KEGG ENZYME: 1.14.14.154

ENZYME: 1.14.14.154

Entry

EC 1.14.14.154              Enzyme

Name

sterol 14alpha-demethylase;
obtusufoliol 14-demethylase;
lanosterol 14-demethylase;
lanosterol 14alpha-demethylase;
sterol 14-demethylase;
CYP51 (gene name);
ERG11 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

sterol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving)

Reaction(IUBMB)

a 14alpha-methylsteroid + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = a Delta14-steroid + formate + 3 [oxidized NADPH---hemoprotein reductase] + 4 H2O (overall reaction) [RN:R12118];
(1a) a 14alpha-methylsteroid + [reduced NADPH---hemoprotein reductase] + O2 = a 14alpha-hydroxymethylsteroid + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12119];
(1b) a 14alpha-hydroxysteroid + [reduced NADPH---hemoprotein reductase] + O2 = a 14alpha-formylsteroid + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R12120];
(1c) a 14alpha-formylsteroid + [reduced NADPH---hemoprotein reductase] + O2 = a Delta14-steroid + formate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12121]

Reaction(KEGG)

R12118 > R05640 R05731;
R12119 R12120 R12121

Substrate

14alpha-methylsteroid [CPD:C21918];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007];
14alpha-hydroxysteroid;
14alpha-formylsteroid [CPD:C21921]

Product

Delta14-steroid [CPD:C21919];
formate [CPD:C00058];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001];
14alpha-hydroxymethylsteroid [CPD:C21920];
14alpha-formylsteroid [CPD:C21921]

Comment

This cytochrome P-450 (heme-thiolate) enzyme acts on a range of steroids with a 14alpha-methyl group, such as obtusifoliol and lanosterol. The enzyme catalyses a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond.

History

EC 1.14.14.154 created 2001 as EC 1.14.13.70, modified 2013, transferred 2018 EC 1.14.14.154

Pathway

ec00100

Steroid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K05917

sterol 14alpha-demethylase

K26422

Mimiviridae probable sterol 14alpha-demethylase

Genes

HSA:	1595(CYP51A1)

PTR:	463527(CYP51A1)

PPS:	100985833(CYP51A1)

GGO:	101127636 115930424

PON:	100171776(CYP51A1) 100456763

PPYG:

129011499 129040053

NLE:

100582853

HMH:

116814118

SSYN:

129479508

MCC:

703490

MCF:	102146764(CYP51A1)

MTHB:

126949911

MNI:

105475493

CSAB:

103226567(CYP51A1)

CATY:

105573073

PANU:

101018881

TGE:

112620077

MLEU:

105546502

RRO:

104654375

RBB:

108544026

TFN:

117073642

PTEH:

111552471

CANG:

105527047

CJC:	100403815(CYP51A1) 103792683

SBQ:

101036999

CIMI:

108309917(CYP51A1)

ANAN:

105716224(CYP51A1)

CSYR:

103250040

MMUR:

105879402

LCAT:

123647306

PCOQ:

105820124

OGA:

100959700

MMU:	13121(Cyp51)

MCAL:

110294823

MPAH:

110316208

RNO:	25427(Cyp51)

ANU:

117720531

ASYL:

127678315

MUN:

110562984

CGE:

100762189

MAUA:

101826047

PROB:

127216488

PLEU:

114688078

MORG:

121463334

MFOT:

126495905

AAMP:

119806414

NGI:

103725250

HGL:

101724157

CPOC:

100730760

CCAN:

109684681

DORD:

105992921 105992922

DSP:	122111838 122111878

PLOP:

125346994 125366408

NCAR:

124991648

MMMA:

107160045

ITI:

101955024

OCU:

100355623

OPI:

101517639

TUP:

102493691

GVR:

103590031

CFA:	475225(CYP51A1)

CLUD:

112674946

VVP:

112923882

VLG:

121475156

NPO:

129498221

AML:

100477744

UMR:

103658707

UAH:

113259854

UAR:

123789300

ELK:

111147264

LLV:

125080667

MPUF:

101671415

MNP:

132015957

MLK:

131829360

NVS:

122904807

ORO:

101381709

EJU:

114221218

ZCA:

113911015

MLX:

118020747

NSU:

110579982

LWW:

102737374

FCA:	101083499(CYP51A1)

PYU:

121028755

PCOO:

112866612

PBG:

122487867

PVIV:

125150647

LRUF:

124522891

LGF:

123607542

AJU:

106969977

PTG:

102954144

PPAD:

109263677

PUC:

125929901

PLEZ:

122207520

HHV:

120224629

BTA:	505060(CYP51A1)

BOM:	102282237(CYP51A1)

BIU:

109558194

BBUB:

102410939

BBIS:

104988467

CHX:

102177400

OAS:

101113583

BTAX:

128046414

CSUM:

138079660(CYP51A1)

ODA:

120877853

CCAD:

122438080

MREE:

136170426(CYP51A1)

OVR:	110135540(CYP51A1)

MBEZ:

129552211

SSC:	403334(CYP51)

CFR:

102515047

CBAI:

105072505

CDK:

105087385

VPC:

102540978

BACU:

103016503

BMUS:

118901012

LVE:

103083607

OOR:

101275315

LALB:

132524710

DLE:

111180826

PCAD:

102992983

PSIU:

116759577

NASI:

112414592

ECB:

100050921

EPZ:	103549183(CYP51A1)

EAI:

106832249

MYB:

102261507

MYD:

102765294

MMYO:

118666242

MLF:

102427291

MDT:

132242926

MYUM:

139016336(CYP51A1)

PKL:

118714312

EFUS:

103292937

MNA:

107541737

DRO:

112319863

SHON:

119000956

AJM:

119042729

PDIC:

114507716

PHAS:

