Entry |
|
Name |
homogentisate 1,2-dioxygenase;
homogentisicase;
homogentisate oxygenase;
homogentisate dioxygenase;
homogentisate oxidase;
homogentisic acid oxidase;
homogentisic acid oxygenase;
homogentisic oxygenase;
homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
|
Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
|
Sysname |
homogentisate:oxygen 1,2-oxidoreductase (ring-opening)
|
Reaction(IUBMB) |
homogentisate + O2 = 4-maleylacetoacetate [RN: R02519]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
4-maleylacetoacetate [CPD: C01036]
|
Comment |
Requires Fe2+.
|
History |
EC 1.13.11.5 created 1961 as EC 1.99.2.5, transferred 1965 to EC 1.13.1.5, transferred 1972 to EC 1.13.11.5
|
Pathway |
ec01120 | Microbial metabolism in diverse environments |
|
Orthology |
K00451 | homogentisate 1,2-dioxygenase |
|
Genes |
OAA: | 100086427 114817468(HGD) |
STOW: | 125437077(HGD) 125437081 |
SANH: | 107663684 107666642 |
CCAR: | 109088610 109095912 |
CAUA: | 113042450 113066221 |
CGIB: | 127946596 128013516 |
MASI: | 127432043 127434355 |
MSAM: | 119908883(hgd) 119911736 |
OMY: | 110489574 110536580(hgd) |
SALP: | 111973385 112069460(hgd) |
CCLU: | 121549899 121569338 |
ARUT: | 117405197 117972906 |
LERI: | 129695143 129702531(hgd) |
LPIC: | 129258871 129258873 |
DSI: | Dsimw501_GD23768(Dsim_GD23768) |
AALB: | 109405872 109407208 |
PPYR: | 116179161 116179263 |
PPOI: | 119114693 119114696 |
CSCU: | 111631667 111631676 |
LPOL: | 106469027 106473344 |
CBR: | CBG_12429(Cbr-hgo-1) |
MAEA: | 128237368 128238556 |
LLON: | 135488045 135488756 |
CSAT: | 104725929 104729209 104761434 |
MINC: | 123195723 123202176 123206139 |
GMX: | 100779961(HGO2) 100801346(HGO1) |
CILL: | 122280501 122288875 |
SSPL: | 121768464 121769793 |
PSOM: | 113287515 113308157 |
TAES: | 123088644 123151102 123164099 |
MFLO: | 136527218 136534987 |
PVIR: | 120671449 120702315 |
ACAK: | 137951183 137960563 137960611 137960630 |
SMO: | SELMODRAFT_151052 SELMODRAFT_267178 |
SLB: | AWJ20_2760 AWJ20_4026 |
NTE: | NEUTE1DRAFT131902(NEUTE1DRAFT_131902) |
SMP: | 10807342(SMAC4_00712) |
PAN: | PODANSg100 PODANSg2853 |
PBEL: | QC761_121290 QC761_403440 |
PPSD: | QC762_121290 QC762_403440 |
PPSP: | QC763_121290 QC763_403440 |
PPSA: | QC764_121290 QC764_403440 |
PPEI: | PpBr36_08738 PpBr36_10021 |
TMN: | UCRPA7_1112 UCRPA7_2142 |
SSCK: | SPSK_00790 SPSK_02446 |
FGR: | FGSG_02347 FGSG_06450 FGSG_08358 |
FPU: | FPSE_03776 FPSE_08970 |
FPOA: | FPOAC1_002454 FPOAC1_004447 |
