Entry
Name
coenzyme F420 hydrogenase;
8-hydroxy-5-deazaflavin-reducing hydrogenase;
F420-reducing hydrogenase;
coenzyme F420-dependent hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
hydrogen:coenzyme F420 oxidoreductase
Reaction(IUBMB)
H2 + oxidized coenzyme F420 = reduced coenzyme F420 [RN:
R03025 ]
Reaction(KEGG)
Substrate
Product
reduced coenzyme F420 [CPD:
C01080 ]
Comment
An iron-sulfur flavoprotein (FAD) containing nickel. The enzyme from some sources contains selenocysteine. The enzyme also reduces the riboflavin analogue of F420, flavins and methyl viologen, but to a lesser extent. The hydrogen acceptor coenzyme F420 is a deazaflavin derivative.
History
EC 1.12.98.1 created 1989 as EC 1.12.99.1, transferred 2002 to EC 1.12.98.1
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K00440 coenzyme F420 hydrogenase subunit alpha
K00441 coenzyme F420 hydrogenase subunit beta
K00443 coenzyme F420 hydrogenase subunit gamma
Genes
PSZ : PSTAB_2397 PSTAB_2411
THIP : N838_25660 N838_32285
HHC : M911_11680 M911_14490
METR : BSY238_1534 BSY238_421
HTQ : FRZ44_21620 FRZ44_28090
HADH : FRZ61_19490 FRZ61_46560
DAT : HRM2_13650 HRM2_33500
DMP : FAK_10630 FAK_14880 FAK_16780
CPRF : K7H06_00440 K7H06_00445
ERZ : ER308_10375 ER308_12355
HAO : PCC7418_1410 PCC7418_1874
TAM : Theam_1117 Theam_1118 Theam_1119
DTE : Dester_0449 Dester_0450 Dester_0451
MINF : MESINF_0685 MESINF_2236
MJA : MJ_0031 MJ_0032 MJ_0725 MJ_0726 MJ_0727 MJ_1349
MFE : Mefer_0177 Mefer_1239 Mefer_1240 Mefer_1242
MVU : Metvu_0629 Metvu_0630 Metvu_0631 Metvu_0895 Metvu_1282 Metvu_1284 Metvu_1285
MFS : MFS40622_0230 MFS40622_0947 MFS40622_0948 MFS40622_0950 MFS40622_1445 MFS40622_1446 MFS40622_1447
MIF : Metin_0065 Metin_0512 Metin_0513 Metin_0515 Metin_0869
MJH : JH146_0253 JH146_1152 JH146_1153 JH146_1154 JH146_1534 JH146_1536 JH146_1537
MESG : MLAUSG7_0242 MLAUSG7_0243 MLAUSG7_0244 MLAUSG7_0824 MLAUSG7_1219(frhB) MLAUSG7_1220(frhG) MLAUSG7_1222(frhA)
MESA : MLASG1_0368 MLASG1_0555(frhA) MLASG1_0557(frhG) MLASG1_0558(frhB) MLASG1_1431 MLASG1_1432 MLASG1_1433
MIG : Metig_0358 Metig_0359 Metig_0360 Metig_1038 Metig_1200 Metig_1202 Metig_1203 Metig_1792 Metig_1793 Metig_1795
MMP : MMP0083 MMP0817(frcB) MMP0818(frcG) MMP0820(frcA) MMP1382(fruA) MMP1384(fruG) MMP1385(fruB)
MMQ : MmarC5_0193 MmarC5_0194 MmarC5_0196 MmarC5_0646 MmarC5_0647 MmarC5_0649 MmarC5_1595
MMX : MmarC6_0585 MmarC6_0866 MmarC6_1288 MmarC6_1289 MmarC6_1291
MMZ : MmarC7_0627 MmarC7_0629 MmarC7_0630 MmarC7_1081
MMD : GYY_00425 GYY_04745 GYY_04750 GYY_04760 GYY_07740 GYY_07750 GYY_07755
MMAK : MMKA1_00860 MMKA1_09020(frhB) MMKA1_09030(frhG) MMKA1_09050(frhA) MMKA1_16060(fruA) MMKA1_16080(frhG) MMKA1_16090(frhB)
MMAO : MMOS7_01110 MMOS7_08800(frhB) MMOS7_08810(frhG) MMOS7_08830(frhA) MMOS7_14870(fruA) MMOS7_14890(frhG) MMOS7_14900(frhB)