123811186

MMF:

118620048

PPAM:

129062902

HAI:

109378118

RFQ:

117012423

PALE:

102886107 102893984

PGIG:

120615039

PVP:

105294534

RAY:

107519059

MJV:

108389928

TOD:

119241973

SARA:

101554364

SFUM:

130027350

SETR:

126001748

LAV:

100670599

TMU:

101349253

ETF:

101643704

DNM:

101427279

MDO:

100028071

GAS:

123248674

SHR:

100916047

AFZ:

127564782

PCW:

110209164

TVP:

118849983

PBRV:

138159879(CYP51A1)

OAA:

100087589

TACU:

119946330

GGA:	420548(CYP51A1)

PCOC:

116243246

MGP:

100538580

CJO:

107309008

TPAI:

128086769

NMEL:

110393597

APLA:

101791330

CATA:

118247423

AFUL:

116485530

TGU:

100220976

LSR:	110482429(CYP51A1)

SCAN:

103812812

PMOA:

120504063

OTC:

121338167

PRUF:

121353175

ATRC:

139590966(CYP51A1)

GFR:

102035109

FAB:

101818100

OMA:

130250413

PHI:

102113235

PMAJ:

107199957

CCAE:

111924212

CCW:

104689183

CBRC:

103612285

ACOE:

138106342(CYP51A1)

ETL:

114062125

ZAB:

102070332

ZLE:

135443724

ACHL:

103805793

SVG:

106852781

MMEA:

130582317

HRT:

120762021

SATI:

136360166(CYP51A1)

CCIC:

134045200

FPG:

101920327

FCH:

102048344

CCRI:

104164522

NNT:

104409125

SHAB:

115612977

ACUN:

113477142

TALA:

104358865

ACHC:

115339099

HALD:

104322344

HLE:

104835138

AGEN:

126037592

HHAR:

128148567

GCL:

127013089

CSTI:

104564066

LDI:

104348974

MNB:

103773112

DPUB:

104298279

PPUS:

135187887

AVIT:

104278257 104280066

BRHI:

104488971

EGZ:

104128884

NNI:

104014027

PCRI:

104025530

PCAO:

104044129

PADL:

103922388

AFOR:

103895930

FGA:

104070484

GSTE:

104251559

CLV:

102092834

MUI:

104537988

PGUU:

104461710

PLET:

104627851

EHS:

104507543

CMAC:

104487517

CUCA:

104057509

TEO:

104377010

BREG:

104636085

OHA:

104330896

ACAR:

104525654

CPEA:

104392200

CVF:

104289014

RTD:

128904732

CRID:

134511208

AAM:

106483616

AROW:

112965897

NPD:

112947354

TGT:

104580673

DNE:

112982314

SCAM:

104143646

ASN:

102386214

AMJ:	102567199(CYP51A1)

CPOO:

109308659

GGN:

109291397

PSS:

102445540

CMY:

102945327

CCAY:

125631422

DCC:

119851586

CPIC:

101934931

TST:

117872199

CABI:

116835338

MRV:

120398753

ACS:

100557431

ASAO:

132778859

PVT:

110074721

SUND:

121935508

PBI:

103065003

PMUR:

107286842

CTIG:

120314506

TSR:

106538331

PGUT:

117655141

APRI:

131196608

PTEX:

113451355

NSS:

113425906

VKO:

123020883

PMUA:

114607228

PRAF:

128398336

ZVI:

118092023

HCG:

128330079

GJA:

107108228

STOW:

125440827

EMC:

129337977

XLA:	100037098(cyp51a1.L) 447600(cyp51a1.S)

XTR:	548948(cyp51a1)

NPR:

108787913

RTEM:

120939926

BBUF:

121000609

BGAR:

122938184

PWL:	138261997(CYP51A1)

MUO:

115468460

GSH:

117354169

DRE:	414331(cyp51)

SRX:

107712294

SANH:

107694387

SGH:

107568024

CCAR:

109111832

CAUA:

113062450 113062498

CGIB:

127935110

PTET:

122335214

LROH:

127182327

OMC:

131525479

PPRM:

120475269 120475282

RKG:

130092375

MAMB:

125276031

CIDE:

127500689

CERY:

137037758(cyp51)

MASI:

127425565

TROS:

130567181

TDW:

130415226

MANU:

129455454

PDAB:

135773974

IPU:

108274811

IFU:

128618520

PHYP:

113525251

SMEO:

124392169

TFD:

113634009

TVC:

132857519

CGAR:

128542896

NGRA:

132882236

TRN:

134333265

AMEX:

103025877

CMAO:

118812765

EEE:

113590695

CHAR:

105904925

SPIL:

134072421

TRU:

101062187

TFS:

130518581

TNG:	GSTEN00032544G001

LCO:

104927570

NCC:

104962954

TBEN:

117477711

CGOB:

115015458

PGEO:

117455132(cyp51)

GACU:

117542669

EMAC:

134874592

ELY:

117263271

EFO:

125905160

PLEP:

121957574

SLUC:

116047367

ECRA:

117957116

ESP:

116701662

PFLV:

114568257

GAT:

120826698

PPUG:

119219440

AFB:

129097308

CLUM:

117739398

PSWI:

130193579

CANA:

137784684(cyp51)

CVE:	137872721(cyp51)

MSAM:

119907680

SCHU:

122864916

CUD:

121523306

SPUL:

138608504(cyp51)

LMIX:

132990880

ALAT:

119016455

ASTR:

137607475(cyp51)

MZE:

101487063

ONL:

100702293

OAU:

116320002

OLA:

101169834

OML:

112148369

CSAI:

133461041

XMA:

102232424

XCO:

114156093

XHE:

116731278

PRET:

103472487

PFOR:

103146847

PLAI:

106958682

PMEI:

106916865

GAF:

122843112

PPRL:

129375175

CVG:

107102957

CTUL:

119779664

GMU:

124879251

NFU:

107394621

KMR:

108238686

ALIM:

106518131

NWH:

119426155

AOCE:

111565075 129350737

EJA:	138214531(cyp51)

BFRE:

138618500(cyp51)

MCEP:

125020515

CSEM:

103394548

POV:

109648114

SSEN:

122786295

SSOE:

131446973

HHIP:

117770886

HSP:

118125232

PPLT:

128462077

SMAU:

118291669

LCF:

108879466

SDU:

111222971

SLAL:

111657606

XGL:

120785950

HCQ:

109512012

SSCV:

125986736(cyp51)

SBIA:

133498052

PEE:

133396184

PTAO:

133471444

BPEC:

110161131

ENY:	140361975 140361976

MALB:

109958704

BSPL:

114866236

SJO:

128374758

SSCO:

133996927

GMH:

115536308

SASA:

106570209 106588568

STRU:

115173678 115175799

OTW:	112229702 112264688

OMY:	110488242 110496341

OGO:	124012635 124043433

ONE:	115128486 115131522

OKI:	109903549 109907429

OKE:	118398089 118399422

OMM:	135549872 135552117

OCLA:

139373536 139392242

SALP:

111955261 111955711

SNH:	120022204 120026999

CCLU:

121585442 123491395

ELS:

105012654

OEP:

134040963

SFM:

108933335

PKI:

111843959

AANG:

118215084

AROT:

135260395

CCOG:

133108059

LOC:

102693705

PSPA:

121315018

ARUT:

117399525 117435357 117972329

PSEX:

120515852

LCM:

102347020

CMK:

103181227

RTP:

109915762

CPLA:

122549967

HOC:

132816096

LERI:

129709571

PMRN:

116945965

LRJ:

133345021

BFO:

118424043

BBEL:

109486589

SPU:	414330(cyp51)

LPIC:

129258956

APLC:

110975221

ARUN:

117299992

AAMU:

139949039

AFIL:

140144500 140151437 140166569 140167009 140169011

SKO:

100367489

PFLL:

139140619

PMEO:

129587499

HRO:	HELRODRAFT_157030

LGI:	LOTGIDRAFT_108695

PVUL:

126814734

PCAN:

112564918

LSAX:

138981315

BGT:

106072162

GAE:

121381676

HRF:

124131072

HRJ:

124283256

HASI:

137256038

HCRA:

139464320

OSN:

115229399

LJP:

135477492

LAK:	106174186 106178983

LLON:

135500228

TAD:	TRIADDRAFT_22633 TRIADDRAFT_22681

AQU:

100636481

ATH:	AT1G11680(CYP51G1)

ALY:

9325951

CRB:	111830156 17896812

CSAT:

104706593 104736309 104739814 104755421 104770430

EUS:	EUTSA_v10007480mg

BRP:	103836218 103842743 103871918

BNA:	106346420 106351696 106353584 106362160 106389549 106401015 111206219 125580295 125597274 125604033

BOE:	106295599 106308893 106311516 106320657 106328416

RSZ:	108809904 108818949

THJ:

104807262

CPAP:

110809570

CIT:

102623201

CIC:	CICLE_v10004850mg

PVY:	116125169 116130907

MINC:

123193412 123193486

TCC:

18608823

GRA:	105764229 105794825

GHI:	107896963 107909508 107941348 107946187

GAB:	108476525 108479419

HSYR:

120178097 120204605 120216110

DZI:	111290770 111309322

EGR:

104433736

RARG:

115753200

GMX:	100799526 100810799

GSJ:	114406543 114418744

PVU:

137812699

VRA:

106774110

VAR:

108347419

VUN:

114166877

VUM:

124847915

CCAJ:

109788471

APRC:

113849840

MTR:	11432420 25500003

TPRA:

123883389

CAM:

101504867

PSAT:

127076752

VVO:

131616078

LJA:

130742524

ADU:

107473174

AIP:

107624804

AHF:	112726731 112735507

LANG:

109325265 109354455

PCIN:

129288567

QSA:	O6P43_002528

FVE:	101305627(cyp51)

AANS:

126790558

RCN:

112197377

PPER:

18790148

PMUM:

103322154

PAVI:

110768705

PDUL:

117625263

MDM:	103433156 103452498

MSYL:

126596405 126607434

PXB:	103944757 103950392

PCOX:

137731153 137737217

ZJU:

107431761

MNT:	112090429 112094949 112095178 21386253

CSAV:

115712160

CSV:

101205062

CMO:

103494635

BHJ:

120073775

MCHA:

111015169

CMAX:

111470769 111480132

CMOS:

111439144 111457642

CPEP:

111790760 111799880

RCU:

8285703

MEAN:

126673746

JCU:

105647292

HBR:	110663613 110664907

MESC:

110603980 110621258

POP:	7481174 7482828

PEU:	105123105 105133781

PALZ:

118042716 118054407

PNZ:	133680593 133701554

JRE:	108997326 109006716 118344169

CILL:

122310454 122313495

CAVE:

132177156

AGLU:

133863660

QSU:

111985032

QLO:

115982020

TWL:	120000140 120007798

VVI:	100242104 100252340

VRI:	117919333 117928729

SLY:	100736446(CYP51)

SPEN:

107003288

SOT:

102601151

SSTN:

125844087

SDUL:

129887944

CANN:

107838742

LBB:

132625803

NTA:	107764727(CYP51) 107779000(NtCYP51-2)

NSY:

104231276

NTO:

104096055

NAU:

109244278

INI:

109176104

ITR:

116002000

SIND:

105168491 105169754

OEU:	111401661 111406212

EGT:	105957739 105968057

SSPL:

121746430 121753326 121796468

SMIL:

131005592

SHIS:

125188731 125208650

APAN:

127241417

HAN:	110920587 118479762

ECAD:

122578423

LSV:

111912345

CCAV:

112502448 112527780

DCR:

108228020

CSIN:

114261517

RVL:

131311892

AEW:	130772574 130791932

DLT:

127810062

BVG:	104905231 104906983

SOE:	110792055 110804460

CQI:	110688005 110689907 110720468 110721571 110726681 110728819 110728821 110728822

ATRI:

130798023 130798024

MOF:

131145159

NNU:	104591877 104592734

MING:

122061785

TSS:	122656514 122656763

PSOM:

113309841 113321918

OSA:	107275589 107275872 112939725 4328054 4329175 4338097 4338803 4350614 9269876

DOSA:

Os02g0113200 Os02g0323600 Os05g0211100 Os05g0416400 Os11g0525200

OBR:	102702392 102706941 102708311 102716753 102721945 102722234

OGL:	127754779 127761435 127763905 127772999 127773122 127774833 127780294

BDI:	100830263 100832594 100838679 100844089 100844692 100845001

ATS:	109733821 109738711 109739759 109743781 109745900 109746137 109748891 109751861 109756453 109759247 109759248 109759250 109759976 109770960 109772803 109776878 109777128 109782869 109787201 123493873

TDC:	119266702 119274369 119286258 119288375 119294231 119294333 119295519 119296732 119296769 119297269 119298738 119298739 119300208 119300586 119306979 119306981 119306983 119307202 119333619 119341833 119352065 119354101 119357397 119358548 119360211 119361868 119366884

TAES:

123038761 123039975 123040112 123043241 123048215 123048277 123048512 123049129 123051110 123056613 123064331 123067667 123074048 123075309 123076015 123086443 123089615 123089617 123089618 123089804 123089860 123090354 123091557 123096508 123100632 123100717 123100829 123101880 123101938 123101939 123101944 123106269 123110066 123115397 123115399 123115526 123119044 123119068 123124059 123124070 123124071 123160214 123163206 123187057 123188223 123191311

TUA:	125506823 125506824 125506825 125516273 125523155 125524664 125524708 125527673 125529024 125529326 125530453 125532590 125532592 125540581 125540619 125541352 125551117 125555410

LPER:

127294404 127295438 127299218 127306063 127306159 127313503 127314227 127317243 127329577 127329907 127330913 127331249 127333022 127335184 127336786 127344539 127349289 139830038 139833416 139835750

LRD:	124647099 124648856 124655801 124657931 124670142 124670456 124670963 124670964 124671190 124671191 124672710 124673024 124673278 124673541 124674437 124674438 124675753 124680401 124693155 124693158 124694294 124703283 124704244 124704676 124704705 124706278

SBI:	8054926 8062049 8062644 8062646 8062647 8062648 8062649 8064404 8071833 8074834 8081764 8083151 8084212

ZMA:	100191975 100273258 100382691 100383359 103635655 103652962 109946003

MFLO:

136480252 136480255 136482466 136489212 136490131 136499815 136503511 136503827 136504197 136504567 136509573 136535066 136535067 136535068 136545988 136549063 136551568

SITA:

101767793 101783068 101783468 101784673

SVS:	117833165 117833335 117833927 117844149

PVIR:

120644517 120644719 120659196 120662878 120686895

PHAI:

112879791 112879821 112887680 112895459 112902479 112902990

PAUA:

133886705 133892008 133900001 133900429

PDA:	103697889 103708119

EGU:	105051084 105060394

MUS:	103987267 135612650 135624677

ZOF:	121967512 122052742

DCT:

110107398

PEQ:

110032189

AOF:

109827282

MSIN:

131239284

ACAK:

137953921 137962421

NCOL:

116248841 116257357

ATR:

18434309

CJF:

131049157

SMO:	SELMODRAFT_155290 SELMODRAFT_178739(CYP51G1)

PPP:

112285583

CRE:	CHLRE_02g092350v5

VCN:	VOLCADRAFT_72667

CSL:	COCSUDRAFT_54016

CVR:	CHLNCDRAFT_56217

APRO:

F751_0875

OLU:	OSTLU_43938

OTA:	OT_ostta11g01340

BPG:	Bathy13g01980

MIS:	MICPUN_63226

MPP:	MICPUCDRAFT_48300

CME:	CYME_CMS319C

GSL:	Gasu_06490

CCP:	CHC_T00009303001

SCE:	YHR007C(ERG11)

SEUB:

DI49_4857

SPAO:

SPAR_H00490

AGO:	AGOS_ADR162W

ERC:

Ecym_6045

KLA:	KLLA0_E03653g

KMX:	KLMA_20551(CYP707A7)

LTH:	KLTH0G05148g

VPO:	Kpol_1004p61 Kpol_1023p61

ZRO:	ZYRO0D14036g

CGR:	2887532(ERG11)

NCS:	NCAS_0G00960(NCAS0G00960)

NDI:	NDAI_0F01100(NDAI0F01100)

TPF:	TPHA_0D02710(TPHA0D02710)

TBL:	TBLA_0E02810(TBLA0E02810)

TGB:	HG536_0A06110

TDL:	TDEL_0A04550(TDEL0A04550)

KAF:	KAFR_0C05720(KAFR0C05720)

KNG:	KNAG_0B03340(KNAG0B03340)

ZMK:	HG535_0D05540

SLUD:

SCDLUD_004912

DHA:	DEHA2E19272g

PIC:	PICST_63421(CP51)

PGU:	PGUG_03415

SPAA:

SPAPADRAFT_61116

LEL:	PVL30_004566(ERG11)

