KEGG   ENZYME: 1.1.3.13
Entry
EC 1.1.3.13                 Enzyme                                 
Name
alcohol oxidase;
ethanol oxidase;
alcohol:oxygen oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
alcohol:oxygen oxidoreductase (H2O2-forming)
Reaction(IUBMB)
a primary alcohol + O2 = an aldehyde + H2O2 [RN:R00637]
Reaction(KEGG)
R00637 > R00608
Substrate
primary alcohol [CPD:C00226];
O2 [CPD:C00007]
Product
aldehyde [CPD:C00071];
H2O2 [CPD:C00027]
Comment
The enzymes from the fungi Candida methanosorbosa and several Basidiomycetes species contain an FAD cofactor [1,3]. The enzyme from the phytopathogenic fungi Colletotrichum graminicola and Colletotrichum gloeosporioides utilize a mononuclear copper-radical mechanism [4]. The enzyme acts on primary alcohols and unsaturated alcohols, and has much lower activity with branched-chain and secondary alcohols.
History
EC 1.1.3.13 created 1972
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K17066  alcohol oxidase
Genes
PPAPAS_chr4_0152 PAS_chr4_0821
OPAHPODL_03886
NCRNCU01853
NTENEUTE1DRAFT54808(NEUTE1DRAFT_54808)
SMPSMAC_06860
PANPODANSg3545 PODANSg873
TTTTHITE_2049403 THITE_2059741
MTMMYCTH_98458
MGRMGG_02127 MGG_09072
PPEIPpBr36_02177 PpBr36_10517
TMNUCRPA7_6115 UCRPA7_6633
FGRFGSG_03638 FGSG_07530
FPUFPSE_01898 FPSE_07499
FVRFVEG_08817 FVEG_12768
FOXFOXG_09652 FOXG_15437 FOXG_17301
NHENECHADRAFT_101489 NECHADRAFT_92276 NECHADRAFT_94976 NECHADRAFT_96512 NECHADRAFT_98136
TRETRIREDRAFT_123978 TRIREDRAFT_80659
TRRM419DRAFT_114133 M419DRAFT_115868
MAWMAC_01220
MAJMAA_09229
CMTCCM_09512
PLJVFPFJ_07642 VFPFJ_10346
VALVDBG_05015 VDBG_07713 VDBG_09553
VDAVDAG_04784 VDAG_09583
CFJCFIO01_02658 CFIO01_03820 CFIO01_05227
CHIGCH63R_13356 CH63R_13520
SAPOSAPIO_CDS2494 SAPIO_CDS4124 SAPIO_CDS9833
ELAUCREL1_1366 UCREL1_2684 UCREL1_2837 UCREL1_2912 UCREL1_5121 UCREL1_5231 UCREL1_6194
PFYPFICI_00437 PFICI_03822 PFICI_03888 PFICI_04164 PFICI_13413 PFICI_13749
SSLSS1G_00840 SS1G_01984
BFUBCIN_03g00640 BCIN_07g03040
MBEMBM_01886 MBM_07247
PSCOLY89DRAFT_332428 LY89DRAFT_608108
GLZGLAREA_02973 GLAREA_06765 GLAREA_10773 GLAREA_12622
ANIAN0567.2
AORAO090001000447 AO090003000309
ANGANI_1_1266134(An15g02200) ANI_1_712164(An18g05480)
AFVAFLA_001379 AFLA_012560
ALUCAKAW2_31084S(AOX1_1) AKAW2_60482A
ACHEACHE_11121S(AOX1_3)
APUUAPUU_11514A(AOX1_2) APUU_30796S
PCSPc12g09950
TMFPMAA_101670
TRGTRUGW13939_02544 TRUGW13939_03395 TRUGW13939_05386
PBLPAAG_01979 PAAG_12459(PAAG_07884)
PBNPADG_00649
AJEHCAG_00023
BGHBDBG_06282
PNOSNOG_03029 SNOG_12980 SNOG_13701
PTEPTT_02545 PTT_15531
BZECOCCADRAFT_85893 COCCADRAFT_90144
BSCCOCSADRAFT_188647 COCSADRAFT_88742
BORCOCMIDRAFT_33906 COCMIDRAFT_9949
AALTCC77DRAFT_928434 CC77DRAFT_947839
ZTRMYCGRDRAFT_67933 MYCGRDRAFT_72883
PFJMYCFIDRAFT_126524 MYCFIDRAFT_166262
FFUCLAFUR5_01283 CLAFUR5_06983 CLAFUR5_10605
BCOMBAUCODRAFT_122385
