KEGG ENZYME: 1.1.98.5

ENZYME: 1.1.98.5

Entry

EC 1.1.98.5                 Enzyme

Name

secondary-alcohol dehydrogenase (coenzyme-F420);
F420-dependent alcohol dehydrogenase;
secondary alcohol:F420 oxidoreductase;
F420-dependent secondary alcohol dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With other, known, physiological acceptors

Sysname

secondary-alcohol:coenzyme F420 oxidoreductase

Reaction(IUBMB)

R-CHOH-R' + oxidized coenzyme F420 = R-CO-R' + reduced coenzyme F420 [RN:R10574]

Reaction(KEGG)

R10574

Substrate

R-CHOH-R' [CPD:C01612];
oxidized coenzyme F420 [CPD:C00876]

Product

R-CO-R' [CPD:C01450];
reduced coenzyme F420 [CPD:C01080]

Comment

The enzyme isolated from the methanogenic archaea Methanogenium liminatans catalyses the reversible oxidation of various secondary and cyclic alcohols to the corresponding ketones.

History

EC 1.1.98.5 created 2013

Orthology

K21835

secondary-alcohol dehydrogenase (coenzyme-F420)

Genes

MRTJ:

KHC33_06890

MEM:	Memar_0783

MBG:	BN140_2377

MEMA:

MMAB1_3164(fgd)

MCHK:

MchiMG62_09070(fgd)

MSUM:

OH143_10630

MPI:

Mpet_1623

MEZ:	Mtc_2316(fgd-2)

HAAD:

MW046_02020

HAKZ:

J0X25_00185

Reference

1 [PMID:1879431]

Authors

Bleicher K, Winter J

Title

Purification and properties of F420- and NADP(+)-dependent alcohol dehydrogenases of Methanogenium liminatans and Methanobacterium palustre, specific for secondary alcohols.

Journal

Eur J Biochem 200:43-51 (1991)
DOI:10.1111/j.1432-1033.1991.tb21046.x

Reference

2 [PMID:15016352]

Authors

Aufhammer SW, Warkentin E, Berk H, Shima S, Thauer RK, Ermler U

Title

Coenzyme binding in F420-dependent secondary alcohol dehydrogenase, a member of the bacterial luciferase family.

Journal

Structure 12:361-70 (2004)
DOI:10.1016/j.str.2004.02.010

Sequence

[ag:CAA77275]