KEGG   Zalophus californianus (California sea lion): 113921975
Entry
113921975         CDS       T07874                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
zca  Zalophus californianus (California sea lion)
Pathway
zca01522  Endocrine resistance
zca04010  MAPK signaling pathway
zca04015  Rap1 signaling pathway
zca04068  FoxO signaling pathway
zca04071  Sphingolipid signaling pathway
zca04114  Oocyte meiosis
zca04148  Efferocytosis
zca04218  Cellular senescence
zca04261  Adrenergic signaling in cardiomyocytes
zca04370  VEGF signaling pathway
zca04380  Osteoclast differentiation
zca04550  Signaling pathways regulating pluripotency of stem cells
zca04611  Platelet activation
zca04613  Neutrophil extracellular trap formation
zca04620  Toll-like receptor signaling pathway
zca04621  NOD-like receptor signaling pathway
zca04622  RIG-I-like receptor signaling pathway
zca04625  C-type lectin receptor signaling pathway
zca04657  IL-17 signaling pathway
zca04658  Th1 and Th2 cell differentiation
zca04659  Th17 cell differentiation
zca04660  T cell receptor signaling pathway
zca04664  Fc epsilon RI signaling pathway
zca04668  TNF signaling pathway
zca04670  Leukocyte transendothelial migration
zca04714  Thermogenesis
zca04722  Neurotrophin signaling pathway
zca04723  Retrograde endocannabinoid signaling
zca04728  Dopaminergic synapse
zca04750  Inflammatory mediator regulation of TRP channels
zca04912  GnRH signaling pathway
zca04914  Progesterone-mediated oocyte maturation
zca04917  Prolactin signaling pathway
zca04926  Relaxin signaling pathway
zca04932  Non-alcoholic fatty liver disease
zca04933  AGE-RAGE signaling pathway in diabetic complications
zca04935  Growth hormone synthesis, secretion and action
zca04936  Alcoholic liver disease
zca05014  Amyotrophic lateral sclerosis
zca05020  Prion disease
zca05022  Pathways of neurodegeneration - multiple diseases
zca05132  Salmonella infection
zca05133  Pertussis
zca05135  Yersinia infection
zca05140  Leishmaniasis
zca05142  Chagas disease
zca05145  Toxoplasmosis
zca05152  Tuberculosis
zca05161  Hepatitis B
zca05163  Human cytomegalovirus infection
zca05167  Kaposi sarcoma-associated herpesvirus infection
zca05169  Epstein-Barr virus infection
zca05170  Human immunodeficiency virus 1 infection
zca05171  Coronavirus disease - COVID-19
zca05205  Proteoglycans in cancer
zca05208  Chemical carcinogenesis - reactive oxygen species
zca05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
zca05415  Diabetic cardiomyopathy
zca05417  Lipid and atherosclerosis
zca05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:zca00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    113921975 (MAPK12)
   04015 Rap1 signaling pathway
    113921975 (MAPK12)
   04370 VEGF signaling pathway
    113921975 (MAPK12)
   04668 TNF signaling pathway
    113921975 (MAPK12)
   04068 FoxO signaling pathway
    113921975 (MAPK12)
   04071 Sphingolipid signaling pathway
    113921975 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    113921975 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    113921975 (MAPK12)
   04218 Cellular senescence
    113921975 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    113921975 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    113921975 (MAPK12)
   04613 Neutrophil extracellular trap formation
    113921975 (MAPK12)
   04620 Toll-like receptor signaling pathway
    113921975 (MAPK12)
   04621 NOD-like receptor signaling pathway
    113921975 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    113921975 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    113921975 (MAPK12)
   04660 T cell receptor signaling pathway
    113921975 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    113921975 (MAPK12)
   04659 Th17 cell differentiation
    113921975 (MAPK12)
   04657 IL-17 signaling pathway
    113921975 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    113921975 (MAPK12)
   04670 Leukocyte transendothelial migration
    113921975 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    113921975 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    113921975 (MAPK12)
   04917 Prolactin signaling pathway
    113921975 (MAPK12)
   04926 Relaxin signaling pathway