FVN: | FVRRES_02743 FVRRES_04955 FVRRES_11110 |
FVR: | FVEG_02332 FVEG_03311 FVEG_04413 FVEG_09414 |
FOX: | FOXG_03463 FOXG_04831 FOXG_10758 FOXG_19494 |
NHE: | NECHADRAFT_32303 NECHADRAFT_40957 NECHADRAFT_46144 NECHADRAFT_67097 NECHADRAFT_94705 NECHADRAFT_97663 |
FFC: | NCS54_00223200 NCS54_00374300 NCS54_00749800 NCS54_00866100 NCS54_01415900 |
FKR: | NCS57_00218500 NCS57_00791300 NCS57_00908100 NCS57_01397600 |
FMU: | J7337_005008 J7337_006228 J7337_006452 J7337_008673 |
TATV: | 25781682(TrAtP1_008515) 25786300(TrAtP1_005500) |
TASP: | 36617862(TrAFT101_002891) |
MAW: | 19245855(J3458_000867) 19246444(J3458_012988) 19249157(J3458_019787) |
MAJ: | MAA_00833 MAA_02383 MAA_06959 |
MBRN: | 26239979(hmgA_0) 26243032(hmgA_1) 26246394(hgd) |
PCHM: | VFPPC_01270 VFPPC_08542 |
AMUS: | LMH87_002195 LMH87_011314 |
PLJ: | 28882318(PLICBS_001645) 28884765(PLICBS_005977) |
PTKZ: | JDV02_008598 JDV02_009807 |
VAL: | VDBG_07081 VDBG_08479 VDBG_09166 VDBG_09257 |
VDA: | VDAG_06721 VDAG_07316 VDAG_07414 VDAG_08144 |
CFJ: | CFIO01_03520 CFIO01_05396 CFIO01_07806 CFIO01_08037 |
CLUP: | CLUP02_04833 CLUP02_15116 CLUP02_16612 CLUP02_18155 |
CHIG: | CH63R_00313 CH63R_04716 CH63R_06442 CH63R_13631 |
CDET: | 87939009(CDEST_02506) 87941785(CDEST_05282) 87947210(CDEST_10710) 87947820(CDEST_11320) |
SAPO: | SAPIO_CDS10917 SAPIO_CDS1219 SAPIO_CDS5012 SAPIO_CDS6382 SAPIO_CDS6861 SAPIO_CDS6868 |
ELA: | UCREL1_2812 UCREL1_7100 UCREL1_8075 |
PFY: | PFICI_01705 PFICI_04567 PFICI_04610 PFICI_05682 PFICI_07598 PFICI_15239 |
PSCO: | LY89DRAFT_573869 LY89DRAFT_611135 LY89DRAFT_656190 LY89DRAFT_688794 LY89DRAFT_689015 LY89DRAFT_701440 LY89DRAFT_719797 |
GLZ: | GLAREA_00182 GLAREA_01457 GLAREA_02218 |
ANI: | ANIA_01897 ANIA_04012 ANIA_06390 |
AFM: | AFUA_2G04220 AFUA_6G10810 |
ACT: | ACLA_084540 ACLA_090310 |
NFI: | NFIA_056580 NFIA_081010 |
AOR: | AO090003000210 AO090012000156 |
ANG: | An01g02960 An11g00430 An11g02180 |
AFV: | AFLA_001483 AFLA_001867 |
ALUC: | AKAW2_20464A AKAW2_80046A AKAW2_80190S |
ACHE: | ACHE_80519S ACHE_80819A |
APUU: | APUU_21177A APUU_40341A APUU_51366S |
PCS: | N7525_001661 N7525_006312 |
PDP: | PDIP_36330 PDIP_39100 |
TMF: | EYB26_001651 EYB26_002021 EYB26_006366 EYB26_008212 |
TRG: | TRUGW13939_00537 TRUGW13939_00897 TRUGW13939_05264 TRUGW13939_05729 TRUGW13939_10127 |
CPW: | 9691344(D8B26_001866) |
PNO: | SNOG_04149 SNOG_06876 SNOG_15060 |
PTE: | PTT_06607 PTT_17327 PTT_19145 |
PTRR: | 6340251(PtrM4_012410) 6345953(PtrM4_139940) 6349700(PtrM4_000790) |
