KEGG   ENZYME: 1.13.11.62
Entry
EC 1.13.11.62               Enzyme                                 
Name
linoleate 10R-lipoxygenase;
10R-DOX;
(10R)-dioxygenase;
10R-dioxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
linoleate:oxygen (10R)-oxidoreductase
Reaction(IUBMB)
linoleate + O2 = (8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [RN:R09811]
Reaction(KEGG)
R09811
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007]
Product
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [CPD:C19937]
Comment
The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp.
History
EC 1.13.11.62 created 2011
Pathway
ec00591  Linoleic acid metabolism
Orthology
K17862  linoleate 10R-lipoxygenase
Genes
NCR: NCU05858
NTE: NEUTE1DRAFT86742(NEUTE1DRAFT_86742)
SMP: 10802108(SMAC4_09193)
PAN: PODANSg1229
PBEL: QC761_501240
PPSD: QC762_501240
PPSP: QC763_501240
PPSA: QC764_501240
MTM: MYCTH_2094824
CTHR: CTHT_0019380
RTHE: 98127441(VTJ83DRAFT_6120)
MGR: MGG_10859
PPEI: PpBr36_03958
PGRI: PgNI_09087
TMN: UCRPA7_3198
SSCK: SPSK_03862
FGR: FGSG_02668 FGSG_10960
FPU: FPSE_00375 FPSE_10969
FPOA: FPOAC1_009706
FVN: FVRRES_10347
FVR: FVEG_09294 FVEG_11670
FOX: FOXG_10645 FOXG_12909
NHE: NECHADRAFT_40259
FFC: NCS54_00640400
FKR: NCS57_00680600
FMU: J7337_010070
TRE: TRIREDRAFT_51893
TRR: M419DRAFT_115103
TATV: 25780309(TrAtP1_008682)
TASP: 36617849(TrAFT101_002751)
MAW: 19244519(J3458_021745)
MAJ: MAA_04954
MBRN: 26242227(ppoC)
PCHM: VFPPC_07783
CMT: CCM_08032
AMUS: LMH87_010707
PLJ: 28883975(PLICBS_005257)
PTKZ: JDV02_004154
VAL: VDBG_03337
VDA: VDAG_02241 VDAG_07521
CFJ: CFIO01_08347
CLUP: CLUP02_13035
CHIG: CH63R_09711
CDET: 87950770(CDEST_14270)
SAPO: SAPIO_CDS10179
SSL: SS1G_10705
BFU: BCIN_04g05000
PSCO: LY89DRAFT_737544
ANI: ANIA_05028
AFM: AFUA_3G12120 AFUA_4G00180
ACT: ACLA_039980
NFI: NFIA_045480 NFIA_065200
AOR: AO090003000772 AO090010000591
ANG: An02g07930
AFV: AFLA_000908 AFLA_014077
ACHE: ACHE_20321A
APUU: APUU_30756S
PCS: N7525_000945
PDP: PDIP_75470
POU: POX_b02996
TMF: EYB26_006288
TRG: TRUGW13939_08648
CIM: CIMG_00042
CPW: 9692317(D8B26_004938)
URE: UREG_00168
ABE: ARB_07881
TVE: TRV_00942
PBL: PAAG_03986
PBN: PADG_03472
AJE: HCAG_01100
BGH: BDBG_06551
BCOM: BAUCODRAFT_34798
NPA: UCRNP2_8049
TML: GSTUM_00000322001
PPL: POSPLDRAFT_98495
TVS: TRAVEDRAFT_64780(LDO2)
DSQ: DICSQDRAFT_80992(LDO1)
PCO: PHACADRAFT_259331 PHACADRAFT_260261
SHS: STEHIDRAFT_131231 STEHIDRAFT_171396
HIR: HETIRDRAFT_155921
PSQ: PUNSTDRAFT_107209 PUNSTDRAFT_146616
ADL: AURDEDRAFT_114269
FME: FOMMEDRAFT_101793 FOMMEDRAFT_15962 FOMMEDRAFT_161482
GTR: GLOTRDRAFT_138220 GLOTRDRAFT_140957
RSX: RhiXN_04882 RhiXN_05342 RhiXN_05531
LBC: LACBIDRAFT_305274 LACBIDRAFT_315146
CCI: CC1G_00844 CC1G_09914
ABP: AGABI1DRAFT114975(AGABI1DRAFT_114975) AGABI1DRAFT90139(AGABI1DRAFT_90139)
ABV: AGABI2DRAFT143643(AGABI2DRAFT_143643) AGABI2DRAFT195360(AGABI2DRAFT_195360)
MRR: Moror_11351 Moror_14920
MORE: E1B28_003838 E1B28_009504
SCM: SCHCO_02517480(SCHCODRAFT_02517480) SCHCO_02619114(SCHCODRAFT_02619114)
CPUT: CONPUDRAFT_83601(LDO2)
SLA: SERLADRAFT_416857 SERLADRAFT_439529
MLR: MELLADRAFT_116583 MELLADRAFT_76882
 » show all
Reference
1  [PMID:19289462]
  Authors
Garscha U, Oliw EH
  Title
Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity.
  Journal
J Biol Chem 284:13755-65 (2009)
DOI:10.1074/jbc.M808665200
  Sequence
[afm:AFUA_3G12120]
Reference
2  [PMID:20045744]
  Authors
Jerneren F, Garscha U, Hoffmann I, Hamberg M, Oliw EH
  Title
Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.
  Journal
Biochim Biophys Acta 1801:503-7 (2010)
DOI:10.1016/j.bbalip.2009.12.012
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.62
IUBMB Enzyme Nomenclature: 1.13.11.62
ExPASy - ENZYME nomenclature database: 1.13.11.62
BRENDA, the Enzyme Database: 1.13.11.62
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