    113921975 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    113921975 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    113921975 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    113921975 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    113921975 (MAPK12)
   04722 Neurotrophin signaling pathway
    113921975 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    113921975 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    113921975 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    113921975 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    113921975 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    113921975 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    113921975 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    113921975 (MAPK12)
   05161 Hepatitis B
    113921975 (MAPK12)
   05171 Coronavirus disease - COVID-19
    113921975 (MAPK12)
   05163 Human cytomegalovirus infection
    113921975 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    113921975 (MAPK12)
   05169 Epstein-Barr virus infection
    113921975 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    113921975 (MAPK12)
   05135 Yersinia infection
    113921975 (MAPK12)
   05133 Pertussis
    113921975 (MAPK12)
   05152 Tuberculosis
    113921975 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    113921975 (MAPK12)
   05140 Leishmaniasis
    113921975 (MAPK12)
   05142 Chagas disease
    113921975 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    113921975 (MAPK12)
   05020 Prion disease
    113921975 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    113921975 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    113921975 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    113921975 (MAPK12)
   05415 Diabetic cardiomyopathy
    113921975 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    113921975 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    113921975 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    113921975 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    113921975 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:zca01001]
    113921975 (MAPK12)
Enzymes [BR:zca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     113921975 (MAPK12)
Protein kinases [BR:zca01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   113921975 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Haspin_kinase
Other DBs
NCBI-GeneID: 113921975
NCBI-ProteinID: XP_027449362
EnsemblRapid: ENSZCAG00025010257
UniProt: A0A6J2D3A2
LinkDB
Position
9:479296..488176
AA seq 389 aa
MSSPPPARRGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDLPPRTQGGDTAGWSWR
CERGTACYLVMPFMGTDLGKLMKHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGN
LAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSAGCIMAE
MITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSADAKNYMKGLPELEKKDFASILT
NASPLAVNLLEKMLVLDAERRVTAAEALTHPYFESLQDTEDEPKAQKYDESFDDMDRTLD
EWKRVTYKEVLSFKPPRQLGTKVSKETAL
NT seq 1170 nt   +upstreamnt  +downstreamnt
atgagctctccaccgcccgcccgcaggggcttttaccgccaggaggtgaccaagacggct
tgggaggtgcgcgccgtgtaccaggacctgcagcccgtgggctccggcgcctacggcgcg
gtgtgctcggccgtggacagccgcactggcgccaaggtggccatcaagaaactgtaccgg
cccttccagtcggagctcttcgccaagcgcgcctaccgcgaactgcgcctcctcaagcac
atgcgccacgagaacgtcatcgggctgctggacgtgttcacccctgatgaaaccctggat
gatttcacagacttgcccccccggacccagggtggtgacacagccgggtggagctggagg
tgtgagcgcgggactgcatgttacctggtgatgccgttcatggggactgacctgggcaag
ctcatgaagcatgagaagctgagtgaggaccgaatccagttccttgtctaccagatgctg
aaggggctaaagtacatccatgctgctggcatcatccatagggacctgaagcccggcaat
ctggcagtgaatgaggactgtgagctgaagatcctggacttcggcctggcgaggcaggca
gacagcgagatgactgggtatgtggtgactcggtggtaccgggcacctgaggtcatcttg
aattggatgcgctacacgcagacagtggatatctggtcggcgggctgcatcatggcggag
atgattacagggaagacgctgttcaagggcagtgaccacctggaccagctgaaggagatc
atgaaggtgacagggacgcctcccgctgagtttgtgcagaggctgcagagtgccgatgcg
aagaactacatgaagggcctccccgagttggagaagaaggatttcgcatccatcctgact
aatgcaagtcctctggctgtgaacctcctggagaaaatgcttgtgctagatgcagagcgg
cgggtgactgcggccgaggcgctgacccacccctacttcgagtcactgcaggacacggag
gatgagcccaaggcccagaagtacgacgagtcctttgatgatatggaccgcacgctggat
gagtggaaacgtgtcacatataaagaagtgctcagcttcaagcctccccggcagctgggg
accaaggtctccaaggagacggccctgtga

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