KEGG   ENZYME: 1.1.1.342
Entry
EC 1.1.1.342                Enzyme                                 
Name
CDP-paratose synthase;
rfbS (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
CDP-alpha-D-paratose:NADP+ 4-oxidoreductase
Reaction(IUBMB)
CDP-alpha-D-paratose + NADP+ = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H+ [RN:R04265]
Reaction(KEGG)
R04265
Substrate
CDP-alpha-D-paratose [CPD:C03598];
NADP+ [CPD:C00006]
Product
CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose [CPD:C04297];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in synthesis of paratose and tyvelose, unusual 3,6-dideoxyhexose sugars that form part of the O-antigen in the lipopolysaccharides of several enteric bacteria. Isolated from Salmonella enterica subsp. enterica serovar Typhi (Salmonella typhi).
History
EC 1.1.1.342 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K12453  CDP-paratose synthetase
Genes
STY: STY2299(rfbS)
STT: t0783(rfbS)
SEX: STBHUCCB_8350
SENT: TY21A_03970
SPT: SPA0777(rfbS)
SEK: SSPA0731
SED: SeD_A2429
SEG: SG2120
SEL: SPUL_0808(rfbS)
SEGA: SPUCDC_0808(rfbS)
SET: SEN2085D(rfbS)
SENA: AU38_10540
SENO: AU37_10550
SENV: AU39_10550
SENQ: AU40_11805
SENL: IY59_10835
SENJ: CFSAN001992_00980
SEEP: I137_03630
KRD: A3780_14940
BUF: D8682_24050
YPE: YPO3112(prt)
YPK: y1071
YPH: YPC_3391(prt)
YPA: YPA_2604
YPN: YPN_0978
YPM: YP_0818(prt)
YPP: YPDSF_2748
YPG: YpAngola_A2900(prt)
YPZ: YPZ3_2741(prt)
YPT: A1122_10405
YPD: YPD4_2729(prt)
YPX: YPD8_2720(prt)
YPW: CH59_2953
YPJ: CH55_1690
YPV: BZ15_415
YPL: CH46_1987
YPS: YPTB1002(prt)
YPO: BZ17_1546
YPI: YpsIP31758_3048(prt)
YPY: YPK_3188
YPB: YPTS_1045
YPU: BZ21_245
YPC: BZ23_521
YPF: BZ19_359
YEW: CH47_2459
YMO: HRD69_10870
YEG: PL78_00700
XBU: HGO23_18930
VGA: BSQ33_09850
SPOL: FH971_05610
SDK: KHX94_02875
SHAO: K0H81_13435
PIN: Ping_0776
MECH: Q9L42_000740
AFRI: E3E15_05600
TCAR: U0034_02765
HEW: HBDW_04780
GCA: Galf_2845
SAQT: GJV85_09680
CCOC: CCON33237_0121
SMUL: SMUL_2477
AELL: AELL_2674
APOC: APORC_0917
HEBR: AEBR_0586
GEF: FO488_01055
GUR: Gura_3787
GEO: Geob_2127(prt)
GBM: Gbem_0858(prt)
BCHS: JNE38_09500
AWO: Awo_c24770
SYNE: Syn6312_0748
CAP: CLDAP_10470
PFER: IRI77_19890
ARAC: E0W69_011185
SPSC: E2P86_16670
MUP: A0256_16620
FKA: KM029_05925
FCR: HYN56_01815
SAF: SULAZ_1205
PMX: PERMA_1994
 » show all
Reference
1  [PMID:2793833]
  Authors
Verma N, Reeves P
  Title
Identification and sequence of rfbS and rfbE, which determine antigenic specificity of group A and group D salmonellae.
  Journal
J Bacteriol 171:5694-701 (1989)
DOI:10.1128/JB.171.10.5694-5701.1989
  Sequence
[sty:STY2299]
Reference
2  [PMID:9538012]
  Authors
Hallis TM, Lei Y, Que NL, Liu H
  Title
Mechanistic studies of the biosynthesis of paratose: purification and characterization of CDP-paratose synthase.
  Journal
Biochemistry 37:4935-45 (1998)
DOI:10.1021/bi9725529
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.342
IUBMB Enzyme Nomenclature: 1.1.1.342
ExPASy - ENZYME nomenclature database: 1.1.1.342
BRENDA, the Enzyme Database: 1.1.1.342
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