BZE: | COCCADRAFT_101645 COCCADRAFT_38639 COCCADRAFT_97519 |
BSC: | COCSADRAFT_119584 COCSADRAFT_202103 COCSADRAFT_41925 |
BOR: | COCMIDRAFT_34972 COCMIDRAFT_35017 COCMIDRAFT_8872 COCMIDRAFT_98703 |
AALT: | CC77DRAFT_1043610 CC77DRAFT_1067544 CC77DRAFT_932428 |
ARAB: | EKO05_0001614 EKO05_0006629 |
PFJ: | MYCFIDRAFT_148993 MYCFIDRAFT_30146 MYCFIDRAFT_37377 |
FFU: | CLAFUR5_01625 CLAFUR5_06809 CLAFUR5_07308 |
CBET: | CB0940_00723 CB0940_09148 |
BCOM: | BAUCODRAFT_172492 BAUCODRAFT_188715 BAUCODRAFT_72326 |
NPA: | UCRNP2_10214 UCRNP2_1358 UCRNP2_61 |
TASA: | A1Q1_01421 A1Q1_06335 |
CCAC: | CcaHIS019_0111860(CcaverHIS019_0111860) CcaHIS019_0212070(CcaverHIS019_0212070) |
TVS: | TRAVEDRAFT_124955 TRAVEDRAFT_20432 |
PCO: | PHACADRAFT_201465 PHACADRAFT_206661 PHACADRAFT_251625 PHACADRAFT_251627 PHACADRAFT_251631 PHACADRAFT_258050 PHACADRAFT_95803 |
HIR: | HETIRDRAFT_157104(hmga1) |
ADL: | AURDEDRAFT_158980 AURDEDRAFT_158981 |
ABP: | AGABI1DRAFT60983(AGABI1DRAFT_60983) AGABI1DRAFT76664(AGABI1DRAFT_76664) |
ABV: | AGABI2DRAFT200921(AGABI2DRAFT_200921) AGABI2DRAFT227930(AGABI2DRAFT_227930) |
SGRA: | EX895_001521 EX895_001903 |
PTM: | GSPATT00008167001 GSPATT00011843001 |
SPAR: | SPRG_01675 SPRG_05357 |
XPH: | XppCFBP6546_09490(hmgA) |
XHD: | LMG31886_05020(hmgA) |
LEZ: | GLE_4302(hmgA) GLE_5298(hmgA) |
LYA: | RDV84_07075(hmgA) RDV84_11545(hmgA) |
LLZ: | LYB30171_02347(hmgA) |
DJI: | CH75_00600 CH75_23680 |
VPG: | LZI70_13815 LZI70_19300 |
PAEB: | NCGM1900_4478(hmgA) |
PVD: | CFBP1590__3431(hmgA) |
PPRC: | PFLCHA0_c09830(hmgA) |
PMUD: | NCTC8068_00968(hmgA) |
PFW: | PF1751_v1c09830(hmgA) |
PPUU: | PputUW4_00825(hmgA) |
PKC: | PKB_4442(homogentisate_1) |
PBZ: | GN234_02870 GN234_23520 |
PTRT: | HU722_0006350(hmgA) |
PTW: | TUM18999_36980(hmgA) |
PTAE: | NCTC10697_03596(hmgA) |
PKH: | JLK41_08870 JLK41_09310 |
SCAA: | TUM17387_23050(hmgA) |
GAG: | Glaag_2943 Glaag_3477 |
PMES: | FX988_01240 FX988_01799 |
SALH: | HMF8227_00846(hmgA) |
LLG: | 44548918_00993(hmgA) |
LJR: | NCTC11533_01176(hmgA) |
LCJ: | NCTC11976_01954(hmgA) |
LWA: | SAMEA4504053_1479(hmgA) |
LSS: | NCTC12082_00264(hmgA) |
LADL: | NCTC12735_00688(hmgA) |
LANT: | TUM19329_15970(hmgA) |
RHEI: | ATY27_04565 ATY27_12375 |
GAI: | IMCC3135_20580(hmgA) |
HAAH: | HALA3H3_470012(hmgA) |
AEL: | NCTC12917_02474(hmgA) |
RNC: | GO999_17540 GO999_24250 |
CNC: | CNE_2c16640(hmgA) CNE_BB2p00950 |
BMV: | BMASAVP1_A0856(hmgA) |
BML: | BMA10229_A2688(hmgA) |
