Ursus maritimus (polar bear): 103668810 Help Entry 103668810         CDS       T03271                                  Gene name CREBBP Definition (RefSeq) CREB binding protein   KO K04498   E1A/CREB-binding protein [EC:2.3.1.48] Organism umr  Ursus maritimus (polar bear) Pathway umr04024   cAMP signaling pathway umr04066   HIF-1 signaling pathway umr04068   FoxO signaling pathway umr04110   Cell cycle umr04310   Wnt signaling pathway umr04330   Notch signaling pathway umr04350   TGF-beta signaling pathway umr04520   Adherens junction umr04630   JAK-STAT signaling pathway umr04720   Long-term potentiation umr04916   Melanogenesis umr04919   Thyroid hormone signaling pathway umr04922   Glucagon signaling pathway umr04935   Growth hormone synthesis, secretion and action umr05016   Huntington disease umr05152   Tuberculosis umr05161   Hepatitis B umr05164   Influenza A umr05165   Human papillomavirus infection umr05166   Human T-cell leukemia virus 1 infection umr05167   Kaposi sarcoma-associated herpesvirus infection umr05200   Pathways in cancer umr05203   Viral carcinogenesis umr05206   MicroRNAs in cancer umr05211   Renal cell carcinoma umr05215   Prostate cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04310 Wnt signaling pathway     103668810 (CREBBP)    04330 Notch signaling pathway     103668810 (CREBBP)    04350 TGF-beta signaling pathway     103668810 (CREBBP)    04630 JAK-STAT signaling pathway     103668810 (CREBBP)    04066 HIF-1 signaling pathway     103668810 (CREBBP)    04068 FoxO signaling pathway     103668810 (CREBBP)    04024 cAMP signaling pathway     103668810 (CREBBP)  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     103668810 (CREBBP)   09144 Cellular community - eukaryotes    04520 Adherens junction     103668810 (CREBBP)  09150 Organismal Systems   09152 Endocrine system    04922 Glucagon signaling pathway     103668810 (CREBBP)    04935 Growth hormone synthesis, secretion and action     103668810 (CREBBP)    04919 Thyroid hormone signaling pathway     103668810 (CREBBP)    04916 Melanogenesis     103668810 (CREBBP)   09156 Nervous system    04720 Long-term potentiation     103668810 (CREBBP)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103668810 (CREBBP)    05206 MicroRNAs in cancer     103668810 (CREBBP)    05203 Viral carcinogenesis     103668810 (CREBBP)   09162 Cancer: specific types    05211 Renal cell carcinoma     103668810 (CREBBP)    05215 Prostate cancer     103668810 (CREBBP)   09164 Neurodegenerative disease    05016 Huntington disease     103668810 (CREBBP)   09171 Infectious disease: bacterial    05152 Tuberculosis     103668810 (CREBBP)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103668810 (CREBBP)    05161 Hepatitis B     103668810 (CREBBP)    05164 Influenza A     103668810 (CREBBP)    05167 Kaposi sarcoma-associated herpesvirus infection     103668810 (CREBBP)    05165 Human papillomavirus infection     103668810 (CREBBP)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03000 Transcription factors [BR:umr03000]     103668810 (CREBBP)    03036 Chromosome and associated proteins [BR:umr03036]     103668810 (CREBBP)    03029 Mitochondrial biogenesis [BR:umr03029]     103668810 (CREBBP) Enzymes [BR:umr01000]  