KEGG ENZYME: 1.1.1.413

ENZYME: 1.1.1.413

Entry

EC 1.1.1.413                Enzyme

Name

A-factor type gamma-butyrolactone 1'-reductase (1S-forming);
barS1 (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one:NADP+ 1'-oxidoreductase

Reaction(IUBMB)

a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP+ = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+ [RN:R11776]

Reaction(KEGG)

R11776

Substrate

(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one [CPD:C21666];
NADP+ [CPD:C00006]

Product

(3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one [CPD:C21668];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme, which is found in bacteria that produce virginiae-butanolide (VB) type gamma-butyrolactone autoregulators, reduces its substrate stereospecifically, forming a hydroxyl group in the (S) configuration.

History

EC 1.1.1.413 created 2017

Orthology

K22322

A-factor type gamma-butyrolactone 1'-reductase (1S-forming)

Genes

VOX:	LCH97_14275

MSEA:

METESE_09550

ERAF:

J9537_10520

SANL:

KZO11_19675

SCYE:

R2B67_04415

SCB:	SCAB_12071

SSX:	SACTE_3174

SHY:	SHJG_4001 SHJG_8653

SHO:	SHJGH_3766 SHJGH_8413

SFA:	Sfla_3301 Sfla_6321

SDV:	BN159_4441

STRP:

F750_0226 F750_3442

SGU:	SGLAU_25510

STRE:

GZL_00105 GZL_09308

SCW:	TU94_11470

SLD:

T261_2142

STRM:

M444_36570

SCZ:	ABE83_19735

SCX:	AS200_24420

SRW:	TUE45_pSRc_0612(linC)

SLE:	sle_45930(sle_45930)

SRN:	A4G23_05427(linC_2)

SCLF:

BB341_16840

SALU:

DC74_7609

SALL:

SAZ_39260

SVU:	B1H20_15520

SGV:	B1H19_37525

SLAU:

SLA_3027

SALJ:

SMD11_6028

SRJ:

SRO_3380

SCYA:

EJ357_35235

SNQ:	CP978_34570

STIR:

DDW44_31510

SNK:	CP967_09555 CP967_17820 CP967_30570

SRK:	FGW37_31680

SFIC:

EIZ62_19140

SSPO:

DDQ41_04305 DDQ41_08115 DDQ41_31050

SGF:	HEP81_03592

SCAV:

CVT27_14850

SSUB:

CP968_00755 CP968_02875 CP968_15820

SCIN:

CP977_28700

SSPB:

CP982_00425 CP982_41465

SHUN:

DWB77_04715(linC)

SLIA:

HA039_29940

SCAL:

I6J39_15535

SFB:	CP974_28890

SANU:

K7396_07605

SDD:	D9753_04940 D9753_06790 D9753_09120

SMAO:

CAG99_21650

SLF:	JEQ17_45420

SAKB:

K1J60_19010

SNIG:

HEK616_52230

SCIR:

STRCI_004203

SLON:

LGI35_23835

SENG:

OJ254_00165

SGK:	PET44_34010

SYUN:

MOV08_00425 MOV08_43540

SFIY:

F0344_18555 F0344_34660 F0344_34855

STPB:

QR97_30360

SCAJ:

O1G22_12255

STRW:

QHG49_20935

SCHE:

QRN89_26405

SGLY:

P8A20_18780

SCAT:

P8A18_33955

STII:

DRB96_10885 DRB96_12505

STIC:

DRB89_13180 DRB89_24355

STRH:

GXP74_01245 GXP74_06795

SUBA:

LQ955_03160

» show all

Reference

1 [PMID:12193632]

Authors

Shikura N, Yamamura J, Nihira T

Title

barS1, a gene for biosynthesis of a gamma-butyrolactone autoregulator, a microbial signaling molecule eliciting antibiotic production in Streptomyces species.

Journal

J Bacteriol 184:5151-7 (2002)
DOI:10.1128/JB.184.18.5151-5157.2002

Sequence

[ag:BAA96298]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.413

IUBMB Enzyme Nomenclature:

1.1.1.413

ExPASy - ENZYME nomenclature database:

1.1.1.413

BRENDA, the Enzyme Database:

1.1.1.413

LinkDB

DBGET integrated database retrieval system