MMAD : MMJJ_01770(frcA) MMJJ_01790(frcG) MMJJ_01800(frcB) MMJJ_10110 MMJJ_14540(fruB) MMJJ_14550(fruG) MMJJ_14570(fruA)
MAE : Maeo_1042 Maeo_1043 Maeo_1045 Maeo_1303
MVN : Mevan_0073 Mevan_0075 Mevan_0076 Mevan_0692 Mevan_0694 Mevan_0695 Mevan_1095
MVO : Mvol_0587 Mvol_0589 Mvol_0590 Mvol_0988 Mvol_0989 Mvol_0991 Mvol_1429
MOK : Metok_0177 Metok_0178 Metok_0180 Metok_0606 Metok_0896 Metok_0898 Metok_0899
METF : CFE53_05470(frhA) CFE53_05480(frhG) CFE53_05485(frhB) CFE53_06285
MTH : MTH_1297 MTH_1298 MTH_1300 MTH_193 MTH_341
MMG : MTBMA_c06440 MTBMA_c16830(frhB) MTBMA_c16840(frhG) MTBMA_c16860(frhA)
MWO : MWSIV6_0607(frhB1) MWSIV6_0735(frhB3) MWSIV6_1686(frhB5) MWSIV6_1687(frhG) MWSIV6_1689(frhA)
MTEE : MTTB_01410 MTTB_01430 MTTB_01440 MTTB_08530 MTTB_13330
METC : MTCT_0158 MTCT_1177 MTCT_1178 MTCT_1180
METE : tca_00175 tca_00310 tca_01251 tca_01252(ndhK) tca_01254
METZ : METMT2_0657 METMT2_1291 METMT2_1292 METMT2_1294
METK : FVF72_01325 FVF72_05075(frhA) FVF72_05085(frhG) FVF72_05090(frhB)
MTHM : FZP57_02890 FZP57_03505 FZP57_08255(frhB) FZP57_08260(frhG) FZP57_08270(frhA)
METJ : FZP68_02500(frhA) FZP68_02510(frhG) FZP68_02515(frhB) FZP68_07920 FZP68_08535
MST : Msp_0668 Msp_1302(frhA) Msp_1304(frhG) Msp_1305(frhB)
METB : AW729_02095 AW729_09105 AW729_09110 AW729_09120
MEIS : PXD04_00890(frhB) PXD04_00895(frhG) PXD04_00905(frhA) PXD04_10765
MRU : mru_2061(frhB1) mru_2062(frhG) mru_2064(frhA) mru_2081(frhB2)
MSI : Msm_0135 Msm_1121 Msm_1122 Msm_1124
MEB : Abm4_0826(frhB2) Abm4_1630(frhB1) Abm4_1632(frhG) Abm4_1634(frhA)
MMIL : sm9_0191(frhA) sm9_0193(frhG) sm9_0194(frhB1) sm9_1453(frhB2)
MEYE : TL18_02075 TL18_09865 TL18_09870 TL18_09880
MOL : YLM1_1805 YLM1_1807 YLM1_1808
MARO : MarbSA_01980 MarbSA_10380 MarbSA_10390 MarbSA_10410
METV : K4897_01125 K4897_05800(frhA) K4897_05810(frhG) K4897_05815(frhB)
MEL : Metbo_0218 Metbo_0220 Metbo_0221 Metbo_0574 Metbo_0863
MEW : MSWAN_1791 MSWAN_2262 MSWAN_2263 MSWAN_2265
METH : MBMB1_1414 MBMB1_1908(frhB) MBMB1_1909(frhG) MBMB1_1911(frhA)
MFC : BRM9_0650(frhB2) BRM9_2249(frhB) BRM9_2250(frhG) BRM9_2252(frhA)
MFI : DSM1535_0622 DSM1535_1181(frhB) DSM1535_1182(frhG) DSM1535_1184(frhA)
MCUB : MCBB_1652(frhB1) MCBB_2184(frhB3) MCBB_2185(frhG) MCBB_2187(frhA3)
MSUB : BK009_06075 BK009_08715 BK009_08720 BK009_08730
METN : BK008_01615 BK008_04365 BK008_04370 BK008_04380
METT : CIT01_04660(frhB) CIT01_04665(frhG) CIT01_04675(frhA) CIT01_09700
METO : CIT02_07975(frhA) CIT02_07985(frhG) CIT02_07990(frhB) CIT02_10915
MEME : HYG87_00830 HYG87_05695(frhB) HYG87_05700(frhG) HYG87_05710(frhA) HYG87_10100 HYG87_10910
MFEG : GCM10025860_05610 GCM10025860_05620 GCM10025860_05640 GCM10025860_28140
MEER : NKF70_03820 NKF70_05940(frhB) NKF70_05945(frhG) NKF70_05955(frhA)
MFV : Mfer_1032 Mfer_1034 Mfer_1035 Mfer_1105