BPM: | BURPS1710b_3228(hmgA) |
BPL: | BURPS1106A_3213(hmgA) |
BCEN: | DM39_631(hmgA) DM39_6327 |
BUE: | BRPE67_ACDS05070(hmgA) |
BUQ: | AC233_02690 AC233_21040 |
BURT: | BTHE68_05150(hmgA_1) BTHE68_57970 BTHE68_62650(hmgA_2) |
BXE: | Bxe_A2725 Bxe_A3900 Bxe_C0994 Bxe_C1025 |
BXB: | DR64_1576(hmgA) DR64_408(hmgA) DR64_7427(hmgA) DR64_7457(hmgA) |
BGE: | BC1002_0545 BC1002_4182 |
BUZ: | AYM40_02690 AYM40_11890 AYM40_12010 |
PSPW: | BJG93_10175(hmgA) BJG93_23965(hmgA) |
PHS: | C2L64_14550 C2L64_23690 C2L64_23775 C2L64_49110 |
PTER: | C2L65_12580 C2L65_26795 C2L65_26880 |
PACP: | FAZ97_02705 FAZ97_21760 |
PPAI: | E1956_00080 E1956_33600 |
PLG: | NCTC10937_01910(hmgA) |
TVL: | FAZ95_18170 FAZ95_29525 |
BTRM: | SAMEA390648701819(hmgA) |
ADY: | HLG70_00725(hmgA) HLG70_25990(hmgA) |
PUS: | CKA81_00540 CKA81_10420 |
CDN: | BN940_02501 BN940_02506 |
PIG: | EGT29_12160 EGT29_27510 EGT29_28040 |
RHF: | EUB48_13380 EUB48_20855 |
VPE: | Varpa_0299 Varpa_3814 |
VAZ: | H7F35_13575 H7F35_29010 |
COF: | FOZ74_13235 FOZ74_14980 |
MLIR: | LPB04_14255 LPB04_17395 |
URU: | DSM104443_03474(hmgA) |
UPL: | DSM104440_02992(hmgA) |
SMEL: | SM2011_c03208(hmgA) |
SFD: | USDA257_c54130(hmgA) |
SAME: | SAMCFNEI73_Ch3371(hmgA) |
REC: | RHECIAT_CH0001827(hmgA) |
REL: | REMIM1_CH01787(hmgA) |
REP: | IE4803_CH01766(hmgA) |
REI: | IE4771_CH01818(hmgA) |
RHL: | LPU83_pLPU83d0038(hmgA) |
RGA: | RGR602_PC00750(hmgA) |
RPHA: | AMC79_CH01800(hmgA) |
RHID: | FFM81_012345 FFM81_027515 |
RLW: | RlegWSM1455_07870(hmgA) |
NPM: | QEO92_18810(hmgA) QEO92_33075(hmgA) |
BSEP: | HAP48_0013645(hmgA) |
BCAN: | BcanWSM471_02520(hmgA) |
VGO: | GJW-30_1_01001(hmgA) |
MAQU: | Maq22A_c05975(hmgA) |
MIND: | mvi_01060(hmgA_1) mvi_47110(hmgA_2) |
CHEL: | AL346_18215 AL346_23590 |
CDQ: | BOQ54_10175 BOQ54_19110 |
PHR: | C6569_03260 C6569_06030 |
RLI: | RLO149_c008120(hmgA) |
PHP: | PhaeoP97_00274(hmgA) |
PPIC: | PhaeoP14_03009(hmgA) |
SINL: | DSM14862_02990(hmgA) |
SPSE: | SULPSESMR1_02733(hmgA) |
AHT: | ANTHELSMS3_02401(hmgA) |
LALG: | LentiSH36_00908(hmgA) |
LVS: | LOKVESSMR4R_00432(hmgA) |
YRH: | AABB31_00450(hmgA) AABB31_11105(hmgA) |
GYJ: | AADW23_09305(hmgA) AADW23_16865(hmgA) |
AALK: | LGT41_0002105(hmgA) |
SPHD: | HY78_04905 HY78_22015 |
SBIN: | SBA_ch1_11320(hmgA) |
SCH: | Sphch_0441 Sphch_3305 Sphch_3716 |
SPAG: | sphantq_02153(hmgA) |
AZL: | AZL_024670(hmgA) AZL_d04870(hmgA) |
ALI: | AZOLI_2566 AZOLI_p40081(hmgA) |
ATI: | AL072_06600 AL072_23070 |
AZM: | DM194_09595 DM194_23730 |
