KEGG   ENZYME: 1.13.11.62
Entry
EC 1.13.11.62               Enzyme                                 
Name
linoleate 10R-lipoxygenase;
10R-DOX;
(10R)-dioxygenase;
10R-dioxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
linoleate:oxygen (10R)-oxidoreductase
Reaction(IUBMB)
linoleate + O2 = (8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [RN:R09811]
Reaction(KEGG)
R09811
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007]
Product
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [CPD:C19937]
Comment
The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp.
History
EC 1.13.11.62 created 2011
Pathway
ec00591  Linoleic acid metabolism
Orthology
K17862  linoleate 10R-lipoxygenase
Genes
NCRNCU05858
NTENEUTE1DRAFT86742(NEUTE1DRAFT_86742)
SMPSMAC_09193
PANPODANSg1229
PBELQC761_501240
PPSDQC762_501240
PPSPQC763_501240
PPSAQC764_501240
MTMMYCTH_2094824
CTHRCTHT_0019380
MGRMGG_10859
PPEIPpBr36_03958
PGRIPgNI_09087
TMNUCRPA7_3198
SSCKSPSK_03862
FGRFGSG_02668 FGSG_10960
FPUFPSE_00375 FPSE_10969
FPOAFPOAC1_009706
FVNFVRRES_10347
FVRFVEG_09294 FVEG_11670
FOXFOXG_10645 FOXG_12909
NHENECHADRAFT_40259
FFCNCS54_00640400
FKRNCS57_00680600
FMUJ7337_010070
TRETRIREDRAFT_51893
TRRM419DRAFT_115103
MAWMAC_00208
MAJMAA_04954
PCHMVFPPC_07783
CMTCCM_08032
AMUSLMH87_010707
PLJVFPFJ_01842
PTKZJDV02_004154
VALVDBG_03337
VDAVDAG_02241 VDAG_07521
CFJCFIO01_08347
CLUPCLUP02_13035
CHIGCH63R_09711
SAPOSAPIO_CDS10179
SSLSS1G_10705
BFUBCIN_04g05000
PSCOLY89DRAFT_737544
ANIANIA_05028
AFMAFUA_3G12120 AFUA_4G00180
ACTACLA_039980
NFINFIA_045480 NFIA_065200
AORAO090003000772 AO090010000591
ANGAn02g07930
AFVAFLA_000908 AFLA_014077
ACHEACHE_20321A
APUUAPUU_30756S
PCSN7525_000945
PDPPDIP_75470
POUPOX_b02996
TMFEYB26_006288
TRGTRUGW13939_08648
CIMCIMG_00042
CPWCPC735_060720
UREUREG_00168
PBLPAAG_03986
PBNPADG_03472
ABEARB_07881
TVETRV_00942
AJEHCAG_01100
BGHBDBG_06551
BCOMBAUCODRAFT_34798
NPAUCRNP2_8049
TMLGSTUM_00000322001
PPLPOSPLDRAFT_98495
TVSTRAVEDRAFT_64780(LDO2)
DSQDICSQDRAFT_80992(LDO1)
PCOPHACADRAFT_259331 PHACADRAFT_260261
SHSSTEHIDRAFT_131231 STEHIDRAFT_171396
HIRHETIRDRAFT_155921
PSQPUNSTDRAFT_107209 PUNSTDRAFT_146616
ADLAURDEDRAFT_114269
FMEFOMMEDRAFT_101793 FOMMEDRAFT_15962 FOMMEDRAFT_161482
GTRGLOTRDRAFT_138220 GLOTRDRAFT_140957
RSXRhiXN_04882 RhiXN_05342 RhiXN_05531
LBCLACBIDRAFT_305274 LACBIDRAFT_315146
CCICC1G_00844 CC1G_09914
ABPAGABI1DRAFT114975(AGABI1DRAFT_114975) AGABI1DRAFT90139(AGABI1DRAFT_90139)
ABVAGABI2DRAFT143643(AGABI2DRAFT_143643) AGABI2DRAFT195360(AGABI2DRAFT_195360)
MRRMoror_11351 Moror_14920
MOREE1B28_003838 E1B28_009504
SCMSCHCO_02517480(SCHCODRAFT_02517480) SCHCO_02619114(SCHCODRAFT_02619114)
CPUTCONPUDRAFT_83601(LDO2)
SLASERLADRAFT_416857 SERLADRAFT_439529
MLRMELLADRAFT_116583 MELLADRAFT_76882
 » show all
Reference
1  [PMID:19289462]
  Authors
Garscha U, Oliw EH
  Title
Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity.
  Journal
J Biol Chem 284:13755-65 (2009)
DOI:10.1074/jbc.M808665200
  Sequence
Reference
2  [PMID:20045744]
  Authors
Jerneren F, Garscha U, Hoffmann I, Hamberg M, Oliw EH
  Title
Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.
  Journal
Biochim Biophys Acta 1801:503-7 (2010)
DOI:10.1016/j.bbalip.2009.12.012
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.62
IUBMB Enzyme Nomenclature: 1.13.11.62
ExPASy - ENZYME nomenclature database: 1.13.11.62
BRENDA, the Enzyme Database: 1.13.11.62
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