2. Transferases   2.3  Acyltransferases    2.3.1  Transferring groups other than aminoacyl groups     2.3.1.48  histone acetyltransferase      103668810 (CREBBP) Transcription factors [BR:umr03000]  Eukaryotic type   Other transcription factors    Pocket domain CBP     103668810 (CREBBP) Chromosome and associated proteins [BR:umr03036]  Eukaryotic type   Histone modification proteins    HATs (histone acetyltransferases)     103668810 (CREBBP) Mitochondrial biogenesis [BR:umr03029]  Mitochondrial quality control factors   Regulator of mitochondrial biogenesis    Coactivators     103668810 (CREBBP) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  HAT_KAT11 KIX DUF902 zf-TAZ Bromodomain ZZ KIX_2 Motif Other DBs NCBI-GeneID:  103668810 NCBI-ProteinID:  XP_008695338 UniProt:  A0A384CKJ2 LinkDB All DBs Position Un AA seq 1931 aa AA seqDB search MVGLLDFGSLFDLENDLPDELIPNGGELSLLNSGNLVPDAASKHKQLSELLRGGSGSSIN PGIGNVSASSPVQQGLGGQAPGQPNSANMASLGAMGKSPLNQGDSAAPSLPKQAASTSGP TPPASQALNPQAQKQVGLVTSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLMNQAQQ GQAQVMNGSLGAAGRGRGAGMPYPAPAMQGATSSVLAETLTQVSPQMAGHAGLNTAQAGG MTKMGMTGNTSPFGQPFSQTGGQQMGAPGVNPQLSSKQSMVNSLPPFPTDIKNASVTNVP NMSQMQTSVGIVPTQAIAAGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLP HCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQ TILGSPASGIQNTIGSVGTGQQNAASLSNPNPIDPSSMQRAYAALGLPYLNQPQTQLQPQ VPGQQPAQPPTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMN DGSSPANIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKD RRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQP ALPAPGAQPPGIPQAQPVRPPNGPMPLPVNRVQVSQGMNSFTPMSLGNVQLPQAPMGPRA ASPMNHSVPMNSMGSVPGMAISPSRMPQPPNMMGAHANNIMAQAPAQNQFLPQNQFQSSS GAMSVNSVGMGQPAAQTGVPQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHQTPPPA STAAGMPSLQHPTAPGMTPPQPAAPTQPSTPASSSGQTPTPTPGSVPSASQTQSTPTVQA AAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVAS AETNSQQPGPDVPMLEVKAEVKTEDTEPDASESKGEPGSAMMEEDLQGSSQVKEETDTTE QKSEPMEVDEKKPEVKVEAKEEEENNANGAASQSTSPSQPRKKIFKPEELRQALMPTLEA LYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLM FNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCT IPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPF VDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRTRKENKFSAKRLQTTRLGNHLED RVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFE EIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEY VKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYK DIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQG DSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAG PVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQ DRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQ SKSPQESRSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQP NPMSPQQHMLSGQPQASHLPGQQMATSLSSQVRSPAPVQSPRPQSQPPHSSPSPRIQPQP SPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPNRSALSSELSLVGDTT GDTLEKFVEGL NT seq 5796 nt NT seq  +upstreamnt  +downstreamnt atggttggactgctagattttggatcattgtttgacttggaaaatgatcttcctgatgag ctgatccccaatggaggagaattaagccttttaaacagtgggaaccttgttccagatgct gcttccaaacataaacaactgtcggagctcctgcgcggaggcagcggctccagtatcaac ccaggaataggaaatgttagcgccagcagccccgtgcagcaaggccttggcggccaggct ccagggcagccgaacagtgcaaacatggccagcttgggtgccatgggcaagagccctctg