Entry
Name
fraxetin 5-hydroxylase;
CYP82C4;
fraxetin 5-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
fraxetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
fraxetin + [reduced NADPH---hemoprotein reductase] + O2 = sideretin (reduced form) + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
R12223 ]
Reaction(KEGG)
Substrate
fraxetin [CPD:
C09265 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product
sideretin [CPD:
C22007 ];
[oxidized NADPH---hemoprotein reductase] [CPD:
C03161 ];
H2O [CPD:
C00001 ]
Comment
A cytochrome P-450 (heme-thiolate) protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.
History
EC 1.14.14.164 created 2018
Pathway
ec00999 Biosynthesis of various plant secondary metabolites
ec01110 Biosynthesis of secondary metabolites
Orthology
Genes
CSAT : 104716994 104720023 104721639 104727626 104730082 104733184
THJ : 104803692 104819460 104819461
RCU : 8260896 8260897 8260900
JCU : 105633709 105633710 105633711
MESC : 110614589 110615124 110616234
PALZ : 118034182 118034206 118036573
LSV : 111876237 111876238 111893788
CSIN : 114289226 114302463 114311935 114311955
MING : 122057355 122057456 122062028 122064336 122064730 122064731 122066479 122069348 122070247 122072865 122072912 122073149 122073602 122074394 122074395 122074740 122074750 122075296 122075812 122075964 122076219 122076251 122077292 122079511 122086196 122086257 122093030
TSS : 122638622 122643304 122643712 122645181 122645182 122645310 122645792 122645793 122645796 122645799 122645805 122646692 122648499 122648500 122648503 122650927 122654093 122654104 122654105 122655608 122665079 122665816 122669424 122669804 122669805 122669806 122672531 122672552
MSIN : 131218600 131218601 131218602 131219075 131219134 131219135 131219136 131219137 131219138 131228921 131229439 131229683 131230491 131231031 131231046 131236884 131247622
ACAK : 137940073 137943178 137943180 137945628 137945631 137945634 137945636 137945637 137946318 137946560 137951154 137951631 137951788 137951879 137952076 137952113 137952114 137952128 137952342 137952553 137952554 137952555 137952556 137952557 137952565 137952566 137952583 137952585 137952592 137952595 137952601 137953219 137953362 137955070 137956437 137963297 137965414
NCOL : 116245832 116245835 116245851 116245854 116245899 116245912 116248524 116249848 116249858 116249984 116249996 116250038 116250385 116252370 116252483 116253042 116253192 116253742
CJF : 131032818 131032848 131032889 131032891 131032904 131048076 131052997 131053004 131056029 131056031 131056034 131056972 131057325 131076765 131076769 131076771 131079478
» show all
Taxonomy
Reference
Authors
Rajniak J, Giehl RFH, Chang E, Murgia I, von Wiren N, Sattely ES
Title
Biosynthesis of redox-active metabolites in response to iron deficiency in plants.
Journal
Sequence
Other DBs
LinkDB
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