| Entry |
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| Name |
carotenoid-9',10'-cleaving dioxygenase;
BCO2 (gene name);
beta-carotene 9',10'-monooxygenase (misleading);
all-trans-beta-carotene:O2 oxidoreductase (9',10'-cleaving)
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
all-trans-beta-carotene:oxygen oxidoreductase (9',10'-cleaving)
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| Reaction(IUBMB) |
all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone [RN: R10559]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
all-trans-10'-apo-beta-carotenal [CPD: C20695];
beta-ionone [CPD: C12287]
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| Comment |
Requires Fe2+. The enzyme catalyses the asymmetric oxidative cleavage of carotenoids. The mammalian enzyme can also cleave all-trans-lycopene.
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| History |
EC 1.13.11.71 created 2012
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| Orthology |
| K10252 | beta,beta-carotene 9',10'-dioxygenase |
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| Genes |
| PGUT: | 117658496(BCO2) 117659305 |
| PRAF: | 128402679(BCO2) 128402847 |
| XLA: | 108696498(bco2l.L) 446869(bco2.L) |
| XTR: | 100487224(bco2l) 448408(bco2) |
| RTEM: | 120915486 120915488 |
| BBUF: | 120989235 120996556 |
| BGAR: | 122926287 122928948(BCO2) |
| PWL: | 138261006 138285127 138285128 |
| DRE: | 678554(bco2b) 793849(bco2a) 84041(bco2l) |
| SRX: | 107709124 107709687 107717256 107744484 |
| SANH: | 107657247 107677445 107681253(bco2) |
| SGH: | 107586303 107587333 107595022 107597692 107601714 |
| CCAR: | 109054838 109073585(bco2l) 109103192(bco2b) 109104806 |
| CAUA: | 113049328 113049898 113074920 113115538 |
| CGIB: | 127933522 127958531 127958552 127972918 128008517 |
| PTET: | 122345816(bco2a) 122346128(bco2l) 122358962(bco2b) |
| LROH: | 127164715(bco2l) 127164873(bco2a) 127176848(bco2b) |
| OMC: | 131540335(bco2a) 131541592(bco2l) 131554198(bco2b) |
| PPRM: | 120469954(bco2a) 120478471(bco2b) 120478981(bco2l) |
| RKG: | 130070739 130070749 130079392(bco2a) 130096713(bco2b) |
| MAMB: | 125248832(bco2b) 125266686(bco2l) 125266748 |
| CIDE: | 127495433 127512566 127513069 |
| CERY: | 137004860(bco2b) 137033765(bco2l) 137034053(bco2a) |
| MASI: | 127424914 127429737 127440189 |
| TROS: | 130546764(bco2l) 130564899(bco2b) 130567036(bco2a) |
| TDW: | 130419244(bco2a) 130419383(bco2l) 130428363(bco2b) |
| MANU: | 129437967(bco2b) 129440060(bco2l) 129440181(bco2a) |
| PDAB: | 135732279(bco2a) 135732372(bco2l) 135770461(bco2b) |
| IFU: | 128603379(bco2a) 128603381 |
| PHYP: | 113531529 113531654 |
| SMEO: | 124379110(bco2a) 124379477 |
| TFD: | 113655076(bco2a) 113655077 |
| NGRA: | 132875832 132876022 |
| AMEX: | 103028302(bco2a) 103030035(bco2b) 103041536(bco2l) |
| CMAO: | 118797741(bco2b) 118814740(bco2a) 118827232(bco2l) |
| CHAR: | 105893730(bco2b) 105902726(bco2l) 105906619(bco2a) |
| SPIL: | 134066581(bco2b) 134080075(bco2a) 134088486(bco2l) |
| TRU: | 101073779 101074587 115247638 |
| TFS: | 130525953(bco2l) 130535155(bco2b) 130537065 |
| TNG: | GSTEN00006488G001 GSTEN00022116G001 |
| NCC: | 104941263 104942314 104948304 |
| TBEN: | 117468986(bco2b) 117490461 117490462 117496760(bco2l) |
| CGOB: | 115013641 115017917(bco2) 115018482 |
| PGEO: | 117452999(bco2l) 117457757(bco2b) 117458955 |
| GACU: | 117561153(bco2l) 117562165(bco2b) 117562697 |
| EMAC: | 134871552 134873521(bco2l) 134880282(bco2b) |
| ELY: | 117252000(bco2l) 117260097(bco2b) 117268778(bco2a) |
| EFO: | 125888422(bco2b) 125890186(bco2l) 125898819(bco2a) |