AZZ: | DEW08_07765 DEW08_20280 |
AOZ: | HUE56_06105 HUE56_12290 |
AZS: | E6C72_02325 E6C72_25585 |
TII: | DY252_04675 DY252_18970 |
THAI: | IT893_02420 IT893_16150 |
TLU: | R1T41_04665 R1T41_11020(hmgA) |
TTB: | MACH01_04900(hmgA) MACH01_31750 |
THGO: | M9H61_10405(hmgA) M9H61_17225 |
SCL: | sce4892(hgo) sce5980 |
SCU: | SCE1572_19485 SCE1572_35540 |
MRM: | A7982_01352 A7982_12505 |
PCAY: | FRD00_16220 FRD00_23665 |
BDA: | FSZ17_10760 FSZ17_12110 |
PASA: | BAOM_0797 BAOM_0884 BAOM_4377 |
MSER: | MTY59_02230(hmgA) MTY59_18930(hmgA) |
MDX: | BTO20_12715 BTO20_24865 |
MFJ: | MFLOJ_19930(hmgA_1) MFLOJ_57000(hmgA_2) |
MSTO: | MSTO_22270(hmgA_1) MSTO_59900(hmgA_2) |
MSAK: | MSAS_17300(hmgA_1) MSAS_50790(hmgA_2) |
MHEK: | JMUB5695_03493(hmgA) |
MKY: | IWGMT90018_15310(hmgA_1) IWGMT90018_44930(hmgA_2) |
MPHL: | MPHLCCUG_01762(hmgA) |
MTHN: | 4412656_01360 4412656_03935 |
MAUB: | MAUB_05750(hmgA_1) MAUB_14600(hmgA_2) |
MPHU: | MPHO_06970(hmgA_1) MPHO_56650(hmgA_2) |
MMUC: | C1S78_014855 C1S78_019000 |
MMAT: | MMAGJ_16070(hmgA_1) MMAGJ_50100(hmgA_2) |
MBOK: | MBOE_42670(hmgA_1) MBOE_54370(hmgA_2) |
ROA: | Pd630_LPD06498 Pd630_LPD12068 |
RRT: | 4535765_00669 4535765_04485(hmgA) |
RCR: | NCTC10994_02055 NCTC10994_02930 |
RKO: | JWS14_12040 JWS14_45925 |
ROZ: | CBI38_22715 CBI38_26755 CBI38_32010 |
RHOJ: | JVH1_25730 JVH1_38320 |
GTA: | BCM27_06725 BCM27_24545 |
GJI: | H1R19_01040 H1R19_22570 |
SPIN: | KV203_02790 KV203_11955 |
SSX: | SACTE_1151 SACTE_6245 |
STRP: | F750_1523 F750_7027 |
STRE: | GZL_00573 GZL_06819 |
SAMB: | SAM23877_1773(hmgA) |
SLE: | sle_54030(sle_54030) |
SCLF: | BB341_23335 BB341_30145 |
SKY: | D0C37_00565 D0C37_27550 |
SGM: | GCM10017557_65570(hmgA) |
SDX: | C4B68_01885 C4B68_02070 C4B68_32000 |
SAQU: | EJC51_11435 EJC51_42805 |
STUI: | GCM10017668_13010(hmgA) |
SPEU: | CGZ69_05780 CGZ69_07135 |
SANU: | K7396_28320(hmgA) K7396_33900 |
SGOB: | test1122_01690(hmgA) |
SDEC: | L3078_09830(hmgA) L3078_44205 |
SRUG: | F0345_01115 F0345_04640 |
SAKB: | K1J60_00640 K1J60_35670(hmgA) |
SVIO: | HWN34_00415 HWN34_25820 |
SCAE: | IHE65_01770 IHE65_35755(hmgA) |
SXT: | KPP03845_101945(hmgA) |
STUD: | STRTU_003718 STRTU_005688(hmgA) |
SYUN: | MOV08_02235 MOV08_31810(hmgA) |
SARG: | HKX69_27555(hmgA) HKX69_35030 |
SLUO: | PS467_10275(hmgA) PS467_35230 |
SCHE: | QRN89_00300 QRN89_06715(hmgA) |
SGLY: | P8A20_29370(hmgA) P8A20_37665 |
ARTP: | E5206_13675 E5206_14425 |
NAQU: | ENKNEFLB_04097(hmgA) |
NFC: | KG111_00775 KG111_03965 |
