KEGG ENZYME: 1.14.14.164

ENZYME: 1.14.14.164

Entry

EC 1.14.14.164              Enzyme

Name

fraxetin 5-hydroxylase;
CYP82C4;
fraxetin 5-monooxygenase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

fraxetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5-hydroxylating)

Reaction(IUBMB)

fraxetin + [reduced NADPH---hemoprotein reductase] + O2 = sideretin (reduced form) + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12223]

Reaction(KEGG)

R12223

Substrate

fraxetin [CPD:C09265];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

sideretin [CPD:C22007];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.

History

EC 1.14.14.164 created 2018

Pathway

ec00999

Biosynthesis of various plant secondary metabolites

ec01110

Biosynthesis of secondary metabolites

Orthology

K23136

fraxetin 5-hydroxylase

Genes

ATH:	AT4G31940(CYP82C4)

ALY:

9303340

CRB:

17879967

CSAT:

104716994 104720023 104721639 104727626 104730082 104733184

BRP:

103835488

BNA:	106390013 106449600

BOE:

106333001

RSZ:

108821793

THJ:	104803692 104819460 104819461

CPAP:

110813494

CIT:

102608597

CIC:	CICLE_v10003803mg

PVY:	116137768 116140031

MINC:

123228524

TCC:

18591293

GRA:

105769156

GHI:	107888141 107942681

GAB:

108471489

HSYR:

120167556

DZI:	111311379 111314823

GMX:

100811993

GSJ:

114408673

PVU:	PHAVU_009G061600g

VRA:

106760470

VAR:

108342698

VUN:

114162602

VUM:

124824491

CCAJ:

109802833

APRC:

113865890

LJA:

130720775

ADU:

107460456

AIP:

107610187

AHF:	112705794 112762412

LANG:

109343928

QSA:	O6P43_018869

FVE:

105350002

PPER:

18789706

PMUM:

103320922

PAVI:

110762562

PDUL:

117615155

MDM:

103441505

MSYL:

126603185

PXB:

103954079

MNT:	112091840 21404129

CSAV:

115725723

RCU:	8260896 8260897 8260900

JCU:	105633709 105633710 105633711

HBR:	110661464 110661466

MESC:

110614589 110615124 110616234

POP:

18104964

PEU:

105130198

PALZ:

118034182 118034206 118036573

PNZ:

133681497

JRE:

109010345

CILL:

122297470

CAVE:

132185629

QSU:

112004233

QLO:

115957904

TWL:

120000202

VVI:

100247206

VRI:

117907345

SLY:

101267593

SPEN:

107007174

SOT:

102581162

SSTN:

125861990

SDUL:

129895103

LBB:

132602552

NTA:	107782393 107790829

NSY:

104246870

NTO:

104094857

NAU:

109215771

INI:

109169781

ITR:

116013393

OEU:

111381794

HAN:	110868438 110914130

ECAD:

122609547

LSV:	111876237 111876238 111893788

CCAV:

112511847

CSIN:

114289226 114302463 114311935 114311955

RVL:	131319191 131319630

NNU:	104594945 104602643

MING:

122057355 122057456 122062028 122064336 122064730 122064731 122066479 122069348 122070247 122072865 122072912 122073149 122073602 122074394 122074395 122074740 122074750 122075296 122075812 122075964 122076219 122076251 122077292 122079511 122086196 122086257 122093030

TSS:	122638622 122643304 122643712 122645181 122645182 122645310 122645792 122645793 122645796 122645799 122645805 122646692 122648499 122648500 122648503 122650927 122654093 122654104 122654105 122655608 122665079 122665816 122669424 122669804 122669805 122669806 122672531 122672552

MSIN:

131218600 131218601 131218602 131219075 131219134 131219135 131219136 131219137 131219138 131228921 131229439 131229683 131230491 131231031 131231046 131236884 131247622

NCOL:

116245832 116245835 116245851 116245854 116245899 116245912 116248524 116249848 116249858 116249984 116249996 116250038 116250385 116252370 116252483 116253042 116253192 116253742