Ursus maritimus (polar bear): 103661038 Help Entry 103661038         CDS       T03271                                  Gene name AKT2 Definition (RefSeq) AKT serine/threonine kinase 2   KO K04456   RAC serine/threonine-protein kinase [EC:2.7.11.1] Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr01522   Endocrine resistance umr01524   Platinum drug resistance umr04010   MAPK signaling pathway umr04012   ErbB signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04066   HIF-1 signaling pathway umr04068   FoxO signaling pathway umr04071   Sphingolipid signaling pathway umr04072   Phospholipase D signaling pathway umr04140   Autophagy - animal umr04150   mTOR signaling pathway umr04151   PI3K-Akt signaling pathway umr04152   AMPK signaling pathway umr04210   Apoptosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04218   Cellular senescence umr04261   Adrenergic signaling in cardiomyocytes umr04370   VEGF signaling pathway umr04371   Apelin signaling pathway umr04380   Osteoclast differentiation umr04510   Focal adhesion umr04550   Signaling pathways regulating pluripotency of stem cells umr04611   Platelet activation umr04613   Neutrophil extracellular trap formation umr04620   Toll-like receptor signaling pathway umr04625   C-type lectin receptor signaling pathway umr04630   JAK-STAT signaling pathway umr04660   T cell receptor signaling pathway umr04662   B cell receptor signaling pathway umr04664   Fc epsilon RI signaling pathway umr04666   Fc gamma R-mediated phagocytosis umr04668   TNF signaling pathway umr04722   Neurotrophin signaling pathway umr04725   Cholinergic synapse umr04728   Dopaminergic synapse umr04910   Insulin signaling pathway umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04917   Prolactin signaling pathway umr04919   Thyroid hormone signaling pathway umr04920   Adipocytokine signaling pathway umr04922   Glucagon signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04926   Relaxin signaling pathway umr04929   GnRH secretion umr04931   Insulin resistance umr04932   Non-alcoholic fatty liver disease umr04933   AGE-RAGE signaling pathway in diabetic complications umr04935   Growth hormone synthesis, secretion and action umr04973   Carbohydrate digestion and absorption umr05010   Alzheimer disease umr05017   Spinocerebellar ataxia umr05132   Salmonella infection umr05135   Yersinia infection umr05142   Chagas disease umr05145   Toxoplasmosis umr05152   Tuberculosis umr05160   Hepatitis C umr05161   Hepatitis B umr05162   Measles umr05163   Human cytomegalovirus infection umr05164   Influenza A umr05165   Human papillomavirus infection umr05166   Human T-cell leukemia virus 1 infection umr05167   Kaposi sarcoma-associated herpesvirus infection umr05168   Herpes simplex virus 1 infection umr05169   Epstein-Barr virus infection umr05170   Human immunodeficiency virus 1 infection umr05200   Pathways in cancer umr05205   Proteoglycans in cancer umr05210   Colorectal cancer umr05211   Renal cell carcinoma umr05212   Pancreatic cancer umr05213   Endometrial cancer umr05214   Glioma umr05215   Prostate cancer umr05218   Melanoma umr05220   Chronic myeloid leukemia umr05221   Acute myeloid leukemia umr05222   Small cell lung cancer umr05223   Non-small cell lung cancer umr05224   Breast cancer umr05225   Hepatocellular carcinoma umr05226   Gastric cancer umr05230   Central carbon metabolism in cancer umr05231   Choline metabolism in cancer umr05235   PD-L1 expression and PD-1 checkpoint pathway in cancer umr05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103661038 (AKT2)    04012 ErbB signaling pathway     103661038 (AKT2)    04014 Ras signaling pathway     103661038 (AKT2)    04015 Rap1 signaling pathway     103661038 (AKT2)    04370 VEGF signaling pathway     103661038 (AKT2)    04371 Apelin signaling pathway     103661038 (AKT2)    04630 JAK-STAT signaling pathway     103661038 (AKT2)    04668 TNF signaling pathway     103661038 (AKT2)    04066 HIF-1 signaling pathway     103661038 (AKT2)    04068 FoxO signaling pathway     103661038 (AKT2)    04072 Phospholipase D signaling pathway     103661038 (AKT2)    04071 Sphingolipid signaling pathway     103661038 (AKT2)    04024 cAMP signaling pathway     103661038 (AKT2)    04022 cGMP-PKG signaling pathway     103661038 (AKT2)    04151 PI3K-Akt signaling pathway     103661038 (AKT2)    04152 AMPK signaling pathway     103661038 (AKT2)    04150 mTOR signaling pathway     103661038 (AKT2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     103661038 (AKT2)   09143 Cell growth and death    04210 Apoptosis     103661038 (AKT2)    04218 Cellular senescence     103661038 (AKT2)   09144 Cellular community - eukaryotes    04510 Focal adhesion     103661038 (AKT2)    04550 Signaling pathways regulating pluripotency of stem cells     103661038 (AKT2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103661038 (AKT2)    04613 Neutrophil extracellular trap formation     103661038 (AKT2)    04620 Toll-like receptor signaling pathway     103661038 (AKT2)    04625 C-type lectin receptor signaling pathway     103661038 (AKT2)    04660 T cell receptor signaling pathway     103661038 (AKT2)    04662 B cell receptor signaling pathway     103661038 (AKT2)    04664 Fc epsilon RI signaling pathway     103661038 (AKT2)    04666 Fc gamma R-mediated phagocytosis     103661038 (AKT2)    04062 Chemokine signaling pathway     103661038 (AKT2)   09152 Endocrine system    04910 Insulin signaling pathway     103661038 (AKT2)    04922 Glucagon signaling pathway     103661038 (AKT2)    04923 Regulation of lipolysis in adipocytes     103661038 (AKT2)    04920 Adipocytokine signaling pathway     103661038 (AKT2)    04929 GnRH secretion     103661038 (AKT2)    04915 Estrogen signaling pathway     103661038 (AKT2)    04914 Progesterone-mediated oocyte maturation     103661038 (AKT2)    04917 Prolactin signaling pathway     103661038 (AKT2)    04926 Relaxin signaling pathway     103661038 (AKT2)    04935 Growth hormone synthesis, secretion and action     103661038 (AKT2)    04919 Thyroid hormone signaling pathway     103661038 (AKT2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103661038 (AKT2)   09154 Digestive system    04973 Carbohydrate digestion and absorption     103661038 (AKT2)   09156 Nervous system    04725 Cholinergic synapse     103661038 (AKT2)    04728 Dopaminergic synapse     103661038 (AKT2)    04722 Neurotrophin signaling pathway     103661038 (AKT2)   09158 Development and regeneration    04380 Osteoclast differentiation     103661038 (AKT2)   09149 Aging    04211 Longevity regulating pathway     103661038 (AKT2)    04213 Longevity regulating pathway - multiple species     103661038 (AKT2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103661038 (AKT2)    05205 Proteoglycans in cancer     103661038 (AKT2)    05230 Central carbon metabolism in cancer     103661038 (AKT2)    05231 Choline metabolism in cancer     103661038 (AKT2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103661038 (AKT2)   09162 Cancer: specific types    05210 Colorectal cancer     103661038 (AKT2)    05212 Pancreatic cancer     103661038 (AKT2)    05225 Hepatocellular carcinoma     103661038 (AKT2)    05226 Gastric cancer     103661038 (AKT2)    05214 Glioma     103661038 (AKT2)    05221 Acute myeloid leukemia     103661038 (AKT2)    05220 Chronic myeloid leukemia     103661038 (AKT2)    05218 Melanoma     103661038 (AKT2)    05211 Renal cell carcinoma     103661038 (AKT2)    05215 Prostate cancer     103661038 (AKT2)    05213 Endometrial cancer     103661038 (AKT2)    05224 Breast cancer     103661038 (AKT2)    05222 Small cell lung cancer     103661038 (AKT2)    05223 Non-small cell lung cancer     103661038 (AKT2)   09164 Neurodegenerative disease    05010 Alzheimer disease     103661038 (AKT2)    05017 Spinocerebellar ataxia     103661038 (AKT2)   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     103661038 (AKT2)   09167 Endocrine and metabolic disease    04932 Non-alcoholic fatty liver disease     103661038 (AKT2)    04931 Insulin resistance     103661038 (AKT2)    04933 AGE-RAGE signaling pathway in diabetic complications     103661038 (AKT2)   09171 Infectious disease: bacterial    05132 Salmonella infection     103661038 (AKT2)    05135 Yersinia infection     103661038 (AKT2)    05152 Tuberculosis     103661038 (AKT2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103661038 (AKT2)    05170 Human immunodeficiency virus 1 infection     103661038 (AKT2)    05161 Hepatitis B     103661038 (AKT2)    05160 Hepatitis C     103661038 (AKT2)    05164 Influenza A     103661038 (AKT2)    05162 Measles     103661038 (AKT2)    05168 Herpes simplex virus 1 infection     103661038 (AKT2)    05163 Human cytomegalovirus infection     103661038 (AKT2)    05167 Kaposi