LBG:	92205256(LODBEIA_P00600) 92206304(LODBEIA_P11080) 92206423(LODBEIA_P12270) 92207256(LODBEIA_P20600) 92208333(LODBEIA_P31370) 92209064(LODBEIA_P38680) 92209874(LODBEIA_P46780) 92209993(LODBEIA_P47970) 92210898(LODBEIA_P57020)

CAL:	CAALFM_C500660CA(ERG11)

CTP:	CTRG_05283

COT:	CORT_0E05900

CDU:	CD36_50660(ERG11)

CTEN:

18247489(ERG11)

CLU:	CLUG_04932

CLUS:

A9F13_03g02992

CAUR:

CJI96_0001197

ASAU:

88175893(PUMCH_004833)

PPA:	PAS_chr3_0957

PKZ:	C5L36_0D02200

BNN:	FOA43_001357(ERG11)

BBRX:

BRETT_002515(ERG11)

OPA:	HPODL_03880

YLI:	2906856(YALI2_C00221g)

SLB:	AWJ20_2398(ERG11)

NCR:

NCU02624

NTE:	NEUTE1DRAFT119039(NEUTE1DRAFT_119039)

SMP:	10803582(SMAC4_05737)

PAN:	PODANSg09698

PBEL:

QC761_104470(ERG11)

PPSD:

QC762_104470(ERG11)

PPSP:

QC763_104470(ERG11)

PPSA:

QC764_104470(ERG11)

TTT:	THITE_135170

MTM:	MYCTH_110187

CTHR:

CTHT_0058120

RTHE:

98125739(VTJ83DRAFT_459)

MGR:	MGG_04432 MGG_04628

PPEI:

PpBr36_00220

PGRI:

PgNI_02936 PgNI_04906

TMN:	UCRPA7_2412 UCRPA7_7986 UCRPA7_8689

SSCK:

SPSK_09044

FGR:	FGSG_01000 FGSG_04092 FGSG_11024

FPU:	FPSE_00109 FPSE_01496 FPSE_02459

FPOA:

FPOAC1_001080(CYP51_1) FPOAC1_006536(CYP51_2) FPOAC1_009798

FVN:	FVRRES_01262 FVRRES_07143 FVRRES_10451

FVR:	FVEG_01123 FVEG_10277 FVEG_12391

FOX:	FOXG_00394 FOXG_11545 FOXG_13138

NHE:	NECHADRAFT_41888 NECHADRAFT_43488 NECHADRAFT_57370

FFC:	NCS54_00085400 NCS54_00743700

FKR:	NCS57_00083700

FMU:	J7337_000889(CYP51B) J7337_007737 J7337_011546(CYP51A)

TRE:	TRIREDRAFT_75468

TRR:	M419DRAFT_107898

TATV:

25778749(TrAtP1_007834) 25784813(TrAtP1_007176)

TASP:

36610304(CYP51)

MAW:	19251414(CYP51_1)

MAJ:	MAA_01342 MAA_04049

MBRN:

26240771(CP51) 26247057(CP51)

PCHM:

VFPPC_00539 VFPPC_17614

CMT:	CCM_03617 CCM_05535

AMUS:

LMH87_001019 LMH87_005964

PLJ:	28885295(PLICBS_006867) 28885802(PLICBS_007320)

PTKZ:

JDV02_005429(ERG11_1) JDV02_007132(ERG11_2)

VAL:	VDBG_04839

VDA:	VDAG_04380

CFJ:	CFIO01_02200 CFIO01_07699

CLUP:

CLUP02_05423

CHIG:

CH63R_00204 CH63R_00557

CDET:

87938903(CDEST_02400) 87939263(CDEST_02760)

SAPO:

SAPIO_CDS3145

ELA:	UCREL1_2130 UCREL1_93

PFY:	PFICI_01425 PFICI_03589

SSL:	SS1G_04805

BFU:	BCIN_01g02780

MBE:

MBM_02571

PSCO:

LY89DRAFT_680632

GLZ:	GLAREA_07764

ANI:	ANIA_01901 ANIA_08283

AFM:	AFUA_4G06890 AFUA_7G03740

ACT:	ACLA_005420 ACLA_046180

NFI:	NFIA_024690 NFIA_109350

AOR:	AO090003000205 AO090020000357 AO090026000842

ANG:	An11g02230 An13g00090

AFV:	AFLA_001488 AFLA_005443 AFLA_010303

ALUC:

AKAW2_20184S(ERG11_1) AKAW2_80194S(ERG11_2)

ACHE:

ACHE_40252S(ERG11_1) ACHE_70438A(ERG11_2)

APUU:

APUU_21172A(ERG11_1) APUU_60531S(ERG11_2)

PCS:	N7525_001490 N7525_009306

PDP:	PDIP_01820 PDIP_80150

POU:	POX_h09602

TMF:	EYB26_005602

TRG:	TRUGW13939_11895

CIM:	CIMG_00573 CIMG_07469

CPW:	9691916(ERG11_1) 9693625(ERG11_2)

URE:	UREG_00593 UREG_07804

ABE:	ARB_00950 ARB_05314

TVE:	TRV_00734 TRV_06889

PBL:	PAAG_00827

PBN:	PADG_04003

AJE:	HCAG_04048 HCAG_04481

BGH:	BDBG_01678 BDBG_04743

PNO:	SNOG_03702

PTE:	PTT_12247 PTT_15951

PTRR:

6346976(PtrM4_031460) 6347720(PtrM4_126540)

BSC:	COCSADRAFT_38642

AALT:

CC77DRAFT_1030793

ADAC:

96088594(ACET3X_008272)

ARAB:

EKO05_0008104

ZTR:	MYCGRDRAFT_110231(CYP-74)

PFJ:	MYCFIDRAFT_30715(CYP51)

