KEGG   Theropithecus gelada (gelada): 112633654
Entry
112633654         CDS       T08041                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
tge  Theropithecus gelada (gelada)
Pathway
tge01522  Endocrine resistance
tge04010  MAPK signaling pathway
tge04015  Rap1 signaling pathway
tge04068  FoxO signaling pathway
tge04071  Sphingolipid signaling pathway
tge04114  Oocyte meiosis
tge04148  Efferocytosis
tge04218  Cellular senescence
tge04261  Adrenergic signaling in cardiomyocytes
tge04370  VEGF signaling pathway
tge04380  Osteoclast differentiation
tge04550  Signaling pathways regulating pluripotency of stem cells
tge04611  Platelet activation
tge04613  Neutrophil extracellular trap formation
tge04620  Toll-like receptor signaling pathway
tge04621  NOD-like receptor signaling pathway
tge04622  RIG-I-like receptor signaling pathway
tge04625  C-type lectin receptor signaling pathway
tge04657  IL-17 signaling pathway
tge04658  Th1 and Th2 cell differentiation
tge04659  Th17 cell differentiation
tge04660  T cell receptor signaling pathway
tge04664  Fc epsilon RI signaling pathway
tge04668  TNF signaling pathway
tge04670  Leukocyte transendothelial migration
tge04714  Thermogenesis
tge04722  Neurotrophin signaling pathway
tge04723  Retrograde endocannabinoid signaling
tge04728  Dopaminergic synapse
tge04750  Inflammatory mediator regulation of TRP channels
tge04912  GnRH signaling pathway
tge04914  Progesterone-mediated oocyte maturation
tge04917  Prolactin signaling pathway
tge04926  Relaxin signaling pathway
tge04932  Non-alcoholic fatty liver disease
tge04933  AGE-RAGE signaling pathway in diabetic complications
tge04935  Growth hormone synthesis, secretion and action
tge04936  Alcoholic liver disease
tge05014  Amyotrophic lateral sclerosis
tge05020  Prion disease
tge05022  Pathways of neurodegeneration - multiple diseases
tge05132  Salmonella infection
tge05133  Pertussis
tge05135  Yersinia infection
tge05140  Leishmaniasis
tge05142  Chagas disease
tge05145  Toxoplasmosis
tge05152  Tuberculosis
tge05161  Hepatitis B
tge05163  Human cytomegalovirus infection
tge05167  Kaposi sarcoma-associated herpesvirus infection
tge05169  Epstein-Barr virus infection
tge05170  Human immunodeficiency virus 1 infection
tge05171  Coronavirus disease - COVID-19
tge05205  Proteoglycans in cancer
tge05208  Chemical carcinogenesis - reactive oxygen species
tge05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tge05415  Diabetic cardiomyopathy
tge05417  Lipid and atherosclerosis
tge05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tge00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112633654 (MAPK12)
   04015 Rap1 signaling pathway
    112633654 (MAPK12)
   04370 VEGF signaling pathway
    112633654 (MAPK12)
   04668 TNF signaling pathway
    112633654 (MAPK12)
   04068 FoxO signaling pathway
    112633654 (MAPK12)
   04071 Sphingolipid signaling pathway
    112633654 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    112633654 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    112633654 (MAPK12)
   04218 Cellular senescence
    112633654 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    112633654 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112633654 (MAPK12)
   04613 Neutrophil extracellular trap formation
    112633654 (MAPK12)
   04620 Toll-like receptor signaling pathway
    112633654 (MAPK12)
   04621 NOD-like receptor signaling pathway
    112633654 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    112633654 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    112633654 (MAPK12)
   04660 T cell receptor signaling pathway
    112633654 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    112633654 (MAPK12)
   04659 Th17 cell differentiation
    112633654 (MAPK12)
   04657 IL-17 signaling pathway
    112633654 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    112633654 (MAPK12)
   04670 Leukocyte transendothelial migration
    112633654 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    112633654 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    112633654 (MAPK12)
   04917 Prolactin signaling pathway
    112633654 (MAPK12)
   04926 Relaxin signaling pathway
    112633654 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    112633654 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112633654 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    112633654 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    112633654 (MAPK12)