sarcoma-associated herpesvirus infection     103661038 (AKT2)    05169 Epstein-Barr virus infection     103661038 (AKT2)    05165 Human papillomavirus infection     103661038 (AKT2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     103661038 (AKT2)    05142 Chagas disease     103661038 (AKT2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103661038 (AKT2)    01524 Platinum drug resistance     103661038 (AKT2)    01522 Endocrine resistance     103661038 (AKT2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:umr01001]     103661038 (AKT2) Enzymes [BR:umr01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      103661038 (AKT2) Protein kinases [BR:umr01001]  Serine/threonine kinases: AGC group   AKT/PKB family    103661038 (AKT2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr PH Kinase-like Pkinase_C PH_11 Motif Other DBs NCBI-GeneID:  103661038 NCBI-ProteinID:  XP_008686928 UniProt:  A0A384BWG0 LinkDB All DBs Position Un AA seq 525 aa AA seqDB search MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPDAPDQTLPPLNNFSVAEC QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDPM DYKCGSPSDPSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKASGRYYAM KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAREVMEHRFFLSVNWQDVVQK KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRFFSSALRQTHLSGLSGPASRILSSP LCPDQNLGDSPLPAPGPGLRAVGEIPVFNQHKPLRGASRGAAGPA NT seq 1578 nt NT seq  +upstreamnt  +downstreamnt atgaacgaggtgtctgtcatcaaggaaggctggctccacaagcgtggtgaatacatcaag acctggaggccccggtacttcctgttgaagagtgacggctccttcattggatacaaggag cggcctgacgcccctgaccagaccctgccccccctgaacaacttctctgtcgcagaatgc cagctgatgaagaccgagagaccacggcccaacacctttgtcatacgctgcctgcagtgg accacggtcatcgagaggaccttccacgtagactctccagatgagagggaggagtggatg cgggccattcagatggttgccaacagcctcaagcagcggggcccaggtgaggaccccatg gactataagtgtggctcccccagcgacccttctgcagccgaggagatggaagtggcagtt agcaaggctcgggccaaggtgaccatgaatgacttcgactatctcaaacttctgggcaag ggcacctttggcaaagtgattctggtgcgggagaaagccagcggccgctactacgccatg aagatcctgcggaaggaagttatcatcgccaaggatgaagtcgcccacacggtcaccgag agccgggtcctccagaacaccaggcacccattcctcaccgcactgaagtatgccttccag acccacgaccgcctgtgcttcgtgatggagtatgccaacggtggtgagctgtttttccac ctgtcccgggagcgtgtcttcacggaggagcgggctcgcttctacggtgcagagatagtc tctgccctcgagtatttgcactcgcgggacgtggtgtaccgcgacatcaagctggaaaac ctcatgctggacaaagatggccacatcaagatcactgacttcggcctgtgcaaagagggc atcagtgacggggccaccatgaaaaccttctgtgggacacccgagtacctggcacccgag gtgctggaggacaacgactacggccgcgcggtggactggtgggggctgggcgtggtcatg tacgagatgatgtgcggccgcctgcctttctacaaccaggaccacgagcgcctcttcgag ctcatcctcatggaggagatccgcttcccgcgcacgctcagccccgaggccaagtccctg cttgctgggctgcttaagaaggaccccaagcagaggctcggcggggggcccagcgatgcc agggaggtcatggagcacaggttcttcctcagcgtcaactggcaggacgtggtacagaag aagcttctgccccccttcaaacctcaggtcacctccgaggttgacacaaggtactttgac gatgagtttaccgcccagtccatcacaatcacgcccccggaccgctttttttcttcagcc ctccgccaaactcacctcagcggtctcagcggccctgcctccaggatcctgtcctcacct ttgtgcccagaccagaatttgggagactctccactgcccgccccaggaccaggccttcgg gcggttggagagattccggtttttaatcaacacaagcccctgcgaggggcgtcgcgtgga gctgcgggtcctgcctga

Ursus maritimus (polar bear): 103666688 Help Entry 103666688         CDS       T03271                                  Gene name AKT3 Definition (RefSeq) AKT serine/threonine kinase 3   KO K04456   RAC serine/threonine-protein kinase [EC:2.7.11.1] Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr01522   Endocrine resistance umr01524   Platinum drug resistance umr04010   MAPK signaling pathway umr04012   ErbB signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04066   HIF-1 signaling pathway umr04068   FoxO signaling pathway umr04071   Sphingolipid signaling pathway umr04072   Phospholipase D signaling pathway umr04140   Autophagy - animal umr04150   mTOR signaling pathway umr04151   PI3K-Akt signaling pathway umr04152   AMPK signaling pathway umr04210   Apoptosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04218   Cellular senescence umr04261   Adrenergic signaling in cardiomyocytes umr04370   VEGF signaling pathway umr04371   Apelin signaling pathway umr04380   Osteoclast differentiation umr04510   Focal adhesion umr04550   Signaling pathways regulating pluripotency of stem cells umr04611   Platelet activation umr04613   Neutrophil extracellular trap formation umr04620   Toll-like receptor signaling pathway umr04625   C-type lectin receptor signaling pathway umr04630   JAK-STAT signaling pathway umr04660   