KEGG ENZYME: 1.14.13.51

ENZYME: 1.14.13.51

Entry

EC 1.14.13.51               Enzyme

Name

6-oxocineole dehydrogenase;
6-oxocineole oxygenase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

6-oxocineole,NADPH:oxygen oxidoreductase

Reaction(IUBMB)

6-oxocineole + NADPH + H+ + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + NADP+ + H2O [RN:R02995]

Reaction(KEGG)

R02995

Substrate

6-oxocineole [CPD:C00848];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one [CPD:C04718];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Comment

The product undergoes non-enzymic cleavage and subsequent ring closure to form the lactone 4,5-dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-one.

History

EC 1.14.13.51 created 1992

Pathway

ec00902

Monoterpenoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Reference

Authors

Williams DR, Trudgill PW, Taylor DG.

Title

Metabolism of 1,8-cineole by Rhodococcus species: ring cleavage reactions.

Journal

J Gen Microbiol 135:1957-1967 (1989)

Other DBs

ExplorEnz - The Enzyme Database:

1.14.13.51

IUBMB Enzyme Nomenclature:

1.14.13.51

ExPASy - ENZYME nomenclature database:

1.14.13.51

BRENDA, the Enzyme Database:

1.14.13.51

CAS:	122933-80-6

LinkDB

DBGET integrated database retrieval system