NPAUCRNP2_7026
TMLGSTUM_00004141001
PPLPOSPLDRAFT_91693
TVSTRAVEDRAFT_144610 TRAVEDRAFT_167157 TRAVEDRAFT_170473 TRAVEDRAFT_43286
DSQDICSQDRAFT_149587 DICSQDRAFT_157363 DICSQDRAFT_173648 DICSQDRAFT_181599
PCOPHACADRAFT_121157 PHACADRAFT_126707 PHACADRAFT_213078 PHACADRAFT_252324
SHSSTEHIDRAFT_120848 STEHIDRAFT_138413 STEHIDRAFT_138938 STEHIDRAFT_155230 STEHIDRAFT_162979 STEHIDRAFT_60502 STEHIDRAFT_68504
HIRHETIRDRAFT_102327(gor6) HETIRDRAFT_181240(gor3) HETIRDRAFT_48370(gor15)
PSQPUNSTDRAFT_112855 PUNSTDRAFT_142948 PUNSTDRAFT_143572 PUNSTDRAFT_64842
ADLAURDEDRAFT_112303 AURDEDRAFT_115327 AURDEDRAFT_138513 AURDEDRAFT_170540 AURDEDRAFT_182614 AURDEDRAFT_68428
FMEFOMMEDRAFT_142298 FOMMEDRAFT_169827 FOMMEDRAFT_169831
GTRGLOTRDRAFT_106260 GLOTRDRAFT_139980
LBCLACBIDRAFT_252832 LACBIDRAFT_318049
MRRMoror_10379 Moror_10380 Moror_11464 Moror_11910 Moror_12916 Moror_9184
MOREE1B28_003002 E1B28_005490 E1B28_011071
CCICC1G_07862 CC1G_07964
SCMSCHCODRAFT_258678 SCHCODRAFT_269933 SCHCODRAFT_61357 SCHCODRAFT_65462
ABPAGABI1DRAFT114404(AGABI1DRAFT_114404) AGABI1DRAFT114408(AGABI1DRAFT_114408) AGABI1DRAFT116682(AGABI1DRAFT_116682) AGABI1DRAFT85725(AGABI1DRAFT_85725) AGABI1DRAFT85732(AGABI1DRAFT_85732)
ABVAGABI2DRAFT191438(AGABI2DRAFT_191438) AGABI2DRAFT191444(AGABI2DRAFT_191444) AGABI2DRAFT191450(AGABI2DRAFT_191450) AGABI2DRAFT195553(AGABI2DRAFT_195553)
PCUBJR316_0005765 JR316_0005766 JR316_0012151
CPUTCONPUDRAFT_110608 CONPUDRAFT_127178 CONPUDRAFT_130356 CONPUDRAFT_52372 CONPUDRAFT_67656
SLASERLADRAFT_361508 SERLADRAFT_471949 SERLADRAFT_491423 SERLADRAFT_491425 SERLADRAFT_491427
MLRMELLADRAFT_93496
 » show all
Reference
1  [PMID:5636370]
  Authors
Janssen FW, Ruelius HW.
  Title
Alcohol oxidase, a flavoprotein from several Basidiomycetes species. Crystallization by fractional precipitation with polyethylene glycol.
  Journal
Biochim Biophys Acta 151:330-42 (1968)
DOI:10.1016/0005-2744(68)90100-9
Reference
2
  Authors
Nishida, A., Ishihara, T. and Hiroi, T.
  Title
Studies on enzymes related to lignan biodegradation.
  Journal
Baiomasu Henkan Keikaku Kenkyu Hokoku 38-59 (1987)
Reference
3  [PMID:9142745]
  Authors
Suye S.
  Title
Purification and properties of alcohol oxidase from Candida methanosorbosa M-2003.
  Journal
Curr Microbiol 34:374-7 (1997)
DOI:10.1007/s002849900198
Reference
4  [PMID:26680532]
  Authors
Yin DT, Urresti S, Lafond M, Johnston EM, Derikvand F, Ciano L, Berrin JG, Henrissat B, Walton PH, Davies GJ, Brumer H
  Title
Structure-function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family.
  Journal
Nat Commun 6:10197 (2015)
DOI:10.1038/ncomms10197
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.13
IUBMB Enzyme Nomenclature: 1.1.3.13
ExPASy - ENZYME nomenclature database: 1.1.3.13
BRENDA, the Enzyme Database: 1.1.3.13
CAS: 9073-63-6
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