   04722 Neurotrophin signaling pathway
    112633654 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    112633654 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112633654 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    112633654 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    112633654 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    112633654 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112633654 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    112633654 (MAPK12)
   05161 Hepatitis B
    112633654 (MAPK12)
   05171 Coronavirus disease - COVID-19
    112633654 (MAPK12)
   05163 Human cytomegalovirus infection
    112633654 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112633654 (MAPK12)
   05169 Epstein-Barr virus infection
    112633654 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112633654 (MAPK12)
   05135 Yersinia infection
    112633654 (MAPK12)
   05133 Pertussis
    112633654 (MAPK12)
   05152 Tuberculosis
    112633654 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    112633654 (MAPK12)
   05140 Leishmaniasis
    112633654 (MAPK12)
   05142 Chagas disease
    112633654 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    112633654 (MAPK12)
   05020 Prion disease
    112633654 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    112633654 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112633654 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    112633654 (MAPK12)
   05415 Diabetic cardiomyopathy
    112633654 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    112633654 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    112633654 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112633654 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    112633654 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tge01001]
    112633654 (MAPK12)
Enzymes [BR:tge01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     112633654 (MAPK12)
Protein kinases [BR:tge01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   112633654 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo
Other DBs
NCBI-GeneID: 112633654
NCBI-ProteinID: XP_025256226
Ensembl: ENSTGEG00000001948
LinkDB
Position
10:477828..487994
AA seq 483 aa
MARCGERGPGGAAGGAGGACAGCPAFPLSGPPRSSAVDSRTGAKVAIKKLYRPFQSELFA
KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED
RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVT
RWYRAPEVILNWMRYTQTGEKLPSDLGLSGCTICFSTSSQRALWWLLPREAVELGWEPGG
WAVSVFPPSPSHPVPLPTGLTMAFISVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAAEALAHPYFESLHDKEDEPQVQKYDDSFDDVDRTLDEWKRELGAPGRACVDPSWGFWA
GPVWTCEWGGSGQGLCGPCGPCAGGQAQSPKSPSLGCRSGEENGRSEGSTGPCGLVEMTS
GWS
NT seq 1452 nt   +upstreamnt  +downstreamnt
atggcgcggtgtggtgagcgcgggccgggcggggcggccggcggggcgggcggggcctgc
gcggggtgcccggccttcccgctaagcggtccgccccgcagctcggccgtggacagccgc
accggcgctaaggtggccatcaagaagctgtaccggcccttccagtccgagctgttcgcc
aagcgcgcctaccgcgagctgcgcctgctcaagcacatgcgccacgagaacgtgattggg
ctgctggatgtgttcactcctgatgagaccctggatgactttacagacttttacctggtg
atgccattcatgggcaccgacctgggcaagctcatgaaacatgagaagctgggcgaggac
cggatccagttcctcgtgtaccagatgctgaaggggctgaggtatatccatgctgccggc
atcatccacagagacctgaagcctggcaacctggctgtgaacgaagactgtgagctgaag
atcctggactttggcctggccaggcaggcagacagcgagatgactggctatgtggtgacc
cggtggtaccgggcacccgaggtcatcttgaattggatgcgctacacgcagacgggtgag
aagctgcctagcgatttgggcctctcgggctgcaccatctgcttctctacttcttcacag
agagccctgtggtggctgctccccagggaggctgttgagctggggtgggagccgggtggg
tgggctgtgtctgtgtttcctccctccccatctcatcccgtccccctgcccacggggctg
accatggcttttatctcagtggacatctggtctgtggggtgcatcatggcggagatgatc
acaggcaagacgctgttcaagggcagcgaccacctggaccagctgaaggagatcatgaaa
gtgacagggacgcctccagctgagtttgtgcagcggctgcagagtgatgaggccaagaac
tacatgaagggcctccctgagttggagaagaaggattttgcctccatcctgaccaatgca
agccctctggctgtgaacctcctggagaagatgctggtgctggatgcggagcagcgggtg
acggcagccgaggcactggcccatccctacttcgagtccctgcatgacaaggaagatgag
ccccaggtccagaagtatgacgactcctttgatgacgtggaccgcacgctggatgaatgg
aagcgtgagctgggggctccgggcagggcctgtgtggacccgagttgggggttctgggca
gggcctgtgtggacctgtgagtgggggggctctgggcagggcctgtgtggaccctgtggg
ccctgtgcaggtggccaggctcagagtcctaaatccccgtccctgggatgcaggtcaggt
gaggagaatgggaggtcagagggcagcacggggccgtgtggcctggtggaaatgacctct
ggctggagctga

DBGET integrated database retrieval system