T cell receptor signaling pathway umr04662   B cell receptor signaling pathway umr04664   Fc epsilon RI signaling pathway umr04666   Fc gamma R-mediated phagocytosis umr04668   TNF signaling pathway umr04722   Neurotrophin signaling pathway umr04725   Cholinergic synapse umr04728   Dopaminergic synapse umr04910   Insulin signaling pathway umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04917   Prolactin signaling pathway umr04919   Thyroid hormone signaling pathway umr04920   Adipocytokine signaling pathway umr04922   Glucagon signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04926   Relaxin signaling pathway umr04929   GnRH secretion umr04931   Insulin resistance umr04932   Non-alcoholic fatty liver disease umr04933   AGE-RAGE signaling pathway in diabetic complications umr04935   Growth hormone synthesis, secretion and action umr04973   Carbohydrate digestion and absorption umr05010   Alzheimer disease umr05017   Spinocerebellar ataxia umr05132   Salmonella infection umr05135   Yersinia infection umr05142   Chagas disease umr05145   Toxoplasmosis umr05152   Tuberculosis umr05160   Hepatitis C umr05161   Hepatitis B umr05162   Measles umr05163   Human cytomegalovirus infection umr05164   Influenza A umr05165   Human papillomavirus infection umr05166   Human T-cell leukemia virus 1 infection umr05167   Kaposi sarcoma-associated herpesvirus infection umr05168   Herpes simplex virus 1 infection umr05169   Epstein-Barr virus infection umr05170   Human immunodeficiency virus 1 infection umr05200   Pathways in cancer umr05205   Proteoglycans in cancer umr05210   Colorectal cancer umr05211   Renal cell carcinoma umr05212   Pancreatic cancer umr05213   Endometrial cancer umr05214   Glioma umr05215   Prostate cancer umr05218   Melanoma umr05220   Chronic myeloid leukemia umr05221   Acute myeloid leukemia umr05222   Small cell lung cancer umr05223   Non-small cell lung cancer umr05224   Breast cancer umr05225   Hepatocellular carcinoma umr05226   Gastric cancer umr05230   Central carbon metabolism in cancer umr05231   Choline metabolism in cancer umr05235   PD-L1 expression and PD-1 checkpoint pathway in cancer umr05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103666688 (AKT3)    04012 ErbB signaling pathway     103666688 (AKT3)    04014 Ras signaling pathway     103666688 (AKT3)    04015 Rap1 signaling pathway     103666688 (AKT3)    04370 VEGF signaling pathway     103666688 (AKT3)    04371 Apelin signaling pathway     103666688 (AKT3)    04630 JAK-STAT signaling pathway     103666688 (AKT3)    04668 TNF signaling pathway     103666688 (AKT3)    04066 HIF-1 signaling pathway     103666688 (AKT3)    04068 FoxO signaling pathway     103666688 (AKT3)    04072 Phospholipase D signaling pathway     103666688 (AKT3)    04071 Sphingolipid signaling pathway     103666688 (AKT3)    04024 cAMP signaling pathway     103666688 (AKT3)    04022 cGMP-PKG signaling pathway     103666688 (AKT3)    04151 PI3K-Akt signaling pathway     103666688 (AKT3)    04152 AMPK signaling pathway     103666688 (AKT3)    04150 mTOR signaling pathway     103666688 (AKT3)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     103666688 (AKT3)   09143 Cell growth and death    04210 Apoptosis     103666688 (AKT3)    04218 Cellular senescence     103666688 (AKT3)   09144 Cellular community - eukaryotes    04510 Focal adhesion     103666688 (AKT3)    04550 Signaling pathways regulating pluripotency of stem cells     103666688 (AKT3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103666688 (AKT3)    04613 Neutrophil extracellular trap formation     103666688 (AKT3)    04620 Toll-like receptor signaling pathway     103666688 (AKT3)    04625 C-type lectin receptor signaling pathway     103666688 (AKT3)    04660 T cell receptor signaling pathway     103666688 (AKT3)    04662 B cell receptor signaling pathway     103666688 (AKT3)    04664 Fc epsilon RI signaling pathway     103666688 (AKT3)    04666 Fc gamma R-mediated phagocytosis     103666688 (AKT3)    04062 Chemokine signaling pathway     103666688 (AKT3)   09152 Endocrine system    04910 Insulin signaling pathway     103666688 (AKT3)    04922 Glucagon signaling pathway     103666688 (AKT3)    04923 Regulation of lipolysis in adipocytes     103666688 (AKT3)    04920 Adipocytokine signaling pathway     103666688 (AKT3)    04929 GnRH secretion     103666688 (AKT3)    04915 Estrogen