KEGG   ENZYME: 1.13.11.59
Entry
EC 1.13.11.59               Enzyme                                 
Name
torulene dioxygenase;
CAO-2;
CarT
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
torulene:oxygen oxidoreductase
Reaction(IUBMB)
torulene + O2 = 4'-apo-beta,psi-caroten-4'-al + 3-methylbut-2-enal [RN:R09782]
Reaction(KEGG)
R09782
Substrate
torulene [CPD:C08613];
O2 [CPD:C00007]
Product
4'-apo-beta,psi-caroten-4'-al [CPD:C19892];
3-methylbut-2-enal [CPD:C07330]
Comment
It is assumed that 3-methylbut-2-enal is formed. The enzyme cannot cleave the saturated 3',4'-bond of gamma-carotene which implies that a 3',4'-double bond is neccessary for this reaction.
History
EC 1.13.11.59 created 2011
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17842  torulene dioxygenase
Genes
CCP: CHC_T00003476001 CHC_T00004955001
YLI: 2909987(YALI2_B00203g)
NCR: NCU11424(cao-2)
NTE: NEUTE1DRAFT147619(NEUTE1DRAFT_147619)
SMP: 10801723(SMAC4_08627)
PAN: PODANSg626
PBEL: QC761_400280
PPSD: QC762_400280
PPSP: QC763_400280
PPSA: QC764_400280
TTT: THITE_2122267
MGR: MGG_08016
PPEI: PpBr36_01466
PGRI: PgNI_03557
SSCK: SPSK_06058
FGR: FGSG_02625
FPU: FPSE_11900
FPOA: FPOAC1_002752
FVN: FVRRES_03062
FVR: FVEG_00042 FVEG_09251
FOX: FOXG_10608
NHE: NECHADRAFT_44844 NECHADRAFT_94642
FFC: NCS54_00854600 NCS54_00909500
FKR: NCS57_00898300 NCS57_00927700
FMU: J7337_005153
TRE: TRIREDRAFT_70646
TRR: M419DRAFT_92905
TATV: 25778023(TrAtP1_009083) 25780543(TrAtP1_006582)
TASP: 36617796(TrAFT101_002397)
MAJ: MAA_07825
MBRN: 26246903(bco1)
PCHM: VFPPC_10722
CMT: CCM_06728
AMUS: LMH87_004016 LMH87_010845 LMH87_011968
PLJ: 28891801(PLICBS_004035)
PTKZ: JDV02_002040
VAL: VDBG_07602
VDA: VDAG_06707 VDAG_09324
CFJ: CFIO01_00407
CLUP: CLUP02_17262
CHIG: CH63R_09466
CDET: 87950665(CDEST_14165)
SAPO: SAPIO_CDS8504
ELA: UCREL1_8011
PFY: PFICI_05578 PFICI_13151
PSCO: LY89DRAFT_687409 LY89DRAFT_707335
ANI: ANIA_01704
AFM: AFUA_1G17340 AFUA_2G14410
ACT: ACLA_073070
NFI: NFIA_008020 NFIA_089590
AOR: AO090001000359 AO090023000740
ANG: An04g02710
AFV: AFLA_007082 AFLA_008701
ALUC: AKAW2_51298A
APUU: APUU_21415S APUU_80923S
PCS: N7525_001617
CIM: CIMG_03017
CPW: 9697408(D8B26_002492)
ABE: ARB_02211
TVE: TRV_00460
PBL: PAAG_08792
PBN: PADG_06579
AJE: HCAG_02156
BGH: BDBG_00313 BDBG_07612
PNO: SNOG_02065
PTE: PTT_16702
PTRR: 6348891(PtrM4_080050)
BZE: COCCADRAFT_28711
BSC: COCSADRAFT_264699
BOR: COCMIDRAFT_95017
AALT: CC77DRAFT_1022121 CC77DRAFT_1044489
ADAC: 96081715(ACET3X_001393)
ARAB: EKO05_0006976
ZTR: MYCGRDRAFT_72589 MYCGRDRAFT_72713
PFJ: MYCFIDRAFT_142919 MYCFIDRAFT_77435
FFU: CLAFUR5_08592
CBET: CB0940_01869 CB0940_04755
BCOM: BAUCODRAFT_63561
TML: GSTUM_00008512001
SHS: STEHIDRAFT_124754
ADL: AURDEDRAFT_109597 AURDEDRAFT_144567 AURDEDRAFT_93828
GTR: GLOTRDRAFT_123044
ABP: AGABI1DRAFT80273(AGABI1DRAFT_80273)
ABV: AGABI2DRAFT207832(AGABI2DRAFT_207832)
MPR: MPER_10489 MPER_10728
MRR: Moror_1658 Moror_1659 Moror_1672 Moror_3094 Moror_3605
MORE: E1B28_003449 E1B28_003452 E1B28_003467
CPUT: CONPUDRAFT_113014
SLA: SERLADRAFT_454411
RIE: OCT59_011087
ACAN: ACA1_282210 ACA1_282220
 » show all
Reference
1  [PMID:17493127]
  Authors
Prado-Cabrero A, Estrada AF, Al-Babili S, Avalos J
  Title
Identification and biochemical characterization of a novel carotenoid oxygenase: elucidation of the cleavage step in the Fusarium carotenoid pathway.
  Journal
Mol Microbiol 64:448-60 (2007)
DOI:10.1111/j.1365-2958.2007.05665.x
  Sequence
[ag:CAL90970 CAL90971]
Reference
2  [PMID:17610084]
  Authors
Saelices L, Youssar L, Holdermann I, Al-Babili S, Avalos J
  Title
Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway.
  Journal
Mol Genet Genomics 278:527-37 (2007)
DOI:10.1007/s00438-007-0269-2
Reference
3  [PMID:18812228]
  Authors
Estrada AF, Maier D, Scherzinger D, Avalos J, Al-Babili S
  Title
Novel apocarotenoid intermediates in Neurospora crassa mutants imply a new biosynthetic reaction sequence leading to neurosporaxanthin formation.
  Journal
Fungal Genet Biol 45:1497-505 (2008)
DOI:10.1016/j.fgb.2008.09.001
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.59
IUBMB Enzyme Nomenclature: 1.13.11.59
ExPASy - ENZYME nomenclature database: 1.13.11.59
BRENDA, the Enzyme Database: 1.13.11.59
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