aaccagggagattctgcagcccccagcctgcccaaacaggcagccagcacctctgggccc actcctcctgcttcccaagcactgaatccgcaagcacaaaagcaagtggggctggtgacc agcagccctgccacgtcgcagacgggacctgggatctgcatgaatgctaactttaaccag acccacccaggcctcctcaatagtaactctggccatagtttaatgaaccaggcccagcaa ggacaggcgcaagtcatgaatggatctcttggggccgctggcagaggaaggggagctggg atgccataccctgctccggccatgcagggggccacgagcagcgtgctggccgagacgtta acacaggtttcaccacaaatggccggtcacgctggactgaacacagcgcaggcaggaggc atgaccaagatgggaatgactggtaacacaagtccattcggacagccctttagtcaaact ggagggcagcaaatgggagcccctggagtgaacccccagttatccagcaaacagagcatg gtcaatagtttgcctcccttccctacagacatcaagaatgcttcagtcaccaatgtgcca aacatgtctcagatgcagacttcggtgggaattgtccccacacaggcgatagccgcgggc cccactgcagatccggagaagcgcaaactgatacagcagcagctggtcctcctgcttcac gctcataagtgtcagagacgagaacaagcgaatggagaggttcgggcctgctctctccca cattgtcgaaccatgaaaaatgttttgaatcacatgacacactgtcaggctgggaaagcc tgtcaagttgcccattgtgcatcttcacgacaaatcatctctcattggaagaactgcaca cgacatgactgtcctgtttgcctccctttgaaaaatgccagtgacaagcgaaaccaacaa accatcctggggtctccagctagtgggattcagaacacgattggttctgttggcacaggc cagcagaatgctgcgtctttaagtaacccaaatcccatagaccccagctccatgcagcgc gcgtacgctgccctcggactcccctacctgaaccagccccagacacagctgcagcctcag gtccccggccagcaaccagcacagcctccaactcaccagcagatgaggaccctcaacccc ctgggaaataacccaatgaacattccagcaggaggaataacaacagatcagcagccacca aacttgatttcagaatcagctcttccaacttcccttggggccacaaatccactgatgaac gatggctcaagccctgcaaacattgggaccctcagcaccatacctacagcggccccacct tccagcaccggtgttcggaaaggctggcacgaacatgttactcaggacctgcggagccat ctagtgcataaactcgtccaagccatctttccaacccctgacccggcagccctgaaggac cgccgcatggagaacctggtggcctacgccaagaaagtggagggggacatgtacgagtct gccaacagcagggatgaatactatcatttactggcagaaaaaatctacaagatacaaaaa gaactagaagaaaaacggaggtcgcgtttgcacaaacaaggcatcttgggtaaccagccc gccctgccggctcccggggcacagcccccagggattccacaggcacagcctgtgaggcct ccaaacggacccatgcccctgccagtgaaccgcgtgcaggtgtcccaagggatgaattca tttaccccaatgtccttggggaatgtacagttgccacaagctcccatgggaccgcgtgca gcatcccccatgaaccactctgtcccgatgaacagcatgggctccgttcccgggatggcc atttctccttcccgaatgcctcagcctccaaacatgatgggcgctcacgccaacaacatt atggcccaggcacctgcgcagaaccagttcctgccacagaaccagttccagtcctccagt ggggcgatgagtgtgaacagcgtgggcatgggtcagccggcggcccagacaggcgtgcca cagggacaggtgcctggtgctgctcttcctaaccctctgaacatgcttgggccccaggcc agccagctgccctgcccaccagtgacacagtcaccgttgcaccagacgccacctcctgct tccacggccgctggcatgccatctctccagcacccgacggcacctgggatgacccctccc cagccagcagctcccacccagccatcgactcccgcgtcgtcttccgggcagactcccacc ccgactcccggctcagtgcccagtgctagccaaacccagagcacccctacggtccaggca gcagcccaggcccaggtgaccccacagcctcagaccccagtccagcccccgtctgtggcc accccgcagtcatcacagcaacagccgacacctgtgcacgcccagcctcctggcacaccg ctttcccaggcagcagccagcatcgataacagggtccccactccttcctcggtggcgagc gccgaaaccaactcccagcagccaggacccgatgtaccaatgctggaggtgaaggcagag gtcaagaccgaggacactgagcctgacgccagtgaatccaagggggagcctggatctgcg atgatggaggaggatctacaaggatcttctcaagttaaagaagaaacagacacaacagaa cagaaatcagaaccaatggaagtggacgagaagaaaccggaagtcaaagtagaagctaaa gaggaagaagagaacaacgctaatggagctgcctctcagtcaacgtctccctcacagcca cgcaaaaaaatctttaagccggaggagttacgccaggctctgatgccaaccctcgaagcg ttgtatcgacaggatccggagtccctaccttttcggcagcctgtagacccccagctccta ggaattccggattattttgacattgtgaagaatcccatggacctttccaccatcaagcgg aagctggatacagggcagtaccaagagccctggcagtatgtggacgatgtctggcttatg ttcaacaatgcctggctctataatcgtaagacgtcgcgggtctataagttctgcagtaaa