signaling pathway     103666688 (AKT3)    04914 Progesterone-mediated oocyte maturation     103666688 (AKT3)    04917 Prolactin signaling pathway     103666688 (AKT3)    04926 Relaxin signaling pathway     103666688 (AKT3)    04935 Growth hormone synthesis, secretion and action     103666688 (AKT3)    04919 Thyroid hormone signaling pathway     103666688 (AKT3)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103666688 (AKT3)   09154 Digestive system    04973 Carbohydrate digestion and absorption     103666688 (AKT3)   09156 Nervous system    04725 Cholinergic synapse     103666688 (AKT3)    04728 Dopaminergic synapse     103666688 (AKT3)    04722 Neurotrophin signaling pathway     103666688 (AKT3)   09158 Development and regeneration    04380 Osteoclast differentiation     103666688 (AKT3)   09149 Aging    04211 Longevity regulating pathway     103666688 (AKT3)    04213 Longevity regulating pathway - multiple species     103666688 (AKT3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103666688 (AKT3)    05205 Proteoglycans in cancer     103666688 (AKT3)    05230 Central carbon metabolism in cancer     103666688 (AKT3)    05231 Choline metabolism in cancer     103666688 (AKT3)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103666688 (AKT3)   09162 Cancer: specific types    05210 Colorectal cancer     103666688 (AKT3)    05212 Pancreatic cancer     103666688 (AKT3)    05225 Hepatocellular carcinoma     103666688 (AKT3)    05226 Gastric cancer     103666688 (AKT3)    05214 Glioma     103666688 (AKT3)    05221 Acute myeloid leukemia     103666688 (AKT3)    05220 Chronic myeloid leukemia     103666688 (AKT3)    05218 Melanoma     103666688 (AKT3)    05211 Renal cell carcinoma     103666688 (AKT3)    05215 Prostate cancer     103666688 (AKT3)    05213 Endometrial cancer     103666688 (AKT3)    05224 Breast cancer     103666688 (AKT3)    05222 Small cell lung cancer     103666688 (AKT3)    05223 Non-small cell lung cancer     103666688 (AKT3)   09164 Neurodegenerative disease    05010 Alzheimer disease     103666688 (AKT3)    05017 Spinocerebellar ataxia     103666688 (AKT3)   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     103666688 (AKT3)   09167 Endocrine and metabolic disease    04932 Non-alcoholic fatty liver disease     103666688 (AKT3)    04931 Insulin resistance     103666688 (AKT3)    04933 AGE-RAGE signaling pathway in diabetic complications     103666688 (AKT3)   09171 Infectious disease: bacterial    05132 Salmonella infection     103666688 (AKT3)    05135 Yersinia infection     103666688 (AKT3)    05152 Tuberculosis     103666688 (AKT3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103666688 (AKT3)    05170 Human immunodeficiency virus 1 infection     103666688 (AKT3)    05161 Hepatitis B     103666688 (AKT3)    05160 Hepatitis C     103666688 (AKT3)    05164 Influenza A     103666688 (AKT3)    05162 Measles     103666688 (AKT3)    05168 Herpes simplex virus 1 infection     103666688 (AKT3)    05163 Human cytomegalovirus infection     103666688 (AKT3)    05167 Kaposi sarcoma-associated herpesvirus infection     103666688 (AKT3)    05169 Epstein-Barr virus infection     103666688 (AKT3)    05165 Human papillomavirus infection     103666688 (AKT3)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     103666688 (AKT3)    05142 Chagas disease     103666688 (AKT3)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103666688 (AKT3)    01524 Platinum drug resistance     103666688 (AKT3)    01522 Endocrine resistance     103666688 (AKT3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:umr01001]     103666688 (AKT3) Enzymes [BR:umr01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      103666688 (AKT3) Protein kinases [BR:umr01001]  Serine/threonine kinases: AGC group   AKT/PKB family    103666688 (AKT3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like FTA2 PH_11 Motif Other DBs NCBI-GeneID:  103666688 NCBI-ProteinID:  XP_008692992 UniProt:  A0A384CDT1 LinkDB All DBs Position Un AA seq 479 aa AA seqDB search MSDVTVVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCVDNERRPHFPQFSYSASGRE NT seq 1440 nt NT seq  +upstreamnt  +downstreamnt atgagcgatgttaccgtcgtgaaagaaggctgggttcagaagaggggagaatatataaaa aactggaggccaagatatttccttttgaagacagatggctcattcataggatataaagag aaacctcaagatgtggatttaccttatcccctcaacaacttttcagtggcaaaatgccag ttaatgaaaacagaacgaccaaagccaaacacatttattatcagatgtctccagtggacc