KEGG   Rhinolophus ferrumequinum (greater horseshoe bat): 117029232
Entry
117029232         CDS       T07722                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
rfq  Rhinolophus ferrumequinum (greater horseshoe bat)
Pathway
rfq01522  Endocrine resistance
rfq04010  MAPK signaling pathway
rfq04015  Rap1 signaling pathway
rfq04068  FoxO signaling pathway
rfq04071  Sphingolipid signaling pathway
rfq04114  Oocyte meiosis
rfq04148  Efferocytosis
rfq04218  Cellular senescence
rfq04261  Adrenergic signaling in cardiomyocytes
rfq04370  VEGF signaling pathway
rfq04380  Osteoclast differentiation
rfq04550  Signaling pathways regulating pluripotency of stem cells
rfq04611  Platelet activation
rfq04613  Neutrophil extracellular trap formation
rfq04620  Toll-like receptor signaling pathway
rfq04621  NOD-like receptor signaling pathway
rfq04622  RIG-I-like receptor signaling pathway
rfq04625  C-type lectin receptor signaling pathway
rfq04657  IL-17 signaling pathway
rfq04658  Th1 and Th2 cell differentiation
rfq04659  Th17 cell differentiation
rfq04660  T cell receptor signaling pathway
rfq04664  Fc epsilon RI signaling pathway
rfq04668  TNF signaling pathway
rfq04670  Leukocyte transendothelial migration
rfq04714  Thermogenesis
rfq04722  Neurotrophin signaling pathway
rfq04723  Retrograde endocannabinoid signaling
rfq04728  Dopaminergic synapse
rfq04750  Inflammatory mediator regulation of TRP channels
rfq04912  GnRH signaling pathway
rfq04914  Progesterone-mediated oocyte maturation
rfq04917  Prolactin signaling pathway
rfq04926  Relaxin signaling pathway
rfq04932  Non-alcoholic fatty liver disease
rfq04933  AGE-RAGE signaling pathway in diabetic complications
rfq04935  Growth hormone synthesis, secretion and action
rfq04936  Alcoholic liver disease
rfq05014  Amyotrophic lateral sclerosis
rfq05020  Prion disease
rfq05022  Pathways of neurodegeneration - multiple diseases
rfq05132  Salmonella infection
rfq05133  Pertussis
rfq05135  Yersinia infection
rfq05140  Leishmaniasis
rfq05142  Chagas disease
rfq05145  Toxoplasmosis
rfq05152  Tuberculosis
rfq05161  Hepatitis B
rfq05163  Human cytomegalovirus infection
rfq05167  Kaposi sarcoma-associated herpesvirus infection
rfq05169  Epstein-Barr virus infection
rfq05170  Human immunodeficiency virus 1 infection
rfq05171  Coronavirus disease - COVID-19
rfq05205  Proteoglycans in cancer
rfq05208  Chemical carcinogenesis - reactive oxygen species
rfq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rfq05415  Diabetic cardiomyopathy
rfq05417  Lipid and atherosclerosis
rfq05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rfq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    117029232 (MAPK12)
   04015 Rap1 signaling pathway
    117029232 (MAPK12)
   04370 VEGF signaling pathway
    117029232 (MAPK12)
   04668 TNF signaling pathway
    117029232 (MAPK12)
   04068 FoxO signaling pathway
    117029232 (MAPK12)
   04071 Sphingolipid signaling pathway
    117029232 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    117029232 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    117029232 (MAPK12)
   04218 Cellular senescence
    117029232 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    117029232 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    117029232 (MAPK12)
   04613 Neutrophil extracellular trap formation
    117029232 (MAPK12)
   04620 Toll-like receptor signaling pathway
    117029232 (MAPK12)
   04621 NOD-like receptor signaling pathway
    117029232 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    117029232 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    117029232 (MAPK12)
   04660 T cell receptor signaling pathway
    117029232 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    117029232 (MAPK12)
   04659 Th17 cell differentiation
    117029232 (MAPK12)
   04657 IL-17 signaling pathway
    117029232 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    117029232 (MAPK12)
   04670 Leukocyte transendothelial migration
    117029232 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    117029232 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    117029232 (MAPK12)
   04917 Prolactin signaling pathway