cttgcagaggtctttgaacaagaaattgaccctgttatgcagtcccttggatattgctgt ggacgaaagtatgagttttccccacagactttgtgctgctacgggaagcagctgtgtaca attcctcgtgacgctgcctactacagctatcagaataggtatcatttctgtgagaagtgt ttcacagagatccagggggagaatgttaccctgggtgacgacccttcacagccccagacg acaatttcaaaggatcagtttgaaaagaagaaaaatgataccttagatcctgaacctttt gtcgattgcaaggagtgtggccggaagatgcatcagatttgtgttctacactatgacatc atttggccttcaggctttgtgtgcgacaactgtttgaagaaaactggcagaactcggaaa gaaaacaagttcagtgctaagagactacagaccacacgattgggcaaccacttggaagac cgagtcaacaagtttttgcggcgacagaatcatcctgaagccggggaggtctttgtccgt gtggtggccagctcagacaagactgtggaagtcaagcctgggatgaagtcacggttcgtg gattctggggaaatgtctgaatctttcccatatcgaaccaaagcactctttgcttttgag gaaattgatggagtggatgtgtgcttctttgggatgcatgtgcaggagtacggctctgac tgcccccctccaaacacaaggcgtgtgtacatatcttacctggacagtattcatttcttc cggccccgatgcctccggacagctgtttaccatgagatccttattggatatttagaatac gtgaagaaattggggtatgtaacaggacacatctgggcctgccccccaagtgaaggagac gactatatcttccattgccacccccctgatcagaaaatccccaaaccaaagcgcctccag gagtggtacaagaagatgctggacaaggcgtttgcggagcggatcattcacgactacaag gacattttcaaacaagcaactgaggacaggctcaccagcgccaaggagctgccctatttt gagggtgacttctggcctaatgtgctggaggagagcattaaggagctggagcaagaagaa gaggagaggaagaaggaggagagcactgcggccagcgagaccacagagggcagccagggt gacagcaagaatgccaagaagaaaaacaacaagaaaaccaacaagaataaaagcagcatc agtcgagccaacaagaagaagcccagcatgcccaacgtgtccaacgacttgtcccagaag ctctatgccaccatggagaagcacaaagaggtcttctttgtgatccacctgcatgctggg cctgtcatcaacacactgccccccatcgttgaccctgaccccctgctcagctgtgacctc atggacgggcgtgacgccttcctcaccctcgccagagataagcactgggagttctcctcc ttgcgccggtccaagtggtccacactgtgcatgctggtggagctgcacacccagggccag gaccgcttcgtctacacctgcaacgagtgcaagcaccacgtggagacgcgctggcactgc accgtgtgcgaggactacgacctttgcatcaactgctacaacacgaagagccacgcccac aagatggtgaagtgggggctgggcctggacgacgagggcagcagccagggcgagccgcag tccaagagcccccaggagtcgcgctccatgggccagatggcggctcagatgggacagctc ggccagatggggcagccggggctaggcgcagacagcacccccaacatccagcaggccctg cagcagcggattttgcagcagcagcagatgaagcagcagattgggtccccgggccagccg aaccccatgagcccccagcagcacatgctctcaggacagccgcaggcctcgcacctcccc ggccagcagatggccacgtccctcagtagccaggtgcggtctccggcccctgtccagtct ccgcggccccagtcccagcctccacattccagcccgtcgccacggatacagccccagcct tcgccacaccacgtctcgccccagactggttccccccacccaggactcgcagtcaccatg gccagctccatagatcagggacacttggggaaccccgaacagagtgcaatgctcccacag ctgaacacccccaacaggagtgcgttgtccagtgagctgtccctggtcggcgacaccaca ggagacaccctagaaaagttcgtggagggtttgtag

Ursus maritimus (polar bear): 103674159 Help Entry 103674159         CDS       T03271                                  Gene name EP300 Definition (RefSeq) E1A binding protein p300   KO K04498   E1A/CREB-binding protein [EC:2.3.1.48] Organism umr  Ursus maritimus (polar bear) Pathway umr04024   cAMP signaling pathway umr04066   HIF-1 signaling pathway umr04068   FoxO signaling pathway umr04110   Cell cycle umr04310   Wnt signaling pathway umr04330   Notch signaling pathway umr04350   TGF-beta signaling pathway umr04520   Adherens junction umr04630   JAK-STAT signaling pathway umr04720   Long-term potentiation umr04916   Melanogenesis umr04919   Thyroid hormone signaling pathway umr04922   Glucagon signaling pathway umr04935   Growth hormone synthesis, secretion and action umr05016   Huntington disease umr05152   Tuberculosis umr05161   Hepatitis B umr05164   Influenza A