Tupaia chinensis (Chinese tree shrew): 102493753 Help Entry 102493753         CDS       T02978                                  Symbol TYK2 Name (RefSeq) tyrosine kinase 2   KO K11219   non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup04217   Necroptosis tup04380   Osteoclast differentiation tup04620   Toll-like receptor signaling pathway tup04621   NOD-like receptor signaling pathway tup04630   JAK-STAT signaling pathway tup04658   Th1 and Th2 cell differentiation tup04659   Th17 cell differentiation tup05145   Toxoplasmosis tup05160   Hepatitis C tup05161   Hepatitis B tup05162   Measles tup05164   Influenza A tup05165   Human papillomavirus infection tup05167   Kaposi sarcoma-associated herpesvirus infection tup05168   Herpes simplex virus 1 infection tup05169   Epstein-Barr virus infection tup05171   Coronavirus disease - COVID-19 Brite KEGG Orthology (KO) [BR:tup00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102493753 (TYK2)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102493753 (TYK2)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     102493753 (TYK2)    04621 NOD-like receptor signaling pathway     102493753 (TYK2)    04658 Th1 and Th2 cell differentiation     102493753 (TYK2)    04659 Th17 cell differentiation     102493753 (TYK2)   09158 Development and regeneration    04380 Osteoclast differentiation     102493753 (TYK2)  09160 Human Diseases   09172 Infectious disease: viral    05161 Hepatitis B     102493753 (TYK2)    05160 Hepatitis C     102493753 (TYK2)    05171 Coronavirus disease - COVID-19     102493753 (TYK2)    05164 Influenza A     102493753 (TYK2)    05162 Measles     102493753 (TYK2)    05168 Herpes simplex virus 1 infection     102493753 (TYK2)    05167 Kaposi sarcoma-associated herpesvirus infection     102493753 (TYK2)    05169 Epstein-Barr virus infection     102493753 (TYK2)    05165 Human papillomavirus infection     102493753 (TYK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102493753 (TYK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:tup01001]     102493753 (TYK2) Enzymes [BR:tup01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102493753 (TYK2) Protein kinases [BR:tup01001]  Non-receptor tyrosine kinases   JAK family [OT]    102493753 (TYK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 Kdo Kinase-like TrpBP ABC1 APH Motif Other DBs NCBI-GeneID:  102493753 NCBI-ProteinID:  XP_006161609 LinkDB All DBs Position Un AA seq 1155 aa AA seqDB search MPRCQRGATARDSKPDGDGAQPIAAMGGLKVLLHWAGPGGGEPWVTFSEASLTAEDICLR VAHKLGITPPCFNLFALFDDQAQVWLPPNHILEISRDTDLTLCFRMRFYFRNWHGMNPQE PAVYRCGPPGTEAAPERVEQGMQLLDPASFEYLFEQGKYEFVNDVASLWELSDEEEIHHF KNESLGMAFLHLCHLALCRGVPLEEVAKKISFKDCIPRSFRRQIQQHNALTRLRLRSVFR KFLRSFQPTCLSQQVVMVKYLATLERLAPRFGSERVPVCRLELLAQAQDEPCYIRDNGQA PADPCPEAAAGPPTHEVLVTGTGGIQWRLRRAEVSGGSDSGREAPWTYFCDFQDISHVVL KERDVTIHRQDNKCLELSLPSRGAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIQ EGIHGPLLEPFLQAKLRSEDGLYLIHWSASHLHRLILTVAQREQAPGPRSVRLRKFPIEQ QDGAFLLEGWGRAFASVRDLWAALQGCLLRAGDDCFSLRRCCLPRPGEISNLIIMRGPRA STRPLNLSQLSFHRVRQDEITQLSHLGQGTRTNVYEGLLRVGGPTEDKMAGEDVPEPGGG PREELRVVLKVLDPSHHDIALAFYETASLMSQVSHAHLVFVHGVCVRGSENIMVTELVEH GPLDVWLRRERGRVSMAWKVAVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLEEGTS PFIKLSDPGVGLGALSREERVERIPWTAPECLPGGTNSLSTAADKWGFGASLLEICFDGE APLQGRCLSEKERFYQKQHRLPEPSCPELATITSQCLNYEPAQRPSFRTILRDLTQLQPH NLLDVLAVNLDCPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL KADCSPQLRSGWRREIDILRMLYHDHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPR HSVGLAQLLLFALQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGH DYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLTHCDSTQSPPSKFIELI GLTQGQMTVLRLTELLDRGERLPQPDKCPCEIYRLMKNCWEAKASCRPTFQNLVPILKTV QEKYEGQAPSVFSVC NT seq 3468 nt NT seq  +upstreamnt  +downstreamnt atgcctcggtgccagcgcggtgccaccgccagggacagcaagcctgatggggacggagct cagcccatagctgccatgggaggcctgaaggttcttctgcactgggccggccctgggggc ggagagccctgggtcaccttcagtgaggcctcgctgacagctgaggacatctgcctccgc gtggcgcacaaactcggcatcactccaccctgcttcaatctcttcgctctctttgacgac caggcccaagtgtggctgcccccaaaccacatcctcgagatctccagagacacggacctg acgctgtgtttccgcatgaggttttacttccggaactggcatggcatgaaccctcaggag ccagcggtgtaccgctgcgggccccccgggactgaggcagccccagaacgggtggagcag ggcatgcaactcctggacccagcctcctttgagtatctctttgagcagggcaagtatgag tttgtgaatgacgtggcctcactgtgggagctgtcagatgaggaggagatccaccacttc aagaacgaaagcctaggcatggcctttctgcacctctgtcacctcgctctctgccgtgga gtccccttggaggaagtggccaaaaagatcagcttcaaggactgcatcccccgctccttt cggcggcagattcagcagcacaacgccctgacgcggctgcgcctgcgcagtgtcttccgc aagttcctgcggtctttccagcccacctgcctgtcccagcaggtggtcatggtcaaatac ctggccacgctggagcgactggcgccgcgtttcggctcggagcgtgtgcccgtgtgccgc ctggagctgctggctcaggctcaggacgagccctgctatatccgggacaacggccaggcc cctgcagacccctgccctgaggctgccgcaggacctcccacccacgaggtgctggtgacg gggaccggtggcatccagtggcgtttgagacgggcagaggtttctggtggcagtgacagc ggcagggaggcaccgtggacctacttctgcgacttccaggacatcagccacgtggtgctg aaagagcgcgacgtcaccatccaccggcaggacaacaagtgcctggagctgagcctgcct tcccgcggggccgccctgtccttcgtgtcgctggtggatggctacttccgcctgacagcg gactccagccactacctgtgccatgaggtggcccccccacggctggttatgagtatccaa gagggaatccacgggcccctgctggagccgttcctgcaggccaagctgagatccgaggac ggcctgtacctcattcactggagcgccagccacctgcaccgtctcatcctgacggtggcc cagcgggagcaggcccccggccctcgtagtgttcgcctccgcaagttcccgattgagcag caggacggcgccttcctcctggagggctggggccgtgccttcgccagcgttcgggatctc tgggccgccctgcagggctgcttgctgcgggctggggacgactgcttctccctgcgccgc tgctgcctgccccggccaggagaaatctccaacctgatcatcatgcgggggccccgggcc agcaccaggccgctcaacctcagtcagctcagcttccaccgcgtccgccaggacgagatc acgcagctgtcccacctgggccagggcacgaggaccaacgtgtatgagggcctcctgcga gtggggggccccacggaagacaagatggctggggaggatgtccccgagcccggcgggggc cccagggaggagctgcgagtggtacttaaagtgctggaccctagtcaccacgacattgcc ctggccttctacgagacagccagtctcatgagccaggtctcccatgcacacttggtgttc gtgcacggcgtctgcgtgcgtggctccgagaatatcatggtgacagagctcgtggagcat ggacccctggatgtgtggctgcggcgagagaggggccgtgtatctatggcctggaaggtg gcggtggcccaacagctggccagcgcactcagctacctggaggacaagaacctggttcat ggtaacgtgtgtggccggaacatcctgctggcccggttggggctggaagagggcaccagc cccttcatcaagctgagtgaccccggcgtgggcctgggcgccctctccagggaggagcgg gtggagcggattccctggacggcccctgaatgcctgcccggaggaaccaacagcctcagc accgcagcagacaagtggggcttcggcgccagccttctagaaatctgcttcgatggggag gcccctttgcagggccgctgcctctccgagaaagagcgtttctaccagaagcagcaccga ctccccgagccctcctgtccagagctggccactatcaccagccagtgcctgaactatgag cccgcccagcgcccgtcattccgcaccatcctgcgtgacctcactcagctgcagccccac aatcttctcgatgtcttggcggtgaacctcgactgccctgcgtcagaccccacggttttc cacaagcgctatttgaaaaagatccgcgatctgggtgagggccacttcggcaaggtcagc ttgtactgctatgacccgaccaacgacggcactggcgagatggtggctgtgaaagcgctc aaggcggactgcagccctcagctccgctctggctggaggcgggaaatcgacatcctgcgc atgctctatcacgaccacatcgtcaagtacaaaggctgctgcgaggaccaaggtgagaag tcagtgcagcttgtcatggagtatgtgcctctgggcagcctccgggactacctgccacgg cacagcgtcgggctggctcagctcctgcttttcgcccttcagatctgcgagggcatggcc tacctgcactcgcagcactacatccaccgagacctagccgcgcgcaacgtgctattggac aacgacaggctggtcaagatcggggactttggcctagccaaggctgtgcccgaaggccac gactactaccgcgtgcgcgaggatggggacagccctgtgttctggtatgccccggagtgc ctgaaggagtgtaagttctactatgcatcggatgtctggtccttcggggtcaccctgtat gagctgctgacgcactgtgactccacccagagtcccccctcgaaattcatagagctcata ggcctcacccaggggcagatgacggtgctgagactcacagagctactggaccgtggggag aggctgccacagcccgacaaatgtccctgtgaaatctatcgtctcatgaaaaactgctgg gaggcaaaggcttcttgtcgcccgaccttccagaatcttgtccccatcctcaagaccgtc caagaaaaatacgaaggccaggccccttcggtgttcagcgtgtgctga

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