KEGG   ENZYME: 1.10.3.4
Entry
EC 1.10.3.4                 Enzyme                                 
Name
o-aminophenol oxidase;
isophenoxazine synthase;
o-aminophenol:O2 oxidoreductase;
2-aminophenol:O2 oxidoreductase
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
Sysname
2-aminophenol:oxygen oxidoreductase
Reaction(IUBMB)
4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O [RN:R00074]
Reaction(KEGG)
R00074;
(other) R08762 R08763
Substrate
2-aminophenol [CPD:C01987];
O2 [CPD:C00007]
Product
2-aminophenoxazin-3-one [CPD:C02161];
H2O [CPD:C00001]
Comment
A flavoprotein which catalyses a 6-electron oxidation. The enzyme from the plant Tecoma stans requires Mn2+ and FAD [1] whereas the fungus Pycnoporus coccineus requires Mn2+ and riboflavin 5'-phosphate [2], the bacteria Streptomyces antibioticus requires Cu2+ [4] and the plant Bauhenia monandra does not require any co-factors [3].
History
EC 1.10.3.4 created 1972, modified 2006
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K20204  grixazone synthase / o-aminophenol oxidase
K20219  o-aminophenol oxidase
Genes
GAMGII34_14885
SGRSGR_4246(griF) SGR_451
SANLKZO11_14645 KZO11_36460
SCYER2B67_01230 R2B67_21105
SHYSHJG_7149
SHOSHJGH_6909
SMALSMALA_8206
SSOII1A49_44770
SALSSLNWT_0196
SCWTU94_26000
SCZABE83_01200
SCXAS200_11930
SCLFBB341_23440
SGSAVL59_11960
SCADDN051_42725
SVUB1H20_33335
SLAUSLA_1218
SALFSMD44_06685(cotA)
SALJSMD11_4561
SFKKY5_6301
SLKSLUN_21385
SCYAEJ357_36225
SKACP970_09510
SRKFGW37_10820
SFYGFH48_03275
SBYH7H31_02485
SRIMCP984_27170
SPACB1H29_00585
SCHACP983_09795
SSPBCP982_31945
SBROGQF42_32885
SCYGS1361_30405(phsA)
SROIIAG44_08720
SXNIAG42_07900
SHKJ2N69_29590
STRYEQG64_33370
SDDD9753_07635
SMAOCAG99_16185 CAG99_20795
SAOVG3H79_07455
SDURM4V62_10970
SLONLGI35_33140
SARGHKX69_07345
SJNRI060_08970
SOVQZH56_24575
SLAIP8A22_31355
SFPQUY26_08165
SINNABB07_08015
STRZOYE22_02440
KBUQ4V64_40400
KITCFP65_6120
YIALO772_07340
STRHGXP74_27850
AGLAOIE69_01240 OIE69_03860
MIOAOA12_11920
GMNGMOLON4_1400
KPLKPaMU14_03240
PBOPACID_21950
AACIASQ49_10910
ACIJJS278_01296(phsA)
PSOIPCC79_10625
SNAHOUQ99_09285
NGNLCN96_42575 LCN96_42620
AMDAMED_6380(cotA)
AMNRAM_32710
AMMAMES_6289(cotA)
AMZB737_6289(cotA)
AMYCCU254_35240
AMYBBKN51_18515
AACDLWP59_01785
APRTMUY14_41215
ATHML1857_04530
AMOGQRX60_16150
ACYNORV05_19720
ANWQP939_18380
PAUTPdca_55480(cotA)
SSYIEKG83_29820
KALKALB_4813
KPHYAOZ06_18215
AHMTL08_10825 TL08_10830
ACTIUA75_11550 UA75_11555
ACADUA74_11465 UA74_11470
AHGAHOG_10805(phsA1) AHOG_10810(phsA2)
SAQSare_1241
 » show all
Reference
1  [PMID:14170322]
  Authors
NAIR PM, VAIDYANATHAN CS.
  Title
ISOPHENOXAZINE SYNTHASE.
  Journal
Biochim Biophys Acta 81:507-16 (1964)
DOI:10.1016/0926-6569(64)90135-x
Reference
2  [PMID:14298835]
  Authors
NAIR PM, VINING LC.
  Title
ESOPHENOXAZINE SYNTHASE APOENZYME FROM PYCNOPORUS COCCINEUS.
  Journal
Biochim Biophys Acta 96:318-27 (1965)
DOI:10.1016/0005-2787(65)90594-0
Reference
3  [PMID:4166439]
  Authors
Subba Rao PV, Vaidyanathan CS.
  Title
Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra.
  Journal
Arch Biochem Biophys 118:388-94 (1967)
DOI:10.1016/0003-9861(67)90365-7
Reference
4  [PMID:2477054]
  Authors
Barry CE 3rd, Nayar PG, Begley TP
  Title
Phenoxazinone synthase: mechanism for the formation of the phenoxazinone chromophore of actinomycin.
  Journal
Biochemistry 28:6323-33 (1989)
DOI:10.1021/bi00441a026
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.10.3.4
IUBMB Enzyme Nomenclature: 1.10.3.4
ExPASy - ENZYME nomenclature database: 1.10.3.4
BRENDA, the Enzyme Database: 1.10.3.4
CAS: 9013-85-8
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