actgttatagagagaacgtttcatgtagatactccagaggaaagggaagagtggacagaa gctattcaggctgtagcagacagacttcagagacaagaagaggagagaatgaattgtagt ccaacttcacaaattgataatataggggaggaagagatggatgcttccacaacccatcat aaaagaaagacaatgaatgattttgactatttgaaactgctaggtaaaggcacttttggg aaagttattttggttcgagagaaggcaagtgggaaatactatgctatgaagattctgaag aaagaagttattattgcaaaggatgaagtggcgcatactctaacggaaagcagagtatta aagaacactagacatccctttttaacatccttgaaatattccttccagacaaaagaccgt ttgtgttttgtgatggaatatgtaaatgggggagagctgtttttccatttgtcgagagag cgggtgttctccgaggaccgcacacgtttctatggtgcagaaattgtctctgctttggac tatctacattccggaaagattgtgtaccgtgatctcaagttggagaatttgatgctggat aaagatggccacataaaaatcacagactttgggctttgcaaagaagggatcacggacgcg gccaccatgaagacgttctgtggcacaccggagtacctggcacctgaggtgttagaagac aacgactatggccgagccgtggattggtggggcctgggggtcgtcatgtatgagatgatg tgtgggaggctacctttctacaaccaggatcatgagaaactttttgaactaatactaatg gaagacattaaatttcctcgaacactctcttcagatgcaaaatcactgctttcagggctc ttgataaaggatccaaataagcgccttggcgggggcccagatgatgcaaaagaaattatg aggcacagtttcttctctggagtcaactggcaagatgtatacgataaaaagcttgtacct ccttttaagcctcaagtaacatctgagacagataccagatattttgatgaagaatttaca gctcagactattacaataacgccacctgaaaaatatgacgaggacggcatggactgcgtg gacaacgagcggcggccacacttccctcagttctcctactctgccagcggccgcgagtaa

Ursus maritimus (polar bear): 103676878 Help Entry 103676878         CDS       T03271                                  Gene name AKT1 Definition (RefSeq) AKT serine/threonine kinase 1   KO K04456   RAC serine/threonine-protein kinase [EC:2.7.11.1] Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr01522   Endocrine resistance umr01524   Platinum drug resistance umr04010   MAPK signaling pathway umr04012   ErbB signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04066   HIF-1 signaling pathway umr04068   FoxO signaling pathway umr04071   Sphingolipid signaling pathway umr04072   Phospholipase D signaling pathway umr04140   Autophagy - animal umr04150   mTOR signaling pathway umr04151   PI3K-Akt signaling pathway umr04152   AMPK signaling pathway umr04210   Apoptosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04218   Cellular senescence umr04261   Adrenergic signaling in cardiomyocytes umr04370   VEGF signaling pathway umr04371   Apelin signaling pathway umr04380   Osteoclast differentiation umr04510   Focal adhesion umr04550   Signaling pathways regulating pluripotency of stem cells umr04611   Platelet activation umr04613   Neutrophil extracellular trap formation umr04620   Toll-like receptor signaling pathway umr04625   C-type lectin receptor signaling pathway umr04630   JAK-STAT signaling pathway umr04660   T cell receptor signaling pathway umr04662   B cell receptor signaling pathway umr04664   Fc epsilon RI signaling pathway umr04666   Fc gamma R-mediated phagocytosis umr04668   TNF signaling pathway umr04722   Neurotrophin signaling pathway umr04725   Cholinergic synapse umr04728   Dopaminergic synapse umr04910   Insulin signaling pathway umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04917   Prolactin signaling pathway umr04919   Thyroid hormone signaling pathway umr04920   Adipocytokine signaling pathway umr04922   Glucagon signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04926   Relaxin signaling pathway umr04929   GnRH secretion umr04931   Insulin resistance umr04932   Non-alcoholic fatty liver disease umr04933   AGE-RAGE signaling pathway in diabetic complications umr04935   Growth hormone synthesis, secretion and action umr04973   Carbohydrate digestion and absorption umr05010   Alzheimer disease umr05017   Spinocerebellar ataxia umr05132   Salmonella infection umr05135   Yersinia infection umr05142   Chagas disease umr05145   Toxoplasmosis umr05152   Tuberculosis umr05160   Hepatitis C umr05161   Hepatitis B umr05162   Measles umr05163   Human cytomegalovirus infection umr05164   Influenza A umr05165   Human papillomavirus infection umr05166   Human T-cell leukemia virus 1 infection umr05167   Kaposi sarcoma-associated herpesvirus infection umr05168   Herpes simplex virus 1 infection umr05169   Epstein-Barr virus infection umr05170   Human immunodeficiency virus 1 infection umr05200   Pathways in cancer umr05205   Proteoglycans in cancer umr05210   Colorectal cancer umr05211   Renal cell carcinoma umr05212   Pancreatic cancer umr05213   Endometrial cancer umr05214   Glioma umr05215   Prostate cancer umr05218   Melanoma umr05220   Chronic myeloid leukemia umr05221   