KEGG   ENZYME: 1.13.11.19
Entry
EC 1.13.11.19               Enzyme                                 
Name
cysteamine dioxygenase;
ADO (gene name);
persulfurase;
cysteamine oxygenase;
cysteamine:oxygen oxidoreductase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
2-aminoethanethiol:oxygen oxidoreductase
Reaction(IUBMB)
cysteamine + O2 = hypotaurine [RN:R02467]
Reaction(KEGG)
R02467
Substrate
cysteamine [CPD:C01678];
O2 [CPD:C00007]
Product
hypotaurine [CPD:C00519]
Comment
A non-heme iron protein that is involved in the biosynthesis of taurine. 3-Aminopropanethiol (homocysteamine) and 2-sulfanylethan-1-ol (2-mercaptoethanol) can also act as substrates, but glutathione, cysteine, and cysteine ethyl- and methyl esters are not good substrates [1,3].
History
EC 1.13.11.19 created 1972, modified 2006
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K10712  cysteamine dioxygenase
Genes
HSA84890(ADO)
PTR748534(ADO)
PPS100991144(ADO)
GGO101136773(ADO)
PON100452250(ADO)
NLE100602024(ADO)
MCC698259(ADO)
MCF102116205(ADO)
CSAB103216129(ADO)
CATY105581496(ADO)
PANU101022242(ADO)
TGE112631511(ADO)
RRO104655645(ADO)
RBB108533154(ADO)
TFN117082116(ADO)
PTEH111537960(ADO)
CJC100405905(ADO)
SBQ101033067(ADO)
CSYR103272752(ADO)
MMUR105870253(ADO)
OGA100951939(ADO)
MMU211488(Ado)
MCAL110303950(Ado)
MPAH110326811(Ado)
RNO309732(Ado)
MCOC116101404(Ado)
MUN110547602(Ado)
CGE113833430
PLEU114698524(Ado)
NGI103737475(Ado)
HGL101713027(Ado)
CPOC101787186(Ado)
CCAN109676110 109700462(Ado)
DORD105986345(Ado)
DSP122121442 122122307(Ado)
NCAR124985512
OCU103351357(ADO)
OPI101531651(ADO)
TUP102479881(ADO)
CFA489003(ADO)
VVP112931044(ADO)
VLG121487977(ADO)
AML100479309(ADO)
UMR103667994(ADO)
UAH113259090(ADO)
UAR123782982(ADO)
ELK111144878
LLV125084873
MPUF101680827(ADO)
ORO101372697(ADO) 101378375
EJU114204659 114224771(ADO)
ZCA113923752(ADO) 113927339
MLX118019594 118020090
FCA101082264(ADO)
PYU121036677(ADO)
PBG122492797(ADO)
PPAD109264307(ADO)
AJU113600159(ADO)
HHV120247451(ADO)
BTA100297937(ADO)
BOM102276184(ADO)
BBUB102393751(ADO)
CHX102174627(ADO)
OAS101121567(ADO)
ODA120865231(ADO)
CCAD122446522(ADO)
SSC100153304(ADO)
CFR116667169(ADO)
CBAI105071295(ADO)
CDK105093860(ADO)
VPC102545758(ADO)
BACU103000138(ADO)
LVE103087408(ADO)
OOR101273659(ADO)
DLE111167611(ADO)
PCAD102985453(ADO)
PSIU116741970(ADO)
ECB100147027(ADO)
EPZ103548677(ADO)
EAI106826174(ADO)
MYB102256478(ADO)
MYD102761687(ADO)
MMYO118670049(ADO)
MLF102430617(ADO)
MNA107543266(ADO)
PKL118719207(ADO)
HAI109380639(ADO)
DRO112305525(ADO)
SHON118998496(ADO)
AJM119055718(ADO)
PDIC114497918(ADO)
PHAS123820896(ADO)
MMF118632484(ADO)
RFQ117035959(ADO)
PALE102883157(ADO)
PGIG120609414(ADO)
PVP105298811(ADO)
RAY107517964(ADO)
MJV108392948(ADO)
TOD119234043(ADO)
SARA101538393(ADO)
LAV100671174(ADO)
TMU101342381
DNM101428176(ADO)
MDO100017045(ADO)
GAS123234420(ADO) 123255166
SHR116421991(ADO)
PCW110216373(ADO)
OAA100079506(ADO)
GGA107053634(ADO)
PCOC116235106(ADO)
CJO107315686(ADO)
APLA113844390(ADO)
AFUL116491538(ADO)
TGU115495853(ADO)
LSR110473322(ADO)
PMOA120507240(ADO)
OTC121336160(ADO)
PRUF121357458(ADO)
FAB101819629(ADO)
PHI102107641(ADO)
PMAJ107207126(ADO)
CCW120410198(ADO)
ETL114073543
ZAB102072657(ADO)
TALA116964492(ADO)
ACHC115348363(ADO)
NPD112950509(ADO)
AMJ102567096(ADO)
CPOO109312432(ADO)
CMY119566776(ADO)
