KEGG   REACTION: R08226
Entry
R08226                      Reaction                               
Name
5,6-dihydro-5-fluorouracil:NADP+ 5-oxidoreductase
Definition
5-FU + NADPH + H+ <=> 5,6-Dihydro-5-fluorouracil + NADP+
Equation
C07649 + C00005 + C00080 <=> C16630 + C00006
Reaction class
RC00001  C00005_C00006
RC02245  C07649_C16630
Enzyme
1.3.1.2
Pathway
rn00983  Drug metabolism - other enzymes
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2
     R08226  5-FU + NADPH + H+ <=> 5,6-Dihydro-5-fluorouracil + NADP+
Orthology
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
LinkDB

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