    117029232 (MAPK12)
   04926 Relaxin signaling pathway
    117029232 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    117029232 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    117029232 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    117029232 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    117029232 (MAPK12)
   04722 Neurotrophin signaling pathway
    117029232 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    117029232 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    117029232 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    117029232 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    117029232 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    117029232 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    117029232 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    117029232 (MAPK12)
   05161 Hepatitis B
    117029232 (MAPK12)
   05171 Coronavirus disease - COVID-19
    117029232 (MAPK12)
   05163 Human cytomegalovirus infection
    117029232 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    117029232 (MAPK12)
   05169 Epstein-Barr virus infection
    117029232 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    117029232 (MAPK12)
   05135 Yersinia infection
    117029232 (MAPK12)
   05133 Pertussis
    117029232 (MAPK12)
   05152 Tuberculosis
    117029232 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    117029232 (MAPK12)
   05140 Leishmaniasis
    117029232 (MAPK12)
   05142 Chagas disease
    117029232 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    117029232 (MAPK12)
   05020 Prion disease
    117029232 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    117029232 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    117029232 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    117029232 (MAPK12)
   05415 Diabetic cardiomyopathy
    117029232 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    117029232 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    117029232 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    117029232 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    117029232 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rfq01001]
    117029232 (MAPK12)
Enzymes [BR:rfq01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     117029232 (MAPK12)
Protein kinases [BR:rfq01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   117029232 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase
Other DBs
NCBI-GeneID: 117029232
NCBI-ProteinID: XP_032974233
Ensembl: ENSRFEG00010003363
LinkDB
Position
10:443942..452708
AA seq 367 aa
MSSPPPARRGFYRQEVTKTTWEVRVVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVMTRWYRAPEVILNWMHYTQTVDIWSAGCIMAEMITGKTLFKGNDHLDQLKEILK
VTGTPPDEFVQRLQSADAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDADQRV
TAAEALTHPYFESLQDTEDEPKAHKYDESCEDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
ASKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcccgcccgcaggggcttttaccgccaggaggtgaccaagaccacc
tgggaggtgcgcgtggtgtaccaggacctgcagcccgtgggctccggcgcctacggcgcc
gtctgctcggccgtggacagccgcacaggcgccaaagtggccatcaagaagctgtaccgg
cccttccaatcggagctgttcgccaagcgcgcctatcgagagctgcgtctcctcaagcac
atgcgccacgagaacgtgatcgggctgctggacgtgttcactcccgatgagaccctggat
gatttcacagacttctacctggtcatgcctttcatgggcaccgacctgggcaagctcatg
aagcacgagaagctgagtgaggaccgaatccagttcctcgtctaccagatgctgaagggg
ttgaagtacatccatgctgctggcatcatccatagggacctaaagcctggcaacctggct
gtgaacgaggactgtgagctgaagatcctggactttggcctggcccggcaggcagacagc
gagatgactggatatgtgatgacccggtggtaccgggctcctgaggtcatcttgaattgg
atgcactacacacagacagtggacatctggtcggcgggctgcatcatggccgagatgatc
acggggaagacgctgttcaagggcaatgaccacctggaccagctgaaggagatcttgaag
gtgacagggacgcctcctgatgagtttgtgcagaggctgcagagtgccgatgcaaagaat
tacatgaagggcctgcccgaattggagaagaaggattttgcctccatcctgaccaacgca
agccctctggctgtgaacctcctggagaaaatgctggtgctggatgcagaccaacgggtg
acggcggccgaggcactgacacacccctacttcgagtcactgcaggacacggaggacgag
cccaaggcccataagtacgacgagtcctgtgaggatgtggaccgtacgctggacgagtgg
aagcgtgtcacgtataaagaggtgctcagcttcaagcctccccggcagctgggcgccagg
gcctccaaggagacggccctgtga

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