KEGG   ENZYME: 1.1.1.138
Entry
EC 1.1.1.138                Enzyme                                 
Name
mannitol 2-dehydrogenase (NADP+);
mannitol 2-dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-mannitol:NADP+ 2-oxidoreductase
Reaction(IUBMB)
D-mannitol + NADP+ = D-fructose + NADPH + H+ [RN:R00870]
Reaction(KEGG)
R00870
Substrate
D-mannitol [CPD:C00392];
NADP+ [CPD:C00006]
Product
D-fructose [CPD:C00095];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.138 created 1972
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:14109183]
  Authors
EDMUNDOWICZ JM, WRISTON JC Jr.
  Title
MANNITOL DEHYDROGENASE FROM AGARICUS CAMPESTRIS.
  Journal
J Biol Chem 238:3539-41 (1963)
Reference
2  [PMID:14320506]
  Authors
STROBEL GA, KOSUGE T.
  Title
POLYOL METABOLISM IN DIPLODIA VITICOLA DESM.
  Journal
Arch Biochem Biophys 109:622-6 (1965)
DOI:10.1016/0003-9861(65)90409-1
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.138
IUBMB Enzyme Nomenclature: 1.1.1.138
ExPASy - ENZYME nomenclature database: 1.1.1.138
BRENDA, the Enzyme Database: 1.1.1.138
CAS: 37250-68-3
LinkDB

KEGG   REACTION: R00870
Entry
R00870                      Reaction                               
Name
D-mannitol:NADP+ 2-oxidoreductase
Definition
Mannitol + NADP+ <=> D-Fructose + NADPH + H+
Equation
C00392 + C00006 <=> C00095 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00085  C00095_C00392
Enzyme
1.1.1.138
Pathway
rn00051  Fructose and mannose metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.138
     R00870  Mannitol + NADP+ <=> D-Fructose + NADPH + H+
Other DBs
RHEA: 16768
LinkDB

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