umr05165   Human papillomavirus infection umr05166   Human T-cell leukemia virus 1 infection umr05167   Kaposi sarcoma-associated herpesvirus infection umr05200   Pathways in cancer umr05203   Viral carcinogenesis umr05206   MicroRNAs in cancer umr05211   Renal cell carcinoma umr05215   Prostate cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04310 Wnt signaling pathway     103674159 (EP300)    04330 Notch signaling pathway     103674159 (EP300)    04350 TGF-beta signaling pathway     103674159 (EP300)    04630 JAK-STAT signaling pathway     103674159 (EP300)    04066 HIF-1 signaling pathway     103674159 (EP300)    04068 FoxO signaling pathway     103674159 (EP300)    04024 cAMP signaling pathway     103674159 (EP300)  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     103674159 (EP300)   09144 Cellular community - eukaryotes    04520 Adherens junction     103674159 (EP300)  09150 Organismal Systems   09152 Endocrine system    04922 Glucagon signaling pathway     103674159 (EP300)    04935 Growth hormone synthesis, secretion and action     103674159 (EP300)    04919 Thyroid hormone signaling pathway     103674159 (EP300)    04916 Melanogenesis     103674159 (EP300)   09156 Nervous system    04720 Long-term potentiation     103674159 (EP300)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103674159 (EP300)    05206 MicroRNAs in cancer     103674159 (EP300)    05203 Viral carcinogenesis     103674159 (EP300)   09162 Cancer: specific types    05211 Renal cell carcinoma     103674159 (EP300)    05215 Prostate cancer     103674159 (EP300)   09164 Neurodegenerative disease    05016 Huntington disease     103674159 (EP300)   09171 Infectious disease: bacterial    05152 Tuberculosis     103674159 (EP300)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103674159 (EP300)    05161 Hepatitis B     103674159 (EP300)    05164 Influenza A     103674159 (EP300)    05167 Kaposi sarcoma-associated herpesvirus infection     103674159 (EP300)    05165 Human papillomavirus infection     103674159 (EP300)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03000 Transcription factors [BR:umr03000]     103674159 (EP300)    03036 Chromosome and associated proteins [BR:umr03036]     103674159 (EP300)    03029 Mitochondrial biogenesis [BR:umr03029]     103674159 (EP300) Enzymes [BR:umr01000]  2. Transferases   2.3  Acyltransferases    2.3.1  Transferring groups other than aminoacyl groups     2.3.1.48  histone acetyltransferase      103674159 (EP300) Transcription factors [BR:umr03000]  Eukaryotic type   Other transcription factors    Pocket domain CBP     103674159 (EP300) Chromosome and associated proteins [BR:umr03036]  Eukaryotic type   Histone modification proteins    HATs (histone acetyltransferases)     103674159 (EP300) Mitochondrial biogenesis [BR:umr03029]  Mitochondrial quality control factors   Regulator of mitochondrial biogenesis    Coactivators     103674159 (EP300) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  HAT_KAT11 KIX Creb_binding zf-TAZ DUF902 Bromodomain ZZ KIX_2 Npa1 Motif Other DBs NCBI-GeneID:  103674159 NCBI-ProteinID:  XP_008701246 UniProt:  A0A384D2M5 LinkDB All DBs Position Un AA seq 2343 aa AA seqDB search MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGD ISQLQTSLGIVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQGMASQPQQNSPGLGLINS MVKSPMAQAGLTSPNMGMGTSGPNQGPTPSAAGMMNSPVNQPAMGMNTGMNAGMNPGMLN AGNGQGMMPNQVMNGSIGAGRGRPNMQYPNPGMGNAGNLMTEPLQQGSPQMGGQTGLRGP QPLKMGMMNNPNPYGSPYTQNSGQQIGAGGLGLQIQTKSVLPNNLSPFAMDKKAVPGGGM PNMGQQQAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANG EVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKN AGDKRNQQSILTGAPVGLGNTSSLGVGQQSTPSLSTVSQIDPSSIERAYAALGLPYQVNQ MPTQPQVQAKNQQNQQSGQSPQGMRPMSNMSASPMGVNGGVGVQTSNLLSDSMLHSAINS QNPMMSENASVASLGPMPTAAQPSNTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAA LKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLP SAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQPGLNQFGQMS MPQPPIGPRQTSPLQHHGQLAQPGTLNPPMGYGPRMQQPSSQSQFLPQTQFSTQGMNVTN MPLAPSGGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPPLPQSALHQNSPSPVPSRT PTPHHTPPSIGAQQPPATAIPAPVPTPPAMPPGPQTQALHPPPRQTPTPPPTQLPPQVQP SLPAAPSADQPPQQPLSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSS TEVNSQTIPEKQPSQEVKMEAKMEVDPPEPADAQPEDIPETKAEDCKMEPTETEERGTEL KTETKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPV DPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVY KYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYH FCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICV LHHEIIWPSGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESG EVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQ EYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACP PSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAK ELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKN KSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLI PCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVET RWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNSQQAPATQSPGDSRRLSIQRCI QSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQEN KCPVPFCLNIKQKLRQQLQQHXQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQ QPATPQTPQPQPPSQPQPTPPNSMPPYLPRTQAAGPVSQGKAEGQGTPPTPPQTAQPPLP GPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPQMTPMAPMGMNPPPMTRGPSGH LEPGMGPTGMQQQPQWVQGGLPQPQQLQPGMPRPAMMSVAQHGQPLNIAPQPGLGQVGVS PLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYASSNPQP LAGQPGMPQGQPGLQPPAIPGQQGPGIGPGMANHNQFQQPQGVGYPPPPQPQQQRMQHHL QQMQPGSMGQMGQLPQALGAEAGAGLQAYQQRLLQQQMGSPAQPNPMSPQQHMLPSQAQS PHLQGQQIPSSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGL VAAQANPMEQGHFASPDQSSMLSQLASNPGMANLHGAGATDLGLGPDNADLNSNLSQSTL DIH NT seq 7032 nt NT seq  +upstreamnt  +downstreamnt atggccgagaatgtggtggaaccggggccgccttcagccaagcggcctaaactctcatct ccggccctctcggcgtcggccagcgatggcacagattttggctctctatttgatttggag catgacttaccagatgaattaatcaactctacagaattgggactaaccaatggtggtgat attagtcagcttcagacaagtcttggcatagtacaagatgcagcctctaaacataaacag ctgtcagagttgctacggtctggtagttcccctaacctcaatatgggggttggtggccca ggccaaggcatggccagccagccccaacagaacagtcctggattaggtttgataaatagc atggttaaaagcccaatggcacaggcaggcttgacttctcccaacatggggatgggcacc agtggaccaaatcaaggtcctacgccatctgcagcaggtatgatgaacagtccagtaaat cagcctgccatgggaatgaacacagggatgaatgctggcatgaatcctggaatgttgaat gcaggcaatggacaggggatgatgcctaatcaagtcatgaacggttcaattggagcaggc cgggggcgacccaatatgcagtacccaaacccaggcatgggaaatgctggcaatttaatg accgagccactgcagcaaggctctcctcagatgggaggacaaacgggattgagaggccct