MKA : MK0537 MK0538 MK0539 MK0929 MK0930 MK0931 MK1202(hyaB)
PYA : PYCH_10960 PYCH_10970 PYCH_10980
PYC : TQ32_09745 TQ32_09750 TQ32_09755
TON : TON_1559 TON_1560 TON_1561
TGA : TGAM_0066(frhB) TGAM_0067(frhG) TGAM_0068(frhA)
THE : GQS_02345 GQS_02350 GQS_02355
THM : CL1_1149 CL1_1150 CL1_1151
THS : TES1_1498 TES1_1499 TES1_1500 TES1_1501
TNU : BD01_1900 BD01_1901 BD01_1902
TEU : TEU_01935 TEU_01940 TEU_01945
TGY : X802_04305 X802_04310 X802_04315
TPIE : A7C91_04330 A7C91_04335 A7C91_04340
TPAF : A3L08_06600 A3L08_06605 A3L08_06610
TIC : FH039_06095 FH039_06100
THEM : FPV09_03250 FPV09_03255 FPV09_03260
MBA : Mbar_A0449 Mbar_A0450 Mbar_A0452 Mbar_A0662 Mbar_A0881 Mbar_A2287 Mbar_A2289 Mbar_A2290
MBY : MSBRM_0112 MSBRM_1453 MSBRM_1454 MSBRM_1455 MSBRM_3017 MSBRM_3018 MSBRM_3020 MSBRM_3227
MBW : MSBRW_0117 MSBRW_0341 MSBRW_0550 MSBRW_0552 MSBRW_0553 MSBRW_2454 MSBRW_2455 MSBRW_2457
MBAR : MSBR2_0948 MSBR2_0949 MSBR2_0950 MSBR2_2268 MSBR2_2975 MSBR2_2978 MSBR2_3187
MBAK : MSBR3_2970 MSBR3_2971 MSBR3_2973 MSBR3_3176
MAC : MA_0975(frhA) MA_0977(frhG) MA_0978(frhB) MA_4220 MA_4520
MMA : MM_0969 MM_1225 MM_3042 MM_3043 MM_3045
MMAZ : MmTuc01_1000 MmTuc01_1266 MmTuc01_3122 MmTuc01_3124
MMJ : MSMAS_0087 MSMAS_0334 MSMAS_1645 MSMAS_1647 MSMAS_1648
MMAC : MSMAC_0093 MSMAC_0352 MSMAC_2996 MSMAC_2998 MSMAC_2999
MVC : MSVAZ_1818 MSVAZ_1820 MSVAZ_3107 MSVAZ_3108 MSVAZ_3110 MSVAZ_3226 MSVAZ_3399
MEK : MSKOL_1795 MSKOL_1796 MSKOL_1798 MSKOL_3070 MSKOL_3071 MSKOL_3073 MSKOL_3194 MSKOL_3359
MLS : MSLAZ_0135 MSLAZ_2767 MSLAZ_3014
METM : MSMTP_0120 MSMTP_0393 MSMTP_0724
MEF : MSWH1_0115 MSWH1_2850
MEQ : MSWHS_0117 MSWHS_2152
MSJ : MSSAC_0973 MSSAC_0974 MSSAC_0976 MSSAC_3568 MSSAC_3863 MSSAC_4279
MSZ : MSSIH_0875 MSSIH_0876 MSSIH_0878 MSSIH_3110 MSSIH_3394 MSSIH_3784
MSW : MSSIT_0909 MSSIT_0910 MSSIT_0912 MSSIT_3167 MSSIT_3464 MSSIT_3753 MSSIT_3861
MTHR : MSTHT_1416 MSTHT_1418 MSTHT_1566
MTHE : MSTHC_1723 MSTHC_1871 MSTHC_1873 MSTHC_1874
MHOR : MSHOH_0103 MSHOH_0435 MSHOH_2436 MSHOH_2438 MSHOH_2439
MFZ : AOB57_006170(frhB) AOB57_006175(frhG) AOB57_006185(frhA) AOB57_006920
MMET : MCMEM_0409 MCMEM_1996
MHAZ : BHR79_03800 BHR79_04710
MPOT : BKM01_00840 BKM01_10085
MZI : HWN40_01910 HWN40_02110 HWN40_05515
MMAV : RE476_08095 RE476_08360
MSEB : RE474_04685 RE474_04955 RE474_12790
MHZ : Metho_0305 Metho_1361
MEHF : MmiHf6_00940(hoxH) MmiHf6_00960(rsxB_2) MmiHf6_00970
MEES : MmiEs2_08900 MmiEs2_08910(rsxB_3) MmiEs2_08930(hoxH)
MHU : Mhun_0783 Mhun_2329 Mhun_2330 Mhun_2332
MRTJ : KHC33_09700 KHC33_15955(frhA) KHC33_15965(frhG) KHC33_15970(frhB)
MLA : Mlab_0012 Mlab_0013 Mlab_0015
MEM : Memar_0331 Memar_0955 Memar_2174 Memar_2176 Memar_2177
MBG : BN140_1378(frhA) BN140_1380(frhG) BN140_1381(frhB) BN140_1566
MEMA : MMAB1_1762 MMAB1_1765(frhG) MMAB1_1766(frhB) MMAB1_2005
