Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

beta-L-fucopyranose:NADP+ 1-oxidoreductase

beta-L-fucopyranose + NADP+ = L-fucono-1,5-lactone + NADPH + H+ [RN:R13105]

R13105
Reaction

beta-L-fucopyranose [CPD:C20836];
NADP+ [CPD:C00006]

The enzyme, characterized from the bacterium Burkholderia multivorans, participates in an L-fucose degradation pathway. The enzyme catalyses the oxidation of beta-L-fucopyranose to L-fucono-1,5-lactone, which is unstable and is rapidly converted to L-fucono-1,4-lactone. The alpha anomer is not recognized. The enzyme can also act on beta-L-galactopyranose and D-arabinose with lower activity. NADP+ is a better cosubstrate than NAD+.

EC 1.1.1.435 created 2022

1  [PMID:23214453]