cagcctcttaagatgggaatgatgaacaaccctaatccttacggttcaccatacactcag aattctggacagcagattggagccggtggccttggtctccagattcagacaaagtctgta ctaccaaataacttatctccatttgcaatggacaaaaaggcagttcctggtggaggaatg cccaacatgggtcaacagcaggccccacaagtccagcagccaggccttgtgactccagtg gcccaagggatgggttctggagcacatacagctgatccagagaagcgcaagctcatccag cagcagcttgttcttcttttacatgctcataagtgccagcgccgggagcaggctaatggg gaagtgaggcagtgcaaccttccccactgtcgcacaatgaagaacgtcctaaaccacatg acacactgccagtcaggcaagtcctgccaagtggcacactgtgcatcttctcgacaaatc atttcacactggaagaattgtacaaggcatgattgtcctgtgtgtctcccccttaaaaat gctggagataagagaaatcagcagtcaattctgactggagcaccagttggacttggaaat actagctctctaggtgtgggtcaacagtctacccctagcctaagcactgttagtcagatt gatcccagctctatagaaagggcctatgcagctcttggtctgccctatcaagtaaatcag atgccgacgcagccccaggtacaagcaaagaaccagcagaatcagcagtctgggcagtct ccccaaggcatgcggcccatgagcaacatgagtgctagtcctatgggagtaaatggaggt gtaggggttcaaacgtcaaatcttctttctgactcaatgttgcattcagccataaattct caaaacccaatgatgagtgaaaatgccagtgtggcctccctgggtcctatgccaacagca gctcaaccatccaatactggaattcggaaacaatggcatgaagatattactcaggatctt cgaaatcatcttgttcacaaacttgttcaagccatatttcctactccggatcctgctgct ttaaaagacagacgaatggaaaacttagttgcatatgcccggaaagtggaaggggacatg tatgaatctgcaaataatcgagcggaatactaccacttgctagctgagaagatctataag atccagaaagaactagaagaaaaacgaaggactagactacagaaacaaaacatgctgccc agtgctgcaggcatggtgccagtttctatgaatccagggcccaatatggggcagccacaa ccaggaatgacttccaatggccctctacctgacccatctatgatccgcggcagtgtgcca aaccagatgatgcctcggataactccacagcctggtttgaatcagtttggccagatgagt atgccccagcccccaattggaccccggcaaacctctcctcttcagcaccatggacagtta gctcagcctggaactctcaacccgcctatgggctatgggcctcgcatgcagcagccttcc agccagagccagttccttccccagactcagttctcaacacagggaatgaatgtaacgaat atgcctttggctccgtctggcggtcaagcaccagtgtctcaagcacaaatgtccagttct tcctgcccagtgaactctcctataatgcctccagggtcgcaagggagccacattcactgt ccccctctccctcaatcagctctgcatcagaattcaccctctccggtacctagtcgcacc cctacacctcaccacactcccccaagcataggggctcagcagccaccagcaacagcaatt ccagcccctgttcctacacctccagccatgccccccgggccgcagacccaggctctacat ccacctccaaggcagacacccacaccaccaccaacgcagcttcctcctcaagttcagcct tcacttcctgctgctccttcggctgaccagccaccgcagcagcctctctcacagcagagc accgcagcatctgttcccaccccaacggcgccgctgctgcccccacagcctgcgactcca ctttcccaaccagctgtaagcattgaaggtcaggtatcaaatcctccatccactagtagc acagaagtgaattctcagaccattcctgagaagcagccgtcacaggaagtgaaaatggag gcaaagatggaagtggatccaccagaaccagcagatgctcagccagaggatattccagag actaaagcagaagactgtaaaatggaacctacagaaacagaagagagaggcactgaatta aaaactgaaacaaaagaggaggaagaccagccaagtacttcagctacacagtcatctcca gccccgggacagtcaaagaagaagattttcaaaccagaagagttacgacaggcactgatg ccaactttggaggcactttaccgacaggatccggaatccctaccctttcgtcaacctgtg gaccctcaacttctaggaatccctgattattttgatattgtgaagagccccatggacctt tctaccatcaagaggaagttagacactggacagtatcaggagccctggcagtatgtggat gacatttggcttatgttcaacaatgcctggttgtataatcggaaaacatctcgggtatac aaatactgctccaagctgtctgaagtctttgaacaagaaattgacccagtaatgcaaagc ctcggatattgttgtggcagaaagttggagttctctccacagacactctgttgctatggc aaacagttatgcacaatccctcgtgatgccacttactacagttaccagaacaggtatcat ttctgtgagaagtgtttcaatgaaatccaaggggagagcgtttctttgggggatgaccct tcccagcctcaaactacgataaataaagaacagttttccaagagaaaaaatgacacactg gatcctgaattatttgttgaatgtacagagtgtggaagaaagatgcatcagatctgtgtt cttcatcatgaaattatctggccatctggatttgtttgtgatggctgcttaaagaaatct gcacgaaccaggaaagaaaataagttttctgctaaaaggttgccatctaccaggcttggc