CPIC101931118(ADO)
TST117880544(ADO)
CABI116822445(ADO)
MRV120369373(ADO)
PVT110078729(ADO)
SUND121927030(ADO)
PMUR114922597(ADO)
PGUT117676138(ADO)
VKO123018169(ADO)
PMUA114597168(ADO)
ZVI118096464(ADO)
GJA107112662(ADO)
STOW125438365(ADO)
XLA108697364(ado.S) 494774(ado.L)
XTR100485786(ado)
NPR108804787(ADO)
RTEM120947052(ADO)
BBUF121004642(ADO)
BGAR122941063(ADO)
DRE406474(adob) 494091(adoa)
SRX107719329 107732747 107739062 107745676 107745677
SANH107653960 107664434 107695516 107703543
SGH107561692 107593521 107596610 107596613
CCAR109052668 109100039 109107231 109107242
CAUA113056332 113060565 113111927 113117099
PPRM120464009(adoa) 120475812(adob)
MAMB125255674(adoa) 125268988(adob)
IPU108270460(adob) 108273399(adoa)
PHYP113527133 113538746
SMEO124388383(adoa) 124390431(adob)
TFD113649369(adoa) 113659785(adob)
AMEX103032129 103046195
EEE113583333 113584632
TRU101064686 101074983(ado)
TNGGSTEN00008477G001 GSTEN00034580G001
LCO104924320 104935916
NCC104946380(ado) 104965501
CGOB115004579 115005543 115025114
ELY117247682(adoa) 117247798(adob)
PLEP121954598(adob) 121958737(adoa)
SLUC116056395(adob) 116067511(adoa)
ECRA117937217(adoa) 117960758
PFLV114548267(ado) 114572434
GAT120819585(adoa) 120820282
PPUG119213270(adoa) 119213898(adob)
MSAM119912148(adob) 119916199(adoa)
CUD121511504(adob) 121527922
MZE101465833 101471343
ONL100711871 100711878
OAU116320181(adoa) 116335532
OLA101157575 110016496
OML112162102(adob) 112162338(adoa)
XMA102220352 102235164
XCO114138062 114150607
XHE116712955 116713785 116727712(ado)
PRET103477378 103482206(ado)
PFOR103131660 103149020
PLAI106939641 106959984
PMEI106909231 106916187
GAF122823103(adoa) 122842818(adob)
CVG107087618(ado) 107097159
CTUL119787357 119795757(adoa)
GMU124858916(adob) 124875432(adoa)
NFU107373913 107396840(ado)
KMR108245155(adoa) 108246615(adob)
ALIM106527984 106534741
NWH119419747(adob) 119424088
AOCE111562823 111569200
CSEM103381678(ado)
POV109627147(ado) 109647914
SSEN122760055(adoa) 122763063
HHIP117752399(adoa) 117776051(adob)
LCF108872892 108876784
SDU111224250 111237081(ado)
SLAL111653567 111664279(ado)
XGL120794894(adoa) 120796542(adob)
HCQ109510061 109529318(ado)
BPEC110153143 110154204(ado)
MALB109953420 109966662
SASA100195766(aedo) 106591225 106607859 106613884
OTW112240379 112253109 112255237
OMY110502543 110511817 110519246 110529936
OGO124017094 124021820 124040740
ONE115113168 115121207 115135035
SALP111951991 111978610 112078271
SNH120017949 120038386 120039584 120046591
ELS105010537 105026306(ado)
SFM108932788 108939586(ado)
PKI111853679(ado) 111858150
AANG118218263(adob) 118219457(adoa)
LOC102685727(ado)
PSPA121321451 121325108
ARUT117415303 117418085
LCM102349105 102349371
CMK103181026(adoa)
RTP109918800(ado)
BFO118412943
BBEL109471516
SPU582096
APLC110977046
SKO100367728
DMEDmel_CG7550(CG7550)
DER6543672
DSE6607845
DSIDsimw501_GD13021(Dsim_GD13021)
DYADyak_GE20374
DAN6493353
DSR110189066
DPODpse_GA20432
DPE6599605
DMN108151986
DWI6643155
DGR6558773
DMODmoj_GI11999
DAZ108614657
DNV108651581
DHE111601734
DVI6624608
CCAT101463338
BOD106614120
MDE101894845
SCAC106092062
LCQ111678517
AGAAgaP_AGAP006807
ACOZ120947890
AARA120894769
AAG5571697
AALB109405169 109408026
CQUCpipJ_CPIJ004549
CPII120429157
CNS116338854
AME724666
ACER107993536
ALAB122715447
BIM100746274
BBIF117216179
BVK117241927
BVAN117159854