FFU:	CLAFUR5_12471

CBET:

CB0940_05116 CB0940_11379

BCOM:

BAUCODRAFT_152483

NPA:	UCRNP2_2683 UCRNP2_9069

TML:	GSTUM_00011943001

SPO:	2542599(erg11)

SOM:	SOMG_01581(erg11)

CNE:

CNA00300

CNB:

CNBA0300

CNG:	CNAG_00040

CGI:	CGB_B0330W

CDEU:

CNBG_0513

CDEP:

91087568(L203_103357)

KMG:	30160494(I203_104372)

KNE:	92178707(IAR55_001448)

TMS:	TREMEDRAFT_38441

TASA:

A1Q1_02098

CCAC:

CcaHIS019_0407180(ERG11)

TVS:	TRAVEDRAFT_149846

DSQ:	DICSQDRAFT_124779 DICSQDRAFT_147974

PCO:	PHACADRAFT_132187 PHACADRAFT_214862

SHS:	STEHIDRAFT_137057 STEHIDRAFT_59772

HIR:	HETIRDRAFT_54612(cpm117)

PSQ:	PUNSTDRAFT_77711

ADL:	AURDEDRAFT_112774 AURDEDRAFT_162003

FME:	FOMMEDRAFT_102953

GTR:	GLOTRDRAFT_122087

RSX:	RhiXN_02876

LBC:	LACBIDRAFT_234769

CCI:	CC1G_07605 CC1G_08364

ABP:	AGABI1DRAFT114898(AGABI1DRAFT_114898)

ABV:	AGABI2DRAFT191124(AGABI2DRAFT_191124)

PCUB:

JR316_0005821 JR316_0009091 JR316_0010058

MPR:	MPER_03805

MRR:	Moror_12879

E1B28_011115

SCM:	SCHCO_02627525(SCHCODRAFT_02627525)

CPUT:

CONPUDRAFT_119932 CONPUDRAFT_155370

SLA:	SERLADRAFT_449218

WSE:	WALSEDRAFT_40560 WALSEDRAFT_59084

WIC:	J056_001735

UMA:	UMAG_03662

PFP:	PFL1_01234

SGRA:

EX895_001104

MGL:

MGL_2415

MRT:

MRET_3233

MSYM:

MSY001_1752

PGR:	PGTG_07202

PTRC:

PtA15_11A79

PSTR:

Pst134EA_017948

MLR:	MELLADRAFT_46108

RIE:	OCT59_014641

MBR:	MONBRDRAFT_38433

SRE:	PTSG_08301

DDI:	DDB_G0279403(CYP51)

DPP:	DICPUDRAFT_93794

DFA:	DFA_04411(CYP51)

ACAN:

ACA1_372720

PTI:	PHATRDRAFT_31339

FCY:	FRACYDRAFT_238997

TPS:	THAPSDRAFT_33926

NGD:	NGA_0373310(CYP51) NGA_0373320(CYP51)

SPAR:

SPRG_09493

TBR:	Tb11.02.4080

TBG:	TbgDal_XI7000

TCR:	506297.260 510101.50

LMA:	LMJF_11_1100

LIF:	LINJ_11_1100

LDO:	LDBPK_111100

LMI:	LMXM_11_1100

LMAT:

92516539(LSCM1_06615)

LBZ:	LBRM_11_0880

LPAN:

LPMP_111090

LOI:	92361909(LSCM4_06050)

LEIS:

94181965(GH5_06673)

LENR:

94174100(CUR178_06940)

LEIN:

94190368(JIQ42_06767)

PHET:

94293073(JKF63_07052)

NGR:	NAEGRDRAFT_48319 NAEGRDRAFT_82952

GTT:	GUITHDRAFT_114338

KAK:	Kalk_07360

SNAN:

I6N98_15680

MCA:	MCA2711(cyp51)

METU:

GNH96_14140

MMEO:

OOT43_14850

MEEF:

JWZ97_04965

MRP:	NM686_021165

MAH:	MEALZ_0770(cyp)

MBUR:

EQU24_17575

MMAI:

sS8_2580

MSZE:

MSZNOR_2690(cyp)

MMOB:

F6R98_20975

MEIN:

methR_P0941

MISZ:

MishRS11D_35610(cyp51)

MESL:

KKZ03_03305

MECH:

Q9L42_015320

MLAU:

ACEPPP_19420

SINI:

GT972_07865

GPB:	HDN1F_11100(cyp51)

NAR:

Saro_3659

NPP:	PP1Y_Mpl3478

NOT:	C7W88_20465

NOVO:

IM701_17875

NTD:	EGO55_03275

CAEN:

K5X80_02775

PAUU:

E8A73_027920

MRM:	A7982_00879

SAMY:

DB32_006288

NANN:

O0S08_14300

MTU:	Rv0764c(cyp51)

MTV:	RVBD_0764c

MTC:

MT0788

MRA:	MRA_0773(cyp51)

MTF:	TBFG_10779

MTB:	TBMG_00779

MTK:	TBSG_00783

MTZ:	TBXG_000772

MTG:	MRGA327_04755

MTI:	MRGA423_04780

MTE:	CCDC5079_0706

MTUR:

CFBS_0803(cyp51)

MTL:	CCDC5180_0698

MTO:	MTCTRI2_0783(cyp51)

MTN:	ERDMAN_0846(cyp51)

MTJ:	J112_04110

MTUB:

MT7199_0785

MTUC:

J113_05390

MTUE:

J114_04080

MTX:	M943_04000

MTUH:

I917_05415

MTUL:

TBHG_00756

MTUT:

HKBT1_0803(cyp51)

MTUU:

HKBT2_0804(cyp51)

MTQ:	HKBS1_0803(cyp51)

