KEGG   ENZYME: 1.1.1.252
Entry
EC 1.1.1.252                Enzyme                                 
Name
tetrahydroxynaphthalene reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
scytalone:NADP+ Delta5-oxidoreductase
Reaction(IUBMB)
scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+ [RN:R02906]
Reaction(KEGG)
R02906;
(other) R03322
Substrate
scytalone [CPD:C00779];
NADP+ [CPD:C00006]
Product
1,3,6,8-tetrahydroxynaphthalene [CPD:C04033];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. Involved with EC 4.2.1.94 scytalone dehydratase in the biosynthesis of melanin in pathogenic fungi.
History
EC 1.1.1.252 created 1992 as EC 1.3.1.50, transferred 1999 to EC 1.1.1.252
Orthology
K17739  tetrahydroxynaphthalene reductase
Genes
NCR: NCU09390(tnr-1)
NTE: NEUTE1DRAFT102704(NEUTE1DRAFT_102704)
SMP: 10806019(SMAC4_05650)
PAN: PODANS72p035 PODANSg1142
PBEL: QC761_501990(THR1_2) QC761_608450
PPSD: QC762_501990(THR1_2) QC762_608450
PPSP: QC763_501990(THR1_2) QC763_608450
PPSA: QC764_501990(THR1_2) QC764_608450
TTT: THITE_2145571
MTM: MYCTH_2064803 MYCTH_2127410
CTHR: CTHT_0020210 CTHT_0037040
RTHE: 98127508(VTJ83DRAFT_6181)
MGR: MGG_02252
PPEI: PpBr36_06854
PGRI: PgNI_05403
TMN: UCRPA7_2613
SSCK: SPSK_02654
PCHM: VFPPC_06847
VAL: VDBG_02748
VDA: VDAG_03665 VDAG_05181
CFJ: CFIO01_05916
CLUP: CLUP02_04511
CHIG: CH63R_03364 CH63R_09544
CDET: 87938203(CDEST_01700) 87950736(CDEST_14236)
ELA: UCREL1_5427 UCREL1_5776
PFY: PFICI_05460 PFICI_06726
SSL: SS1G_10677
BFU: BCIN_04g04800(Bcbrn1) BCIN_10g00140
MBE: MBM_00285
PSCO: LY89DRAFT_581099 LY89DRAFT_689141
GLZ: GLAREA_02255
ANI: ANIA_00146
NFI: NFIA_101580
APUU: APUU_12003S APUU_22040A
PDP: PDIP_50160
POU: POX_a00751
TMF: EYB26_001621 EYB26_006510
TRG: TRUGW13939_00030
PNO: SNOG_11990
PTE: PTT_12898 PTT_20021
PTRR: 6340950(PtrM4_063020) 6341545(PtrM4_069460)
BZE: COCCADRAFT_105268 COCCADRAFT_21397
BSC: COCSADRAFT_275042 COCSADRAFT_33820 COCSADRAFT_37812
BOR: COCMIDRAFT_106821 COCMIDRAFT_22732 COCMIDRAFT_26577
AALT: CC77DRAFT_528893
ADAC: 96080805(ACET3X_000483)
ARAB: EKO05_0009597
ZTR: MYCGRDRAFT_87994
PFJ: MYCFIDRAFT_145765
FFU: CLAFUR5_12822 CLAFUR5_12910
CBET: CB0940_02504 CB0940_09636
BCOM: BAUCODRAFT_30716 BAUCODRAFT_61485
NPA: UCRNP2_5079
GTR: GLOTRDRAFT_114557
 » show all
Reference
1
  Authors
Wheeler MH, Greenblatt GA.
  Title
The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease.
  Journal
Exp Mycol 12:151-160 (1988)
Reference
2  [PMID:8112349]
  Authors
Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M
  Title
Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing.
  Journal
Eur J Biochem 219:985-92 (1994)
DOI:10.1111/j.1432-1033.1994.tb18581.x
  Sequence
[mgr:MGG_02252]
Reference
3  [PMID:9048570]
  Authors
Thompson JE, Basarab GS, Andersson A, Lindqvist Y, Jordan DB.
  Title
Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism.
  Journal
Biochemistry 36:1852-60 (1997)
DOI:10.1021/bi962355u
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.252
IUBMB Enzyme Nomenclature: 1.1.1.252
ExPASy - ENZYME nomenclature database: 1.1.1.252
BRENDA, the Enzyme Database: 1.1.1.252
CAS: 141350-13-2
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