SAIU: | J4H86_20460 J4H86_24415 |
AGRA: | AGRA3207_001951 AGRA3207_003754 AGRA3207_004983 AGRA3207_005030 AGRA3207_005283 |
AMAZ: | LUW76_23225 LUW76_25680 |
SPIQ: | OHA34_21860 OHA34_27450 |
SVI: | Svir_07000 Svir_18910 |
AACD: | LWP59_06205 LWP59_14370(hmgA) |
ATHM: | L1857_12660 L1857_17400(hmgA) |
ARHD: | VSH64_10335 VSH64_37895 |
ACYN: | ORV05_13615 ORV05_20910(hmgA) ORV05_26910 |
PSEE: | FRP1_17230 FRP1_28410 |
PSEH: | XF36_15965 XF36_28950 |
PSEQ: | AD006_07585 AD006_24685 |
PECQ: | AD017_04275 AD017_15400 |
PBRO: | HOP40_08550 HOP40_21325 HOP40_21825 |
KUT: | JJ691_65480(hmgA_1) JJ691_76360(hmgA_2) |
MSAG: | GCM10017556_20820(hmgA) |
ACTR: | Asp14428_51650(hmgA) |
EKE: | EK0264_09525 EK0264_12230 |
BALA: | DSM104299_01744(hmgA) DSM104299_04055 |
LEPV: | J4558_10645 J4558_24195 |
GEP: | Q9293_02400 Q9293_02410 |
FOK: | KK2020170_05720(hmgA) |
PHG: | KCTC32516_00506(hmgA) |
AALG: | AREALGSMS7_02133(hmgA) |
FAY: | Q4Q34_05915 Q4Q34_10755 |
KOS: | KORDIASMS9_00876(hmgA) |
KAN: | IMCC3317_31320(hmgA) |
SPON: | HME9304_02092(hmgA) |
FBU: | UJ101_00093(HGD|hmgA) |
PTAN: | CRYO30217_00118(hmgA) |
» show all
|
Reference |
|
Authors |
Adachi K, Iwayama Y, Tanioka H, Takeda Y. |
Title |
Purification and properties of homogentisate oxygenase from Pseudomonas fluorescens. |
Journal |
|
Reference |
|
Authors |
CRANDALL DI, HALIKIS DN. |
Title |
Homogentisic acid oxidase. I. Distribution in animal tissue and relation to tyrosine metabolism in rat kidney. |
Journal |
J Biol Chem 208:629-38 (1954) |
Reference |
3 |
Authors |
Hayaishi O. |
Title |
Direct oxygenation by O2, oxygenases. |
Journal |
In: Boyer PD, Lardy H, Myrback K (eds). The Enzymes. 2nd ed. Vol. 8. New York: Academic Press; 1963. p. 353-371. |
Reference |
|
Authors |
KITA H, KAMIMOTO M, SENOH S, ADACHI T, TAKEDA Y. |
Title |
CRYSTALLIZATION AND SOME PROPERTIES OF 3,4-DIHYDROXYPHENYLACETATE-2,3-OXYGENASE. |
Journal |
|
Reference |
|
Authors |
KNOX WE, EDWARDS SW. |
Title |
Homogentisate oxidase of liver. |
Journal |
J Biol Chem 216:479-87 (1955) |
Reference |
|
Authors |
RAVDIN RG, CRANDALL DI. |
Title |
The enzymatic conversion of homogentisic acid to 4-fumarylacetoacetic acid. |
Journal |
J Biol Chem 189:137-49 (1951) |
Other DBs |
ExPASy - ENZYME nomenclature database: | 1.13.11.5 |
UM-BBD (Biocatalysis/Biodegradation Database): | 1.13.11.5 |
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LinkDB |
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