| PLEP: | 121943153 121944461(bco2l) 121952681 |
| SLUC: | 116039036(bco2b) 116054421(bco2l) 116064962 |
| ECRA: | 117942170(bco2b) 117944447(bco2l) 117955648 |
| ESP: | 116687067(bco2) 116690194 116700618 |
| PFLV: | 114552708(bco2) 114555882 114566784 |
| GAT: | 120822014(bco2a) 120829416(bco2b) 120830626(bco2l) |
| PPUG: | 119213922 119215150 119225548(bco2l) |
| AFB: | 129093105(bco2b) 129100854(bco2l) 129113578 |
| CLUM: | 117736241(bco2l) 117741183(bco2b) 117742643 |
| PSWI: | 130197108(bco2l) 130211771(bco2a) |
| CANA: | 137790464 137802788 137804998(bco2l) |
| CVE: | 137867593(bco2l) 137868778 137876548 |
| MSAM: | 119882622 119891991(bco2l) 119895289 |
| SCHU: | 122876993(bco2l) 122879525 122888861 |
| CUD: | 121510121(bco2l) 121518372 121524502 |
| SPUL: | 138596757 138604553 138610373(bco2l) |
| LMIX: | 132974147(bco2l) 132980106 132988897 |
| ALAT: | 119007313 119019879(bco2l) 119031869 |
| ASTR: | 137592681(bco2l) 137605670(bco2a) |
| MZE: | 101470456 101478921 101485476 101485762 |
| ONL: | 100692914 100698224 100708996 109194197 |
| OAU: | 116313085 116313923(bco2l) 116330510 116336183 |
| OLA: | 101159767 101160828(bco2) 101170850 |
| OML: | 112142706(bco2a) 112148480(bco2l) 112149801(bco2b) |
| CSAI: | 133442220 133451258(bco2l) 133459694 |
| XMA: | 102216602 102227947 102235330 |
| XCO: | 114133655 114153023 114155276 |
| XHE: | 116728287 116729130 116737583(bco2) |
| PRET: | 103470486 103475801 103475802 |
| PFOR: | 103145662 103147097 103147103 |
| PLAI: | 106941789 106941799 106959573 |
| PMEI: | 106915735 106928038 |
| GAF: | 122827976(bco2l) 122832387(bco2b) 122844836(bco2a) |
| PPRL: | 129368707(bco2a) 129372133(bco2l) |
| CVG: | 107083819 107099243(bco2) 107103837 |
| CTUL: | 119776413(bco2l) 119791847(bco2b) 119797910 |
| GMU: | 124876082 124877740(bco2l) 124883668(bco2b) |
| NFU: | 107380750(bco2) 107386477 107393786 |
| KMR: | 108236467(bco2l) 108245248(bco2a) |
| NWH: | 119413456(bco2l) 119420144 |
| AOCE: | 111570765(bco2l) 111571487 111575208 |
| EJA: | 138191503(bco2l) 138196503 138196953 |
| BFRE: | 138621532(bco2l) 138631446 138632468 |
| MCEP: | 125012024(bco2l) 125013019(bco2b) 125021675 |
| CSEM: | 103377768(bco2) 103398249 |
| POV: | 109628365 109633856 109639361(bco2) |
| SSEN: | 122770118(bco2l) 122773125 122780126 |
| SSOE: | 131458416 131462651 131464495(bco2l) |
| HHIP: | 117767457(bco2l) 117773094(bco2b) 117774501 |
| HSP: | 118106791(bco2b) 118115556(bco2l) 124854849 |
| PPLT: | 128438799(bco2l) 128440785 128456838 |
| SMAU: | 118295074 118301269 118314288(bco2l) |
| LCF: | 108878660(bco2l) 108893913 108899889(bco2b) |
| SDU: | 111229717 111234576 111234786(bco2) |
| SLAL: | 111663912 111666238 111671321(bco2) |
| XGL: | 120803158 120805849(bco2l) |
| HCQ: | 109510777(bco2) 109512427 109512430 109512432 109525362 |
| SSCV: | 125965862(bco2l) 125972782(bco2b) 125982120 125982121 |
| SBIA: | 133492074 133499172(bco2l) 133504378(bco2b) |
| PEE: | 133400632(bco2l) 133405442 133415579 133415580 133415787 |
| PTAO: | 133467698 133467699 133467700 133475013(bco2l) 133482205(bco2b) |
| BPEC: | 110158495 110161952(bco2) 110169833 |
| ENY: | 140346924(bco2l) 140360871 140371537 |
| MALB: | 109957023 109959541(bco2) |
| BSPL: | 114862817(bco2l) 114869224(bco2a) |
| SJO: | 128360426(bco2b) 128365184(bco2l) 128371228 |
| SSCO: | 133978473(bco2l) 133980907(bco2b) 133993729 |
| GMH: | 115528873(bco2) 115545438 115546992 |
| SASA: | 101448036(bco2a) 101448037(bco2b) 101448038 106585363 106602811 106612548 |
| STRU: | 115154949 115154950 115163243 115164791 115206182 |
| OTW: | 112228999 112234693(bco2l) 112265401 112266923 |
