KEGG   ENZYME: 1.1.1.225
Entry
EC 1.1.1.225                Enzyme                                 
Name
chlordecone reductase;
CDR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
chlordecone-alcohol:NADP+ 2-oxidoreductase
Reaction(IUBMB)
chlordecone alcohol + NADP+ = chlordecone + NADPH + H+ [RN:R03716]
Reaction(KEGG)
R03716
Substrate
chlordecone alcohol [CPD:C02817];
NADP+ [CPD:C00006]
Product
chlordecone [CPD:C01792];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Chlordecone is an organochlorine pesticide.
History
EC 1.1.1.225 created 1989
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Genes
HSA: 1109(AKR1C4)
PTR: 450274(AKR1C4)
PPS: 100987989(AKR1C4)
GGO: 101148343
PON: 100434557(AKR1C4)
PPYG: 129006876(AKR1C4)
NLE: 100605385
HMH: 116461800(AKR1C4)
SSYN: 129491834
MCC: 722483 722490(AKR1C4)
MCF: 102116844 102117205
MTHB: 126963007
MNI: 105490779
CSAB: 103237814
CATY: 105597444 105597447
PANU: 101022938
TGE: 112631314
MLEU: 105535763
RRO: 104674748
RBB: 108521035
TFN: 117082119 117082359
CANG: 105521699 105521705
CJC: 100405255 100405615(AKR1C4)
SBQ: 101041915
CIMI: 108292324(AKR1C4) 108292325
ANAN: 105710841 105710886
OGA: 100940488
MMMA: 107150202
GVR: 103581518
ECB: 100057251
EPZ: 103540777
EAI: 106827243
LAV: 100660861
DNM: 101426998
XLA: 108712557(akr1c4.S)
XTR: 496490(akr1c4)
NPR: 108799292
RTEM: 120932842
ACAT: 141132846 141132847
PADS: 140323238 140324978
BBUF: 121003666
BGAR: 122926607
DTC: 141083281
PWL: 138287511 138287512 138287514
 ยป show all
Reference
1  [PMID:2427522]
  Authors
Molowa DT, Shayne AG, Guzelian PS.
  Title
Purification and characterization of chlordecone reductase from human liver.
  Journal
J Biol Chem 261:12624-7 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.225
IUBMB Enzyme Nomenclature: 1.1.1.225
ExPASy - ENZYME nomenclature database: 1.1.1.225
BRENDA, the Enzyme Database: 1.1.1.225
CAS: 102484-73-1
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