Streptococcus pyogenes MGAS10270 (serotype M2): MGAS10270_Spy0936
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Entry
MGAS10270_Spy0936 CDS
T00355
Symbol
folC1
Name
(GenBank) Folylpolyglutamate synthase / Dihydrofolate synthase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
sph
Streptococcus pyogenes MGAS10270 (serotype M2)
Pathway
sph00790
Folate biosynthesis
sph01100
Metabolic pathways
sph01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
sph00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
MGAS10270_Spy0936 (folC1)
Enzymes [BR:
sph01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
MGAS10270_Spy0936 (folC1)
6.3.2.17 tetrahydrofolate synthase
MGAS10270_Spy0936 (folC1)
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-ProteinID:
ABF34001
UniProt:
Q1JGZ3
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All DBs
Position
889878..891254
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AA seq
458 aa
AA seq
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MFGEDKKKKGTTLGYLLSLFFIYGILKIDVRYEMTYEETLEWIHDHLVFGIKPGLKRMLW
VLGQLGNPQKNVKGVHIVGTNGKGSTVNHLQHIFTTAGYEVGTFTSPYIMDFKERISING
RMISEKDLVIAANRIRPLTERLVQETDFGEVTEFEVITLIMFLYFGDMHPVDIAIIEAGL
GGLYDSTNVFQAMVVVCPSIGLDHQAILGETYADIAAQKAGVLEGGETLVFAVENPSARE
VFLTKAEQVGASIWEWQEQFQMAENASGYRFTSPLGVISDIHIAMPGHHQVSNAALAIMT
CLTLQDRYPRLTPDHIREGLANSLWLGRTELLAPNLMIDGAHNNESVAALVAVLKNNYND
KKLHILFGAIDTKPIVDMLVALEQIGDLQVTSFHYPNAYPLEKYPERFGRVADFKDFLAL
RKHAKADDFFVITGSLYFISEIRRYWKKHIEKSVLLTH
NT seq
1377 nt
NT seq
+upstream
nt +downstream
nt
gtgtttggtgaggataagaaaaaaaagggtactactctaggttatctgctgtcacttttt
tttatatatggtatactaaagatagatgtgaggtatgaaatgacttatgaagagactcta
gaatggattcatgatcacttagttttcggcatcaagccaggcttaaaacgtatgctttgg
gttcttggacagttaggaaatccccaaaaaaatgtcaagggagtgcatatcgttggaact
aacggaaaaggttccacggtcaatcatttacaacacatctttacgacagctggttatgaa
gtggggacctttacctctccttatattatggatttcaaagaacgtattagcataaatggt
cgaatgatttcagaaaaagatttggttattgctgctaatcgtattcgtcctttgacagag
cgtctagttcaagagactgattttggagaggtaactgaatttgaagtgattactttgatc
atgttcctctattttggtgatatgcatcctgtagatattgctattattgaagcaggcctt
ggcggtctttatgattcgaccaatgtttttcaagcaatggttgtggtctgtccctcaatt
ggtttagatcaccaagctattttgggagagacttacgctgatattgccgcccaaaaagct
ggtgttttagaagggggcgagacccttgtttttgccgttgaaaacccgtcagctcgagag
gtttttttaacaaaagctgagcaggttggtgcttcaatctgggaatggcaagagcagttt
caaatggctgagaacgcatctggctatcgttttactagtcctttaggagttatttcagat
attcacatcgctatgccaggacaccaccaagtgtctaatgcagctttagctattatgact
tgcttaaccttgcaagaccgctatcctaggctaactccagatcatataagggaaggtctg
gcaaatagtttgtggctaggccgtaccgaattattagcaccaaatctaatgattgatgga
gctcataacaatgaaagcgttgctgctttggtagccgtcttaaaaaataactacaatgat
aaaaagcttcatattttgtttggtgcgatcgacaccaagcctattgtagatatgttggtt
gctcttgagcaaataggtgacttgcaggttactagctttcattaccctaacgcctatcca
ttggaaaaatacccagaacgttttggtagggttgctgatttcaaagatttcttggccttg
cgtaagcatgctaaagcagatgactttttcgtgattacagggtcactatattttatttca
gaaattagacggtattggaaaaaacatattgaaaaaagcgttcttttaacccattaa
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