KEGG   ENZYME: 1.13.11.59
Entry
EC 1.13.11.59               Enzyme                                 
Name
torulene dioxygenase;
CAO-2;
CarT
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
torulene:oxygen oxidoreductase
Reaction(IUBMB)
torulene + O2 = 4'-apo-beta,psi-caroten-4'-al + 3-methylbut-2-enal [RN:R09782]
Reaction(KEGG)
R09782
Substrate
torulene [CPD:C08613];
O2 [CPD:C00007]
Product
4'-apo-beta,psi-caroten-4'-al [CPD:C19892];
3-methylbut-2-enal [CPD:C07330]
Comment
It is assumed that 3-methylbut-2-enal is formed. The enzyme cannot cleave the saturated 3',4'-bond of gamma-carotene which implies that a 3',4'-double bond is neccessary for this reaction.
History
EC 1.13.11.59 created 2011
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17842  torulene dioxygenase
Genes
MMER123544482
QSU111989873 112000604
CCPCHC_T00003476001 CHC_T00004955001
YLIYALI0C18029g
NCRNCU11424(cao-2)
NTENEUTE1DRAFT147619(NEUTE1DRAFT_147619)
SMPSMAC_08627
PANPODANSg626
TTTTHITE_2122267
MGRMGG_08016
PPEIPpBr36_01466
SSCKSPSK_06058
FGRFGSG_02625
FPUFPSE_11900
FVRFVEG_00042 FVEG_09251
FOXFOXG_10608
NHENECHADRAFT_44844 NECHADRAFT_94642
TRETRIREDRAFT_70646
TRRM419DRAFT_92905
MAWMAC_04503
MAJMAA_07825
CMTCCM_06728
PLJVFPFJ_09683
VALVDBG_07602
VDAVDAG_06707 VDAG_09324
CFJCFIO01_00407
CHIGCH63R_09466
SAPOSAPIO_CDS8504
ELAUCREL1_8011
PFYPFICI_05578 PFICI_13151
PSCOLY89DRAFT_687409 LY89DRAFT_707335
ANIAN1704.2
AFMAFUA_1G17340 AFUA_2G14410
ACTACLA_073070
NFINFIA_008020 NFIA_089590
AORAO090001000359 AO090023000740
ANGANI_1_1676184(An04g02710)
AFVAFLA_007082 AFLA_008701
ALUCAKAW2_51298A
APUUAPUU_21415S APUU_80923S
PCSPc12g09530
CIMCIMG_03017
CPWCPC735_000140
PBLPAAG_08792
PBNPADG_06579
ABEARB_02211
TVETRV_00460
AJEHCAG_02156
BGHBDBG_00313 BDBG_07612
PNOSNOG_02065
PTEPTT_16702
BZECOCCADRAFT_28711
BSCCOCSADRAFT_264699
BORCOCMIDRAFT_95017
AALTCC77DRAFT_1022121 CC77DRAFT_1044489
ZTRMYCGRDRAFT_72589 MYCGRDRAFT_72713
PFJMYCFIDRAFT_142919 MYCFIDRAFT_77435
FFUCLAFUR5_08592
BCOMBAUCODRAFT_63561
TMLGSTUM_00008512001
SHSSTEHIDRAFT_124754
ADLAURDEDRAFT_109597 AURDEDRAFT_144567 AURDEDRAFT_93828
GTRGLOTRDRAFT_123044
MPRMPER_10489 MPER_10728
MRRMoror_1658 Moror_1659 Moror_1672 Moror_3094 Moror_3605
MOREE1B28_003449 E1B28_003452 E1B28_003467
ABPAGABI1DRAFT80273(AGABI1DRAFT_80273)
ABVAGABI2DRAFT207832(AGABI2DRAFT_207832)
CPUTCONPUDRAFT_113014
SLASERLADRAFT_454411
ACANACA1_282210 ACA1_282220
 » show all
Reference
1  [PMID:17493127]
  Authors
Prado-Cabrero A, Estrada AF, Al-Babili S, Avalos J
  Title
Identification and biochemical characterization of a novel carotenoid oxygenase: elucidation of the cleavage step in the Fusarium carotenoid pathway.
  Journal
Mol Microbiol 64:448-60 (2007)
DOI:10.1111/j.1365-2958.2007.05665.x
  Sequence
Reference
2  [PMID:17610084]
  Authors
Saelices L, Youssar L, Holdermann I, Al-Babili S, Avalos J
  Title
Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway.
  Journal
Mol Genet Genomics 278:527-37 (2007)
DOI:10.1007/s00438-007-0269-2
Reference
3  [PMID:18812228]
  Authors
Estrada AF, Maier D, Scherzinger D, Avalos J, Al-Babili S
  Title
Novel apocarotenoid intermediates in Neurospora crassa mutants imply a new biosynthetic reaction sequence leading to neurosporaxanthin formation.
  Journal
Fungal Genet Biol 45:1497-505 (2008)
DOI:10.1016/j.fgb.2008.09.001
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.59
IUBMB Enzyme Nomenclature: 1.13.11.59
ExPASy - ENZYME nomenclature database: 1.13.11.59
BRENDA, the Enzyme Database: 1.13.11.59
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