KEGG ENZYME: 1.13.11.46

ENZYME: 1.13.11.46

Entry

EC 1.13.11.46               Enzyme

Name

4-hydroxymandelate synthase;
4-hydroxyphenylpyruvate dioxygenase II

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)

Reaction(IUBMB)

4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 [RN:R06632]

Reaction(KEGG)

R06632;
(other) R05778

Substrate

4-hydroxyphenylpyruvate [CPD:C01179];
O2 [CPD:C00007]

Product

(S)-4-hydroxymandelate [CPD:C03198];
CO2 [CPD:C00011]

Comment

Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.

History

EC 1.13.11.46 created 2001

Pathway

ec00261

Monobactam biosynthesis

ec01055

Biosynthesis of vancomycin group antibiotics

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K16421

4-hydroxymandelate synthase

Genes

BNU:	N3Z17_07100(hppD)

THAA:

CFI11_12525

MSD:	MYSTI_03600

MFB:	MFUL124B02_19465

MLAN:

JY572_08610(hppD)

AGE:	AA314_04078

CFUS:

CYFUS_002913

NTP:	CRH09_30890(hppD)

NHU:	H0264_30685(hppD)

SCO:	SCO3229(SCE63.04)

SVL:	Strvi_8789

SRC:	M271_09160 M271_27680

SANT:

QR300_24025(hppD)

SBH:

SBI_01126

SLV:	SLIV_21545

SVT:	SVTN_32165 SVTN_32295

STRE:

GZL_08687

SLC:	SL103_26560

STRC:

AA958_31850

SAMB:

SAM23877_5652

SRW:	TUE45_06938

SPAV:

Spa2297_02915 Spa2297_26610 Spa2297_32985

STSI:

A4E84_04200 A4E84_32820

SKY:	D0C37_28235(hppD)

SALW:

CP975_31965(hppD)

SNR:	SNOUR_39385

SALU:

DC74_563

SALL:

SAZ_03310

SPLU:

LK06_002715 LK06_031630

SSIA:

A7J05_04105

SLAU:

SLA_6884

STRO:

STRMOE7_29130

SFK:	KY5_6265c KY5_6719 KY5_7437c

SVQ:	N6Q81_27900(hppD)

SCYA:

EJ357_01680(hppD)

SKA:	CP970_03010(hppD) CP970_07050(hppD) CP970_09760(hppD)

SRK:	FGW37_00515(hppD)

SGAL:

CP966_31740

SVR:	CP971_02370(hppD) CP971_08110(hppD)

SFY:	GFH48_02890(hppD) GFH48_36325(hppD)

SBY:	H7H31_03515(hppD)

SRIM:

CP984_06500(hppD)

SFUG:

CNQ36_25575(hppD)

STSU:

B7R87_00120 B7R87_00865

SCHA:

CP983_01445(hppD) CP983_10855(hppD)

SGX:	H4W23_38355(hppD)

SATA:

C5746_00990(hppD) C5746_42245(hppD)

SAUH:

SU9_002080(hppD)

SANU:

K7396_35155(hppD)

SINE:

KI385_01575(hppD) KI385_38530(hppD)

SDUR:

M4V62_39095(hppD)

SRUG:

F0345_27930(hppD)

SNIG:

HEK616_29510 HEK616_51390 HEK616_51650

SENG:

OJ254_30510(hppD) OJ254_30635(hppD)

SYUN:

MOV08_40300(hppD)

SFIY:

F0344_35060(hppD)

SHAU:

K9S39_10855(hppD)

STRZ:

OYE22_03385(hppD)

KBU:	Q4V64_04815(hppD)

SLUO:

PS467_34840(hppD)

SMIB:

SMIR_40390 SMIR_40425(hppD)

STRL:

HEP84_04675(hppD) HEP84_04710

SMOD:

POD33_23095(hppD)

SPOF:

P8A21_11040(hppD) P8A21_16235(hppD)

SSLI:

R2D22_32360(hppD)

STYI:

C9F11_05655 C9F11_35070

SSIR:

WAB15_00300(hppD)

SSTO:

ACE1OC_15590(hppD)

STGO:

KBP30_09490

SSEC:

ABZO29_03005(hppD)

KSK:	KSE_65080 KSE_67340

KAU:	B6264_28345

KIT:	CFP65_1222

KIS:	HUT16_30870 HUT16_31070(hppD) HUT16_31790(hppD)

KCH:	O1G21_10155(hppD) O1G21_34405(hppD)

KNB:	ACF9IK_03425(hppD) ACF9IK_29090(hppD)

KIC:	KCMC57_up02790(hppD_1) KCMC57_up61110(hppD_3)

KPUR:

ACFCLZ_34855(hppD)

STRH:

GXP74_15495(hppD) GXP74_26090(hppD)

ABRY:

NYE86_02870(hppD)

KFL:

Kfla_6066

KSL:	OG809_05925(hppD)

KRI:	OX958_06450(hppD)

THAO:

NI17_008240(hppD)

NEC:	KGD82_24210(hppD)

AGRA:

AGRA3207_002325 AGRA3207_007458

AMAZ:

LUW76_44620(hppD)

SRO:

Sros_6970

NOA:	BKM31_54205

NCX:	Nocox_13265(noc2)

NGN:	LCN96_07790(hppD) LCN96_24325(hppD)

FRA:	Francci3_2454

AOI:	AORI_1495(hppD)

AJA:	AJAP_32040

AMYB:

BKN51_28930 BKN51_41520

AORI:

SD37_16610 SD37_33645

AROO:

NQK81_15410(hppD) NQK81_30300(hppD)

AMOG:

QRX60_51090(hppD)

ACOR:

LCL61_00260(hppD)

ANW:	QP939_27915(hppD)

ABAR:

AMYBAR_003242(aba26)

AMYE:

MJQ72_33905(hppD)

AMYS:

CVV72_21515(hppD)

AMI:

Amir_4590

SSYI:

EKG83_29580(hppD) EKG83_30955(hppD)

SACX:

IOD16_14555(hppD)

KAL:

KALB_6132

KUT:	JJ691_47820 JJ691_70350

ACTI:

UA75_15380

ACAD:

UA74_14810

ACTA:

C1701_23410(hppD)

ACAU:

ACOJVX_14435(hppD)

AAUR:

V5P93_001197(knm25) V5P93_004530(hppD)

STP:	Strop_2490 Strop_2727

SAQ:

Sare_2673

MAU:	Micau_3482

MIL:

ML5_4909

MICB:

MicB006_2537

MTUA:

CSH63_07635(hppD)

MICH:

FJK98_16440(hppD)

MTEM:

GCE86_13405(hppD)

MCAB:

HXZ27_18210(hppD)

MSAG:

GCM10017556_53780

VMA:	VAB18032_22230

MCHL:

PVK74_07655(hppD)

MFEU:

H1D33_22995(hppD) H1D33_24960(hppD)

MHAW:

RMN56_24450(hppD)

MCAY:

PVK37_21320(hppD)

AOU:	ACTOB_006460(hppD)

PFLA:

Pflav_007570

PSUU:

Psuf_064610

ATL:	Athai_13960

PRY:	Prubr_36840 Prubr_65200

CATI:

CS0771_77170

DVC:	Dvina_13810(hppD) Dvina_18685(hppD)

DFU:	Dfulv_12455(hppD)

DAUR:

Daura_12945(hppD)

DMAT:

Dmats_13345(hppD)

DACT:

KZZ52_12680(hppD)

CAI:

Caci_3256

HAU:

Haur_1888

» show all

Reference

1 [PMID:11137816]

Authors

Hubbard BK, Thomas MG, Walsh CT

Title

Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.

Journal

Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0

Sequence

[ag:CAA11761]

Reference

Authors

Choroba OW, Williams DH, Spencer JB.

Title

Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine.

Journal

J Am Chem Soc 122:5389-5390 (2000)

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.46

IUBMB Enzyme Nomenclature:

1.13.11.46

ExPASy - ENZYME nomenclature database:

1.13.11.46

BRENDA, the Enzyme Database:

1.13.11.46

CAS:	280566-04-3

LinkDB

DBGET integrated database retrieval system