MBO:	BQ2027_MB0787C(cyp51)

MBB:	BCG_0816c(cyp51)

MBT:	JTY_0786(cyp51)

MBM:	BCGMEX_0787c(cyp51)

MBK:	K60_008170

MBX:

BCGT_0565

MAF:	MAF_07760(cyp51)

MMIC:

RN08_0853

MCE:	MCAN_07681(cyp51)

MCQ:	BN44_10834(cyp)

MCV:	BN43_20199(cyp)

MCX:	BN42_20522(cyp)

MCZ:	BN45_20033(cyp)

MORY:

MO_000819(cyp51)

MPA:

MAP_0598c

MAO:

MAP4_3267

MAVI:

RC58_16215

MAVU:

RE97_16245

MAV:

MAV_0708

MAVM:

MAA44156_00612

MIT:	OCO_06010 OCO_10820

MIA:

OCU_06050

MID:

MIP_01081

MYO:

OEM_06100

MCHI:

AN480_02995

MIR:

OCQ_06160

MMAL:

CKJ54_02940

MMAN:

MMAN_49000

MSER:

MTY59_25430

MSA:	Mycsm_05681

MUL:	MUL_0473(cyp51B1)

MMI:	MMAR_4932(cyp51B1)

MMAE:

MMARE11_47420(cyp51B1)

MSHO:

MSHO_03830(cyp51)

MMC:

Mmcs_4582

MKM:

Mkms_4670

MJL:

Mjls_4965

MMM:

W7S_02950

MKN:	MKAN_11280

MYV:	G155_05100

MYE:	AB431_25980

MHAD:

B586_05055

MDX:	BTO20_30830

MSHG:

MSG_04432

MFJ:	MFLOJ_41800

MSTO:

MSTO_45820

MSIM:

MSIM_30210

MSAK:

MSAS_27680 MSAS_51760

MKU:	I2456_00480 I2456_25125

MLW:	MJO58_24490

MXE:	MYXE_06880(cyp51)

MNV:	MNVI_11300(cyp51)

MPAG:

C0J29_26970

MNM:	MNVM_24760

MGOR:

H0P51_25155

MCOO:

MCOO_25730

MBAI:

MB901379_04318

MSEO:

MSEO_33450

MHEK:

JMUB5695_00600(cyp51)

MGAU:

MGALJ_37100

MLJ:	MLAC_00920(cyp51)

MBRD:

MBRA_21600(cyp51)

MSHJ:

MSHI_39930(cyp51)

MMAM:

K3U93_22040

MSPG:

F6B93_19920

MOT:	LTS72_00505

MPAA:

MKK62_03015

MKY:	IWGMT90018_56090

MADI:

A7U43_07365

MWU:	PT015_14930

MYW:	BVC93_08575

MYJ:	BCA37_03420

MSM:	MSMEG_5863

MSG:	MSMEI_5704(cyp51)

MSB:	LJ00_28995

MSN:	LI99_29000

MSH:	LI98_29005

MVA:

Mvan_5161

MGI:

Mflv_1596

MSP:	Mspyr1_09820

MCB:	Mycch_4522

MNE:	D174_23860

MYN:	MyAD_23405

MFT:	XA26_09840

MPHL:

MPHLCCUG_00651

MVQ:

MYVA_5043

MLL:	B1R94_24600

MRH:	MycrhN_2410

MTHN:

4412656_03988

MHAS:

MHAS_03647

MDU:	MDUV_50400

MCHT:

MCHIJ_20730

MAUU:

NCTC10437_04921

MMAG:

MMAD_47320

MMOR:

MMOR_13190

MFX:	MFAL_34240

MAIC:

MAIC_06480

MIJ:	MINS_42560

MALV:

MALV_43560

MTY:	MTOK_23560

MPSC:

MPSYJ_17000

MARZ:

MARA_49270

MGAD:

MGAD_36230

MHEV:

MHEL_28850 MHEL_39460

MSAR:

MSAR_10030

MANY:

MANY_32040

MAUB:

MAUB_38880

MPOF:

MPOR_52660

MPHU:

MPHO_31220

MMUC:

C1S78_002305

MMAT:

MMAGJ_35600

MBOK:

MBOE_20920

MFG:	K6L26_06095

MSEI:

MSEDJ_01170

MFLV:

NCTC10271_00605

MCEE:

MCEL_39170

MMON:

EWR22_24800

MGO:	AFA91_11405

MHOL:

K3U96_03730

MSEN:

K3U95_24735

MPAE:

K0O64_25440

MRF:	MJO55_23520

MDF:	K0O62_25075

MCRO:

MI149_25745

MGRO:

FZ046_02245

MAUS:

JN090_25640

MFRE:

EXE63_19435

MBUG:

MU0053_000507

MKR:	MKOR_36980(cyp51)

MPAK:

MIU77_02625 MIU77_05560

MAB:

MAB_1214c

MMV:	MYCMA_0649

MABB:

MASS_1212

MABL:

MMASJCM_1241

MCHE:

BB28_06025

MIZ:	BAB75_06615

MSTE:

MSTE_01180

MSAO:

MYCSP_05360

MSAL:

DSM43276_01080

MJD:	JDM601_3604(cyp51B1)

MTER:

4434518_03583(cyp51B1)

MMIN:

MMIN_11340(cyp51)

MHIB:

MHIB_30060(cyp51)

MHER:

K3U94_20360

MVM:	MJO54_20275

MKK:	MU0083_003340

NFA:	NFA_25890(cyp51)

NFR:	ERS450000_01506

NCY:	NOCYR_4381(cyp)

NBR:	O3I_020205

NNO:	NONO_c19250(cyp51)