Acute myeloid leukemia umr05222   Small cell lung cancer umr05223   Non-small cell lung cancer umr05224   Breast cancer umr05225   Hepatocellular carcinoma umr05226   Gastric cancer umr05230   Central carbon metabolism in cancer umr05231   Choline metabolism in cancer umr05235   PD-L1 expression and PD-1 checkpoint pathway in cancer umr05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103676878 (AKT1)    04012 ErbB signaling pathway     103676878 (AKT1)    04014 Ras signaling pathway     103676878 (AKT1)    04015 Rap1 signaling pathway     103676878 (AKT1)    04370 VEGF signaling pathway     103676878 (AKT1)    04371 Apelin signaling pathway     103676878 (AKT1)    04630 JAK-STAT signaling pathway     103676878 (AKT1)    04668 TNF signaling pathway     103676878 (AKT1)    04066 HIF-1 signaling pathway     103676878 (AKT1)    04068 FoxO signaling pathway     103676878 (AKT1)    04072 Phospholipase D signaling pathway     103676878 (AKT1)    04071 Sphingolipid signaling pathway     103676878 (AKT1)    04024 cAMP signaling pathway     103676878 (AKT1)    04022 cGMP-PKG signaling pathway     103676878 (AKT1)    04151 PI3K-Akt signaling pathway     103676878 (AKT1)    04152 AMPK signaling pathway     103676878 (AKT1)    04150 mTOR signaling pathway     103676878 (AKT1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     103676878 (AKT1)   09143 Cell growth and death    04210 Apoptosis     103676878 (AKT1)    04218 Cellular senescence     103676878 (AKT1)   09144 Cellular community - eukaryotes    04510 Focal adhesion     103676878 (AKT1)    04550 Signaling pathways regulating pluripotency of stem cells     103676878 (AKT1)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103676878 (AKT1)    04613 Neutrophil extracellular trap formation     103676878 (AKT1)    04620 Toll-like receptor signaling pathway     103676878 (AKT1)    04625 C-type lectin receptor signaling pathway     103676878 (AKT1)    04660 T cell receptor signaling pathway     103676878 (AKT1)    04662 B cell receptor signaling pathway     103676878 (AKT1)    04664 Fc epsilon RI signaling pathway     103676878 (AKT1)    04666 Fc gamma R-mediated phagocytosis     103676878 (AKT1)    04062 Chemokine signaling pathway     103676878 (AKT1)   09152 Endocrine system    04910 Insulin signaling pathway     103676878 (AKT1)    04922 Glucagon signaling pathway     103676878 (AKT1)    04923 Regulation of lipolysis in adipocytes     103676878 (AKT1)    04920 Adipocytokine signaling pathway     103676878 (AKT1)    04929 GnRH secretion     103676878 (AKT1)    04915 Estrogen signaling pathway     103676878 (AKT1)    04914 Progesterone-mediated oocyte maturation     103676878 (AKT1)    04917 Prolactin signaling pathway     103676878 (AKT1)    04926 Relaxin signaling pathway     103676878 (AKT1)    04935 Growth hormone synthesis, secretion and action     103676878 (AKT1)    04919 Thyroid hormone signaling pathway     103676878 (AKT1)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103676878 (AKT1)   09154 Digestive system    04973 Carbohydrate digestion and absorption     103676878 (AKT1)   09156 Nervous system    04725 Cholinergic synapse     103676878 (AKT1)    04728 Dopaminergic synapse     103676878 (AKT1)    04722 Neurotrophin signaling pathway     103676878 (AKT1)   09158 Development and regeneration    04380 Osteoclast differentiation     103676878 (AKT1)   09149 Aging    04211 Longevity regulating pathway     103676878 (AKT1)    04213 Longevity regulating pathway - multiple species     103676878 (AKT1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103676878 (AKT1)    05205 Proteoglycans in cancer     103676878 (AKT1)    05230 Central carbon metabolism in cancer     103676878 (AKT1)    05231 Choline metabolism in cancer     103676878 (AKT1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103676878 (AKT1)   09162 Cancer: specific types    05210 Colorectal cancer     103676878 (AKT1)    05212 Pancreatic cancer     103676878 (AKT1)    05225 Hepatocellular carcinoma     103676878 (AKT1)    05226 Gastric cancer     103676878 (AKT1)    05214 Glioma     103676878 (AKT1)    05221 Acute myeloid leukemia     103676878 (AKT1)    05220 Chronic myeloid leukemia     103676878 (AKT1)    05218 Melanoma     103676878 (AKT1)    05211 Renal cell carcinoma     103676878 (AKT1)    05215 Prostate cancer     103676878 (AKT1)    05213 Endometrial cancer     103676878 (AKT1)    05224 Breast cancer     103676878 (AKT1)    05222 Small cell lung cancer     103676878 (AKT1)    05223 Non-small cell lung cancer     103676878 (AKT1)   09164 Neurodegenerative disease    05010 Alzheimer disease     103676878 (AKT1)    05017 Spinocerebellar ataxia     103676878 (AKT1)   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     103676878 (AKT1)   09167 Endocrine and metabolic disease    04932 Non-alcoholic fatty liver disease     103676878 (AKT1)    04931 Insulin resistance     103676878 (AKT1)    04933 AGE-RAGE signaling pathway in diabetic complications     103676878 (AKT1)   09171 Infectious disease: bacterial    05132 Salmonella infection     103676878 (AKT1)    05135 Yersinia infection     103676878 (AKT1)    05152 Tuberculosis     103676878 (AKT1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103676878 (AKT1)    05170 Human immunodeficiency virus 1 infection     103676878 (AKT1)    05161 Hepatitis B     103676878 (AKT1)    05160 Hepatitis C     103676878 (AKT1)    05164 Influenza A     103676878 (AKT1)    05162 Measles     103676878 (AKT1)    05168 Herpes simplex virus 1 infection     103676878 (AKT1)    05163 Human cytomegalovirus infection     103676878 (AKT1)    05167 Kaposi sarcoma-associated herpesvirus infection     103676878 (AKT1)    05169 Epstein-Barr virus infection     103676878 (AKT1)    05165 Human papillomavirus infection     103676878 (AKT1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     103676878 (AKT1)    05142 Chagas disease     103676878 (AKT1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103676878 (AKT1)    01524 Platinum drug resistance     103676878 (AKT1)    01522 Endocrine resistance     103676878 (AKT1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:umr01001]     103676878 (AKT1) Enzymes [BR:umr01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      103676878 (AKT1) Protein kinases [BR:umr01001]  Serine/threonine kinases: AGC group   AKT/PKB family    103676878 (AKT1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_11 Seadorna_VP7 Pkinase_fungal APH Motif Other DBs NCBI-GeneID:  103676878 NCBI-ProteinID:  XP_008704315 UniProt:  A0A384DC20 LinkDB All DBs Position Un AA seq 515 aa AA seqDB search MVGERMSSSTCHPSAGHGADASSQPHLPSEPCLQEDPVTAALGEAPSRGAGEYIKTWRPR YFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIE RTFHVETPEEREEWTTAIQTVADGLKRQEEEMMDFRSGSPSDNSGAEEMEVSLAKPKHRV TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFPEDRARFYGAEIVSALDYLH SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND YGRAVDWWGLGVVMYEMLCGRLPFYNQDHEKLFELILMEELRFPRTLSPEAKSLLSGLLK KDPKQRLGGGSDDAKEIMQHRFFASIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQ MITITPPDQGDNMEGEDSERRPHFPQFSYSASGTA NT seq 1548 nt NT seq  +upstreamnt  +downstreamnt atggtaggggagcgtatgtcctcctccacatgtcacccctctgctgggcacggagcggat gcctcctcccagccacacctgccgtccgagccctgcctccaggaggaccccgtgactgct gccctcggagaggctccgtctcgaggagcaggggagtacatcaaaacctggcggccccgc tacttcctcctcaagaatgacggcaccttcatcggctacaaggagcggccccaggatgtc gagcagcgagagtcccctctcaacaacttctctgtggctcaatgtcagctgatgaagacg gagcggccccggcccaacaccttcatcatccgctgcctgcagtggaccacggtgatcgag cgcaccttccacgtggagacacccgaggagcgggaggagtggacaactgccatccagacg gtggccgacgggctcaagaggcaggaggaagagatgatggacttccggtcgggctcaccg agcgacaactccggcgccgaggagatggaggtgtccctggccaagcccaagcaccgtgtg accatgaacgagtttgagtacttgaagctgctgggcaagggcacgtttgggaaggtgatt ctggtgaaggagaaggccacgggccgctactacgccatgaagatcctgaagaaggaggtc attgtggccaaggacgaggttgcccacacgctcacggagaaccgtgttctgcagaactcg aggcatcccttcctgacggccctgaagtactcctttcagacccacgaccgcctctgcttc gtcatggagtacgccaacgggggtgagctcttcttccacctgtcccgggagcgcgtgttc cctgaggaccgggcccgcttctacggtgccgagatcgtgtctgccttggactacctgcac tcggagaagaacgtggtttaccgcgacctcaagctggagaacctcatgctggataaggac gggcacatcaagatcacggactttggcctgtgcaaggagggcatcaaggacggggccacc atgaagaccttctgcgggacgcccgagtacctggcccccgaggtgctggaggacaatgac tacggccgggcggtggactggtgggggctgggcgtggtcatgtacgagatgctgtgtggc cggctgcccttctacaaccaggaccacgagaagctcttcgaactcatcctcatggaggag ctccgcttcccgcgcacgctcagccctgaggccaagtccctgctctcggggctgctcaag aaggaccccaagcagaggctcggagggggctcagacgacgccaaggagatcatgcagcac cgcttcttcgctagcatcgtgtggcaggacgtgtacgagaagaagctcagtccacccttc aagccccaggtcacatcagagacagacaccaggtattttgatgaggagttcacggctcag atgatcaccatcacgccacccgaccaaggtgacaacatggagggggaggacagcgagcgg aggccccacttcccgcagttctcctactcggccagtggcacagcctga

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