acctttctggagaatcgtgtaaatgactttcttaggcgacagaatcaccccgagtccggg gaagtcactgttcgggtagttcatgcttctgacaaaactgtggaagtgaaaccaggaatg aaagcaaggtttgtagatagtggagagatggcagaatcctttccataccgaaccaaagcc ctctttgcctttgaagagatcgacggtgttgacttgtgtttctttggcatgcacgttcaa gagtatggctctgactgccctccacccaaccagaggagagtttacatttcataccttgac agtgttcatttcttccgtcctaaatgcttgaggactgcagtctatcatgaaattctaatt ggatatttagaatacgtcaagaaattagggtacacaacagggcatatttgggcttgtccc ccaagtgagggagacgactatatcttccattgccatcctcctgaccagaagatacccaag cccaagcgactgcaggagtggtacaaaaagatgcttgacaaggccgtgtctgagcgaatc gtccatgactacaaggatatttttaaacaagcgactgaagatcgactaacaagcgcaaag gagctgccttactttgagggcgatttctggcccaacgttctggaagagagcattaaggaa ctggaacaggaggaggaagagcgaaagcgagaggagaacaccagcaatgagagcacagat gtgacgaagggagacagcaaaaatgctaaaaagaaaaataataagaaaaccagcaaaaac aagagcagcctgagtaggggcaacaagaagaagcccggcatgcctaatgtctccaacgac ctctcgcagaagctgtacgccacgatggagaagcacaaggaggtcttctttgtgatccgt ctcatcgctggccctgccgccaactccctgccccccatcgtcgatcccgaccccctcatc ccctgcgatctgatggatgggcgggacgccttccttaccctcgcaagggacaagcacctg gagttctcttcactccgaagagcccagtggtccaccatgtgcatgctggtggagctgcac acccagagccaggaccgctttgtctacacctgcaacgagtgcaagcaccacgtggagacg cgctggcactgcactgtctgcgaggattatgatctgtgtatcacctgctataacactaaa aaccatgaccacaaaatggagaaactaggtctgggcttagatgacgagagcaacagccag caggccccagccacccagagcccgggggactcgcggcgcctgagcatccagcgctgcatc cagtccctggtgcacgcctgccagtgccgcaacgccaactgctcgctgccgtcctgccag aagatgaagcgggtggtgcagcacaccaagggctgcaagcggaaaaccaacggcggctgc cccatctgcaagcagctcatcgccctctgctgctaccacgccaagcactgccaggagaac aagtgcccggtgcccttctgcctcaacatcaagcagaagctgcggcagcagctgcagcag cacnnccaggcccagatgctccgcaggaggatggccagcatgcagcggaccggtgtggtg gggcagcagcaaggcctgccctcccccactcctgccactcccaccactccgacgggccag cagccggccaccccgcagacgccccagccccagcctccctctcagcctcagcccacgcct cccaacagcatgcccccctacttgcccaggactcaggctgctggccctgtctcccagggt aaggcagagggccaggggacccctcccacacccccccagactgctcagccacccctcccg gggcccccacctgccgcagtggaaatggcaatgcagattcagagggcggctgagacgcag cgccagatggcccacgtgcaaatttttcaaaggccaatacagcaccagatgccccagatg actccaatggctcccatgggtatgaacccaccccctatgaccagaggtcccagtgggcat ttggagccagggatggggcccacagggatgcagcagcagccacagtgggtccaaggaggg ttgcctcagccccagcagctacagcccgggatgccgaggccagccatgatgtcagtggcc cagcacggccagcccttgaatatagctccccagccaggactgggccaggtaggtgtgagc cctctcaaaccaggcactgtgtctcaacaagccttacaaaaccttttgcggactctcagg tctcccagctctcccctacagcagcaacaggtgctcagtatccttcacgccaacccccag ctgttggctgcattcatcaagcagcgggctgccaagtacgccagctcgaatccgcagccc ctcgctgggcagcccggcatgccccagggccagccggggctgcagccacctgccatccct ggccagcaggggcccgggatcggtcccgggatggccaaccataaccagttccagcaaccg caaggggtgggctaccccccgccgccacagccgcagcagcagcgcatgcagcaccacctg cagcagatgcaaccggggagcatggggcagatgggccagctcccccaggccttgggagcg gaggcgggggccggcctgcaggcgtatcagcaacgactcctccagcagcagatggggtcc cctgctcagcccaaccccatgagcccccagcagcatatgctcccaagccaggcgcagtcc ccacacctccaaggccagcagatcccttcttctctctccaatcaagtgcgctctccccag cctgtcccttctccacggccgcagtcccagcccccccactccagcccttccccaaggatg cagcctcagccttcgccacaccacgtctccccgcagaccagttctccacatccgggactg gtcgccgcccaggccaaccccatggaacaagggcattttgccagcccggaccagagctcg atgctttctcagctcgctagcaatccgggcatggcaaacctccacggtgcgggcgccacg gacctggggctcggccccgataacgcggacttgaattcgaacctctcgcagagtacgcta gacatacactag

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