| OMY: | 110503763 110507165 110525113 110534238 110534240 |
| OGO: | 123993960 124004791 124005302 124034505(bco2l) |
| ONE: | 115111382 115135407 115136873 115141707 |
| OKI: | 109873345 109876965 109906067 109909388 |
| OKE: | 118370613(bco2l) 118373665 118390597(bco2a) 118397333 |
| OMM: | 135532392(bco2l) 135546303 135550177(bco2a) 135552786 |
| OCLA: | 139382700 139385560 139410732 139418734 139419634 |
| SALP: | 111951109 111959902 111974295 111982597 |
| SNH: | 120018273 120029197 120053353(bco2l) 120057368(bco2a) |
| CCLU: | 121567619(bco2b) 121579700(bco2a) 121584640 |
| ELS: | 105008707 105014498 105024037(bco2) |
| OEP: | 134015353(bco2l) 134028625(bco2b) 134039614 |
| SFM: | 108928652(bco2) 108936233 |
| AANG: | 118209519 118236232 |
| AROT: | 135235521 135242638 135263466 |
| CCOG: | 133107548 133134094 133134095 |
| ARUT: | 117397252 117966694 |
| BFO: | 118405340 118422787 118426367 118430143 |
| BBEL: | 109462202 109466559 109478965 109479070 109480113 109485646 |
| LPIC: | 129275072 129282301 |
| AJJ: | 139975578 139975580 139975995 |
| APLC: | 110986828 110986847 |
| ARUN: | 117291312 117303598 117303780 |
| AAMU: | 139939580 139952837 139953233 |
| SKO: | 100374086 100378360 102806764 |
| PFLL: | 139115077 139115094 139115105 139115112 139115121 139115465 139116787 139118584 139118670 139123524 139130679 139130686 139130688 139133504 139136486 139143880 |
| PVM: | 113807452 113807453 113828381 |
| PJA: | 122253355 122253356 122253357 122254393 122254963 122256731 |
| PCHN: | 125025090 125025091 125039792 125041119 |
| PMOO: | 119572849 119592077 119592078 |
| HAME: | 121865949 121869974 |
| PCLA: | 123746051 123756717 |
| MNZ: | 135199410 135199471 135205838 135207713 135208667 |
| MRJ: | 136829755 136845090 136845926 |
| PORN: | 139749237 139756101 139762688 |
| TCF: | 131881213 131881657 131881659 131890591 |
| PPOI: | 119100134 119100135 119101855 |
| RSAN: | 119389398 119389708 |
| TUT: | 107362151 107365605 107365606 107368310 |
| ABRU: | 129988112 129989206 |
| LPOL: | 106462687 106463062 106463116 106463584 106465040 |
| PVUL: | 126809677 126827130 |
| CANU: | 128161360 128163877 |
| AIRR: | 138307313 138307319 138315275 138315863 138316148 138316579 138316580 |
| MMER: | 123527023 123527545 123527854 123546058 123546755 123547836 |
| RPHI: | 132724619 132724621 132726963 132728193 132728197 132728201 132750779 132752490 132754376 |
| DPOL: | 127832108 127832109 127842167 127881918 |
| MAEA: | 128203172 128238245 128243501 |
| LAK: | 106163250 106178001 106181210 |
| MCAZ: | 138020081 138026412 138026899 |
| MFOO: | 137978767 137979243 137980110 137994899 |
| PDAM: | 113671272 113672890 113677527 |
| SPIS: | 111339979 111345287 111345292 |
| DGT: | 114517012 114523451 114523478 114523479 114528168 |
| KBS: | EPA93_05040 EPA93_13485 EPA93_29360 |
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| Reference |
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| Authors |
Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, von Lintig J |
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| Title |
Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Lindqvist A, He YG, Andersson S |
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| Title |
Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues. |
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| Journal |
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| Sequence |
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| Other DBs |
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| LinkDB |
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