Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy

beta-amyrin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating)

beta-amyrin + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = 11-oxo-beta-amyrin + 2 [oxidized NADPH---hemoprotein reductase] + 3 H2O (overall reaction) [RN:R09817];
(1a) beta-amyrin + [reduced NADPH---hemoprotein reductase] + O2 = 11alpha-hydroxy-beta-amyrin + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R09815];
(1b) 11alpha-hydroxy-beta-amyrin + [reduced NADPH---hemoprotein reductase] + O2 = 11-oxo-beta-amyrin + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R09816]

R09815 R09816 R09817
Reaction

beta-amyrin [CPD:C08616];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007];
11alpha-hydroxy-beta-amyrin [CPD:C19942]

A cytochrome P-450 (heme-thiolate) protein from the plant Glycyrrhiza uralensis (Chinese licorice) that participates in the glycyrrhizin biosynthesis pathway. The enzyme is also able to oxidize 30-hydroxy-beta-amyrin to 11alpha,30-dihydroxy-beta-amyrin but this is not thought to be part of glycyrrhizin biosynthesis.

EC 1.14.14.152 created 2011 as EC 1.14.13.134, transferred 2018 to EC 1.14.14.152

1  [PMID:18779566]