KEGG   ENZYME: 1.1.1.384
Entry
EC 1.1.1.384                Enzyme                                 
Name
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase;
KijD10;
dTDP-4-keto-2,6-dideoxy-D-glucose 3-oxidoreductase;
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose 3-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose:NADP+ 3-oxidoreductase
Reaction(IUBMB)
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP+ = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + NADPH + H+ [RN:R05526]
Reaction(KEGG)
R05526
Substrate
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose [CPD:C11922];
NADP+ [CPD:C00006]
Product
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose [CPD:C06620];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in the biosynthesis of several deoxysugars, including L-digitoxose, L- and D-olivose, L-oliose, D-mycarose and forosamine.
History
EC 1.1.1.384 created 2015
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13327  dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase
Genes
LEZGLE_2525
VCXVAA049_3443
SDESde_2126
TLRThiosp_04675(gfo)
BGZXH91_11585
GURGura_4277
GEOGeob_0429
DMADMR_07590
DCBC3Y92_16660
DSADesal_3611
LYGC1N55_04680
PPYPPE_03773
PPMPPSC2_19910(gfo1)
PPOPPM_3988(gfo1)
PPOLX809_36015
PPQPPSQR21_040170
PPOYRE92_17275
PMQPM3016_4486
PTAHPL003_00790
PAEHH70357_22130
PPEOABE82_19920
PBVAR543_09655
PDHB9T62_17435 B9T62_36235
PKBB4V02_05395
PAIHASL14_17985
DMIDesmer_4106
LBWC3V36_01185
LCGL3BBH23_23150
AHQNMU03_10405
ERBA4V01_21325
CIUG4D55_18800
NBRO3I_015245
NTPCRH09_20625
NAHF5544_10985
NWLNWFMUON74_25930
NIEKV110_14285
TPRTpau_3482
SFISFUL_5283
SANLKZO11_24430 KZO11_29555
SCYER2B67_24615
SCBSCAB_84001
SRCM271_00410
SBHSBI_06875
SVESVEN_5995
SDVBN159_2520
SALSSLNWT_0707
SCIB446_13495
SVTSVTN_18810
STREGZL_01617
SLDT261_6843
SLCSL103_12595
SXISXIM_35770
SAMBSAM23877_5610(srm27)
SPRISPRI_0254 SPRI_7099
SCXAS200_01190
SRWTUE45_01311(gfo_2)
SPAVSpa2297_32820
SGSAVL59_46220
SALWCP975_00185
SGMGCM10017557_73690
SPHWNFX46_24945
SLSSLINC_8305
SNRSNOUR_06850
SALUDC74_6605
SALLSAZ_34340
SNWBBN63_25025
SVUB1H20_29855
SLXSLAV_40170(afr2)
STROSTRMOE7_07495
SFKKY5_6078
SLKSLUN_13815
SDXC4B68_09685
SGDELQ87_00875 ELQ87_08055
SNQCP978_29665
STIRDDW44_27875
SKACP970_10570 CP970_39860
SRKFGW37_16320
SGALCP966_28985
SGFHEP81_07919
SCAVCVT27_24495
SPHVF9278_28210
SCINCP977_27975
SPACB1H29_00610 B1H29_36450
STSUB7R87_21935
SBROGQF42_07480
SCHFIPT68_29235
SHUNDWB77_05138(gfo_1)
SHARHUT13_24975
SCYGS1361_04985(afr1) S1361_29925(afr3)
SDWK7C20_32555
SCALI6J39_29660
SAUHSU9_033130
SMOBJ7W19_17600
SXNIAG42_36055
SHKJ2N69_28805
SANUK7396_04540 K7396_33695
SDDD9753_11225
SGOBtest1122_15660
SINEKI385_25290
SDECL3078_20650
SCAEIHE65_08930
STUBMMF93_33235
SSPNLXH13_14105
SCIRSTRCI_006073
STUDSTRTU_006766
SYUNMOV08_06765
SJNRI060_18370
SHAUK9S39_40575
SKGKJK29_16170
SLAIP8A22_08975
KISHUT16_23830
STRIC7M71_025690
YIALO772_07330
ABRYNYE86_15405 NYE86_16015
MDBOVN18_02320
KQIF1D05_09195
NDANdas_4698
NALB005_1464
NAKEKGD83_01665
SNAHOUQ99_30485
ACTWF7P10_30180
AGRAAGRA3207_007760
AMAZLUW76_46775
SPIQOHA34_04045
MMARMODMU_0768
SACGFDZ84_24210
AMDAMED_0642 AMED_5447
AMNRAM_03280 RAM_27765
AMMAMES_0640 AMES_5382
AMZB737_0641 B737_5382
AABA4R43_01805
AMYYYIM_08350(afr1) YIM_11650(afr3) YIM_22845(gfo2)
APRTMUY14_22490
AMOGQRX60_49390
PSEHXF36_05040
PHHAFB00_29745(selSVI)
AMIAmir_4534
SESPBN6_58940(sam33)
AHMTL08_15910
AHGAHOG_15155(afr3) AHOG_15190(gfo1)
ACTUActkin_02416(perS1)
CROSN8J89_20365
STPStrop_2218
SAQSare_1266
MAUMicau_3990
MILML5_4431
MCABHXZ27_04095(evdS8)
MFEUH1D33_25595
MPRNQ3V37_18345
PLKCIK06_11045
DVCDvina_05910 Dvina_31365
DFUDfulv_18285 Dfulv_29105
DROSDrose_26845
DAURDaura_30025
DMATDmats_05390 Dmats_26460
CCAZCOUCH_16045
OBGVerru16b_02068(gfo_5)
RBARB1063
RULUC8_43180(afr_5)
LKBLPTSP3_g21190
EDAGWR55_15425
BFRBF0810
BFBVU15_03405
BCELBcellWH2_00544(gfo_1) BcellWH2_04966(gfo_2)
ASXCDL62_18265
FLSGLV81_12385
RUFTH63_02830
GFOGFO_2034
FNKE1750_13620
FAYQ4Q34_07120
FBUUJ101_00307(iolG) UJ101_00546
PROCPtc2401_00808(afr)
NINNADRNF5_2145
NIWNisw_04220
NUEC5F50_00900
NBVT478_0168
NIUDSQ19_09595
 » show all
Reference
1  [PMID:10770761]
  Authors
Aguirrezabalaga I, Olano C, Allende N, Rodriguez L, Brana AF, Mendez C, Salas JA
  Title
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.
  Journal
Antimicrob Agents Chemother 44:1266-75 (2000)
DOI:10.1128/AAC.44.5.1266-1275.2000
  Sequence
Reference
2  [PMID:11932454]
  Authors
Wang L, White RL, Vining LC
  Title
Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.
  Journal
Microbiology 148:1091-103 (2002)
DOI:10.1099/00221287-148-4-1091
  Sequence
Reference
3  [PMID:18345667]
  Authors
Hong L, Zhao Z, Melancon CE 3rd, Zhang H, Liu HW
  Title
In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa.
  Journal
J Am Chem Soc 130:4954-67 (2008)
DOI:10.1021/ja0771383
Reference
4  [PMID:21598943]
  Authors
Kubiak RL, Holden HM
  Title
Combined structural and functional investigation of a C-3''-ketoreductase involved in the biosynthesis of dTDP-L-digitoxose.
  Journal
Biochemistry 50:5905-17 (2011)
DOI:10.1021/bi200514b
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.384
IUBMB Enzyme Nomenclature: 1.1.1.384
ExPASy - ENZYME nomenclature database: 1.1.1.384
BRENDA, the Enzyme Database: 1.1.1.384
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