KEGG ENZYME: 1.14.14.131

ENZYME: 1.14.14.131

Entry

EC 1.14.14.131              Enzyme

Name

bursehernin 5'-monooxygenase;
CYP71CU1 (gene name);
bursehernin 5'-hydroxylase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

(-)-bursehernin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5'-hydroxylating)

Reaction(IUBMB)

(-)-bursehernin + [reduced NADPH---hemoprotein reductase] + O2 = (-)-5'-demethylyatein + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11211]

Reaction(KEGG)

R11211

Substrate

(-)-bursehernin [CPD:C21183];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

(-)-5'-demethylyatein [CPD:C21184];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum. The enzyme is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.

History

EC 1.14.14.131 created 2016 as EC 1.14.13.213, transferred 2018 to EC 1.14.14.131

Pathway

ec00999

Biosynthesis of various plant secondary metabolites

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K21205

bursehernin 5'-monooxygenase