MCHK : MchiMG62_04480 MchiMG62_24880(frhA) MchiMG62_24900(frhG) MchiMG62_24910(frhB)
MSUM : OH143_05155(frhA) OH143_05165(frhG) OH143_05170(frhB) OH143_08360
MRC : R6Y96_03425(frhA) R6Y96_03435(frhG) R6Y96_03440(frhB)
MPI : Mpet_0590 Mpet_0592 Mpet_0593 Mpet_1260
MEND : L6E24_05985(frhA) L6E24_05995(frhG) L6E24_06000(frhB) L6E24_13815
MEFW : F1737_05595 F1737_08250(frhB) F1737_08255(frhG) F1737_08265(frhA)
MAQE : RJ40_04920 RJ40_08170(frhA) RJ40_08180(frhG) RJ40_08185(frhB)
MFK : E2N92_05115 E2N92_08390(frhA) E2N92_08400(frhG) E2N92_08405(frhB)
MOU : OU421_07320(frhA) OU421_07330(frhG) OU421_07335(frhB) OU421_10355
MESB : L1S32_01555 L1S32_10725(frhA) L1S32_10735(frhG) L1S32_10740(frhB)
MANQ : L1994_05565 L1994_08480(frhB) L1994_08485(frhG) L1994_08495(frhA)
MBN : Mboo_0476 Mboo_0477 Mboo_0479 Mboo_1693 Mboo_2023
MFO : Metfor_1221 Metfor_2713 Metfor_2715 Metfor_2716
MESK : METHP_00492 METHP_00494 METHP_00495
MPL : Mpal_0084 Mpal_0086 Mpal_0087 Mpal_2707
MPD : MCP_2174(frhB-1) MCP_2409(frhA-1) MCP_2411(frhG-1) MCP_2412(frhB-2) MCP_2452(frhA-2) MCP_2453(frhG-2) MCP_2454(frhB-3)
MEZ : Mtc_0999(frhB-1) Mtc_1000(frhG-1) Mtc_1001(frhA-1) Mtc_1195(frhB-3) Mtc_2127(frhA-2) Mtc_2129(frhG-2) Mtc_2130(frhB-2)
RCI : RCIX1471(frhB-3) RCIX2136(frhB-2) RCIX2137(frhG-2) RCIX2138(frhA-2) RCIX2388(frhA-1) RCIX2390(frhG-1) RCIX2391(frhB-1) RCIX2759(frhB-4)
MJK : N2V74_00330 N2V74_05525 N2V74_06060 N2V74_06570
HASV : SVXHr_0299(frhB) SVXHr_1509(frhB2)
HABN : HBNXHr_0287(frhB) HBNXHr_1493(frhB2)
HARC : HARCEL1_09110 HARCEL1_13195
HXA : Halxa_0685 Halxa_1303 Halxa_1972
NPE : Natpe_0727 Natpe_3732
HJT : DVR14_08720 DVR14_12970
HLO : J0X27_10355 J0X27_13720
NOU : Natoc_0114 Natoc_4170
LOKI : Lokiarch_07380(frhB_1) Lokiarch_09930(frhB_3) Lokiarch_10850(frhB_4) Lokiarch_12690(fpoF_1) Lokiarch_19690(frhB_5) Lokiarch_21140(frhB_6) Lokiarch_51590(frhB_9)
» show all
Taxonomy
Reference
Authors
Adams MW, Mortenson LE, Chen JS.
Title
Hydrogenase.
Journal
Reference
Authors
Yamazaki S.
Title
A selenium-containing hydrogenase from Methanococcus vannielii. Identification of the selenium moiety as a selenocysteine residue.
Journal
J Biol Chem 257:7926-9 (1982)
Reference
Authors
Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT.
Title
8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization.
Journal
Sequence
Reference
Authors
Muth E, Morschel E, Klein A.
Title
Purification and characterization of an 8-hydroxy-5-deazaflavin-reducing hydrogenase from the archaebacterium Methanococcus voltae.
Journal
Reference
Authors
Baron SF, Ferry JG.
Title
Purification and properties of the membrane-associated coenzyme F420-reducing hydrogenase from Methanobacterium formicicum.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.12.98.1
LinkDB
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