BTER100643470
BPYO122568051
CCAL108622031 108628408
OBB114875961
MGEN117218416
NMEA116433371
CGIG122399416
SOC105198180
MPHA105833737
AEC105151949
ACEP105625013
PBAR105424153 105428986
VEM105565220
HST105183995
DQU106746200
FEX115237060
LHU105679866
PGC109860287
OBO105282374
PCF106791493
PFUC122517456
VPS122629223
NVI100123227
CSOL105368049
TPRE106659597
MDL103573176
CGLO123275434
FAS105272185
DAM107043258
AGIF122854372
CCIN107263121
TCA663771
DPA109542797
SOY115880163
ATD109599098
CSET123313195
AGB108917686
LDC111512073
NVL108562236
APLN108736482 112906418
PPYR116176705
OTU111415160 111419054
BMOR101739372
BMAN114244255
MSEX115442833
DPLKGM_207212
BANY112053317
PMAC106720496
PPOT106102945
PXU106116159
PRAP110997264
ZCE119837806
HAW110373588
TNL113495500
SLIU111357250
OFU114356065
API100163420
DNX107164682
AGS114124423
RMD113548361
BTAB109043882
DCI103517497
CLEC106666739
HHAL106679570
NLU111048066 120348727
PHUPhum_PHUM289820
FOC113208597
ZNE110834893
CSEC111866936
FCD110851131
DPXDAPPUDRAFT_33990
DMK116917203
PVM113810371
PJA122243663
PCHN125037216
HAME121865170
PCLA123759462
PTRU123505367
HAZT108674529
EAF111707871
LSM121118317 121123889
ISCIscW_ISCW024001
DSV119446703
RSAN119389480
RMP119181717
VDE111248813
VJA111270102
TUT107368105
DPTE113797786
DFR124491452
CSCU111620740
PTEP107450775
SDM118205214
BMYBM_BM6707(Bm6707)
LOALOAG_10003
TSPTsp_04201
HROHELRODRAFT_124593
LGILOTGIDRAFT_123657
PCAN112563606
BGT106061337
GAE121383353
HRF124137622 124138050
HRJ124267542 124284827
CRG105321217
MYI110464677
PMAX117339918
MMER123546598
OBI106869111
OSN115226919 115229697 115231080
LAK106153676
SMMSmp_118780
SHXMS3_0012720
OVIT265_10643
EGLEGR_05074
NVE5507566
EPA110250879
ATEN116306309
ADF107334487
AMIL114976328
PDAM113668893
SPIS111326167
DGT114543433
XEN124434642
HMG100208908
TADTRIADDRAFT_58321
AQU100637030
DDIDDB_G0273031 DDB_G0274043
DPPDICPUDRAFT_152760
TETTTHERM_000723389
PTMGSPATT00002373001 GSPATT00006838001 GSPATT00032915001
PIFPITG_02792
TBRTb927.7.5810
TCR508173.129
 » show all
Reference
1  [PMID:5912113]
  Authors
Cavallini D, De Marco C, Scandurra R, Dupre S, Graziani MT.
  Title
The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme.
  Journal
J Biol Chem 241:3189-96 (1966)
Reference
2  [PMID:6052430]
  Authors
Wood JL, Cavallini D.
  Title
Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor.
  Journal
Arch Biochem Biophys 119:368-72 (1967)
DOI:10.1016/0003-9861(67)90467-5
Reference
3  [PMID:1157952]
  Authors
Cavallini D, Federici G, Ricci G, Dupre S, Antonucci A.
  Title
The specificity of cysteamine oxygenase.
  Journal
FEBS Lett 56:348-51 (1975)
DOI:10.1016/0014-5793(75)81124-0
Reference
4  [PMID:3657558]
  Authors
Richerson RB, Ziegler DM.
  Title
Cysteamine dioxygenase.
  Journal
Methods Enzymol 143:410-5 (1987)
DOI:10.1016/0076-6879(87)43071-1
Reference
5  [PMID:17581819]
  Authors
Dominy JE Jr, Simmons CR, Hirschberger LL, Hwang J, Coloso RM, Stipanuk MH
  Title
Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.
  Journal
J Biol Chem 282:25189-98 (2007)
DOI:10.1074/jbc.M703089200
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.19
IUBMB Enzyme Nomenclature: 1.13.11.19
ExPASy - ENZYME nomenclature database: 1.13.11.19
BRENDA, the Enzyme Database: 1.13.11.19
CAS: 9033-41-4
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