KEGG ENZYME: 1.1.1.384

ENZYME: 1.1.1.384

Entry

EC 1.1.1.384                Enzyme

Name

dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase;
KijD10;
dTDP-4-keto-2,6-dideoxy-D-glucose 3-oxidoreductase;
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose 3-oxidoreductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose:NADP+ 3-oxidoreductase

Reaction(IUBMB)

dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP+ = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + NADPH + H+ [RN:R05526]

Reaction(KEGG)

R05526

Substrate

dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose [CPD:C11922];
NADP+ [CPD:C00006]

Product

dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose [CPD:C06620];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme is involved in the biosynthesis of several deoxysugars, including L-digitoxose, L- and D-olivose, L-oliose, D-mycarose and forosamine.

History

EC 1.1.1.384 created 2015

Pathway

ec00523

Polyketide sugar unit biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K13327

dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase

Genes

LEZ:

GLE_2525

VCX:	VAA049_3443

SDE:

Sde_2126

TLR:	Thiosp_04675(gfo)

BGZ:	XH91_11585

GUR:

Gura_4277

GEO:

Geob_0429

DMA:

DMR_07590

DCB:	C3Y92_16660

DSA:	Desal_3611

OBG:	Verru16b_02068(gfo_5)

RBA:

RB1063

RUL:	UC8_43180(afr_5)

LKB:	LPTSP3_g21190

EDA:	GWR55_15425

BFR:

BF0810

BFB:	VU15_03405

BCEL:

BcellWH2_00544(gfo_1) BcellWH2_04966(gfo_2)

ASX:	CDL62_18265

FLS:	GLV81_12385

RUF:	TH63_02830

GFO:

GFO_2034

FNK:	E1750_13620

FAY:	Q4Q34_07120

FBU:	UJ101_00307(iolG) UJ101_00546

PROC:

Ptc2401_00808(afr)

LYG:	C1N55_04680

PPY:

PPE_03773

PPM:	PPSC2_19910(gfo1)

PPO:	PPM_3988(gfo1)

PPOL:

X809_36015

PPQ:	PPSQR21_040170

PPOY:

RE92_17275

PMQ:	PM3016_4486

PTA:	HPL003_00790

PAEH:

H70357_22130

PPEO:

ABE82_19920

PBV:	AR543_09655

PDH:	B9T62_17435 B9T62_36235

PKB:	B4V02_05395

PAIH:

ASL14_17985

PLZH:

C0638_13555

CIU:	G4D55_18800

DMI:	Desmer_4106

LBW:	C3V36_01185

LBP:	V1224_13285

LCG:	L3BBH23_23150

AHQ:	NMU03_10405

ERB:	A4V01_21325

CBEL:

ABMV07_03895

NBR:	O3I_015245

NTP:	CRH09_20625

NAH:	F5544_10985

NWL:	NWFMUON74_25930

NIE:	KV110_14285

NVU:	V7968_23005

TPR:

Tpau_3482

SFI:

SFUL_5283

SANL:

KZO11_24430 KZO11_29555

SCYE:

R2B67_24615

SCB:	SCAB_84001

SRC:	M271_00410

SBH:

SBI_06875

SVE:

SVEN_5995

SDV:	BN159_2520

SALS:

SLNWT_0707

SCI:	B446_13495

SVT:	SVTN_18810

STRE:

GZL_01617

SLD:

T261_6843

SLC:	SL103_12595

SXI:	SXIM_35770

SAMB:

SAM23877_5610(srm27)

SPRI:

SPRI_0254 SPRI_7099

SCX:	AS200_01190

SRW:	TUE45_01311(gfo_2)

SPAV:

Spa2297_32820

SGS:	AVL59_46220

SALW:

CP975_00185

SGM:	GCM10017557_73690

SPHW:

NFX46_24945

SLS:	SLINC_8305

SNR:	SNOUR_06850

SALU:

DC74_6605

SALL:

SAZ_34340

SNW:	BBN63_25025

SVU:	B1H20_29855

SLX:	SLAV_40170(afr2)

STRO:

STRMOE7_07495

SFK:

KY5_6078

SLK:	SLUN_13815

SDX:	C4B68_09685

SGD:	ELQ87_00875 ELQ87_08055

SNQ:	CP978_29665

STIR:

DDW44_27875

SKA:	CP970_10570 CP970_39860

SRK:	FGW37_16320

SGAL:

CP966_28985

SGF:	HEP81_07919

SCAV:

CVT27_24495

SPHV:

F9278_28210

SCIN:

CP977_27975

SPAC:

B1H29_00610 B1H29_36450

STSU:

B7R87_21935

SBRO:

GQF42_07480

SCHF:

IPT68_29235

SHUN:

DWB77_05138(gfo_1)

SHAR:

HUT13_24975

SCYG:

S1361_04985(afr1) S1361_29925(afr3)

SDW:	K7C20_32555

SCAL:

I6J39_29660

SAUH:

SU9_033130

SMOB:

J7W19_17600

SXN:	IAG42_36055

SHK:	J2N69_28805

SANU:

K7396_04540 K7396_33695

SDD:	D9753_11225

SGOB:

test1122_15660

SINE:

KI385_25290

SDEC:

L3078_20650

SCAE:

IHE65_08930

STUB:

MMF93_33235

SSPN:

LXH13_14105

SCIR:

STRCI_006073

STUD:

STRTU_006766

SYUN:

MOV08_06765

SJN:	RI060_18370

SHAU:

K9S39_40575

SKG:	KJK29_16170

SLAI:

P8A22_08975

SARM:

DVA86_12535 DVA86_23870 DVA86_32775

SRPZ:

HEP85_00900 HEP85_01225

SCAT:

P8A18_33640

STRV:

EZV63_00120

SPIH:

ABXR15_08710 ABXR15_16280

KIS:	HUT16_23830

STRI:

C7M71_025690

YIA:	LO772_07330

ABRY:

NYE86_15405 NYE86_16015

AREV:

RVR_2938

MDB:	OVN18_02320

KQI:	F1D05_09195

NDA:

Ndas_4698

NAL:

B005_1464

NAKE:

KGD83_01665

SNAH:

OUQ99_30485

ACTW:

F7P10_30180

AGRA:

AGRA3207_007760

AMAZ:

LUW76_46775

SPIQ:

OHA34_04045

MMAR:

MODMU_0768

SACG:

FDZ84_24210

AMD:	AMED_0642 AMED_5447

AMN:	RAM_03280 RAM_27765

AMM:	AMES_0640 AMES_5382

AMZ:	B737_0641 B737_5382

AAB:	A4R43_01805

AMYY:

YIM_08350(afr1) YIM_11650(afr3) YIM_22845(gfo2)

APRT:

MUY14_22490

AMOG:

QRX60_49390

AMYZ:

HUW46_07980(iolG_8)

AMYD:

K1T34_34135

PSEH:

XF36_05040

PHH:	AFB00_29745(selSVI)

AMI:

Amir_4534

SESP:

BN6_58940(sam33)

KBR:	Q4V65_05520 Q4V65_19905

AHM:	TL08_15910

AHG:	AHOG_15155(afr3) AHOG_15190(gfo1)

ACTU:

Actkin_02416(perS1)

CROS:

N8J89_20365

STP:	Strop_2218

SAQ:

Sare_1266

MAU:	Micau_3990

MIL:

ML5_4431

MCAB:

HXZ27_04095(evdS8)

MFEU:

H1D33_25595

MPRN:

Q3V37_18345

MICF:

QQG74_13775

PLK:	CIK06_11045

DVC:	Dvina_05910 Dvina_31365

DFU:	Dfulv_18285 Dfulv_29105

DROS:

Drose_26845

DAUR:

Daura_30025

DMAT:

Dmats_05390 Dmats_26460

DACT:

KZZ52_34290

CCAZ:

COUCH_16045

NIN:	NADRNF5_2145

NIW:	Nisw_04220

NUE:	C5F50_00900

NBV:

T478_0168

NIU:	DSQ19_09595

» show all

Reference

1 [PMID:10770761]

Authors

Aguirrezabalaga I, Olano C, Allende N, Rodriguez L, Brana AF, Mendez C, Salas JA

Title

Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.

Journal

Antimicrob Agents Chemother 44:1266-75 (2000)
DOI:10.1128/AAC.44.5.1266-1275.2000

Sequence

[ag:AAD55450]

Reference

2 [PMID:11932454]

Authors

Wang L, White RL, Vining LC

Title

Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.

Journal

Microbiology 148:1091-103 (2002)
DOI:10.1099/00221287-148-4-1091

Sequence

[ag:AAL14250]

Reference

3 [PMID:18345667]

Authors

Hong L, Zhao Z, Melancon CE 3rd, Zhang H, Liu HW

Title

In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa.

Journal

J Am Chem Soc 130:4954-67 (2008)
DOI:10.1021/ja0771383