NSL:	BOX37_22000

NSR:	NS506_00432

NOZ:	DMB37_00325

NOD:	FOH10_29895

NAD:	NCTC11293_04154

NWL:	NWFMUON74_28910

NIE:	KV110_20635

NTC:	KHQ06_07700

NHU:	H0264_02880

NYA:	LTV02_29840

NGP:	LTT66_31140

NSPU:

IFM12276_41700(cyp51)

NYU:	D7D52_03595

NVU:	V7968_27865

RHA:	RHA1_ro04671

RER:	RER_33770(cyp51)

REY:

O5Y_15560

REB:	XU06_15795

RQI:	C1M55_16810

ROP:	ROP_47700(cyp51)

ROA:	Pd630_LPD01177

RBY:	CEJ39_06630

RAV:	AAT18_05725

RRZ:	CS378_20960

RHQ:	IM25_09960

RHOD:

AOT96_26995

RRT:	4535765_00833

RCR:	NCTC10994_01884

RKO:	JWS14_25880

RGO:	KYT97_05650

ROZ:	CBI38_04920

RPSK:

JWS13_18620

RGOR:

NMQ04_03620

RHOO:

RA302_16020

RHOU:

KZJ41_06265

RHOW:

A4U64_18825

RHOJ:

JVH1_12895

RHOS:

QWW67_23210

RHOQ:

QWW98_23220

RHOY:

QNA09_03530

RHOH:

CPI83_13190

RHJS:

OYT95_13395

REQ:

REQ_13820

PSOW:

ABI214_06290

WHR:	OG579_07790

GBR:

Gbro_3843

GPO:	GPOL_c37060(cyp)

GOR:

KTR9_3783

GOQ:	ACH46_16315

GTA:	BCM27_19805

GOC:	CXX93_18550

GRU:	GCWB2_19410

GOM:	D7316_04872

GAV:	C5O27_08725

GOD:	GKZ92_18340

GOS:	QAD21_18740

GOJ:	GR168_18105

GAM:	GII34_18275

GPD:	GII33_17740

GJI:	H1R19_18145

GOI:	LK459_15350

GHN:	MVF96_18740

GAMI:

IHQ52_22320

GMG:	NWF22_03795

GSI:	P5P27_02155

GOO:	HUN08_14570

GOP:	ACE11G_14645

SPIN:

KV203_10825

DTM:	BJL86_2462

DIZ:	CT688_12055

DPC:	A6048_12595

DLU:	A6035_11680

DKN:	NHB83_12045

TOY:	FO059_16600

SRK:	FGW37_00280 FGW37_00295

NANO:

G5V58_09230

NARO:

CFH99_04145

NPI:	G7071_10675

NPC:	KUV85_16450

NMAR:

HPC71_15450

NFC:	KG111_02625

NBI:	SHK19_12770

NOCR:

OSR43_15430

NOCW:

ABFU82_24970

NOCL:

KM427_18740

NOCD:

QJ852_22465

NOCQ:

QI633_03520

PSIM:

KR76_04945

ACTW:

F7P10_05445

ACIR:

OG979_06985

SPIQ:

OHA34_32910

NOA:	BKM31_07880

NGN:	LCN96_33425

SEN:	SACE_3928(cyp51)

ACYN:

ORV05_11385

SESP:

BN6_77630(cyp51)

MICF:

QQG74_13255

ABAI:

IMCC26256_1118

AQZ:	KSP35_03565

IAM:	HC251_06735

IMA:	PO878_16000

DHI:	LH044_07640

NOSQ:

PQG02_34225

PBF:	CFX0092_B0442

» show all

Reference

Authors

Alexander K, Akhtar M, Boar RB, McGhie JF, Barton DHR.

Title

The removal of the 32-carbon atom as formic acid in cholesterol biosynthesis.

Journal

J Chem Soc Chem Commun 383-385 (1972)

Reference

2 [PMID:6363414]

Authors

Yoshida Y, Aoyama Y

Title

Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. I. Purification and spectral properties.

Journal

J Biol Chem 259:1655-60 (1984)

Reference

3 [PMID:6420412]

Authors

Aoyama Y, Yoshida Y, Sato R

Title

Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. II. Lanosterol metabolism by purified P-450(14)DM and by intact microsomes.

Journal

J Biol Chem 259:1661-6 (1984)

Reference

4 [PMID:1872829]

Authors

Aoyama Y, Yoshida Y

Title

Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of Saccharomyces cerevisiae and rat liver for 24-methylene-24,25-dihydrolanosterol and 24,25-dihydrolanosterol.

Journal

Biochem Biophys Res Commun 178:1064-71 (1991)
DOI:10.1016/0006-291X(91)91000-3

Reference

5 [PMID:1567403]

Authors

Aoyama Y, Yoshida Y.

Title

The 4 beta-methyl group of substrate does not affect the activity of lanosterol 14 alpha-demethylase (P-450(14)DM) of yeast: difference between the substrate recognition by yeast and plant sterol 14 alpha-demethylases.

Journal

Biochem Biophys Res Commun 183:1266-72 (1992)
DOI:10.1016/S0006-291X(05)80327-4

Reference

6 [PMID:9076987]

Authors

Bak S, Kahn RA, Olsen CE, Halkier BA

Title

Cloning and expression in Escherichia coli of the obtusifoliol 14 alpha-demethylase of Sorghum bicolor (L.) Moench, a cytochrome P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and mammals.

Journal

Plant J 11:191-201 (1997)
DOI:10.1046/j.1365-313X.1997.11020191.x

Sequence

[sbi:8074834]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.154

IUBMB Enzyme Nomenclature:

1.14.14.154

ExPASy - ENZYME nomenclature database:

1.14.14.154

BRENDA, the Enzyme Database:

1.14.14.154

CAS:	60063-87-8

LinkDB

DBGET integrated database retrieval system