KEGG ENZYME: 1.1.99.27

ENZYME: 1.1.99.27

Entry

EC 1.1.99.27                Enzyme

Name

(R)-pantolactone dehydrogenase (flavin);
2-dehydropantolactone reductase (flavin);
2-dehydropantoyl-lactone reductase (flavin);
(R)-pantoyllactone dehydrogenase (flavin)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors

Sysname

(R)-pantolactone:acceptor oxidoreductase (flavin-containing)

Reaction(IUBMB)

(R)-pantolactone + acceptor = 2-dehydropantolactone + reduced acceptor [RN:R03156]

Reaction(KEGG)

R03156

Substrate

(R)-pantolactone [CPD:C01012];
acceptor [CPD:C00028]

Product

2-dehydropantolactone [CPD:C01125];
reduced acceptor [CPD:C00030]

Comment

High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound.

History

EC 1.1.99.27 created 1999

Reference

1 [PMID:1541293]

Authors

Kataoka M, Shimizu S, Yamada H.

Title

Purification and characterization of a novel FMN-dependent enzyme. Membrane-bound L-(+)-pantoyl lactone dehydrogenase from Nocardia asteroides.

Journal

Eur J Biochem 204:799-806 (1992)
DOI:10.1111/j.1432-1033.1992.tb16698.x

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